LAMA3_HUMAN - dbPTM
LAMA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAMA3_HUMAN
UniProt AC Q16787
Protein Name Laminin subunit alpha-3
Gene Name LAMA3
Organism Homo sapiens (Human).
Sequence Length 3333
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
Protein Description Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes..
Protein Sequence MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNYYFPDLHHMKYEIEDGSTPNGRDLRFGFDPLAFPEFSWRGYAQMTSVQNDVRITLNVGKSSGSLFRVILRYVNPGTEAVSGHITIYPSWGAAQSKEIIFLPSKEPAFVTVPGNGFADPFSITPGIWVACIKAEGVLLDYLVLLPRDYYEASVLQLPVTEPCAYAGPPQENCLLYQHLPVTRFPCTLACEARHFLLDGEPRPVAVRQPTPAHPVMVDLSGREVELHLRLRIPQVGHYVVVVEYSTEAAQLFVVDVNVKSSGSVLAGQVNIYSCNYSVLCRSAVIDHMSRIAMYELLADADIQLKGHMARFLLHQVCIIPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPTALILDVLSGRPFPHLPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLGRYVFVIHFYQAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRDQVIAEGQIEFDISEPEVAATVKVPEGKSLVLVRVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADRVDIPVSFNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVEPCRRRKEESDKNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIKIGKLQKRMWINVDVQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGSPIFKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISSSRQSLRLGGSNFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLMLLKGSTRFNKTKTFRINQLLQDTPVASPRSVKVWQDACSPLPKTQANHGALQFGDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTGTKNSFMALYLSKGRLVFALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAPVYLGSPPSGKPKSLPTNSFVGCLKNFQLDSKPLYTPSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQPGKHLCVYLEAGKVTASMDSGAGGTSTSVTPKQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAGQIPFPPASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNHIPVPVTEALEVQGPVSLNGCPDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129PhosphorylationGSERWWQSPPLSSGT
CCCCCCCCCCCCCCC		18.1124043423
133PhosphorylationWWQSPPLSSGTQYNR
CCCCCCCCCCCCCCE		32.2824043423
134PhosphorylationWQSPPLSSGTQYNRV
CCCCCCCCCCCCCEE		54.2524043423
136PhosphorylationSPPLSSGTQYNRVNL
CCCCCCCCCCCEEEE		29.8124043423
138PhosphorylationPLSSGTQYNRVNLTL
CCCCCCCCCEEEEEE		12.5524043423
142N-linked_GlycosylationGTQYNRVNLTLDLGQ
CCCCCEEEEEEEHHH		24.87UniProtKB CARBOHYD
163PhosphorylationILIKFANSPRPDLWV
HHHHHHCCCCCCEEE		20.8924719451
242N-linked_GlycosylationNGRPGAKNFTFSHTL
CCCCCCCCCCCCCHH		40.43UniProtKB CARBOHYD
256PhosphorylationLREFTKATNIRLRFL
HHHHHHHHCCEEEHH		32.5030576142
274PhosphorylationTLLGHLISKAQRDPT
HHHHHHHHHHHCCCC		28.44-
281PhosphorylationSKAQRDPTVTRRYYY
HHHHCCCCCCEEEEE		38.51-
286PhosphorylationDPTVTRRYYYSIKDI
CCCCCEEEEEEEEEE		11.94-
287PhosphorylationPTVTRRYYYSIKDIS
CCCCEEEEEEEEEEE		6.74-
288PhosphorylationTVTRRYYYSIKDISI
CCCEEEEEEEEEEEE		8.59-
289PhosphorylationVTRRYYYSIKDISIG
CCEEEEEEEEEEEEC		13.6724719451
343 (in isoform 4)Phosphorylation-14.7929083192
477O-linked_GlycosylationIPIFPVSTPSSEDPV
EEEECCCCCCCCCCC		27.68OGP
574PhosphorylationDRCLSGAYDFPHCQG
CCCCCCCCCCCCCCC		22.9530576142
591PhosphorylationSACDPAGTINSNLGY
CCCCCCCCCCCCCCE		21.0630576142
822PhosphorylationKEIIFLPSKEPAFVT
CEEEEECCCCCCEEE		52.3724719451
1085PhosphorylationALILDVLSGRPFPHL
EEEEHHHCCCCCCCC		32.3824719451
1236PhosphorylationITNCGKNSFYLDPQT
HHCCCCCCEECCHHH		20.82-
1342PhosphorylationPQCEVCETHSFSFHP
CCCEECCCCCEEEEC		20.0724043423
1344PhosphorylationCEVCETHSFSFHPMA
CEECCCCCEEEECCC		29.9724043423
1346PhosphorylationVCETHSFSFHPMAGC
ECCCCCEEEECCCCC		26.1724043423
1359PhosphorylationGCEGCNCSRRGTIEA
CCCCCCCCCCCCEEE		15.8324043423
1764PhosphorylationCKAGYTGTQCERCAP
EECCCCCCCCCCCCC		23.4228258704
1828PhosphorylationDCDSCVMTLLNDLAT
CHHHHHHHHHHHHHH		14.01-
1835PhosphorylationTLLNDLATMGEQLRL
HHHHHHHHHHHHHHH		32.76-
1936SumoylationSAKELDVKIKNVIRN
HHHHHCHHHHHHHHH		47.86-
1952 (in isoform 3)Phosphorylation-32.9029083192
2036PhosphorylationNEYEAKLSDLRARLQ
HHHHHHHHHHHHHHH		33.6124719451
2083PhosphorylationLQSDFTKYLTTADSS
CCCHHHHHHHHCCHH		13.2619835603
2089PhosphorylationKYLTTADSSLLQTNI
HHHHHCCHHHHHHHH		22.0319835603
2090PhosphorylationYLTTADSSLLQTNIA
HHHHCCHHHHHHHHH		33.3819835603
2136PhosphorylationLSRSAGKTSLVEEAE
HHHHCCCCCHHHHHH		26.7828509920
2137PhosphorylationSRSAGKTSLVEEAEK
HHHCCCCCHHHHHHH		33.6228509920
2218PhosphorylationDLPRKAKTLSSNSDK
HCCCHHHHCCCCHHH		36.4116674116
2220PhosphorylationPRKAKTLSSNSDKLL
CCHHHHCCCCHHHHH		32.4816674116
2286PhosphorylationGDIDAMISSAKSMVR
CCHHHHHHHHHHHHH		15.9123403867
2287PhosphorylationDIDAMISSAKSMVRK
CHHHHHHHHHHHHHH		28.8827251275
2290PhosphorylationAMISSAKSMVRKAND
HHHHHHHHHHHHHHH		23.4027251275
2365N-linked_GlycosylationQQLLPLGNISDNMDR
HHHCCCCCCCCCHHH		37.97UniProtKB CARBOHYD
2478PhosphorylationLQVDQILTKSETKEA
CCCEEEECHHHHHHH		33.8729978859
2480PhosphorylationVDQILTKSETKEAVM
CEEEECHHHHHHHHH		45.3129978859
2482PhosphorylationQILTKSETKEAVMDR
EEECHHHHHHHHHHH		41.0729978859
2502N-linked_GlycosylationIYQFARLNYTKGATS
HHHHHCCCCCCCCCC		36.55UniProtKB CARBOHYD
2503PhosphorylationYQFARLNYTKGATSS
HHHHCCCCCCCCCCC		17.8919835603
2510PhosphorylationYTKGATSSKPETPGV
CCCCCCCCCCCCCCE		48.1219835603
2523MethylationGVYDMDGRNSNTLLN
CEECCCCCCCCCCCC		38.86115386695
2558PhosphorylationSRLSFPPYKGCIELD
CCCCCCCCCCCEEHH		21.91-
2584N-linked_GlycosylationFKKTFNLNTTEVEPC
CCEEECCCCCCCCCC		46.16UniProtKB CARBOHYD
2658PhosphorylationDGKLMVRYKLNSELP
CCCEEEEEECCCCCC		14.3924732914
2662PhosphorylationMVRYKLNSELPKERG
EEEEECCCCCCHHCC		51.4524732914
2753PhosphorylationGVVRLNDTVGVTKKC
CEEEECCCCCCCCCC		20.3429052541
2757PhosphorylationLNDTVGVTKKCSEDW
ECCCCCCCCCCCCCC		20.8929052541
2771PhosphorylationWKLVRSASFSRGGQL
CEEEEEECCCCCCCE		25.6324719451
2879PhosphorylationSKRLKHISSSRQSLR
CHHHHHHHCCCCCHH		23.2124905233
2880PhosphorylationKRLKHISSSRQSLRL
HHHHHHHCCCCCHHC		29.0124905233
2881PhosphorylationRLKHISSSRQSLRLG
HHHHHHCCCCCHHCC		27.7823898821
2884PhosphorylationHISSSRQSLRLGGSN
HHHCCCCCHHCCCCC		17.8523898821
2915PhosphorylationPEVLDLTSNSLKRDV
HHHHHCCCCCCCCCC		31.55-
2923PhosphorylationNSLKRDVSLGGCSLN
CCCCCCCCCCCCCCC		26.11-
2975O-linked_GlycosylationKVWQDACSPLPKTQA
EEEHHCCCCCCCCCC		31.06OGP
3050PhosphorylationRLVFALGTDGKKLRI
CEEEEECCCCCEEEE		42.2919413330
3093PhosphorylationGLRAREGSLPGNSTI
CCEECCCCCCCCCEE		27.0028258704
3101PhosphorylationLPGNSTISIRAPVYL
CCCCCEEEEECCEEE		13.2024719451
3135PhosphorylationLKNFQLDSKPLYTPS
HHCCCCCCCCCCCCC		44.7724719451
3229PhosphorylationGAGGTSTSVTPKQSL
CCCCCCCCCCCCHHH		24.6224719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAMA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAMA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAMA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SDC2_HUMANSDC2physical
11373281
PLMN_HUMANPLGphysical
10956663
TPA_HUMANPLATphysical
10956663
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
226700Epidermolysis bullosa, junctional, Herlitz type (H-JEB)
245660Laryngoonychocutaneous syndrome (LOCS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAMA3_HUMAN

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Related Literatures of Post-Translational Modification

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