dbPTM

KHDR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KHDR2_HUMAN
UniProt AC	Q5VWX1
Protein Name	KH domain-containing, RNA-binding, signal transduction-associated protein 2
Gene Name	KHDRBS2
Organism	Homo sapiens (Human).
Sequence Length	349
Subcellular Localization	Nucleus .
Protein Description	RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis..
Protein Sequence	MEEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGIRGRGIRIAPTAPSRGRGGAIPPPPPPGRGVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGYGGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQRSARGGYREHPYGRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEEEKYLPELMAE --CCHHHHHHHHHHC	30.67	20068231
16	Phosphorylation	ELMAEKDSLDPSFVH HHHHCCCCCCHHHHH	45.82	26074081
20	Phosphorylation	EKDSLDPSFVHASRL CCCCCCHHHHHHHHH	39.30	24719451
25	Phosphorylation	DPSFVHASRLLAEEI CHHHHHHHHHHHHHH	14.48	26074081
54	O-linked_Glycosylation	KKYLDVISNKNIKLS HHHHHHHHCCCCCCC	41.42	30379171
56	Acetylation	YLDVISNKNIKLSER HHHHHHCCCCCCCCC	53.94	30589657
69	Acetylation	ERVLIPVKQYPKFNF CCEEEEHHHCCCCCC	38.47	163895
69	Ubiquitination	ERVLIPVKQYPKFNF CCEEEEHHHCCCCCC	38.47	21890473
73	Ubiquitination	IPVKQYPKFNFVGKL EEHHHCCCCCCHHHH	48.26	73
73	Acetylation	IPVKQYPKFNFVGKL EEHHHCCCCCCHHHH	48.26	22647397
79	Methylation	PKFNFVGKLLGPRGN CCCCCHHHHHCCCCH	34.93	72622551
79	Acetylation	PKFNFVGKLLGPRGN CCCCCHHHHHCCCCH	34.93	72622551
95	Phosphorylation	LKRLQEETGAKMSIL HHHHHHHHCCCEEHH	41.51	20068231
100	Phosphorylation	EETGAKMSILGKGSM HHHCCCEEHHCCCHH	17.60	20068231
106	Phosphorylation	MSILGKGSMRDKAKE EEHHCCCHHHHHHHH	17.71	20068231
112	Acetylation	GSMRDKAKEEELRKS CHHHHHHHHHHHHHH	71.98	19818047
117	Methylation	KAKEEELRKSGEAKY HHHHHHHHHHCCHHH	34.08	-
119	Phosphorylation	KEEELRKSGEAKYAH HHHHHHHHCCHHHHC	35.12	24719451
128	Phosphorylation	EAKYAHLSDELHVLI CHHHHCHHHCCEEEE	21.12	24719451
146	Phosphorylation	APPGEAYSRMSHALE CCCCHHHHHHHHHHH	28.67	24719451
163	Phosphorylation	KKFLVPDYNDEIRQE HHHHCCCCCHHHHHH	20.60	-
230	Methylation	PRGSTVTRGALPVPP CCCCCCCCCCCCCCC	24.85	-
240	Methylation	LPVPPVARGVPTPRA CCCCCCCCCCCCCCC	47.04	-
244	Phosphorylation	PVARGVPTPRARGAP CCCCCCCCCCCCCCC	24.01	24719451
346	Phosphorylation	GGYREHPYGRY---- CCCCCCCCCCC----	19.01	-
348	Methylation	YREHPYGRY------ CCCCCCCCC------	28.30	-
349	Phosphorylation	REHPYGRY------- CCCCCCCC-------	20.67	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KHDR2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KHDR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KHDR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX17_HUMAN	DDX17	physical	17643375
DDX5_HUMAN	DDX5	physical	17643375
ROA1_HUMAN	HNRNPA1	physical	17643375
ROA2_HUMAN	HNRNPA2B1	physical	17643375
HNRH1_HUMAN	HNRNPH1	physical	17643375
HNRPK_HUMAN	HNRNPK	physical	17643375
HNRPR_HUMAN	HNRNPR	physical	17643375
HNRPQ_HUMAN	SYNCRIP	physical	17643375
HNRPC_HUMAN	HNRNPC	physical	17643375
IF2B1_HUMAN	IGF2BP1	physical	17643375
ANM1_HUMAN	PRMT1	physical	17643375
ILF2_HUMAN	ILF2	physical	17643375
KHDR1_HUMAN	KHDRBS1	physical	17643375
RBMX_HUMAN	RBMX	physical	17643375
HNRDL_HUMAN	HNRNPDL	physical	17643375
EHBP1_HUMAN	EHBP1	physical	17643375
ARID2_HUMAN	ARID2	physical	17643375
TAF3_HUMAN	TAF3	physical	17643375
DSG1_HUMAN	DSG1	physical	17643375
ROA0_HUMAN	HNRNPA0	physical	17643375
IF2B3_HUMAN	IGF2BP3	physical	17643375
HNRPL_HUMAN	HNRNPL	physical	17643375
HNRL2_HUMAN	HNRNPUL2	physical	17643375
RBM39_HUMAN	RBM39	physical	17643375
ILF3_HUMAN	ILF3	physical	17643375
HNRH3_HUMAN	HNRNPH3	physical	17643375
ANM5_HUMAN	PRMT5	physical	17643375
RS3_HUMAN	RPS3	physical	17643375
FIBA_HUMAN	FGA	physical	17643375
YBOX1_HUMAN	YBX1	physical	17643375
FIBG_HUMAN	FGG	physical	17643375
HNRPD_HUMAN	HNRNPD	physical	17643375
RT27_HUMAN	MRPS27	physical	17643375
TADBP_HUMAN	TARDBP	physical	17643375
NUSAP_HUMAN	NUSAP1	physical	17643375
SAFB1_HUMAN	SAFB	physical	17643375
MEP50_HUMAN	WDR77	physical	17643375
MOV10_HUMAN	MOV10	physical	17643375
HORN_HUMAN	HRNR	physical	17643375
KHDR3_HUMAN	KHDRBS3	physical	17643375
FIBB_HUMAN	FGB	physical	17643375
DEK_HUMAN	DEK	physical	17643375
FBW1B_HUMAN	FBXW11	physical	17643375
LRC15_HUMAN	LRRC15	physical	17643375
HS90B_HUMAN	HSP90AB1	physical	17643375
KHDR2_HUMAN	KHDRBS2	physical	25416956
TYMOS_HUMAN	TYMSOS	physical	25416956
ATX2_HUMAN	ATXN2	physical	26344197
DDX43_HUMAN	DDX43	physical	26344197
HNRPR_HUMAN	HNRNPR	physical	26344197
HNRPQ_HUMAN	SYNCRIP	physical	26344197
KHDR2_HUMAN	KHDRBS2	physical	21516116
TYK2_HUMAN	TYK2	physical	21516116
TM14B_HUMAN	TMEM14B	physical	21516116
KHDR3_HUMAN	KHDRBS3	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
FBW1A_HUMAN	BTRC	physical	28514442
ATG7_HUMAN	ATG7	physical	28514442
KHDR1_HUMAN	KHDRBS1	physical	28514442
WIPI3_HUMAN	WDR45B	physical	28514442
YRDC_HUMAN	YRDC	physical	28514442
CRBN_HUMAN	CRBN	physical	28514442
PLCG1_HUMAN	PLCG1	physical	28514442
PTER_HUMAN	PTER	physical	28514442
ACOX1_HUMAN	ACOX1	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442
SPT5H_HUMAN	SUPT5H	physical	28514442
KLH42_HUMAN	KLHL42	physical	28514442
UBP7_HUMAN	USP7	physical	28514442
CTC1_HUMAN	CTC1	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
NAGK_HUMAN	NAGK	physical	28514442
THIK_HUMAN	ACAA1	physical	28514442
MK03_HUMAN	MAPK3	physical	28514442
AURKA_HUMAN	AURKA	physical	28514442
KIME_HUMAN	MVK	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KHDR2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-73, AND MASS SPECTROMETRY.	19608861 [Abstract]