dbPTM

TBG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBG1_HUMAN
UniProt AC	P23258
Protein Name	Tubulin gamma-1 chain
Gene Name	TUBG1
Organism	Homo sapiens (Human).
Sequence Length	451
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description	Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation..
Protein Sequence	MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQEQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	LCAEHGISPEGIVEE HHHHCCCCCCHHHHH	22.84	28509920
42	Phosphorylation	GIVEEFATEGTDRKD HHHHHHHCCCCCCCC	40.02	28509920
45	Phosphorylation	EEFATEGTDRKDVFF HHHHCCCCCCCCEEE	26.80	28509920
48	Ubiquitination	ATEGTDRKDVFFYQA HCCCCCCCCEEEEEC	62.14	21906983
80	Phosphorylation	VIHSILNSPYAKLYN HHHHHHCCCCHHHCC	18.82	25159151
82	Phosphorylation	HSILNSPYAKLYNPE HHHHCCCCHHHCCHH	19.05	23186163
84	Ubiquitination	ILNSPYAKLYNPENI HHCCCCHHHCCHHHE	45.74	21906983
113	Ubiquitination	SGFSQGEKIHEDIFD CCCCCCCCHHHHHHH	57.07	29967540
129	Phosphorylation	IDREADGSDSLEGFV HCCCCCCCCCCCEEE	25.27	22067460
131	Phosphorylation	READGSDSLEGFVLC CCCCCCCCCCEEEEE	29.98	22817900
163	Ubiquitination	RLNDRYPKKLVQTYS HHHHCCCCCCEEEEE	50.21	22817900
164	Ubiquitination	LNDRYPKKLVQTYSV HHHCCCCCCEEEEEC	49.76	21906983
168	Phosphorylation	YPKKLVQTYSVFPNQ CCCCCEEEEECCCCC	15.41	23401153
169	Phosphorylation	PKKLVQTYSVFPNQD CCCCEEEEECCCCCC	5.92	23401153
170	Phosphorylation	KKLVQTYSVFPNQDE CCCEEEEECCCCCCC	22.22	23401153
179	Phosphorylation	FPNQDEMSDVVVQPY CCCCCCCCCCEEEEC	25.80	23401153
186	Phosphorylation	SDVVVQPYNSLLTLK CCCEEEECCHHHHHH	10.57	23401153
188	Phosphorylation	VVVQPYNSLLTLKRL CEEEECCHHHHHHHH	20.93	23401153
191	Phosphorylation	QPYNSLLTLKRLTQN EECCHHHHHHHHHCC	35.21	23401153
193	Ubiquitination	YNSLLTLKRLTQNAD CCHHHHHHHHHCCCC	39.88	21906983
201	Glutathionylation	RLTQNADCVVVLDNT HHHCCCCEEEEECCH	2.02	22555962
249	Sulfoxidation	TLRYPGYMNNDLIGL CCCCCCCCCCCHHHH	4.72	28183972
263	Phosphorylation	LIASLIPTPRLHFLM HHHHHCCCCCEEEEC	17.66	28060719
274	Phosphorylation	HFLMTGYTPLTTDQS EEECCCCCCCCCCCH	17.11	24719451
277	Phosphorylation	MTGYTPLTTDQSVAS CCCCCCCCCCCHHHH	29.54	23403867
278	Phosphorylation	TGYTPLTTDQSVASV CCCCCCCCCCHHHHC	39.46	30576142
281	Phosphorylation	TPLTTDQSVASVRKT CCCCCCCHHHHCCHH	23.59	23403867
284	Phosphorylation	TTDQSVASVRKTTVL CCCCHHHHCCHHHHH	21.94	28348404
287	Ubiquitination	QSVASVRKTTVLDVM CHHHHCCHHHHHHHH	46.52	21906983
295	Methylation	TTVLDVMRRLLQPKN HHHHHHHHHHHCCCC	26.41	-
301	Ubiquitination	MRRLLQPKNVMVSTG HHHHHCCCCEEEECC	49.57	23000965
306	Phosphorylation	QPKNVMVSTGRDRQT CCCCEEEECCCCCCC	13.67	-
307	Phosphorylation	PKNVMVSTGRDRQTN CCCEEEECCCCCCCC	25.48	-
335	Ubiquitination	VDPTQVHKSLQRIRE CCHHHHHHHHHHHHH	54.74	33845483
336	Phosphorylation	DPTQVHKSLQRIRER CHHHHHHHHHHHHHH	18.17	27251275
344	Ubiquitination	LQRIRERKLANFIPW HHHHHHHHHHHCCCC	47.39	15367667
363	Ubiquitination	IQVALSRKSPYLPSA HHHHHHCCCCCCCCH	53.02	27667366
364	Phosphorylation	QVALSRKSPYLPSAH HHHHHCCCCCCCCHH	20.05	22067460
385	Phosphorylation	MANHTSISSLFERTC CCCCCCHHHHHHHHH	22.28	-
397	Acetylation	RTCRQYDKLRKREAF HHHHHHHHHHHHHHH	45.30	7824011
400	Acetylation	RQYDKLRKREAFLEQ HHHHHHHHHHHHHHH	66.09	7824019
400	Ubiquitination	RQYDKLRKREAFLEQ HHHHHHHHHHHHHHH	66.09	-
410	Ubiquitination	AFLEQFRKEDMFKDN HHHHHHHHHHHHHCC	60.39	21906983
415	Ubiquitination	FRKEDMFKDNFDEMD HHHHHHHHCCCCCCH	45.16	22817900
423	Phosphorylation	DNFDEMDTSREIVQQ CCCCCCHHHHHHHHH	28.51	-
424	Phosphorylation	NFDEMDTSREIVQQL CCCCCHHHHHHHHHH	24.53	-
435	Phosphorylation	VQQLIDEYHAATRPD HHHHHHHHHHHHCCC	7.94	25072903
439	Phosphorylation	IDEYHAATRPDYISW HHHHHHHHCCCCCCC	43.44	25072903
443	Phosphorylation	HAATRPDYISWGTQE HHHHCCCCCCCCCCC	10.27	27642862
448	Phosphorylation	PDYISWGTQEQ---- CCCCCCCCCCC----	23.75	26714015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
80	S	Phosphorylation	Kinase	CDK2	P24941	PSP
131	S	Phosphorylation	Kinase	BRSK1	Q8TDC3	Uniprot
131	S	Phosphorylation	Kinase	BRSK1	Q8TDC3-2	GPS
385	S	Phosphorylation	Kinase	BRSK1	Q8TDC3	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BRCA1	P38398	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
131	S	Phosphorylation		-
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDE1_HUMAN	NDE1	physical	11163258
PDC6I_HUMAN	PDCD6IP	physical	12771190
PSMD8_HUMAN	PSMD8	physical	10225950
PSME1_HUMAN	PSME1	physical	10225950
HSP74_HUMAN	HSPA4	physical	10225950
HS90A_HUMAN	HSP90AA1	physical	10225950
AURKA_HUMAN	AURKA	physical	20603326
ARC1B_HUMAN	ARPC1B	physical	20603326
GCP5_HUMAN	TUBGCP5	physical	21135143
GCP3_HUMAN	TUBGCP3	physical	21135143
TBG1_HUMAN	TUBG1	physical	21135143
GCP4_HUMAN	TUBGCP4	physical	21135143
CK5P3_HUMAN	CDK5RAP3	physical	21465471
CP110_HUMAN	CCP110	physical	12361598
BRCA1_HUMAN	BRCA1	physical	22833046
PRDX4_HUMAN	PRDX4	physical	22863883
SAMH1_HUMAN	SAMHD1	physical	22863883
ACTB_HUMAN	ACTB	physical	23443559
AGRIN_HUMAN	AGRN	physical	23443559
ARMC5_HUMAN	ARMC5	physical	23443559
BAG2_HUMAN	BAG2	physical	23443559
MZT1_HUMAN	MZT1	physical	23443559
PYR1_HUMAN	CAD	physical	23443559
CCDC8_HUMAN	CCDC8	physical	23443559
TCPB_HUMAN	CCT2	physical	23443559
TCPG_HUMAN	CCT3	physical	23443559
TCPD_HUMAN	CCT4	physical	23443559
TCPE_HUMAN	CCT5	physical	23443559
TCPZ_HUMAN	CCT6A	physical	23443559
TCPH_HUMAN	CCT7	physical	23443559
TCPQ_HUMAN	CCT8	physical	23443559
COIA1_HUMAN	COL18A1	physical	23443559
TBB5_HUMAN	TUBB	physical	23443559
RS18_HUMAN	RPS18	physical	23443559
DDA1_HUMAN	DDA1	physical	23443559
DSG1_HUMAN	DSG1	physical	23443559
DESP_HUMAN	DSP	physical	23443559
EF1A1_HUMAN	EEF1A1	physical	23443559
EF1A2_HUMAN	EEF1A2	physical	23443559
DSC1_HUMAN	DSC1	physical	23443559
RL17_HUMAN	RPL17	physical	23443559
RL24_HUMAN	RPL24	physical	23443559
RL23_HUMAN	RPL23	physical	23443559
MZT2B_HUMAN	MZT2B	physical	23443559
FGF2_HUMAN	FGF2	physical	23443559
FGF3_HUMAN	FGF3	physical	23443559
FILA_HUMAN	FLG	physical	23443559
GTF2I_HUMAN	GTF2I	physical	23443559
H2AV_HUMAN	H2AFV	physical	23443559
ECHA_HUMAN	HADHA	physical	23443559
ECHB_HUMAN	HADHB	physical	23443559
HNRPU_HUMAN	HNRNPU	physical	23443559
HS90A_HUMAN	HSP90AA1	physical	23443559
HS90B_HUMAN	HSP90AB1	physical	23443559
HS71L_HUMAN	HSPA1L	physical	23443559
GRP78_HUMAN	HSPA5	physical	23443559
HSP7C_HUMAN	HSPA8	physical	23443559
GRP75_HUMAN	HSPA9	physical	23443559
CH60_HUMAN	HSPD1	physical	23443559
IRS4_HUMAN	IRS4	physical	23443559
LAMA3_HUMAN	LAMA3	physical	23443559
LAMC1_HUMAN	LAMC1	physical	23443559
LAMP2_HUMAN	LAMP2	physical	23443559
LEG7_HUMAN	LGALS7	physical	23443559
LONM_HUMAN	LONP1	physical	23443559
MAGD2_HUMAN	MAGED2	physical	23443559
MMP27_HUMAN	MMP27	physical	23443559
RT34_HUMAN	MRPS34	physical	23443559
RT07_HUMAN	MRPS7	physical	23443559
NDKA_HUMAN	NME1	physical	23443559
NDK7_HUMAN	NME7	physical	23443559
RL13_HUMAN	RPL13	physical	23443559
PDCD5_HUMAN	PDCD5	physical	23443559
PFD2_HUMAN	PFDN2	physical	23443559
PKP1_HUMAN	PKP1	physical	23443559
PRPF3_HUMAN	PRPF3	physical	23443559
PTN23_HUMAN	PTPN23	physical	23443559
RAVR1_HUMAN	RAVER1	physical	23443559
RL10A_HUMAN	RPL10A	physical	23443559
RL10L_HUMAN	RPL10L	physical	23443559
RL13A_HUMAN	RPL13A	physical	23443559
RL14_HUMAN	RPL14	physical	23443559
RL18A_HUMAN	RPL18A	physical	23443559
RL21_HUMAN	RPL21	physical	23443559
RL22_HUMAN	RPL22	physical	23443559
RL26_HUMAN	RPL26	physical	23443559
RL26L_HUMAN	RPL26L1	physical	23443559
RL3_HUMAN	RPL3	physical	23443559
RL31_HUMAN	RPL31	physical	23443559
RL5_HUMAN	RPL5	physical	23443559
RL6_HUMAN	RPL6	physical	23443559
RL7_HUMAN	RPL7	physical	23443559
RLA0_HUMAN	RPLP0	physical	23443559
RLA2_HUMAN	RPLP2	physical	23443559
RS10_HUMAN	RPS10	physical	23443559
RS11_HUMAN	RPS11	physical	23443559
RS13_HUMAN	RPS13	physical	23443559
RS14_HUMAN	RPS14	physical	23443559
RS15_HUMAN	RPS15	physical	23443559
RS15A_HUMAN	RPS15A	physical	23443559
RS16_HUMAN	RPS16	physical	23443559
RS17_HUMAN	RPS17	physical	23443559
RS2_HUMAN	RPS2	physical	23443559
RS23_HUMAN	RPS23	physical	23443559
RS25_HUMAN	RPS25	physical	23443559
RS3_HUMAN	RPS3	physical	23443559
RS3A_HUMAN	RPS3A	physical	23443559
RS4X_HUMAN	RPS4X	physical	23443559
RS6_HUMAN	RPS6	physical	23443559
RS8_HUMAN	RPS8	physical	23443559
RS9_HUMAN	RPS9	physical	23443559
SKP1_HUMAN	SKP1	physical	23443559
SPIT2_HUMAN	SPINT2	physical	23443559
SPTB2_HUMAN	SPTBN1	physical	23443559
SPT6H_HUMAN	SUPT6H	physical	23443559
TCPA_HUMAN	TCP1	physical	23443559
TIM13_HUMAN	TIMM13	physical	23443559
TBA1A_HUMAN	TUBA1A	physical	23443559
TBA1C_HUMAN	TUBA1C	physical	23443559
TBA4A_HUMAN	TUBA4A	physical	23443559
TBB1_HUMAN	TUBB1	physical	23443559
TBB4B_HUMAN	TUBB4B	physical	23443559
GCP2_HUMAN	TUBGCP2	physical	23443559
GCP3_HUMAN	TUBGCP3	physical	23443559
GCP4_HUMAN	TUBGCP4	physical	23443559
GCP6_HUMAN	TUBGCP6	physical	23443559
UBB_HUMAN	UBB	physical	23443559
UBR5_HUMAN	UBR5	physical	23443559
UNC5B_HUMAN	UNC5B	physical	23443559
ZFAN3_HUMAN	ZFAND3	physical	23443559
OLA1_HUMAN	OLA1	physical	24289923
AUP1_HUMAN	AUP1	physical	26496610
KCC2G_HUMAN	CAMK2G	physical	26496610
TCPZ_HUMAN	CCT6A	physical	26496610
COX41_HUMAN	COX4I1	physical	26496610
CPSM_HUMAN	CPS1	physical	26496610
CPT1A_HUMAN	CPT1A	physical	26496610
HS90A_HUMAN	HSP90AA1	physical	26496610
HS90B_HUMAN	HSP90AB1	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
DNJB1_HUMAN	DNAJB1	physical	26496610
LG3BP_HUMAN	LGALS3BP	physical	26496610
PFD2_HUMAN	PFDN2	physical	26496610
RPN1_HUMAN	RPN1	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
LIPA1_HUMAN	PPFIA1	physical	26496610
DPM1_HUMAN	DPM1	physical	26496610
BAG2_HUMAN	BAG2	physical	26496610
KEAP1_HUMAN	KEAP1	physical	26496610
GCP3_HUMAN	TUBGCP3	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
GCP2_HUMAN	TUBGCP2	physical	26496610
TEST_HUMAN	PRSS21	physical	26496610
STIP1_HUMAN	STIP1	physical	26496610
GCN1_HUMAN	GCN1L1	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
GANAB_HUMAN	GANAB	physical	26496610
TIM13_HUMAN	TIMM13	physical	26496610
GCP4_HUMAN	TUBGCP4	physical	26496610
NDK7_HUMAN	NME7	physical	26496610
PKN3_HUMAN	PKN3	physical	26496610
CAB45_HUMAN	SDF4	physical	26496610
DJB11_HUMAN	DNAJB11	physical	26496610
XRN1_HUMAN	XRN1	physical	26496610
SQOR_HUMAN	SQRDL	physical	26496610
WIZ_HUMAN	WIZ	physical	26496610
FAKD5_HUMAN	FASTKD5	physical	26496610
TFB2M_HUMAN	TFB2M	physical	26496610
PDCL3_HUMAN	PDCL3	physical	26496610
CLP1L_HUMAN	CLPTM1L	physical	26496610
SGPP1_HUMAN	SGPP1	physical	26496610
TBA1C_HUMAN	TUBA1C	physical	26496610
LMNB2_HUMAN	LMNB2	physical	26496610
GCP6_HUMAN	TUBGCP6	physical	26496610
TIM50_HUMAN	TIMM50	physical	26496610
GCP5_HUMAN	TUBGCP5	physical	26496610
NEDD1_HUMAN	NEDD1	physical	26496610
RICTR_HUMAN	RICTOR	physical	26496610
LAMA1_HUMAN	LAMA1	physical	26496610
MZT2A_HUMAN	MZT2A	physical	26496610
KAPCA_HUMAN	PRKACA	physical	26496610
NDK7_HUMAN	NME7	physical	27173435
GCP4_HUMAN	TUBGCP4	physical	27173435
TCHP_HUMAN	TCHP	physical	27173435
FANCA_HUMAN	FANCA	physical	23806870

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615412	Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00570	Vinblastine

Regulatory Network of TBG1_HUMAN

Related Literatures of Post-Translational Modification

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