dbPTM

FABPI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FABPI_HUMAN
UniProt AC	P12104
Protein Name	Fatty acid-binding protein, intestinal
Gene Name	FABP2
Organism	Homo sapiens (Human).
Sequence Length	132
Subcellular Localization	Cytoplasm.
Protein Description	FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor..
Protein Sequence	MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQEGNKFTVKESSAFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNELNTVREIIGDELVQTYVYEGVEAKRIFKKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAFDSTWKV ------CCCCCCCCC	19.56	-
12	Phosphorylation	STWKVDRSENYDKFM CCCCCCCCCCHHHHH	26.23	29759185
15	Phosphorylation	KVDRSENYDKFMEKM CCCCCCCHHHHHHHH	19.23	-
49	Phosphorylation	TQEGNKFTVKESSAF EEECCEEEECCCCCC	32.07	24719451
71	Phosphorylation	ELGVTFNYNLADGTE EECEEEEEECCCCCE	13.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FABPI_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FABPI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FABPI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
AGR2_HUMAN	AGR2	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FABPI_HUMAN

Related Literatures of Post-Translational Modification