AGR2_HUMAN - dbPTM
AGR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGR2_HUMAN
UniProt AC O95994
Protein Name Anterior gradient protein 2 homolog
Gene Name AGR2
Organism Homo sapiens (Human).
Sequence Length 175
Subcellular Localization Secreted . Endoplasmic reticulum.
Protein Description Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. [PubMed: 23274113]
Protein Sequence MEKIPVSAFLLLVALSYTLARDTTVKPGAKKDTKDSRPKLPQTLSRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPADTALLLDNMKKALKLLKTEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationAKKDTKDSRPKLPQT
CCCCCCCCCCCCCHH		52.6350564017
55PhosphorylationWGDQLIWTQTYEEAL
CCCEEEEEEHHHHHH		12.2126657352
952-HydroxyisobutyrylationKKVFAENKEIQKLAE
HHHHHCCHHHHHHHH		47.93-
111PhosphorylationFVLLNLVYETTDKHL
HHHHHHHHHCCCCCC		15.666947735
113PhosphorylationLLNLVYETTDKHLSP
HHHHHHHCCCCCCCC		23.7046160571
114PhosphorylationLNLVYETTDKHLSPD
HHHHHHCCCCCCCCC		30.9846160577
116AcetylationLVYETTDKHLSPDGQ
HHHHCCCCCCCCCCC		44.3325825284
119PhosphorylationETTDKHLSPDGQYVP
HCCCCCCCCCCCEEC		22.2123312004
124PhosphorylationHLSPDGQYVPRIMFV
CCCCCCCEECEEEEE		20.2511896147
134PhosphorylationRIMFVDPSLTVRADI
EEEEECCCCEEEEEE		32.0128348404
136PhosphorylationMFVDPSLTVRADITG
EEECCCCEEEEEECC		16.5728348404
145PhosphorylationRADITGRYSNRLYAY
EEEECCCCCCCEEEE		16.1922210691
146PhosphorylationADITGRYSNRLYAYE
EEECCCCCCCEEEEC		17.7022210691
150PhosphorylationGRYSNRLYAYEPADT
CCCCCCEEEECCCCH		12.1476972927
152PhosphorylationYSNRLYAYEPADTAL
CCCCEEEECCCCHHH		14.6476972933
157PhosphorylationYAYEPADTALLLDNM
EEECCCCHHHHHHHH		22.70110738527
165AcetylationALLLDNMKKALKLLK
HHHHHHHHHHHHHHH		40.94155405
166AcetylationLLLDNMKKALKLLKT
HHHHHHHHHHHHHHH		48.46156175
172AcetylationKKALKLLKTEL----
HHHHHHHHHCC----		50.8425825284
173PhosphorylationKALKLLKTEL-----
HHHHHHHHCC-----		42.3524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AGR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRD7_HUMANBRD7physical
16169070
CC90B_HUMANCCDC90Bphysical
16169070
MED31_HUMANMED31physical
16169070
DPYL1_HUMANCRMP1physical
16169070
DAG1_HUMANDAG1physical
12592373
LYPD3_HUMANLYPD3physical
12592373
A4_HUMANAPPphysical
21832049
UBQL1_HUMANUBQLN1physical
25416956
N62CL_HUMANNUP62CLphysical
25416956
CTSR1_HUMANCATSPER1physical
25416956
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGR2_HUMAN

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Related Literatures of Post-Translational Modification

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