dbPTM

CKAP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CKAP5_HUMAN
UniProt AC	Q14008
Protein Name	Cytoskeleton-associated protein 5
Gene Name	CKAP5
Organism	Homo sapiens (Human).
Sequence Length	2032
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Detected on centrosomes and kinetochores during interphase and mitos
Protein Description	Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. [PubMed: 23532825 Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments]
Protein Sequence	MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYIEIEKGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAVRDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEALESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKPGPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELMDRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVVSMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQSPPAPTRGISKHSTSGTDEGEDGDEPDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPGLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLERIKSSRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	KLWKARLSGYEEALK HHHHHHHCCHHHHHH	33.50	28348404
42	Ubiquitination	FQKIKDEKSPEWSKF HHHHCCCCCHHHHHH	79.87	-
48	Acetylation	EKSPEWSKFLGLIKK CCCHHHHHHHHHHHH	45.76	19608861
48	Ubiquitination	EKSPEWSKFLGLIKK CCCHHHHHHHHHHHH	45.76	22817900
48 (in isoform 1)	Ubiquitination	-	45.76	21890473
48 (in isoform 2)	Ubiquitination	-	45.76	21890473
48 (in isoform 3)	Ubiquitination	-	45.76	21890473
150	Ubiquitination	ACIETLRKALSEFGS HHHHHHHHHHHHHCC	57.71	29967540
150 (in isoform 3)	Ubiquitination	-	57.71	-
153	Phosphorylation	ETLRKALSEFGSKII HHHHHHHHHHCCHHH	35.42	20860994
158	Acetylation	ALSEFGSKIILLKPI HHHHHCCHHHHHHHH	33.86	19817325
163	Acetylation	GSKIILLKPIIKVLP CCHHHHHHHHHHHHH	30.63	23749302
171	Acetylation	PIIKVLPKLFESREK HHHHHHHHHHHCHHH	62.74	25953088
220	Ubiquitination	ELEEEWVKLPTSAPR HHHHHHHCCCCCCCC	50.23	29967540
247	Phosphorylation	AKLEQQQSAGGDAEG HHHHHHHHCCCCCCC	25.25	28270605
268	Phosphorylation	EVPQIDAYELLEAVE CCCCCCHHHHHHHHH	11.89	22817900
287	Ubiquitination	LPKDFYDKIEAKKWQ CCHHHHHHHHHHHHH	30.94	29967540
308	Ubiquitination	ESVEVLIKNPKLEAG HHCHHHHHCCCCCCC	64.14	29967540
311	Ubiquitination	EVLIKNPKLEAGDYA HHHHHCCCCCCCCHH	69.24	29967540
317	Phosphorylation	PKLEAGDYADLVKAL CCCCCCCHHHHHHHH	10.91	22817900
322	Ubiquitination	GDYADLVKALKKVVG CCHHHHHHHHHHHHC	56.13	29967540
332	Phosphorylation	KKVVGKDTNVMLVAL HHHHCCCHHHHHHHH	32.95	-
335	Sulfoxidation	VGKDTNVMLVALAAK HCCCHHHHHHHHHHH	2.43	21406390
354	Acetylation	LAVGLRKKFGQYAGH HHHHHHHHHHHHHCC	48.57	25953088
423	Phosphorylation	TSLFIARSFRHCTAS HHHHHHHHHCCCCCC	20.01	22817900
427	S-nitrosylation	IARSFRHCTASTLPK HHHHHCCCCCCCCCH	2.72	2212679
435	Phosphorylation	TASTLPKSLLKPFCA CCCCCCHHHHHHHHH	36.67	24719451
438	Acetylation	TLPKSLLKPFCAALL CCCHHHHHHHHHHHH	41.14	26051181
438	Ubiquitination	TLPKSLLKPFCAALL CCCHHHHHHHHHHHH	41.14	-
438 (in isoform 3)	Ubiquitination	-	41.14	-
468	Ubiquitination	EALGTALKVVGEKAV HHHHHHHHHHHHHHH	32.20	29967540
473	Acetylation	ALKVVGEKAVNPFLA HHHHHHHHHHCHHHH	52.27	25953088
473	Ubiquitination	ALKVVGEKAVNPFLA HHHHHHHHHHCHHHH	52.27	32015554
515	Acetylation	AADKKEFKPLPGRTA CCCCCCCCCCCCCCC	46.89	25953088
521	Phosphorylation	FKPLPGRTAASGAAG CCCCCCCCCCCCCCC	32.27	22817900
536	Phosphorylation	DKDTKDISAPKPGPL CCCCCCCCCCCCCCC	48.96	28555341
569	Phosphorylation	APGGAGNTGTKNKKG CCCCCCCCCCCCCCC	45.36	23403867
571	Phosphorylation	GGAGNTGTKNKKGLE CCCCCCCCCCCCCCC	29.43	23403867
619	Glutathionylation	NWKERLACMEEFQKA CHHHHHHHHHHHHHH	4.11	22555962
632	Methylation	KAVELMDRTEMPCQA HHHHHHHCCCCHHHH	20.72	-
689	Ubiquitination	VLDGLVDKIGDVKCG HHHHHHHHHCCCCCC	40.90	29967540
689 (in isoform 3)	Ubiquitination	-	40.90	-
733	Phosphorylation	QKNPKNQSETLNWLS CCCCCCHHHHHHHHH	41.78	21712546
754	Ubiquitination	GFSGLNVKAFISNVK CCCCCCHHHHHHHHH	36.18	21890473
754 (in isoform 1)	Ubiquitination	-	36.18	21890473
754 (in isoform 2)	Ubiquitination	-	36.18	21890473
754 (in isoform 3)	Ubiquitination	-	36.18	21890473
816	Phosphorylation	FEKMQGQSPPAPTRG HHHHCCCCCCCCCCC	39.41	29255136
821	Phosphorylation	GQSPPAPTRGISKHS CCCCCCCCCCCCCCC	43.57	29255136
825	Phosphorylation	PAPTRGISKHSTSGT CCCCCCCCCCCCCCC	27.43	30624053
828	Phosphorylation	TRGISKHSTSGTDEG CCCCCCCCCCCCCCC	28.18	23401153
829	Phosphorylation	RGISKHSTSGTDEGE CCCCCCCCCCCCCCC	30.78	22167270
830	Phosphorylation	GISKHSTSGTDEGED CCCCCCCCCCCCCCC	42.59	22167270
832	Phosphorylation	SKHSTSGTDEGEDGD CCCCCCCCCCCCCCC	30.55	22167270
845	Phosphorylation	GDEPDDGSNDVVDLL CCCCCCCCCCHHHHC	36.53	22167270
855	Phosphorylation	VVDLLPRTEISDKIT HHHHCCCCHHCHHHH	35.41	21406692
858	Phosphorylation	LLPRTEISDKITSEL HCCCCHHCHHHHHHH	26.98	21406692
862	Phosphorylation	TEISDKITSELVSKI CHHCHHHHHHHHHHH	23.14	30206219
863	Phosphorylation	EISDKITSELVSKIG HHCHHHHHHHHHHHC	32.19	30206219
875	Malonylation	KIGDKNWKIRKEGLD HHCCCCCHHCCCCHH	41.86	26320211
878	Ubiquitination	DKNWKIRKEGLDEVA CCCCHHCCCCHHHHH	60.65	29967540
906	Ubiquitination	GELPTALKGRLNDSN CCCCHHHCCCCCCCC	39.25	29967540
906 (in isoform 3)	Ubiquitination	-	39.25	-
953	Phosphorylation	IITVLGDSKNNVRAA EEEEECCCCCHHHHH	35.17	21712546
954	Ubiquitination	ITVLGDSKNNVRAAA EEEECCCCCHHHHHH	58.23	32015554
1058	Phosphorylation	YEKMAKATGKLKPTS HHHHHHHHCCCCCCC	33.86	23911959
1065	Phosphorylation	TGKLKPTSKDQVLAM HCCCCCCCHHHHHHH	42.64	23911959
1066	Ubiquitination	GKLKPTSKDQVLAML CCCCCCCHHHHHHHH	55.44	29967540
1072	Sulfoxidation	SKDQVLAMLEKAKVN CHHHHHHHHHHHCCC	4.31	21406390
1088	Phosphorylation	PAKPAPPTKATSKPM CCCCCCCCCCCCCCC	32.05	20860994
1091	Phosphorylation	PAPPTKATSKPMGGS CCCCCCCCCCCCCCC	38.55	21406692
1092	Phosphorylation	APPTKATSKPMGGSA CCCCCCCCCCCCCCC	39.35	21406692
1093	"N6,N6-dimethyllysine"	PPTKATSKPMGGSAP CCCCCCCCCCCCCCC	34.37	-
1093	Methylation	PPTKATSKPMGGSAP CCCCCCCCCCCCCCC	34.37	-
1095	Sulfoxidation	TKATSKPMGGSAPAK CCCCCCCCCCCCCCC	12.49	30846556
1098	Phosphorylation	TSKPMGGSAPAKFQP CCCCCCCCCCCCCCC	25.91	21406692
1102	Acetylation	MGGSAPAKFQPASAP CCCCCCCCCCCCCCC	43.40	26051181
1107	Phosphorylation	PAKFQPASAPAEDCI CCCCCCCCCCHHHHC	41.28	28555341
1115	Phosphorylation	APAEDCISSSTEPKP CCHHHHCCCCCCCCC	25.27	23312004
1116	Phosphorylation	PAEDCISSSTEPKPD CHHHHCCCCCCCCCC	22.74	23312004
1117	Phosphorylation	AEDCISSSTEPKPDP HHHHCCCCCCCCCCH	29.96	23312004
1118	Phosphorylation	EDCISSSTEPKPDPK HHHCCCCCCCCCCHH	59.25	23312004
1121	Acetylation	ISSSTEPKPDPKKAK CCCCCCCCCCHHHCC	56.68	26051181
1121	Ubiquitination	ISSSTEPKPDPKKAK CCCCCCCCCCHHHCC	56.68	22817900
1121 (in isoform 1)	Ubiquitination	-	56.68	21890473
1121 (in isoform 2)	Ubiquitination	-	56.68	21890473
1121 (in isoform 3)	Ubiquitination	-	56.68	21890473
1125	Ubiquitination	TEPKPDPKKAKAPGL CCCCCCHHHCCCCCC	73.14	22817900
1126	Ubiquitination	EPKPDPKKAKAPGLS CCCCCHHHCCCCCCC	61.58	22817900
1138	Phosphorylation	GLSSKAKSAQGKKMP CCCHHHHHHCCCCCC	30.59	22817900
1146	Phosphorylation	AQGKKMPSKTSLKED HCCCCCCCCCCCCCC	45.10	28270605
1148	Phosphorylation	GKKMPSKTSLKEDED CCCCCCCCCCCCCCC	43.56	28060719
1149	Phosphorylation	KKMPSKTSLKEDEDK CCCCCCCCCCCCCCC	40.98	26657352
1182	Ubiquitination	EKGLKVLKWNFTTPR CCCCEEEECCCCCCH	42.98	-
1197	Ubiquitination	DEYIEQLKTQMSSCV HHHHHHHHHHHHHHH	36.08	29967540
1256	Phosphorylation	LTLRFFDTNTSVLMK HHHHHCCCCHHHHHH	34.93	-
1258	Phosphorylation	LRFFDTNTSVLMKAL HHHCCCCHHHHHHHH	23.46	-
1259	Phosphorylation	RFFDTNTSVLMKALE HHCCCCHHHHHHHHH	18.47	-
1262	Sulfoxidation	DTNTSVLMKALEYLK CCCHHHHHHHHHHHH	1.93	21406390
1302	Ubiquitination	VVKVGEPKDVIRKDV EEECCCCHHHHHHHH	61.39	29967540
1315	Methylation	DVRAILNRMCLVYPA HHHHHHHHHCHHHCH	17.47	-
1317	Glutathionylation	RAILNRMCLVYPASK HHHHHHHCHHHCHHH	1.78	22555962
1323	Phosphorylation	MCLVYPASKMFPFIM HCHHHCHHHHHHHHH	21.83	23322592
1324	Methylation	CLVYPASKMFPFIME CHHHCHHHHHHHHHC	46.82	-
1363	Phosphorylation	GMNVCQPTPGKALKE CCCCCCCCCCHHHHH	20.85	22067460
1369	Acetylation	PTPGKALKEIAVHIG CCCCHHHHHHHHHHC	52.51	156407
1409	Phosphorylation	FKLIGNLSEKDMSML HHHHCCCCHHHHHHH	46.75	22210691
1411	Acetylation	LIGNLSEKDMSMLEE HHCCCCHHHHHHHHH	56.19	25953088
1411	Ubiquitination	LIGNLSEKDMSMLEE HHCCCCHHHHHHHHH	56.19	32015554
1414	Phosphorylation	NLSEKDMSMLEERIK CCCHHHHHHHHHHHH	30.28	22210691
1421	Acetylation	SMLEERIKRSAKRPS HHHHHHHHHHCCCCC	46.66	19822151
1428	Phosphorylation	KRSAKRPSAAPIKQV HHHCCCCCCCCCHHH	40.89	27134283
1433	Acetylation	RPSAAPIKQVEEKPQ CCCCCCCHHHHCCCH	47.43	26051181
1433	Ubiquitination	RPSAAPIKQVEEKPQ CCCCCCCHHHHCCCH	47.43	29967540
1438	Ubiquitination	PIKQVEEKPQRAQNI CCHHHHCCCHHHHHH	32.70	24816145
1446	Phosphorylation	PQRAQNISSNANMLR CHHHHHHHHHHHHHH	25.70	20860994
1447	Phosphorylation	QRAQNISSNANMLRK HHHHHHHHHHHHHHC	35.84	20860994
1451	Sulfoxidation	NISSNANMLRKGPAE HHHHHHHHHHCCCHH	3.39	21406390
1454	Ubiquitination	SNANMLRKGPAEDMS HHHHHHHCCCHHHHH	66.34	24816145
1463	Acetylation	PAEDMSSKLNQARSM CHHHHHHHHHHHHHH	44.12	25953088
1469	Phosphorylation	SKLNQARSMSGHPEA HHHHHHHHHCCCHHH	21.95	25159151
1470	Sulfoxidation	KLNQARSMSGHPEAA HHHHHHHHCCCHHHH	4.66	30846556
1471	Phosphorylation	LNQARSMSGHPEAAQ HHHHHHHCCCHHHHH	34.89	25159151
1479	Sulfoxidation	GHPEAAQMVRREFQL CCHHHHHHHHHHHCC	1.86	30846556
1509	Ubiquitination	MPELVQHKLDDIFEP CHHHHHHCCCCCCCC	36.20	29967540
1523	Ubiquitination	PVLIPEPKIRAVSPH CCCCCCCCCCEECCC	43.07	22817900
1523 (in isoform 1)	Ubiquitination	-	43.07	21890473
1523 (in isoform 2)	Ubiquitination	-	43.07	21890473
1523 (in isoform 3)	Ubiquitination	-	43.07	21890473
1528	Phosphorylation	EPKIRAVSPHFDDMH CCCCCEECCCCCCCC	16.21	27422710
1536	Phosphorylation	PHFDDMHSNTASTIN CCCCCCCCCCHHHHH	29.28	21406692
1538	Phosphorylation	FDDMHSNTASTINFI CCCCCCCCHHHHHHH	25.62	21406692
1540	Phosphorylation	DMHSNTASTINFIIS CCCCCCHHHHHHHHH	27.99	21406692
1541	Phosphorylation	MHSNTASTINFIISQ CCCCCHHHHHHHHHH	19.92	21406692
1547	Phosphorylation	STINFIISQVASGDI HHHHHHHHHHHCCCC	17.49	21406692
1551	Phosphorylation	FIISQVASGDINTSI HHHHHHHCCCCHHHH	37.84	21406692
1556	Phosphorylation	VASGDINTSIQALTQ HHCCCCHHHHHHHHH	27.78	21406692
1557	Phosphorylation	ASGDINTSIQALTQI HCCCCHHHHHHHHHH	14.28	21406692
1562	Phosphorylation	NTSIQALTQIDEVLR HHHHHHHHHHHHHHC	26.88	20363803
1612	Ubiquitination	LEKDEIIKLYSCIIG CCHHHHHHHHHHHHH	47.21	-
1636	Phosphorylation	SLAREASTGVLKDLM HHHHHHCHHHHHHHH	38.05	-
1648	Phosphorylation	DLMHGLITLMLDSRI HHHHHHHHHHHCCCC	15.91	24043423
1653	Phosphorylation	LITLMLDSRIEDLEE HHHHHHCCCCCCHHH	31.06	24043423
1692	Ubiquitination	LSALLVLLQDSLLAT HHHHHHHHHHHHHHC	4.08	29967540
1701	Ubiquitination	DSLLATASSPKFSEL HHHHHCCCCHHHHHH	42.70	29967540
1709	Ubiquitination	SPKFSELVMKCLWRM CHHHHHHHHHHHHHH	2.79	22817900
1711	Ubiquitination	KFSELVMKCLWRMVR HHHHHHHHHHHHHHH	20.78	22817900
1714	Ubiquitination	ELVMKCLWRMVRLLP HHHHHHHHHHHHHCH	8.87	21890473
1714 (in isoform 2)	Ubiquitination	-	8.87	21890473
1725	Ubiquitination	RLLPDTINSINLDRI HHCHHHHHHCCHHHH	38.64	29967540
1739	Ubiquitination	ILLDIHIFMKVFPKE HHHHHHHHHHHCCHH	2.10	29967540
1748	Ubiquitination	KVFPKEKLKQCKSEF HHCCHHHHHHCCCCC	4.93	24816145
1752	Ubiquitination	KEKLKQCKSEFPIRT HHHHHHCCCCCCHHH	50.99	29967540
1761	Acetylation	EFPIRTLKTLLHTLC CCCHHHHHHHHHHHH	36.19	25953088
1761	Ubiquitination	EFPIRTLKTLLHTLC CCCHHHHHHHHHHHH	36.19	29967540
1769	Acetylation	TLLHTLCKLKGPKIL HHHHHHHHCCCCHHH	57.24	25953088
1769	Ubiquitination	TLLHTLCKLKGPKIL HHHHHHHHCCCCHHH	57.24	22817900
1771	Ubiquitination	LHTLCKLKGPKILDH HHHHHHCCCCHHHHE	59.67	22817900
1774	Ubiquitination	LCKLKGPKILDHLTM HHHCCCCHHHHEEEE	65.65	22817900
1774 (in isoform 1)	Ubiquitination	-	65.65	21890473
1775 (in isoform 3)	Phosphorylation	-	6.51	28450419
1778	Ubiquitination	KGPKILDHLTMIDNK CCCHHHHEEEECCCC	21.54	29967540
1785	Ubiquitination	HLTMIDNKNESELEA EEEECCCCCHHHHHH	59.34	29967540
1787	Ubiquitination	TMIDNKNESELEAHL EECCCCCHHHHHHHH	47.39	29967540
1787 (in isoform 3)	Phosphorylation	-	47.39	28450419
1788	Phosphorylation	MIDNKNESELEAHLC ECCCCCHHHHHHHHH	57.80	-
1797	Ubiquitination	LEAHLCRMMKHSMDQ HHHHHHHHHHHHHHC	4.02	29967540
1799	Ubiquitination	AHLCRMMKHSMDQTG HHHHHHHHHHHHCCC	24.16	29967540
1801	Phosphorylation	LCRMMKHSMDQTGSK HHHHHHHHHHCCCCC	20.66	28348404
1805	Phosphorylation	MKHSMDQTGSKSDKE HHHHHHCCCCCCHHH	38.88	28985074
1807	Phosphorylation	HSMDQTGSKSDKETE HHHHCCCCCCHHHHH	32.16	29449344
1808	Ubiquitination	SMDQTGSKSDKETEK HHHCCCCCCHHHHHH	65.11	24816145
1809	Phosphorylation	MDQTGSKSDKETEKG HHCCCCCCHHHHHHH	56.46	24719451
1813	Phosphorylation	GSKSDKETEKGASRI CCCCHHHHHHHHHHC	49.06	29449344
1824	Phosphorylation	ASRIDEKSSKAKVND HHHCCHHHHHHHHHH	34.72	30576142
1825	Phosphorylation	SRIDEKSSKAKVNDF HHCCHHHHHHHHHHH	47.93	30576142
1828	Acetylation	DEKSSKAKVNDFLAE CHHHHHHHHHHHHHH	45.36	26051181
1828	Ubiquitination	DEKSSKAKVNDFLAE CHHHHHHHHHHHHHH	45.36	-
1835 (in isoform 3)	Ubiquitination	-	51.62	-
1838	Ubiquitination	DFLAEIFKKIGSKEN HHHHHHHHHHCCCCC	49.49	29967540
1847	Ubiquitination	IGSKENTKEGLAELY HCCCCCCHHHHHHHH	62.46	29967540
1854	Phosphorylation	KEGLAELYEYKKKYS HHHHHHHHHHHHHCC	14.55	-
1857	Ubiquitination	LAELYEYKKKYSDAD HHHHHHHHHHCCCCC	30.74	29967540
1859	Ubiquitination	ELYEYKKKYSDADIE HHHHHHHHCCCCCCH	45.92	29967540
1860	Phosphorylation	LYEYKKKYSDADIEP HHHHHHHCCCCCCHH	22.21	23927012
1861	Phosphorylation	YEYKKKYSDADIEPF HHHHHHCCCCCCHHH	34.89	28355574
1861 (in isoform 3)	Phosphorylation	-	34.89	27642862
1870	Methylation	ADIEPFLKNSSQFFQ CCCHHHHCCHHHHHH	55.98	-
1870	Ubiquitination	ADIEPFLKNSSQFFQ CCCHHHHCCHHHHHH	55.98	-
1872	Phosphorylation	IEPFLKNSSQFFQSY CHHHHCCHHHHHHHH	24.75	-
1873	Phosphorylation	EPFLKNSSQFFQSYV HHHHCCHHHHHHHHH	40.16	21712546
1878	Phosphorylation	NSSQFFQSYVERGLR CHHHHHHHHHHHCCE	26.45	24076635
1882	Methylation	FFQSYVERGLRVIEM HHHHHHHHCCEEEEE	39.13	-
1898	O-linked_Glycosylation	REGKGRISTSTGISP ECCCCCEECCCCCCC	18.23	30379171
1898	Phosphorylation	REGKGRISTSTGISP ECCCCCEECCCCCCC	18.23	25627689
1899	Phosphorylation	EGKGRISTSTGISPQ CCCCCEECCCCCCCC	28.12	25627689
1901	Phosphorylation	KGRISTSTGISPQME CCCEECCCCCCCCEE	38.33	26074081
1904	O-linked_Glycosylation	ISTSTGISPQMEVTC EECCCCCCCCEEEEE	15.49	30379171
1904	Phosphorylation	ISTSTGISPQMEVTC EECCCCCCCCEEEEE	15.49	25159151
1905	Ubiquitination	STSTGISPQMEVTCV ECCCCCCCCEEEEEE	35.30	29967540
1921	Ubiquitination	TPTSTVSSIGNTNGE CCCCCCCCCCCCCCC	30.13	23000965
1921 (in isoform 2)	Ubiquitination	-	30.13	21890473
1935	Phosphorylation	EEVGPSVYLERLKIL CCCCCHHHHHHHHHH	13.74	-
1960	Phosphorylation	QDDRPPLTSLLSKPA CCCCCCHHHHHCCCC	24.09	21406692
1961	Phosphorylation	DDRPPLTSLLSKPAV CCCCCHHHHHCCCCC	34.69	24719451
1964	Phosphorylation	PPLTSLLSKPAVPTV CCHHHHHCCCCCCCC	41.72	25159151
1965	Acetylation	PLTSLLSKPAVPTVA CHHHHHCCCCCCCCC	36.64	26051181
1965	Ubiquitination	PLTSLLSKPAVPTVA CHHHHHCCCCCCCCC	36.64	29967540
1970	Phosphorylation	LSKPAVPTVASSTDM HCCCCCCCCCCCHHH	23.31	21406692
1973	Phosphorylation	PAVPTVASSTDMLHS CCCCCCCCCHHHHHH	29.45	21406692
1974	Phosphorylation	AVPTVASSTDMLHSK CCCCCCCCHHHHHHH	20.77	21406692
1975	Phosphorylation	VPTVASSTDMLHSKL CCCCCCCHHHHHHHH	23.96	21406692
1980	Phosphorylation	SSTDMLHSKLSQLRE CCHHHHHHHHHHHHH	31.19	25159151
1981	Acetylation	STDMLHSKLSQLRES CHHHHHHHHHHHHHH	41.22	25953088
1981	Ubiquitination	STDMLHSKLSQLRES CHHHHHHHHHHHHHH	41.22	23000965
1981 (in isoform 1)	Ubiquitination	-	41.22	21890473
1983	Phosphorylation	DMLHSKLSQLRESRE HHHHHHHHHHHHHHH	30.79	25159151
1988 (in isoform 3)	Ubiquitination	-	34.38	21890473
2002	Phosphorylation	SDLDSNQTHSSGTVT CCCCCCCCCCCCCEE	28.16	30576142
2007	Phosphorylation	NQTHSSGTVTSSSST CCCCCCCCEECCCCC	23.66	30576142
2009	Phosphorylation	THSSGTVTSSSSTAN CCCCCCEECCCCCCC	23.80	30576142
2010	Phosphorylation	HSSGTVTSSSSTANI CCCCCEECCCCCCCH	24.72	30576142
2021	Acetylation	TANIDDLKKRLERIK CCCHHHHHHHHHHHH	42.73	7379983
2022	Acetylation	ANIDDLKKRLERIKS CCHHHHHHHHHHHHH	70.30	24431261
2030	Phosphorylation	RLERIKSSRK----- HHHHHHHHCC-----	38.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CKAP5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CKAP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CKAP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TACC1_HUMAN	TACC1	physical	14603251
CKAP5_HUMAN	CKAP5	physical	20360068
SLAI2_HUMAN	SLAIN2	physical	20360068
SNW1_HUMAN	SNW1	physical	20360068
TACC3_HUMAN	TACC3	physical	20360068
TACC2_HUMAN	TACC2	physical	20360068
INT2_HUMAN	INTS2	physical	26344197
MARE1_HUMAN	MAPRE1	physical	26344197
MARE3_HUMAN	MAPRE3	physical	26344197
ACADV_HUMAN	ACADVL	physical	26496610
XIAP_HUMAN	XIAP	physical	26496610
DHC24_HUMAN	DHCR24	physical	26496610
H33_HUMAN	H3F3A	physical	26496610
GRP78_HUMAN	HSPA5	physical	26496610
LDHA_HUMAN	LDHA	physical	26496610
LDHB_HUMAN	LDHB	physical	26496610
TAU_HUMAN	MAPT	physical	26496610
PFKAM_HUMAN	PFKM	physical	26496610
RT12_HUMAN	MRPS12	physical	26496610
RS16_HUMAN	RPS16	physical	26496610
RS17_HUMAN	RPS17	physical	26496610
TACC1_HUMAN	TACC1	physical	26496610
TAP2_HUMAN	TAP2	physical	26496610
TOP2A_HUMAN	TOP2A	physical	26496610
ZNHI3_HUMAN	ZNHIT3	physical	26496610
TACC3_HUMAN	TACC3	physical	26496610
TACC2_HUMAN	TACC2	physical	26496610
INT7_HUMAN	INTS7	physical	26496610
ACAD8_HUMAN	ACAD8	physical	26496610
TRM6_HUMAN	TRMT6	physical	26496610
KLHL7_HUMAN	KLHL7	physical	26496610
SLAI2_HUMAN	SLAIN2	physical	26496610
DDX31_HUMAN	DDX31	physical	26496610
DOT1L_HUMAN	DOT1L	physical	26496610
CAVN3_HUMAN	PRKCDBP	physical	26496610
CCYL1_HUMAN	CCNYL1	physical	26496610
CAVN1_HUMAN	PTRF	physical	26496610
NDC80_HUMAN	NDC80	physical	27156448

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CKAP5_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816, AND MASSSPECTROMETRY.	15302935 [Abstract]