| UniProt ID | HECW2_HUMAN | |
|---|---|---|
| UniProt AC | Q9P2P5 | |
| Protein Name | E3 ubiquitin-protein ligase HECW2 | |
| Gene Name | HECW2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1572 | |
| Subcellular Localization | Cytoplasm. Cytoplasm, cytoskeleton, spindle . | |
| Protein Description | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. [PubMed: 12890487 Involved in the regulation of mitotic metaphase/anaphase transition] | |
| Protein Sequence | MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASSAREHLL -----CCCCHHHHHH | 36.07 | 22617229 | |
| 4 | Phosphorylation | ----MASSAREHLLF ----CCCCHHHHHHH | 38.10 | 22617229 | |
| 30 | Phosphorylation | LSPENLQSLAAQSSM CCHHHHHHHHHHCCC | 24.12 | 22210691 | |
| 35 | Phosphorylation | LQSLAAQSSMPENMT HHHHHHHCCCCCCCC | 24.71 | 22210691 | |
| 36 | Phosphorylation | QSLAAQSSMPENMTL HHHHHHCCCCCCCCE | 26.69 | 27251275 | |
| 42 | Phosphorylation | SSMPENMTLQRANSD CCCCCCCCEECCCCC | 31.18 | 22210691 | |
| 48 | Phosphorylation | MTLQRANSDTDLVTS CCEECCCCCCCCCCC | 40.68 | 19664994 | |
| 50 | Phosphorylation | LQRANSDTDLVTSES EECCCCCCCCCCCCC | 30.93 | 22617229 | |
| 54 | Phosphorylation | NSDTDLVTSESRSSL CCCCCCCCCCCHHHH | 33.79 | 23403867 | |
| 55 | Phosphorylation | SDTDLVTSESRSSLT CCCCCCCCCCHHHHH | 26.54 | 23403867 | |
| 153 | Phosphorylation | ISGALRATTPCITVK CCHHHHCCCCEEEEC | 25.49 | 23532336 | |
| 183 (in isoform 1) | Ubiquitination | - | 57.14 | 21890473 | |
| 183 | Ubiquitination | SGNLHSRKLVSFTLS CCCCCCCCEEEEEHH | 57.14 | 21890473 | |
| 190 | Phosphorylation | KLVSFTLSDLRAVGL CEEEEEHHHHHHCCC | 31.38 | 24719451 | |
| 198 | Ubiquitination | DLRAVGLKKGMFFNP HHHHCCCCCCCCCCC | 41.16 | - | |
| 199 | Methylation | LRAVGLKKGMFFNPD HHHCCCCCCCCCCCC | 61.73 | - | |
| 208 | Phosphorylation | MFFNPDPYLKMSIQP CCCCCCCCCCEECCC | 26.74 | - | |
| 210 | Ubiquitination | FNPDPYLKMSIQPGK CCCCCCCCEECCCCC | 25.43 | - | |
| 218 | Ubiquitination | MSIQPGKKSSFPTCA EECCCCCCCCCCCCC | 58.19 | - | |
| 219 | Phosphorylation | SIQPGKKSSFPTCAH ECCCCCCCCCCCCCC | 40.47 | 27251275 | |
| 220 | Phosphorylation | IQPGKKSSFPTCAHH CCCCCCCCCCCCCCC | 44.09 | 27251275 | |
| 270 | Phosphorylation | IKDKFAKSRPIIKRF CHHHHHHCCHHHHHH | 39.60 | 24719451 | |
| 381 | Phosphorylation | EDSAADGTPKHSFRT CCCCCCCCCCCCCCC | 29.70 | 23403867 | |
| 388 | Phosphorylation | TPKHSFRTSSTLEID CCCCCCCCCCEEEEC | 25.64 | 26657352 | |
| 389 | Phosphorylation | PKHSFRTSSTLEIDT CCCCCCCCCEEEECH | 19.64 | 26699800 | |
| 390 | Phosphorylation | KHSFRTSSTLEIDTE CCCCCCCCEEEECHH | 36.08 | 26699800 | |
| 391 | Phosphorylation | HSFRTSSTLEIDTEE CCCCCCCEEEECHHH | 28.33 | 28857561 | |
| 396 | Phosphorylation | SSTLEIDTEELTSTS CCEEEECHHHHHCCC | 36.70 | 26699800 | |
| 400 | Phosphorylation | EIDTEELTSTSSRTS EECHHHHHCCCCCCC | 32.99 | 26699800 | |
| 401 | Phosphorylation | IDTEELTSTSSRTSP ECHHHHHCCCCCCCC | 38.63 | 26699800 | |
| 402 | Phosphorylation | DTEELTSTSSRTSPP CHHHHHCCCCCCCCC | 26.03 | 26699800 | |
| 403 | Phosphorylation | TEELTSTSSRTSPPR HHHHHCCCCCCCCCC | 20.00 | 26699800 | |
| 404 | Phosphorylation | EELTSTSSRTSPPRG HHHHCCCCCCCCCCC | 39.40 | 26699800 | |
| 406 | Phosphorylation | LTSTSSRTSPPRGRQ HHCCCCCCCCCCCCC | 47.75 | 24719451 | |
| 407 | Phosphorylation | TSTSSRTSPPRGRQD HCCCCCCCCCCCCCC | 31.62 | 26699800 | |
| 415 | Phosphorylation | PPRGRQDSLNDYLDA CCCCCCCCHHHHHHH | 22.27 | 26471730 | |
| 419 | Phosphorylation | RQDSLNDYLDAIEHN CCCCHHHHHHHHHHC | 12.86 | 26471730 | |
| 433 | Phosphorylation | NGHSRPGTATCSERS CCCCCCCCCCCCCCC | 22.83 | 22210691 | |
| 435 | Phosphorylation | HSRPGTATCSERSMG CCCCCCCCCCCCCCC | 19.19 | 22210691 | |
| 437 | Phosphorylation | RPGTATCSERSMGAS CCCCCCCCCCCCCCC | 31.52 | 22210691 | |
| 444 | Phosphorylation | SERSMGASPKLRSSF CCCCCCCCCCHHHCC | 19.48 | 24719451 | |
| 449 | Phosphorylation | GASPKLRSSFPTDTR CCCCCHHHCCCCCCC | 46.93 | 27251275 | |
| 450 | Phosphorylation | ASPKLRSSFPTDTRL CCCCHHHCCCCCCCE | 28.89 | 27251275 | |
| 453 | Phosphorylation | KLRSSFPTDTRLNAM CHHHCCCCCCCEEEE | 48.25 | 26699800 | |
| 465 | Phosphorylation | NAMLHIDSDEEDHEF EEEEECCCCCCCCHH | 46.44 | 22468782 | |
| 480 | Phosphorylation | QQDLGYPSSLEEEGG HHHHCCCCCHHCCCC | 38.79 | 22468782 | |
| 504 | Phosphorylation | ADDGSLTSQTKLEDN CCCCCCCCCCCCCCC | 40.94 | 17929957 | |
| 506 | Phosphorylation | DGSLTSQTKLEDNPV CCCCCCCCCCCCCCC | 37.05 | 17929957 | |
| 742 | Phosphorylation | EVWQRRGSLEGAAAA HHHHHHCCHHHHHHH | 22.80 | - | |
| 791 | Phosphorylation | NGHQPLRSLPSVRQD CCCCCCCCCHHHHHC | 52.92 | 28674151 | |
| 794 | Phosphorylation | QPLRSLPSVRQDVSR CCCCCCHHHHHCHHH | 34.91 | 24719451 | |
| 832 | Phosphorylation | YVDHVNRTTTWQRPT EEEECCCCCCCCCCC | 24.31 | - | |
| 850 | Phosphorylation | APQVLQRSNSIQQME CCHHHHCCCHHHHHH | 23.20 | 22617229 | |
| 852 | Phosphorylation | QVLQRSNSIQQMEQL HHHHCCCHHHHHHHH | 24.03 | 22617229 | |
| 865 | Phosphorylation | QLNRRYQSIRRTMTN HHHHHHHHHHHHHCC | 14.77 | 24719451 | |
| 907 | Phosphorylation | RENILPHSTSRSRIT HHCCCCCCCCCCCEE | 26.58 | 26434776 | |
| 908 | Phosphorylation | ENILPHSTSRSRITL HCCCCCCCCCCCEEE | 25.73 | 26434776 | |
| 909 | Phosphorylation | NILPHSTSRSRITLL CCCCCCCCCCCEEEE | 31.13 | 26434776 | |
| 911 | Phosphorylation | LPHSTSRSRITLLLQ CCCCCCCCCEEEEEC | 28.00 | 23612710 | |
| 1011 | Phosphorylation | VDHNSRTTTFIDPRL ECCCCCEEEEECCCC | 20.71 | 23612710 | |
| 1012 | Phosphorylation | DHNSRTTTFIDPRLP CCCCCEEEEECCCCC | 20.27 | 23612710 | |
| 1022 | Phosphorylation | DPRLPLQSSRPTSAL CCCCCCCCCCCCHHH | 35.68 | 26434776 | |
| 1023 | Phosphorylation | PRLPLQSSRPTSALV CCCCCCCCCCCHHHH | 29.35 | 23403867 | |
| 1026 | Phosphorylation | PLQSSRPTSALVHRQ CCCCCCCCHHHHHHH | 26.06 | 23403867 | |
| 1027 | Phosphorylation | LQSSRPTSALVHRQH CCCCCCCHHHHHHHH | 23.45 | 23403867 | |
| 1040 | Phosphorylation | QHLTRQRSHSAGEVG HHHHHCCCCCCCCCC | 17.29 | 30242111 | |
| 1042 | Phosphorylation | LTRQRSHSAGEVGED HHHCCCCCCCCCCCC | 38.93 | 21955146 | |
| 1050 | Phosphorylation | AGEVGEDSRHAGPPV CCCCCCCCCCCCCCC | 22.97 | 29449344 | |
| 1062 | Phosphorylation | PPVLPRPSSTFNTVS CCCCCCCCCCCCCCC | 43.20 | 27251275 | |
| 1063 | Phosphorylation | PVLPRPSSTFNTVSR CCCCCCCCCCCCCCC | 39.44 | 27251275 | |
| 1064 | Phosphorylation | VLPRPSSTFNTVSRP CCCCCCCCCCCCCCC | 25.83 | 19651622 | |
| 1067 | Phosphorylation | RPSSTFNTVSRPQYQ CCCCCCCCCCCCCCC | 18.70 | 27251275 | |
| 1069 | Phosphorylation | SSTFNTVSRPQYQDM CCCCCCCCCCCCCCC | 35.88 | 27251275 | |
| 1167 | Phosphorylation | YCQSPRGSPVSSPQN HCCCCCCCCCCCCCC | 24.33 | 25849741 | |
| 1170 | Phosphorylation | SPRGSPVSSPQNSPG CCCCCCCCCCCCCCC | 39.42 | 27732954 | |
| 1171 | Phosphorylation | PRGSPVSSPQNSPGT CCCCCCCCCCCCCCC | 30.64 | 20363803 | |
| 1175 | Phosphorylation | PVSSPQNSPGTQRAN CCCCCCCCCCCCCCC | 21.32 | 22617229 | |
| 1178 | Phosphorylation | SPQNSPGTQRANARA CCCCCCCCCCCCCCC | 20.47 | 28192239 | |
| 1237 | Phosphorylation | FNQIMGYSRKDLQRN HHHHHCCCHHHHHHC | 27.42 | - | |
| 1310 | Phosphorylation | HHEWFRFSGRILGLA CCHHHHHHHHHHHHH | 23.94 | 27966365 | |
| 1398 | Phosphorylation | GGANIPVTEKNKKEY CCCCCCCCCCCHHHH | 35.57 | - | |
| 1439 | Phosphorylation | VVDARLVSVFDAREL HHCCEEEEEEEHHCE | 22.97 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HECW2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HECW2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48 AND SER-852, AND MASSSPECTROMETRY. | |
