dbPTM

LDHA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LDHA_HUMAN
UniProt AC	P00338
Protein Name	L-lactate dehydrogenase A chain
Gene Name	LDHA
Organism	Homo sapiens (Human).
Sequence Length	332
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATLKDQLI ------CCCHHHHHH	22.95	22223895
3	Phosphorylation	-----MATLKDQLIY -----CCCHHHHHHH	32.80	28857561
5	Ubiquitination	---MATLKDQLIYNL ---CCCHHHHHHHHH	38.79	21890473
5	Acetylation	---MATLKDQLIYNL ---CCCHHHHHHHHH	38.79	19608861
5	Methylation	---MATLKDQLIYNL ---CCCHHHHHHHHH	38.79	19608861
5	Succinylation	---MATLKDQLIYNL ---CCCHHHHHHHHH	38.79	-
5	Succinylation	---MATLKDQLIYNL ---CCCHHHHHHHHH	38.79	23954790
5	Ubiquitination	---MATLKDQLIYNL ---CCCHHHHHHHHH	38.79	21890473
10	Nitration	TLKDQLIYNLLKEEQ CHHHHHHHHHHHHCC	14.35	-
10	Phosphorylation	TLKDQLIYNLLKEEQ CHHHHHHHHHHHHCC	14.35	21945579
14	Ubiquitination	QLIYNLLKEEQTPQN HHHHHHHHHCCCCCC	63.47	21890473
14	Acetylation	QLIYNLLKEEQTPQN HHHHHHHHHCCCCCC	63.47	19608861
14	Succinylation	QLIYNLLKEEQTPQN HHHHHHHHHCCCCCC	63.47	23954790
14	Sumoylation	QLIYNLLKEEQTPQN HHHHHHHHHCCCCCC	63.47	19608861
14	Ubiquitination	QLIYNLLKEEQTPQN HHHHHHHHHCCCCCC	63.47	21890473
14 (in isoform 1)	Ubiquitination	-	63.47	21890473
14 (in isoform 2)	Ubiquitination	-	63.47	21890473
18	Phosphorylation	NLLKEEQTPQNKITV HHHHHCCCCCCCEEE	30.07	21945579
22	Acetylation	EEQTPQNKITVVGVG HCCCCCCCEEEEECH	34.21	69955
24	Phosphorylation	QTPQNKITVVGVGAV CCCCCCEEEEECHHH	15.68	20860994
27	Ubiquitination	QNKITVVGVGAVGMA CCCEEEEECHHHHHH	14.06	-
27 (in isoform 3)	Ubiquitination	-	14.06	-
34 (in isoform 3)	Ubiquitination	-	3.60	-
39	Phosphorylation	GMACAISILMKDLAD HHHHHHHHHHHHHHH	3.40	27642862
43	Acetylation	AISILMKDLADELAL HHHHHHHHHHHHHHH	32.88	19608861
43	Ubiquitination	AISILMKDLADELAL HHHHHHHHHHHHHHH	32.88	19608861
43 (in isoform 3)	Ubiquitination	-	32.88	-
57	Acetylation	LVDVIEDKLKGEMMD HHHHHHHHHCCCCEE	39.03	19608861
57	Sumoylation	LVDVIEDKLKGEMMD HHHHHHHHHCCCCEE	39.03	28112733
57	Ubiquitination	LVDVIEDKLKGEMMD HHHHHHHHHCCCCEE	39.03	21906983
57 (in isoform 2)	Ubiquitination	-	39.03	21890473
59	Ubiquitination	DVIEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	21890473
59	Acetylation	DVIEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	26051181
59	Malonylation	DVIEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	33225896
59	Ubiquitination	DVIEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	21890473
59 (in isoform 1)	Ubiquitination	-	59.57	21890473
59 (in isoform 2)	Ubiquitination	-	59.57	21890473
62	Sulfoxidation	EDKLKGEMMDLQHGS HHHHCCCCEECCCCC	3.27	28465586
63	Sulfoxidation	DKLKGEMMDLQHGSL HHHCCCCEECCCCCE	3.96	28465586
69	O-linked_Glycosylation	MMDLQHGSLFLRTPK CEECCCCCEEEECCC	17.52	31373491
69	Phosphorylation	MMDLQHGSLFLRTPK CEECCCCCEEEECCC	17.52	27080861
74	Phosphorylation	HGSLFLRTPKIVSGK CCCEEEECCCCCCCC	30.95	-
76	Ubiquitination	SLFLRTPKIVSGKDY CEEEECCCCCCCCCC	55.94	21890473
76 (in isoform 1)	Ubiquitination	-	55.94	21890473
76 (in isoform 2)	Ubiquitination	-	55.94	21890473
79	Phosphorylation	LRTPKIVSGKDYNVT EECCCCCCCCCCEEC	43.53	28152594
81	Acetylation	TPKIVSGKDYNVTAN CCCCCCCCCCEECCC	49.92	19608861
81	Malonylation	TPKIVSGKDYNVTAN CCCCCCCCCCEECCC	49.92	33225896
81	Ubiquitination	TPKIVSGKDYNVTAN CCCCCCCCCCEECCC	49.92	20639865
81 (in isoform 1)	Ubiquitination	-	49.92	21890473
81 (in isoform 2)	Ubiquitination	-	49.92	21890473
83	Phosphorylation	KIVSGKDYNVTANSK CCCCCCCCEECCCCE	18.28	28152594
86	Acetylation	SGKDYNVTANSKLVI CCCCCEECCCCEEEE	19.24	19608861
86	Phosphorylation	SGKDYNVTANSKLVI CCCCCEECCCCEEEE	19.24	26437602
86	Ubiquitination	SGKDYNVTANSKLVI CCCCCEECCCCEEEE	19.24	19608861
88	Ubiquitination	KDYNVTANSKLVIIT CCCEECCCCEEEEEE	30.25	21890473
88 (in isoform 3)	Ubiquitination	-	30.25	-
89	Phosphorylation	DYNVTANSKLVIITA CCEECCCCEEEEEEC	25.54	28152594
90	Ubiquitination	YNVTANSKLVIITAG CEECCCCEEEEEECC	46.73	90473
90 (in isoform 2)	Ubiquitination	-	46.73	21890473
95	Phosphorylation	NSKLVIITAGARQQE CCEEEEEECCCCCCH	14.12	28857561
97	Ubiquitination	KLVIITAGARQQEGE EEEEEECCCCCCHHC	16.79	21890473
105	Ubiquitination	ARQQEGESRLNLVQR CCCCHHCHHHHHHHH	53.58	21890473
105	Phosphorylation	ARQQEGESRLNLVQR CCCCHHCHHHHHHHH	53.58	30622161
105 (in isoform 3)	Ubiquitination	-	53.58	-
110	Ubiquitination	GESRLNLVQRNVNIF HCHHHHHHHHHHCCH	4.97	21890473
110	Acetylation	GESRLNLVQRNVNIF HCHHHHHHHHHHCCH	4.97	19608861
110	Ubiquitination	GESRLNLVQRNVNIF HCHHHHHHHHHHCCH	4.97	19608861
110 (in isoform 3)	Ubiquitination	-	4.97	-
112	Phosphorylation	SRLNLVQRNVNIFKF HHHHHHHHHHCCHHH	41.40	27642862
115	Phosphorylation	NLVQRNVNIFKFIIP HHHHHHHCCHHHHCC	37.21	27251275
118	Acetylation	QRNVNIFKFIIPNVV HHHHCCHHHHCCCCE	31.68	19608861
118	Methylation	QRNVNIFKFIIPNVV HHHHCCHHHHCCCCE	31.68	88375
118	Succinylation	QRNVNIFKFIIPNVV HHHHCCHHHHCCCCE	31.68	-
118	Succinylation	QRNVNIFKFIIPNVV HHHHCCHHHHCCCCE	31.68	23954790
118	Ubiquitination	QRNVNIFKFIIPNVV HHHHCCHHHHCCCCE	31.68	19608861
118 (in isoform 1)	Ubiquitination	-	31.68	21890473
118 (in isoform 2)	Ubiquitination	-	31.68	21890473
124	Phosphorylation	FKFIIPNVVKYSPNC HHHHCCCCEEECCCC	3.09	27251275
126	Acetylation	FIIPNVVKYSPNCKL HHCCCCEEECCCCEE	35.41	19608861
126	Malonylation	FIIPNVVKYSPNCKL HHCCCCEEECCCCEE	35.41	26320211
126	Ubiquitination	FIIPNVVKYSPNCKL HHCCCCEEECCCCEE	35.41	21890473
126 (in isoform 1)	Ubiquitination	-	35.41	21890473
126 (in isoform 2)	Ubiquitination	-	35.41	21890473
127	Phosphorylation	IIPNVVKYSPNCKLL HCCCCEEECCCCEEE	20.11	26437602
128	Phosphorylation	IPNVVKYSPNCKLLI CCCCEEECCCCEEEE	12.15	-
131	S-palmitoylation	VVKYSPNCKLLIVSN CEEECCCCEEEEECC	3.59	29575903
132	Acetylation	VKYSPNCKLLIVSNP EEECCCCEEEEECCC	53.63	21466224
132	Ubiquitination	VKYSPNCKLLIVSNP EEECCCCEEEEECCC	53.63	21906983
132 (in isoform 2)	Ubiquitination	-	53.63	21890473
137	O-linked_Glycosylation	NCKLLIVSNPVDILT CCEEEEECCCHHHHH	28.55	31373491
144	Phosphorylation	SNPVDILTYVAWKIS CCCHHHHHHHHHHCC	19.11	28348404
145	Phosphorylation	NPVDILTYVAWKISG CCHHHHHHHHHHCCC	5.68	25147952
147	Ubiquitination	VDILTYVAWKISGFP HHHHHHHHHHCCCCC	7.45	21890473
147	Acetylation	VDILTYVAWKISGFP HHHHHHHHHHCCCCC	7.45	19608861
147	Ubiquitination	VDILTYVAWKISGFP HHHHHHHHHHCCCCC	7.45	19608861
147 (in isoform 3)	Ubiquitination	-	7.45	-
149	Acetylation	ILTYVAWKISGFPKN HHHHHHHHCCCCCCC	19.77	21466224
155	Ubiquitination	WKISGFPKNRVIGSG HHCCCCCCCCEECCC	55.94	21890473
155	Acetylation	WKISGFPKNRVIGSG HHCCCCCCCCEECCC	55.94	19608861
155	Ubiquitination	WKISGFPKNRVIGSG HHCCCCCCCCEECCC	55.94	21890473
155 (in isoform 1)	Ubiquitination	-	55.94	21890473
155 (in isoform 2)	Ubiquitination	-	55.94	21890473
155 (in isoform 3)	Ubiquitination	-	55.94	-
157	Methylation	ISGFPKNRVIGSGCN CCCCCCCCEECCCCC	27.79	-
161	Phosphorylation	PKNRVIGSGCNLDSA CCCCEECCCCCCCHH	29.11	24114839
163	S-palmitoylation	NRVIGSGCNLDSARF CCEECCCCCCCHHHH	4.97	29575903
164	Acetylation	RVIGSGCNLDSARFR CEECCCCCCCHHHHH	50.86	19608861
164	Ubiquitination	RVIGSGCNLDSARFR CEECCCCCCCHHHHH	50.86	19608861
167	Phosphorylation	GSGCNLDSARFRYLM CCCCCCCHHHHHHHH	25.22	21712546
169	Methylation	GCNLDSARFRYLMGE CCCCCHHHHHHHHCC	22.11	-
172	Phosphorylation	LDSARFRYLMGERLG CCHHHHHHHHCCCCC	9.79	25147952
174	Ubiquitination	SARFRYLMGERLGVH HHHHHHHHCCCCCCC	3.77	21890473
184	Ubiquitination	RLGVHPLSCHGWVLG CCCCCEEECCCEEEC	14.44	21890473
184	Phosphorylation	RLGVHPLSCHGWVLG CCCCCEEECCCEEEC	14.44	-
185	Ubiquitination	LGVHPLSCHGWVLGE CCCCEEECCCEEECC	4.54	21890473
196	Phosphorylation	VLGEHGDSSVPVWSG EECCCCCCCCCCCCC	37.52	28348404
197	Phosphorylation	LGEHGDSSVPVWSGM ECCCCCCCCCCCCCC	34.87	28348404
204	Sulfoxidation	SVPVWSGMNVAGVSL CCCCCCCCCCCCEEE	2.81	30846556
212	Acetylation	NVAGVSLKTLHPDLG CCCCEEECCCCCCCC	41.35	26051181
212	Ubiquitination	NVAGVSLKTLHPDLG CCCCEEECCCCCCCC	41.35	-
213	Phosphorylation	VAGVSLKTLHPDLGT CCCEEECCCCCCCCC	35.28	26437602
220	Ubiquitination	TLHPDLGTDKDKEQW CCCCCCCCCCCHHHH	47.36	21890473
220	Acetylation	TLHPDLGTDKDKEQW CCCCCCCCCCCHHHH	47.36	19608861
220	Ubiquitination	TLHPDLGTDKDKEQW CCCCCCCCCCCHHHH	47.36	19608861
222	Acetylation	HPDLGTDKDKEQWKE CCCCCCCCCHHHHHH	71.22	23954790
222	Ubiquitination	HPDLGTDKDKEQWKE CCCCCCCCCHHHHHH	71.22	21906983
222 (in isoform 2)	Ubiquitination	-	71.22	21890473
224	Acetylation	DLGTDKDKEQWKEVH CCCCCCCHHHHHHHH	58.51	23749302
224	Ubiquitination	DLGTDKDKEQWKEVH CCCCCCCHHHHHHHH	58.51	-
228	Acetylation	DKDKEQWKEVHKQVV CCCHHHHHHHHHHHH	49.94	22424773
228	Succinylation	DKDKEQWKEVHKQVV CCCHHHHHHHHHHHH	49.94	23954790
228	Ubiquitination	DKDKEQWKEVHKQVV CCCHHHHHHHHHHHH	49.94	-
232	Acetylation	EQWKEVHKQVVESAY HHHHHHHHHHHHHHH	50.38	23954790
232	Malonylation	EQWKEVHKQVVESAY HHHHHHHHHHHHHHH	50.38	26320211
232	Ubiquitination	EQWKEVHKQVVESAY HHHHHHHHHHHHHHH	50.38	21890473
232 (in isoform 1)	Ubiquitination	-	50.38	21890473
232 (in isoform 2)	Phosphorylation	-	50.38	24719451
233 (in isoform 2)	Phosphorylation	-	29.61	24719451
237	Phosphorylation	VHKQVVESAYEVIKL HHHHHHHHHHHHHHH	25.25	21945579
239	Phosphorylation	KQVVESAYEVIKLKG HHHHHHHHHHHHHCC	21.73	25159151
243	Acetylation	ESAYEVIKLKGYTSW HHHHHHHHHCCCCHH	49.69	23954790
243	Ubiquitination	ESAYEVIKLKGYTSW HHHHHHHHHCCCCHH	49.69	21890473
243 (in isoform 1)	Ubiquitination	-	49.69	21890473
245	Ubiquitination	AYEVIKLKGYTSWAI HHHHHHHCCCCHHHH	44.89	-
247	Phosphorylation	EVIKLKGYTSWAIGL HHHHHCCCCHHHHHC	8.94	20068231
248	Phosphorylation	VIKLKGYTSWAIGLS HHHHCCCCHHHHHCC	26.85	20068231
249	Phosphorylation	IKLKGYTSWAIGLSV HHHCCCCHHHHHCCH	13.16	20068231
251	Acetylation	LKGYTSWAIGLSVAD HCCCCHHHHHCCHHH	5.92	19608861
251	Ubiquitination	LKGYTSWAIGLSVAD HCCCCHHHHHCCHHH	5.92	19608861
251 (in isoform 3)	Ubiquitination	-	5.92	-
253 (in isoform 3)	Ubiquitination	-	12.26	-
255	Phosphorylation	TSWAIGLSVADLAES CHHHHHCCHHHHHHH	15.28	20068231
260	Acetylation	GLSVADLAESIMKNL HCCHHHHHHHHHHHH	14.72	19608861
260	Ubiquitination	GLSVADLAESIMKNL HCCHHHHHHHHHHHH	14.72	19608861
261	Ubiquitination	LSVADLAESIMKNLR CCHHHHHHHHHHHHC	48.36	21890473
261 (in isoform 3)	Ubiquitination	-	48.36	-
262	Phosphorylation	SVADLAESIMKNLRR CHHHHHHHHHHHHCC	23.52	20068231
264	Sulfoxidation	ADLAESIMKNLRRVH HHHHHHHHHHHCCCC	3.07	30846556
266	Phosphorylation	LAESIMKNLRRVHPV HHHHHHHHHCCCCCH	22.77	27251275
268	Phosphorylation	ESIMKNLRRVHPVST HHHHHHHCCCCCHHH	48.22	27642862
269	Methylation	SIMKNLRRVHPVSTM HHHHHHCCCCCHHHH	33.97	115481941
270	Ubiquitination	IMKNLRRVHPVSTMI HHHHHCCCCCHHHHH	4.90	21890473
272	Ubiquitination	KNLRRVHPVSTMIKG HHHCCCCCHHHHHHH	20.92	21890473
272 (in isoform 3)	Ubiquitination	-	20.92	-
274	Phosphorylation	LRRVHPVSTMIKGLY HCCCCCHHHHHHHHH	19.40	29802988
274 (in isoform 3)	Ubiquitination	-	19.40	-
275	Phosphorylation	RRVHPVSTMIKGLYG CCCCCHHHHHHHHHC	24.13	29802988
276	Sulfoxidation	RVHPVSTMIKGLYGI CCCCHHHHHHHHHCC	2.02	30846556
278	Acetylation	HPVSTMIKGLYGIKD CCHHHHHHHHHCCCC	31.85	23954790
278	Malonylation	HPVSTMIKGLYGIKD CCHHHHHHHHHCCCC	31.85	26320211
278	Methylation	HPVSTMIKGLYGIKD CCHHHHHHHHHCCCC	31.85	22639955
278	Ubiquitination	HPVSTMIKGLYGIKD CCHHHHHHHHHCCCC	31.85	21890473
278 (in isoform 1)	Ubiquitination	-	31.85	21890473
284	Succinylation	IKGLYGIKDDVFLSV HHHHHCCCCCEEEEC	43.44	23954790
284	Ubiquitination	IKGLYGIKDDVFLSV HHHHHCCCCCEEEEC	43.44	-
284 (in isoform 2)	Ubiquitination	-	43.44	21890473
305	Ubiquitination	NGISDLVKVTLTSEE CCCCCCEEEECCCHH	36.48	-
307	Ubiquitination	ISDLVKVTLTSEEEA CCCCEEEECCCHHHH	20.71	21890473
307	Acetylation	ISDLVKVTLTSEEEA CCCCEEEECCCHHHH	20.71	19608861
307	Phosphorylation	ISDLVKVTLTSEEEA CCCCEEEECCCHHHH	20.71	21815630
307	Ubiquitination	ISDLVKVTLTSEEEA CCCCEEEECCCHHHH	20.71	19608861
307 (in isoform 3)	Ubiquitination	-	20.71	-
309	Phosphorylation	DLVKVTLTSEEEARL CCEEEECCCHHHHHH	25.40	29255136
310	Phosphorylation	LVKVTLTSEEEARLK CEEEECCCHHHHHHH	46.23	29255136
317	Ubiquitination	SEEEARLKKSADTLW CHHHHHHHHHHHHHH	38.85	-
318	Acetylation	EEEARLKKSADTLWG HHHHHHHHHHHHHHH	56.31	19608861
318	Malonylation	EEEARLKKSADTLWG HHHHHHHHHHHHHHH	56.31	26320211
318	Succinylation	EEEARLKKSADTLWG HHHHHHHHHHHHHHH	56.31	-
318	Succinylation	EEEARLKKSADTLWG HHHHHHHHHHHHHHH	56.31	-
318	Ubiquitination	EEEARLKKSADTLWG HHHHHHHHHHHHHHH	56.31	19608861
318 (in isoform 2)	Ubiquitination	-	56.31	21890473
319	Phosphorylation	EEARLKKSADTLWGI HHHHHHHHHHHHHHH	29.77	22777824
322	Phosphorylation	RLKKSADTLWGIQKE HHHHHHHHHHHHHHH	24.91	20873877
328	Acetylation	DTLWGIQKELQF--- HHHHHHHHHHCC---	59.48	22424773
328	Succinylation	DTLWGIQKELQF--- HHHHHHHHHHCC---	59.48	23954790
328	Sumoylation	DTLWGIQKELQF--- HHHHHHHHHHCC---	59.48	-
328	Ubiquitination	DTLWGIQKELQF--- HHHHHHHHHHCC---	59.48	21890473
328 (in isoform 1)	Ubiquitination	-	59.48	21890473
328 (in isoform 2)	Ubiquitination	-	59.48	21890473
338	Phosphorylation	QF------------- CC-------------		27251275
346 (in isoform 3)	Ubiquitination	-		-
347	Acetylation	---------------------- ----------------------		19608861
347	Ubiquitination	---------------------- ----------------------		19608861
347 (in isoform 3)	Ubiquitination	-		-
357	Ubiquitination	-------------------------------- --------------------------------		21890473
357 (in isoform 3)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3	T	Phosphorylation	Kinase	MAP3K7	O43318	GPS
10	Y	Phosphorylation	Kinase	ERBB2	P04626	GPS
10	Y	Phosphorylation	Kinase	FGFR1	P11362	PSP
10	Y	Phosphorylation	Kinase	SRC	P12931	PSP
83	Y	Phosphorylation	Kinase	FGFR1	P11362	PSP
248	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LDHA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LDHA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCJ11_HUMAN	KCNJ11	physical	12145195
ABCC9_HUMAN	ABCC9	physical	12145195
MDHC_HUMAN	MDH1	physical	22939629
LDHB_HUMAN	LDHB	physical	22939629
LDHA_HUMAN	LDHA	physical	21988832
LDHB_HUMAN	LDHB	physical	21988832
BZW1_HUMAN	BZW1	physical	22863883
CNDP2_HUMAN	CNDP2	physical	22863883
GNAI3_HUMAN	GNAI3	physical	22863883
GSHR_HUMAN	GSR	physical	22863883
6PGD_HUMAN	PGD	physical	22863883
KS6A1_HUMAN	RPS6KA1	physical	22863883
DHSO_HUMAN	SORD	physical	22863883
LDHB_HUMAN	LDHB	physical	25416956
MK10_HUMAN	MAPK10	physical	25416956
GABT_HUMAN	ABAT	physical	26344197
ACADM_HUMAN	ACADM	physical	26344197
ADK_HUMAN	ADK	physical	26344197
AL1B1_HUMAN	ALDH1B1	physical	26344197
ALDH2_HUMAN	ALDH2	physical	26344197
AL4A1_HUMAN	ALDH4A1	physical	26344197
APT_HUMAN	APRT	physical	26344197
ARF4_HUMAN	ARF4	physical	26344197
ARF5_HUMAN	ARF5	physical	26344197
CATA_HUMAN	CAT	physical	26344197
TCPG_HUMAN	CCT3	physical	26344197
TCPW_HUMAN	CCT6B	physical	26344197
CATD_HUMAN	CTSD	physical	26344197
ENOA_HUMAN	ENO1	physical	26344197
ETFA_HUMAN	ETFA	physical	26344197
FAAA_HUMAN	FAH	physical	26344197
FAHD1_HUMAN	FAHD1	physical	26344197
FUMH_HUMAN	FH	physical	26344197
LYAG_HUMAN	GAA	physical	26344197
GSTO1_HUMAN	GSTO1	physical	26344197
IDE_HUMAN	IDE	physical	26344197
MIF_HUMAN	MIF	physical	26344197
NDKB_HUMAN	NME2	physical	26344197
PARK7_HUMAN	PARK7	physical	26344197
ODPA_HUMAN	PDHA1	physical	26344197
PEPD_HUMAN	PEPD	physical	26344197
PGK1_HUMAN	PGK1	physical	26344197
PGM1_HUMAN	PGM1	physical	26344197
KPYM_HUMAN	PKM	physical	26344197
PPIA_HUMAN	PPIA	physical	26344197
PPT1_HUMAN	PPT1	physical	26344197
PCP_HUMAN	PRCP	physical	26344197
PRDX2_HUMAN	PRDX2	physical	26344197
PRDX5_HUMAN	PRDX5	physical	26344197
GLU2B_HUMAN	PRKCSH	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
RAB5A_HUMAN	RAB5A	physical	26344197
RAB6B_HUMAN	RAB6B	physical	26344197
SDHB_HUMAN	SDHB	physical	26344197
DHSO_HUMAN	SORD	physical	26344197
SPRE_HUMAN	SPR	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
UFD1_HUMAN	UFD1L	physical	26344197
LDHB_HUMAN	LDHB	physical	21516116
LDHC_HUMAN	LDHC	physical	28514442
LDHB_HUMAN	LDHB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612933	Glycogen storage disease 11 (GSD11)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LDHA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-5; LYS-14; LYS-57; LYS-81;LYS-118; LYS-126; LYS-222; LYS-278 AND LYS-318, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-10 AND TYR-239, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-239, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-239, AND MASSSPECTROMETRY.	15592455 [Abstract]