AL1B1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL1B1_HUMAN
• UniProt AC: P30837
• Protein Name: Aldehyde dehydrogenase X, mitochondrial
• Gene Name: ALDH1B1
• Organism: Homo sapiens (Human).
• Sequence Length: 517
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation..
• Protein Sequence: MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	FLAPRLLSLQGRTAR CHHHHHHHCCCCCCC	24.20	50564579
21	Phosphorylation	GRTARYSSAAALPSP CCCCCCCCCCCCCCC	17.00	46161947
27	Phosphorylation	SSAAALPSPILNPDI CCCCCCCCCCCCCCC	25.98	46161953
51	Acetylation	EWQDAVSKKTFPTVN CHHHHHHCCCCCCCC	49.59	-
52	Acetylation	WQDAVSKKTFPTVNP HHHHHHCCCCCCCCC	48.14	-
52	Ubiquitination	WQDAVSKKTFPTVNP HHHHHHCCCCCCCCC	48.14	-
52	Succinylation	WQDAVSKKTFPTVNP HHHHHHCCCCCCCCC	48.14	-
52	Succinylation	WQDAVSKKTFPTVNP HHHHHHCCCCCCCCC	48.14	-
52	Malonylation	WQDAVSKKTFPTVNP HHHHHHCCCCCCCCC	48.14	26320211
73	Methylation	GHVAEGDRADVDRAV EECCCCCHHHHHHHH	43.47	-
81	Succinylation	ADVDRAVKAAREAFR HHHHHHHHHHHHHHH	35.03	-
81	Succinylation	ADVDRAVKAAREAFR HHHHHHHHHHHHHHH	35.03	-
135	Phosphorylation	GKPFQESYALDLDEV CCCCCCEECCCHHHH	15.49	71731
155	Acetylation	YFAGWADKWHGKTIP HHHCCCHHHCCEEEC	33.09	23236377
202	Phosphorylation	KLAPALATGNTVVMK EEEHHHHCCCEEEEE	31.64	21406692
205	Phosphorylation	PALATGNTVVMKVAE HHHHCCCEEEEEEHH	18.80	21406692
214	Phosphorylation	VMKVAEQTPLSALYL EEEEHHCCCHHHHHH	20.08	26503514
217	Phosphorylation	VAEQTPLSALYLASL EHHCCCHHHHHHHHH	19.89	110743611
220	Phosphorylation	QTPLSALYLASLIKE CCCHHHHHHHHHHHH	10.43	26503514
223	Phosphorylation	LSALYLASLIKEAGF HHHHHHHHHHHHHCC	28.21	24719451
263	Phosphorylation	DKVAFTGSTEVGHLI CEEEEECCHHHHHHH	20.52	25690035
264	Phosphorylation	KVAFTGSTEVGHLIQ EEEEECCHHHHHHHH	35.71	25690035
272	Malonylation	EVGHLIQKAAGDSNL HHHHHHHHHHCCCCC	32.96	26320211
283	Phosphorylation	DSNLKRVTLELGGKS CCCCCEEEEECCCCC	20.67	20166139
330	Phosphorylation	SRTFVEESIYNEFLE CCHHCHHHHHHHHHH	19.50	110743619
332	Phosphorylation	TFVEESIYNEFLERT HHCHHHHHHHHHHHH	20.23	110743627
347	Ubiquitination	VEKAKQRKVGNPFEL HHHHHHCCCCCCCCC	52.58	-
364	Succinylation	QQGPQVDKEQFERVL CCCCCCCHHHHHHHH	55.34	-
364	Succinylation	QQGPQVDKEQFERVL CCCCCCCHHHHHHHH	55.34	-
364	Ubiquitination	QQGPQVDKEQFERVL CCCCCCCHHHHHHHH	55.34	-
364	Acetylation	QQGPQVDKEQFERVL CCCCCCCHHHHHHHH	55.34	23236377
373	Phosphorylation	QFERVLGYIQLGQKE HHHHHHHHHHCCCCC	4.94	28152594
379	Acetylation	GYIQLGQKEGAKLLC HHHHCCCCCCCEEEE	57.21	23236377
379	Malonylation	GYIQLGQKEGAKLLC HHHHCCCCCCCEEEE	57.21	26320211
383	Succinylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	-
383	Ubiquitination	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	-
383	Acetylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	-
383	Succinylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	-
383	Malonylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	26320211
399	Acetylation	GERGFFIKPTVFGGV CCCCCEECCEEECCC	29.49	23236377
399	Succinylation	GERGFFIKPTVFGGV CCCCCEECCEEECCC	29.49	-
399	Ubiquitination	GERGFFIKPTVFGGV CCCCCEECCEEECCC	29.49	-
399	Succinylation	GERGFFIKPTVFGGV CCCCCEECCEEECCC	29.49	23954790
401	Phosphorylation	RGFFIKPTVFGGVQD CCCEECCEEECCCCC	24.38	46161959
414	Acetylation	QDDMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	-
414	Ubiquitination	QDDMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	-
414	Succinylation	QDDMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	-
414	Succinylation	QDDMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	-
426	Acetylation	GPVQPLFKFKKIEEV CCCHHCCCCCCHHHH	65.05	23236377
426	Ubiquitination	GPVQPLFKFKKIEEV CCCHHCCCCCCHHHH	65.05	21890473
426	Succinylation	GPVQPLFKFKKIEEV CCCHHCCCCCCHHHH	65.05	23954790
426	Succinylation	GPVQPLFKFKKIEEV CCCHHCCCCCCHHHH	65.05	-
429	Succinylation	QPLFKFKKIEEVVER HHCCCCCCHHHHHHH	59.49	27452117
429	Acetylation	QPLFKFKKIEEVVER HHCCCCCCHHHHHHH	59.49	21339330
442	Phosphorylation	ERANNTRYGLAAAVF HHHHCCCCEEEEEHC	17.91	28152594
500	Succinylation	ELGEDGLKAYTEVKT EECCCHHHHEEEEEE	44.89	23954790
500	Ubiquitination	ELGEDGLKAYTEVKT EECCCHHHHEEEEEE	44.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL1B1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL1B1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL1B1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
QCR7_HUMAN	UQCRB	physical	22939629
FABPI_HUMAN	FABP2	physical	21988832
FUMH_HUMAN	FH	physical	22863883
HEXB_HUMAN	HEXB	physical	22863883
PDC10_HUMAN	PDCD10	physical	22863883
FEM1B_HUMAN	FEM1B	physical	26186194
SUFU_HUMAN	SUFU	physical	26186194
DHRS4_HUMAN	DHRS4	physical	26186194
ESTD_HUMAN	ESD	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26344197
PGM1_HUMAN	PGM1	physical	26344197
SRP68_HUMAN	SRP68	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
XPP1_HUMAN	XPNPEP1	physical	26344197
FEM1B_HUMAN	FEM1B	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.