CTC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTC1_HUMAN
• UniProt AC: Q2NKJ3
• Protein Name: CST complex subunit CTC1
• Gene Name: CTC1
• Organism: Homo sapiens (Human).
• Sequence Length: 1217
• Subcellular Localization: Nucleus . Chromosome, telomere . A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
• Protein Description: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. [PubMed: 19854130 However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha]
• Protein Sequence: MAAGRAQVPSSEQAWLEDAQVFIQKTLCPAVKEPNVQLTPLVIDCVKTVWLSQGRNQGSTLPLSYSFVSVQDLKTHQRLPCCSHLSWSSSAYQAWAQEAGPNGNPLPREQLLLLGTLTDLSADLEQECRNGSLYVRDNTGVLSCELIDLDLSWLGHLFLFPRWSYLPPARWNSSGEGHLELWDAPVPVFPLTISPGPVTPIPVLYPESASCLLRLRNKLRGVQRNLAGSLVRLSALVKSKQKAYFILSLGRSHPAVTHVSIIVQVPAQLVWHRALRPGTAYVLTELRVSKIRGQRQHVWMTSQSSRLLLLKPECVQELELELEGPLLEADPKPLPMPSNSEDKKDPESLVRYSRLLSYSGAVTGVLNEPAGLYELDGQLGLCLAYQQFRGLRRVMRPGVCLQLQDVHLLQSVGGGTRRPVLAPCLRGAVLLQSFSRQKPGAHSSRQAYGASLYEQLVWERQLGLPLYLWATKALEELACKLCPHVLRHHQFLQHSSPGSPSLGLQLLAPTLDLLAPPGSPVRNAHNEILEEPHHCPLQKYTRLQTPSSFPTLATLKEEGQRKAWASFDPKALLPLPEASYLPSCQLNRRLAWSWLCLLPSAFCPAQVLLGVLVASSHKGCLQLRDQSGSLPCLLLAKHSQPLSDPRLIGCLVRAERFQLIVERDVRSSFPSWKELSMPGFIQKQQARVYVQFFLADALILPVPRPCLHSATPSTPQTDPTGPEGPHLGQSRLFLLCHKEALMKRNFCVPPGASPEVPKPALSFYVLGSWLGGTQRKEGTGWGLPEPQGNDDNDQKVHLIFFGSSVRWFEFLHPGQVYRLIAPGPATPMLFEKDGSSCISRRPLELAGCASCLTVQDNWTLELESSQDIQDVLDANKSLPESSLTDLLSDNFTDSLVSFSAEILSRTLCEPLVASLWMKLGNTGAMRRCVKLTVALETAECEFPPHLDVYIEDPHLPPSLGLLPGARVHFSQLEKRVSRSHNVYCCFRSSTYVQVLSFPPETTISIPLPHIYLAELLQGGQSPFQATASCHIVSVFSLQLFWVCAYCTSICRQGKCTRLGSTCPTQTAISQAIIRLLVEDGTAEAVVTCRNHHVAAALGLCPREWASLLDFVQVPGRVVLQFAGPGAQLESSARVDEPMTMFLWTLCTSPSVLRPIVLSFELERKPSKIVPLEPPRLQRFQCGELPFLTHVNPRLRLSCLSIRESEYSSSLGILASSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	DAQVFIQKTLCPAVK HHHHHHHHHCCHHHC	38.35	29967540
32	Ubiquitination	KTLCPAVKEPNVQLT HHCCHHHCCCCCCCC	70.34	29967540
47	Ubiquitination	PLVIDCVKTVWLSQG HHHHHHHEEEEECCC	43.63	-
74 (in isoform 2)	Ubiquitination	-	52.85	21906983
74 (in isoform 1)	Ubiquitination	-	52.85	21906983
74	Ubiquitination	FVSVQDLKTHQRLPC EEEHHHCCCCCCCCC	52.85	21906983
132	Phosphorylation	EQECRNGSLYVRDNT HHHHHCCCEEEECCC	21.78	24719451
238	Ubiquitination	VRLSALVKSKQKAYF HHHHHHHHCCCCEEE	53.43	21906983
238 (in isoform 1)	Ubiquitination	-	53.43	21906983
240	Ubiquitination	LSALVKSKQKAYFIL HHHHHHCCCCEEEEE	50.53	22817900
242	Ubiquitination	ALVKSKQKAYFILSL HHHHCCCCEEEEEEC	49.11	22817900
257	Ubiquitination	GRSHPAVTHVSIIVQ CCCCCCCCEEEEEEE	20.75	22817900
374	Ubiquitination	NEPAGLYELDGQLGL CCCCCEEEECCHHHH	45.48	22817900
477	Ubiquitination	ATKALEELACKLCPH HHHHHHHHHHHHCHH	5.04	22817900
480	Ubiquitination	ALEELACKLCPHVLR HHHHHHHHHCHHHHH	47.74	29967540
496	Ubiquitination	HQFLQHSSPGSPSLG HHHHCCCCCCCCCHH	31.02	22817900
513	Ubiquitination	LLAPTLDLLAPPGSP HHHHHHHHHCCCCCC	5.03	22817900
519	Phosphorylation	DLLAPPGSPVRNAHN HHHCCCCCCCCCCCH	26.46	26329039
521	Ubiquitination	LAPPGSPVRNAHNEI HCCCCCCCCCCCHHH	8.69	22817900
521 (in isoform 2)	Ubiquitination	-	8.69	21906983
539	Ubiquitination	PHHCPLQKYTRLQTP CCCCCCHHCCCCCCC	57.16	29967540
540	Phosphorylation	HHCPLQKYTRLQTPS CCCCCHHCCCCCCCC	5.55	22468782
545	Phosphorylation	QKYTRLQTPSSFPTL HHCCCCCCCCCCCCH	29.72	22468782
556 (in isoform 1)	Ubiquitination	-	49.73	21906983
556	Ubiquitination	FPTLATLKEEGQRKA CCCHHHHHHHCCCCH	49.73	21906983
562	Ubiquitination	LKEEGQRKAWASFDP HHHHCCCCHHHCCCH	40.15	29967540
580	Phosphorylation	LPLPEASYLPSCQLN CCCCCHHHCCCCHHH	29.67	18452278
583	Phosphorylation	PEASYLPSCQLNRRL CCHHHCCCCHHHHHH	16.35	18452278
630	Ubiquitination	LRDQSGSLPCLLLAK HHCCCCCCCEEEEEC	3.86	22817900
637	Ubiquitination	LPCLLLAKHSQPLSD CCEEEEECCCCCCCC	43.70	-
638	Ubiquitination	PCLLLAKHSQPLSDP CEEEEECCCCCCCCH	26.51	22817900
638 (in isoform 2)	Ubiquitination	-	26.51	21906983
673	Ubiquitination	RSSFPSWKELSMPGF HHCCCCHHHHCCCCC	53.79	22817900
673 (in isoform 1)	Ubiquitination	-	53.79	21906983
675	Ubiquitination	SFPSWKELSMPGFIQ CCCCHHHHCCCCCCH	4.76	22817900
683	Ubiquitination	SMPGFIQKQQARVYV CCCCCCHHHHHHHHH	39.29	-
689	Phosphorylation	QKQQARVYVQFFLAD HHHHHHHHHHHHHCC	5.29	28348404
709	Phosphorylation	VPRPCLHSATPSTPQ CCCCCCCCCCCCCCC	22.38	23312004
711	Phosphorylation	RPCLHSATPSTPQTD CCCCCCCCCCCCCCC	22.31	23312004
713	Phosphorylation	CLHSATPSTPQTDPT CCCCCCCCCCCCCCC	48.65	23312004
714	Phosphorylation	LHSATPSTPQTDPTG CCCCCCCCCCCCCCC	22.18	23312004
717	Phosphorylation	ATPSTPQTDPTGPEG CCCCCCCCCCCCCCC	45.19	23312004
733	Ubiquitination	HLGQSRLFLLCHKEA CCCHHHHHHHHHHHH	4.81	22817900
741 (in isoform 2)	Ubiquitination	-	4.33	21906983
741	Ubiquitination	LLCHKEALMKRNFCV HHHHHHHHHHCCCCC	4.33	22817900
752	Ubiquitination	NFCVPPGASPEVPKP CCCCCCCCCCCCCCC	27.90	22817900
753	Phosphorylation	FCVPPGASPEVPKPA CCCCCCCCCCCCCCC	27.75	25159151
760	Ubiquitination	SPEVPKPALSFYVLG CCCCCCCCEEEEEEE	23.20	22817900
760 (in isoform 2)	Ubiquitination	-	23.20	21906983
776	Ubiquitination	WLGGTQRKEGTGWGL HHCCCCCCCCCCCCC	51.16	21906983
776 (in isoform 1)	Ubiquitination	-	51.16	21906983
795	Ubiquitination	GNDDNDQKVHLIFFG CCCCCCCEEEEEEEC	34.19	22817900
795 (in isoform 1)	Ubiquitination	-	34.19	21906983
835	Phosphorylation	MLFEKDGSSCISRRP EEEECCCCCCCCCCC	31.97	29262532
836	Phosphorylation	LFEKDGSSCISRRPL EEECCCCCCCCCCCH	22.47	29262532
839	Phosphorylation	KDGSSCISRRPLELA CCCCCCCCCCCHHHC	26.94	29262532
904	Phosphorylation	SFSAEILSRTLCEPL HHCHHHHHHHCCHHH	28.96	24719451
918	Ubiquitination	LVASLWMKLGNTGAM HHHHHHHHHCCCHHH	41.48	-
931	Ubiquitination	AMRRCVKLTVALETA HHHHHHHHEEEEEEE	2.02	22817900
939	Ubiquitination	TVALETAECEFPPHL EEEEEEEECCCCCCE	41.84	22817900
939 (in isoform 2)	Ubiquitination	-	41.84	21906983
974 (in isoform 1)	Ubiquitination	-	67.69	21906983
974	Ubiquitination	VHFSQLEKRVSRSHN EEHHHHHHHHHHCCC	67.69	27667366
1060	Phosphorylation	GKCTRLGSTCPTQTA CCCCCCCCCCCCHHH	31.28	-
1064	Phosphorylation	RLGSTCPTQTAISQA CCCCCCCCHHHHHHH	40.47	-
1066	Phosphorylation	GSTCPTQTAISQAII CCCCCCHHHHHHHHH	28.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CTC1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612199: Cerebroretinal microangiopathy with calcifications and cysts (CRMCC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.