| UniProt ID | CTSR1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NEC5 | |
| Protein Name | Cation channel sperm-associated protein 1 | |
| Gene Name | CATSPER1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 780 | |
| Subcellular Localization |
Cell projection, cilium, flagellum membrane Multi-pass membrane protein . Specifically located in the principal piece of sperm tail. |
|
| Protein Description | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.. | |
| Protein Sequence | MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 333 | Phosphorylation | SIPHTSRSLIHDAPG CCCCCCCCHHCCCCC | 31.29 | 21888424 | |
| 344 | Phosphorylation | DAPGPAASRTGVFPY CCCCCCHHHCCCCCC | 32.26 | 21888424 | |
| 396 | Acetylation | KHSEDWGKEEGQFQK HCCCCHHCCCCCHHH | 48.62 | 7666317 | |
| 403 | Acetylation | KEEGQFQKRKTGRLQ CCCCCHHHCCCCCCC | 58.09 | 7666325 | |
| 550 | Phosphorylation | RILKVFKSLRALRAI HHHHHHHHHHHHHHH | 16.18 | 24719451 | |
| 701 | Phosphorylation | QEKLLEDSLTELRAA HHHHHHHHHHHHHHC | 28.02 | 30622161 | |
| 703 | Phosphorylation | KLLEDSLTELRAAEP HHHHHHHHHHHHCCC | 36.60 | 30622161 | |
| 715 | Phosphorylation | AEPKEVASEGTMLKR CCCHHHHCCCHHHHH | 41.56 | 30622161 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CTSR1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTSR1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTSR1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CTSR1_HUMAN | CATSPER1 | physical | 25416956 | |
| KHDR2_HUMAN | KHDRBS2 | physical | 25416956 | |
| RFX6_HUMAN | RFX6 | physical | 25416956 | |
| KR109_HUMAN | KRTAP10-9 | physical | 25416956 | |
| KR101_HUMAN | KRTAP10-1 | physical | 25416956 | |
| KR10B_HUMAN | KRTAP10-11 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| KRA56_HUMAN | KRTAP5-6 | physical | 25416956 | |
| KR411_HUMAN | KRTAP4-11 | physical | 25416956 | |
| RGS20_HUMAN | RGS20 | physical | 21516116 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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