AUP1_HUMAN - dbPTM
AUP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AUP1_HUMAN
UniProt AC Q9Y679
Protein Name Ancient ubiquitous protein 1
Gene Name AUP1
Organism Homo sapiens (Human).
Sequence Length 476
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type III membrane protein
Cytoplasmic side .
Protein Description May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome..
Protein Sequence MELPSGPGPERLFDSHRLPGDCFLLLVLLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHSVRVLISNHVTPFDHNIVNLLTTCSTVSESEAESATGRFPGAQLKAPLSPLAFRMEDTEALPLTPILYPTCQFFFFIFLNIFLLAFSSPGSQPLLNSPPSFVCWSRGFMEMNGRGELVESLKRFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLRPVHRQLGEANEEFALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATLAQRVKEVLPHVPLGVIQRDLAKTGCVDLTITNLLEGAVAFMPEDITKGTQSLPTASASKFPSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERRAQEAD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MELPSGPG
-------CCCCCCCC		12.3122223895
5Phosphorylation---MELPSGPGPERL
---CCCCCCCCHHHC		70.9624043423
15PhosphorylationGPERLFDSHRLPGDC
CHHHCCCCCCCCHHH		11.8124043423
31PhosphorylationLLLVLLLYAPVGFCL
HHHHHHHHHHHHHHH		14.6124043423
68PhosphorylationLRRFVVRTMCAVLGL
HHHHHHHHHHHHHHH		12.6516674116
82PhosphorylationLVARQEDSGLRDHSV
HHHCCCCCCCCCCCE		38.6916674116
143UbiquitinationSPLAFRMEDTEALPL
CCCEECCCCCCCCCC		58.4827667366
143 (in isoform 2)Ubiquitination-58.4821890473
143 (in isoform 3)Ubiquitination-58.4821890473
200UbiquitinationRGFMEMNGRGELVES
CCCHHCCCCCHHHHH		37.3527667366
207PhosphorylationGRGELVESLKRFCAS
CCCHHHHHHHHHHHH		31.5421815630
209 (in isoform 1)Ubiquitination-53.3521890473
209UbiquitinationGELVESLKRFCASTR
CHHHHHHHHHHHHCC		53.3521890473
220PhosphorylationASTRLPPTPLLLFPE
HHCCCCCCCEEECCH		25.3221815630
250 (in isoform 3)Ubiquitination-2.1721890473
250 (in isoform 2)Ubiquitination-2.1721890473
250UbiquitinationWPFSIQDVVQPLTLQ
CCCCHHHHHHCCEEE		2.1723000965
264 (in isoform 2)Ubiquitination-21.5421890473
264 (in isoform 3)Ubiquitination-21.5421890473
264UbiquitinationQVQRPLVSVTVSDAS
EECCCEEEEEECCHH		21.5423000965
269 (in isoform 2)Ubiquitination-40.0421890473
269UbiquitinationLVSVTVSDASWVSEL
EEEEEECCHHHHHHH		40.0423000965
269 (in isoform 3)Ubiquitination-40.0421890473
288PhosphorylationFVPFTVYQVRWLRPV
HCCCEEEHHHHHHHH		17.6018691976
288 (in isoform 2)Phosphorylation-17.6024719451
292PhosphorylationTVYQVRWLRPVHRQL
EEEHHHHHHHHHHHH		2.8818669648
305UbiquitinationQLGEANEEFALRVQQ
HHHHCCHHHHHHHHH		35.7133845483
307UbiquitinationGEANEEFALRVQQLV
HHCCHHHHHHHHHHH		9.5723000965
316UbiquitinationRVQQLVAKELGQTGT
HHHHHHHHHHCCCCC		46.0922053931
316 (in isoform 1)Ubiquitination-46.0921890473
321UbiquitinationVAKELGQTGTRLTPA
HHHHHCCCCCCCCHH		38.4321890473
323PhosphorylationKELGQTGTRLTPADK
HHHCCCCCCCCHHHH		26.3729214152
326UbiquitinationGQTGTRLTPADKAEH
CCCCCCCCHHHHHHH		17.0923000965
326PhosphorylationGQTGTRLTPADKAEH
CCCCCCCCHHHHHHH		17.0925159151
330 (in isoform 1)Ubiquitination-58.7521890473
330UbiquitinationTRLTPADKAEHMKRQ
CCCCHHHHHHHHHHC		58.7521890473
335 (in isoform 1)Ubiquitination-47.4921890473
335UbiquitinationADKAEHMKRQRHPRL
HHHHHHHHHCCCCCC		47.4921906983
346PhosphorylationHPRLRPQSAQSSFPP
CCCCCCCHHHHCCCC		30.8422199227
347UbiquitinationPRLRPQSAQSSFPPS
CCCCCCHHHHCCCCC		14.1833845483
349PhosphorylationLRPQSAQSSFPPSPG
CCCCHHHHCCCCCCC		33.3922199227
350PhosphorylationRPQSAQSSFPPSPGP
CCCHHHHCCCCCCCC		29.6828450419
354PhosphorylationAQSSFPPSPGPSPDV
HHHCCCCCCCCCHHH		42.6030266825
358PhosphorylationFPPSPGPSPDVQLAT
CCCCCCCCHHHHHHH		39.3830266825
359UbiquitinationPPSPGPSPDVQLATL
CCCCCCCHHHHHHHH		49.2623000965
359 (in isoform 2)Ubiquitination-49.2621890473
363PhosphorylationGPSPDVQLATLAQRV
CCCHHHHHHHHHHHH		3.8518669648
365PhosphorylationSPDVQLATLAQRVKE
CHHHHHHHHHHHHHH		31.0818669648
367PhosphorylationDVQLATLAQRVKEVL
HHHHHHHHHHHHHHC		7.2618691976
367 (in isoform 2)Phosphorylation-7.2624719451
377UbiquitinationVKEVLPHVPLGVIQR
HHHHCCCCCHHHHHH		3.8523000965
377 (in isoform 2)Ubiquitination-3.8521890473
385 (in isoform 2)Phosphorylation-34.3024719451
388UbiquitinationVIQRDLAKTGCVDLT
HHHHHHHHHCCCEEE		53.39-
390UbiquitinationQRDLAKTGCVDLTIT
HHHHHHHCCCEEEHH		14.5623000965
413UbiquitinationFMPEDITKGTQSLPT
ECCCHHCCCCCCCCC		61.36-
415PhosphorylationPEDITKGTQSLPTAS
CCHHCCCCCCCCCCC		19.2824173317
416UbiquitinationEDITKGTQSLPTASA
CHHCCCCCCCCCCCC		52.1923000965
417PhosphorylationDITKGTQSLPTASAS
HHCCCCCCCCCCCCC		35.8324173317
420PhosphorylationKGTQSLPTASASKFP
CCCCCCCCCCCCCCC		38.2425159151
422PhosphorylationTQSLPTASASKFPSS
CCCCCCCCCCCCCCC		35.2425159151
424PhosphorylationSLPTASASKFPSSGP
CCCCCCCCCCCCCCC		32.1321815630
425 (in isoform 1)Ubiquitination-62.1021890473
425UbiquitinationLPTASASKFPSSGPV
CCCCCCCCCCCCCCC		62.1021890473
425AcetylationLPTASASKFPSSGPV
CCCCCCCCCCCCCCC		62.1026051181
428PhosphorylationASASKFPSSGPVTPQ
CCCCCCCCCCCCCCC		51.5725159151
429PhosphorylationSASKFPSSGPVTPQP
CCCCCCCCCCCCCCC		47.5625159151
433PhosphorylationFPSSGPVTPQPTALT
CCCCCCCCCCCCHHH		21.2427273156
434UbiquitinationPSSGPVTPQPTALTF
CCCCCCCCCCCHHHH		38.0923000965
437PhosphorylationGPVTPQPTALTFAKS
CCCCCCCCHHHHHHC		29.1128450419
440PhosphorylationTPQPTALTFAKSSWA
CCCCCHHHHHHCHHH		21.0528450419
443 (in isoform 1)Ubiquitination-40.6121890473
443UbiquitinationPTALTFAKSSWARQE
CCHHHHHHCHHHHHH		40.6121890473
447UbiquitinationTFAKSSWARQESLQE
HHHHCHHHHHHHHHH		12.7723000965
451PhosphorylationSSWARQESLQERKQA
CHHHHHHHHHHHHHH		27.3221815630
456UbiquitinationQESLQERKQALYEYA
HHHHHHHHHHHHHHH		38.89-
460PhosphorylationQERKQALYEYARRRF
HHHHHHHHHHHHHHH		15.2028796482
462PhosphorylationRKQALYEYARRRFTE
HHHHHHHHHHHHHHH		7.5828796482
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AUP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AUP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AUP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ITA2B_HUMANITGA2Bphysical
12042322
ITA1_HUMANITGA1physical
12042322
ITA2_HUMANITGA2physical
12042322
ITAV_HUMANITGAVphysical
12042322
ITAM_HUMANITGAMphysical
12042322
ITA5_HUMANITGA5physical
12042322
TERA_HUMANVCPphysical
21857022
UB2G2_HUMANUBE2G2physical
21857022
SE1L1_HUMANSEL1Lphysical
21857022
OS9_HUMANOS9physical
21857022
FAF2_HUMANFAF2physical
21857022
SYVN1_HUMANSYVN1physical
21857022
RPN2_HUMANRPN2physical
21857022
OST48_HUMANDDOSTphysical
21857022
ACSF3_HUMANACSF3physical
21857022
SPTC1_HUMANSPTLC1physical
21857022
PCAT1_HUMANLPCAT1physical
21857022
STT3B_HUMANSTT3Bphysical
21857022
UB2J1_HUMANUBE2J1physical
21857022
UBC_HUMANUBCphysical
21857022
CAPR2_HUMANCAPRIN2physical
22119785
UB2G2_HUMANUBE2G2physical
22119785
DIP2B_HUMANDIP2Bphysical
22119785
SE1L1_HUMANSEL1Lphysical
22119785
SURF4_HUMANSURF4physical
22119785
PRKDC_HUMANPRKDCphysical
22119785
CKAP5_HUMANCKAP5physical
22119785
SYVN1_HUMANSYVN1physical
22119785
ABRX2_HUMANFAM175Bphysical
26186194
APOB_HUMANAPOBphysical
26186194
FNTB_HUMANFNTBphysical
26186194
PCMD2_HUMANPCMTD2physical
26186194
TP4A1_HUMANPTP4A1physical
26186194
RN114_HUMANRNF114physical
26186194
ABRX2_HUMANFAM175Bphysical
28514442
FNTB_HUMANFNTBphysical
28514442
RN114_HUMANRNF114physical
28514442
APOB_HUMANAPOBphysical
28514442
TP4A1_HUMANPTP4A1physical
28514442
APOB_HUMANAPOBphysical
28183703
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AUP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354; SER-358; SER-422;SER-429 AND THR-433, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-433, AND MASSSPECTROMETRY.

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