ARMC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMC5_HUMAN
• UniProt AC: Q96C12
• Protein Name: Armadillo repeat-containing protein 5 {ECO:0000305}
• Gene Name: ARMC5 {ECO:0000312|HGNC:HGNC:25781}
• Organism: Homo sapiens (Human).
• Sequence Length: 935
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production. [PubMed: 24283224]
• Protein Sequence: MAAAKPTLTDSLSFCLAQLAAAAGEALGGEKDPATNETPLSRALLALRTRHIKAAGGIERFRARGGLRPLLALLRRAAAAGSAPSQAGPGSAPSSAASGASSPAPASGPAPSAVSSSSPTPPVRLRKTLDLALSILADCCTEGACRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGNLAMEPESCGDIHCAGAVPLLVESLTACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDAALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAINRARLRDAGGLDLLMGLLRDPRASAWHPRIVAALVGFLYDTGALGRLQALGLVPLLAGQLCGEAGEEEEEGREAASWDFPEERTPERAQGGSFRSLRSWLISEGYATGPDDISPDWSPEQCPPEPMEPASPAPTPTSLRAPRTQRTPGRSPAAAIEEPWGREGPALLLLSRFSQAPDPSGALVTGPALYGLLTYVTGAPGPPSPRALRILSRLTCNPACLEAFVRSYGAALLRAWLVLGVAPDDWPAPRARPTLHSRHRELGERLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTLPFICRKPSLWRRLLLEQGGLRLLLAALTRPAPHPLFLFFAADSLSCLQDLVSPTVSPAVPQAVPMDLDSPSPCLYEPLLGPAPVPAPDLHFLLDSGLQLPAQRAASATASPFFRALLSGSFAEAQMDLVPLRGLSPGAAWPVLHHLHGCRGCGAALGPVPPPGQPLLGSEAEEALEAAGRFLLPGLEEELEEAVGRIHLGPQGGPESVGEVFRLGRPRLAAHCARWTLGSEQCPRKRGLALVGLVEAAGEEAGPLTEALLAVVMGIELGARVPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	KDPATNETPLSRALL CCCCCCCCHHHHHHH	31.44	21815630
53	Ubiquitination	ALRTRHIKAAGGIER HHHHHHHHHCCCHHH	26.51	-
82	Phosphorylation	RRAAAAGSAPSQAGP HHHHHCCCCCCCCCC	32.07	28450419
85	Phosphorylation	AAAGSAPSQAGPGSA HHCCCCCCCCCCCCC	32.17	28450419
91	Phosphorylation	PSQAGPGSAPSSAAS CCCCCCCCCCCCCCC	39.89	28450419
94	Phosphorylation	AGPGSAPSSAASGAS CCCCCCCCCCCCCCC	32.12	28450419
95	Phosphorylation	GPGSAPSSAASGASS CCCCCCCCCCCCCCC	27.13	28450419
98	Phosphorylation	SAPSSAASGASSPAP CCCCCCCCCCCCCCC	34.31	28450419
101	Phosphorylation	SSAASGASSPAPASG CCCCCCCCCCCCCCC	40.14	28450419
102	Phosphorylation	SAASGASSPAPASGP CCCCCCCCCCCCCCC	25.25	28450419
107	Phosphorylation	ASSPAPASGPAPSAV CCCCCCCCCCCCCCC	44.22	28450419
112	Phosphorylation	PASGPAPSAVSSSSP CCCCCCCCCCCCCCC	43.33	28450419
115	Phosphorylation	GPAPSAVSSSSPTPP CCCCCCCCCCCCCCC	24.99	28450419
116	Phosphorylation	PAPSAVSSSSPTPPV CCCCCCCCCCCCCCC	28.39	28450419
117	Phosphorylation	APSAVSSSSPTPPVR CCCCCCCCCCCCCCC	32.60	28450419
118	Phosphorylation	PSAVSSSSPTPPVRL CCCCCCCCCCCCCCH	34.44	28450419
120	Phosphorylation	AVSSSSPTPPVRLRK CCCCCCCCCCCCHHH	42.02	28450419
167	Phosphorylation	TILQCMKTDSIQNRT HHHHHHCCHHHHHHH	14.22	30622161
169	Phosphorylation	LQCMKTDSIQNRTAR HHHHCCHHHHHHHHH	31.16	30622161
294	Ubiquitination	VSLASHPKRAVREGT HHHHCCCCHHHHHCH	47.79	-
341	Phosphorylation	RRDPNGASPTSQQPL CCCCCCCCCCHHHHH	30.06	26055452
343	Phosphorylation	DPNGASPTSQQPLVR CCCCCCCCHHHHHHH	36.35	28450419
344	Phosphorylation	PNGASPTSQQPLVRA CCCCCCCHHHHHHHH	30.15	28450419
384	Phosphorylation	LLRDPRASAWHPRIV HHHCCCHHHCCHHHH	32.92	23532336
444	Phosphorylation	WDFPEERTPERAQGG CCCCCCCCCCHHCCC	32.55	28674419
455	Phosphorylation	AQGGSFRSLRSWLIS HCCCCHHHHHHHHHH	26.56	-
467	Phosphorylation	LISEGYATGPDDISP HHHCCCCCCCCCCCC	40.54	28348404
473	Phosphorylation	ATGPDDISPDWSPEQ CCCCCCCCCCCCHHH	24.65	28348404
477	Phosphorylation	DDISPDWSPEQCPPE CCCCCCCCHHHCCCC	26.41	28348404
503	Phosphorylation	TSLRAPRTQRTPGRS CCCCCCCCCCCCCCC	22.73	21712546
506	Phosphorylation	RAPRTQRTPGRSPAA CCCCCCCCCCCCHHH	21.93	21815630
510	Phosphorylation	TQRTPGRSPAAAIEE CCCCCCCCHHHHCCC	25.47	21815630
586	Phosphorylation	CLEAFVRSYGAALLR HHHHHHHHHHHHHHH	23.71	27499020
587	Phosphorylation	LEAFVRSYGAALLRA HHHHHHHHHHHHHHH	10.54	23911959
667	Ubiquitination	TLPFICRKPSLWRRL CHHHHHCCHHHHHHH	34.25	-
669	Phosphorylation	PFICRKPSLWRRLLL HHHHCCHHHHHHHHH	43.53	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMC5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ARMC5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615954: ACTH-independent macronodular adrenal hyperplasia 2 (AIMAH2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.