CUL1_HUMAN - dbPTM
CUL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CUL1_HUMAN
UniProt AC Q13616
Protein Name Cullin-1
Gene Name CUL1
Organism Homo sapiens (Human).
Sequence Length 776
Subcellular Localization
Protein Description Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. [PubMed: 27565346 In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68]
Protein Sequence MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSTRSQNP
------CCCCCCCCC
40.1825159151
3Phosphorylation-----MSSTRSQNPH
-----CCCCCCCCCC
26.9225159151
4Phosphorylation----MSSTRSQNPHG
----CCCCCCCCCCC
27.3426074081
6Phosphorylation--MSSTRSQNPHGLK
--CCCCCCCCCCCHH
34.1029514088
13AcetylationSQNPHGLKQIGLDQI
CCCCCCHHHCCHHHH
44.4526051181
32PhosphorylationRAGIQQVYTRQSMAK
HHHHHHHHHHHHHHH
7.5920068231
40PhosphorylationTRQSMAKSRYMELYT
HHHHHHHHHHHHHHH
21.0722210691
50PhosphorylationMELYTHVYNYCTSVH
HHHHHHHHHHHHHHH
7.8822210691
63MethylationVHQSNQARGAGVPPS
HHHHCCCCCCCCCCC
26.2324129315
70PhosphorylationRGAGVPPSKSKKGQT
CCCCCCCCCCCCCCC
43.4120068231
73MethylationGVPPSKSKKGQTPGG
CCCCCCCCCCCCCCC
65.74-
74UbiquitinationVPPSKSKKGQTPGGA
CCCCCCCCCCCCCCC
64.44-
77PhosphorylationSKSKKGQTPGGAQFV
CCCCCCCCCCCCCCH
32.3521815630
99PhosphorylationLKEFLKNYLTNLLKD
HHHHHHHHHHHHHHC
17.2026657352
101PhosphorylationEFLKNYLTNLLKDGE
HHHHHHHHHHHHCCC
17.2920068231
114PhosphorylationGEDLMDESVLKFYTQ
CCCCCCHHHHHHHHH
28.6129209046
131UbiquitinationEDYRFSSKVLNGICA
CHHCCCHHHHHHHHH
49.9321906983
290UbiquitinationTQDELARKCEQVLIE
CHHHHHHHHHHHHHH
36.19-
327PhosphorylationGRMYNLVSRIQDGLG
HHHHHHHHHHHHCHH
27.1727762562
337AcetylationQDGLGELKKLLETHI
HHCHHHHHHHHHHHC
36.7527452117
3372-HydroxyisobutyrylationQDGLGELKKLLETHI
HHCHHHHHHHHHHHC
36.75-
342PhosphorylationELKKLLETHIHNQGL
HHHHHHHHHCHHHHH
26.5430576142
383PhosphorylationKYNALVMSAFNNDAG
HHCHHHHHHHCCCHH
23.4129507054
409PhosphorylationFINNNAVTKMAQSSS
HHCHHHHHHHHHCCC
16.82-
410UbiquitinationINNNAVTKMAQSSSK
HCHHHHHHHHHCCCC
26.1621906983
417UbiquitinationKMAQSSSKSPELLAR
HHHHCCCCCHHHHHH
72.48-
425PhosphorylationSPELLARYCDSLLKK
CHHHHHHHHHHHHHH
8.5921406692
428PhosphorylationLLARYCDSLLKKSSK
HHHHHHHHHHHHHCC
31.8524719451
431AcetylationRYCDSLLKKSSKNPE
HHHHHHHHHHCCCHH
56.7723749302
432UbiquitinationYCDSLLKKSSKNPEE
HHHHHHHHHCCCHHH
60.99-
464UbiquitinationEDKDVFQKFYAKMLA
CCHHHHHHHHHHHHH
28.9521890473
464MalonylationEDKDVFQKFYAKMLA
CCHHHHHHHHHHHHH
28.9526320211
466PhosphorylationKDVFQKFYAKMLAKR
HHHHHHHHHHHHHHH
16.6123403867
468AcetylationVFQKFYAKMLAKRLV
HHHHHHHHHHHHHHH
24.0626051181
468UbiquitinationVFQKFYAKMLAKRLV
HHHHHHHHHHHHHHH
24.0621890473
468MalonylationVFQKFYAKMLAKRLV
HHHHHHHHHHHHHHH
24.0626320211
472NeddylationFYAKMLAKRLVHQNS
HHHHHHHHHHHHCCC
42.16-
493UbiquitinationASMISKLKQACGFEY
HHHHHHHHHHHCCCC
39.32-
503AcetylationCGFEYTSKLQRMFQD
HCCCCHHHHHHHHHH
40.6226051181
522UbiquitinationKDLNEQFKKHLTNSE
CCHHHHHHHHCCCCC
38.69-
583PhosphorylationGRKLTWLYQLSKGEL
CCCEEEEEECCCCCE
10.0426437602
587UbiquitinationTWLYQLSKGELVTNC
EEEEECCCCCEECHH
66.06-
6472-HydroxyisobutyrylationLQILLKSKLLVLEDE
HHHHHHCCCEEEECC
44.23-
688SulfoxidationRVNINVPMKTEQKQE
EEEEECCCCCHHHHH
7.9521406390
689UbiquitinationVNINVPMKTEQKQEQ
EEEECCCCCHHHHHH
42.7221906983
689AcetylationVNINVPMKTEQKQEQ
EEEECCCCCHHHHHH
42.7271287
693UbiquitinationVPMKTEQKQEQETTH
CCCCCHHHHHHHHCC
49.96-
708UbiquitinationKNIEEDRKLLIQAAI
CCHHHHHHHHHHHHH
61.0321906983
720UbiquitinationAAIVRIMKMRKVLKH
HHHHHHHHHHHHHHH
32.93-
720NeddylationAAIVRIMKMRKVLKH
HHHHHHHHHHHHHHH
32.9312504026
751UbiquitinationPRVPVIKKCIDILIE
CCCHHHHHHHHHHHH
25.87-
751MalonylationPRVPVIKKCIDILIE
CCCHHHHHHHHHHHH
25.8726320211
769UbiquitinationLERVDGEKDTYSYLA
HHHCCCCCCCCCCCC
61.9821906983
769NeddylationLERVDGEKDTYSYLA
HHHCCCCCCCCCCCC
61.98-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CUL1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CUL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CUL1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAND1_HUMANCAND1physical
12609982
SKP1_HUMANSKP1physical
12609982
RBX1_HUMANRBX1physical
12609982
FBW1A_HUMANBTRCphysical
12609982
FBH1_HUMANFBXO18physical
11956208
RBX1_HUMANRBX1physical
11956208
RBX1_MOUSERbx1physical
11384984
E2F1_HUMANE2F1physical
10559858
RBX1_HUMANRBX1physical
11961546
SKP2_HUMANSKP2physical
11961546
SKP1_HUMANSKP1physical
11961546
SKP1_HUMANSKP1physical
10230407
RBX1_HUMANRBX1physical
10230407
SKP2_HUMANSKP2physical
18173839
CAND1_HUMANCAND1physical
18173839
CSN8_HUMANCOPS8physical
18173839
SKP2_HUMANSKP2physical
17439941
CAND1_HUMANCAND1physical
17439941
PSA6_HUMANPSMA6physical
16759355
SKP1_HUMANSKP1physical
16759355
RBX1_HUMANRBX1physical
16759355
CAND1_HUMANCAND1physical
16036220
CSN1_HUMANGPS1physical
16036220
CSN2_HUMANCOPS2physical
16036220
CSN4_HUMANCOPS4physical
16036220
CSN5_HUMANCOPS5physical
16036220
FBW1A_HUMANBTRCphysical
15966899
SKP1_HUMANSKP1physical
15966899
CAND1_HUMANCAND1physical
12706828
RBX1_HUMANRBX1physical
12706828
CSN2_HUMANCOPS2physical
11967155
RBX1_HUMANRBX1physical
11861641
FBW1A_HUMANBTRCphysical
11850407
UB2R1_HUMANCDC34physical
11032804
SKP1_HUMANSKP1physical
10713156
RBX1_HUMANRBX1physical
10713156
SKP1_HUMANSKP1physical
10648623
RBX1_HUMANRBX1physical
10648623
SKP2_HUMANSKP2physical
10230406
SKP1_HUMANSKP1physical
10230406
RBX1_HUMANRBX1physical
10230406
COMD1_HUMANCOMMD1physical
21778237
CAND1_HUMANCAND1physical
21778237
SKP1_HUMANSKP1physical
21778237
CUL1_HUMANCUL1physical
21778237
CLUS_HUMANCLUphysical
20068069
ING3_HUMANING3physical
19935701
FBW1A_HUMANBTRCphysical
18056411
CORO7_HUMANCORO7physical
21130766
SKP1_HUMANSKP1physical
18094045
FBX8_HUMANFBXO8physical
18094045
SKP1_HUMANSKP1physical
19933270
RBX1_HUMANRBX1physical
19933270
FBXL5_HUMANFBXL5physical
19762596
MDM2_HUMANMDM2physical
20708156
RICTR_HUMANRICTORphysical
20832730
SKP1_HUMANSKP1physical
20832730
RBX1_HUMANRBX1physical
20832730
ASB2_HUMANASB2physical
21119685
CAND1_HUMANCAND1physical
21249194
CSN5_HUMANCOPS5physical
21249194
SKP2_HUMANSKP2physical
21249194
FBW1A_HUMANBTRCphysical
21249194
SKP1_HUMANSKP1physical
21249194
RBX2_MOUSERnf7physical
19037258
SKP1_HUMANSKP1physical
18818696
SKP1_HUMANSKP1physical
9990852
FBW1A_HUMANBTRCphysical
9990852
MED6_HUMANMED6physical
22479149
GLMN_HUMANGLMNphysical
22405651
RBX1_HUMANRBX1physical
22405651
CAND1_HUMANCAND1physical
22405651
FAF1_HUMANFAF1physical
22730322
VGFR2_HUMANKDRphysical
22711876
SKP1_HUMANSKP1physical
10023660
FBW1A_HUMANBTRCphysical
10023660
RBX1_HUMANRBX1physical
22822056
CAND1_HUMANCAND1physical
12504026
CASB_HUMANCSN2physical
21903097
CSN5_HUMANCOPS5physical
21903097
CAND1_HUMANCAND1physical
16861300
RBX1_HUMANRBX1physical
12904573
SKP1_HUMANSKP1physical
12904573
CAND1_HUMANCAND1physical
12684064
HSP74_HUMANHSPA4physical
12684064
CH60_HUMANHSPD1physical
12684064
SKP1_HUMANSKP1physical
12684064
RBX1_HUMANRBX1physical
12684064
IRF3_HUMANIRF3physical
17015689
CUL1_HUMANCUL1physical
21169563
CAND1_HUMANCAND1physical
21169563
CAND2_HUMANCAND2physical
21169563
SKP1_HUMANSKP1physical
21169563
RBX1_HUMANRBX1physical
21169563
CSN1_HUMANGPS1physical
21169563
CAND1_HUMANCAND1physical
17079684
CHK1_HUMANCHEK1physical
19808933
SKP1_HUMANSKP1physical
22767593
RBX1_HUMANRBX1physical
22767593
CSN5_HUMANCOPS5physical
22767593
CAND1_HUMANCAND1physical
22767593
DCAF1_HUMANVPRBPphysical
18606781
CAND1_HUMANCAND1physical
22013077
CSN5_HUMANCOPS5physical
22013077
UBXN7_HUMANUBXN7physical
22466964
CAND1_HUMANCAND1physical
17438373
SKP2_HUMANSKP2physical
17438373
FXL18_HUMANFBXL18physical
21145461
FBH1_HUMANFBXO18physical
21145461
PSMF1_HUMANPSMF1physical
21145461
FBXW2_HUMANFBXW2physical
21145461
FBX42_HUMANFBXO42physical
21145461
FBX9_HUMANFBXO9physical
21145461
FBX30_HUMANFBXO30physical
21145461
FBX33_HUMANFBXO33physical
21145461
FBXL8_HUMANFBXL8physical
21145461
FBXW7_HUMANFBXW7physical
21145461
MYO1D_HUMANMYO1Dphysical
21145461
CUL1_HUMANCUL1physical
21145461
CAND1_HUMANCAND1physical
21145461
FXL15_HUMANFBXL15physical
21145461
EFCC1_HUMANEFCC1physical
21145461
FBXW8_HUMANFBXW8physical
21145461
FBX21_HUMANFBXO21physical
21145461
FBX7_HUMANFBXO7physical
21145461
FBX31_HUMANFBXO31physical
21145461
FBX3_HUMANFBXO3physical
21145461
FBXW5_HUMANFBXW5physical
21145461
FBW1A_HUMANBTRCphysical
21145461
FBX11_HUMANFBXO11physical
21145461
FBW1B_HUMANFBXW11physical
21145461
FBX22_HUMANFBXO22physical
21145461
CCNA2_HUMANCCNA2physical
21145461
CDK2_HUMANCDK2physical
21145461
CKS1_HUMANCKS1Bphysical
21145461
FBX17_HUMANFBXO17physical
21145461
HNRPU_HUMANHNRNPUphysical
21145461
PSA1_HUMANPSMA1physical
21145461
SKP2_HUMANSKP2physical
21145461
FBX10_HUMANFBXO10physical
21145461
PSB3_HUMANPSMB3physical
21145461
RL32_HUMANRPL32physical
21145461
CAPR1_HUMANCAPRIN1physical
21145461
FBXW9_HUMANFBXW9physical
21145461
CSN4_HUMANCOPS4physical
21145461
FXL14_HUMANFBXL14physical
21145461
FBX44_HUMANFBXO44physical
21145461
CSN5_HUMANCOPS5physical
21145461
CSN2_HUMANCOPS2physical
21145461
CSN1_HUMANGPS1physical
21145461
ARI1_HUMANARIH1physical
21145461
CCNA1_HUMANCCNA1physical
21145461
CLPX_HUMANCLPXphysical
21145461
CSN6_HUMANCOPS6physical
21145461
SKP1_HUMANSKP1physical
21145461
RS28_HUMANRPS28physical
21145461
CSN3_HUMANCOPS3physical
21145461
CSN7A_HUMANCOPS7Aphysical
21145461
MYO1B_HUMANMYO1Bphysical
21145461
DYL1_HUMANDYNLL1physical
21145461
CSN7B_HUMANCOPS7Bphysical
21145461
PSA2_HUMANPSMA2physical
21145461
RL27A_HUMANRPL27Aphysical
21145461
CDK3_HUMANCDK3physical
21145461
CSN8_HUMANCOPS8physical
21145461
LONM_HUMANLONP1physical
21145461
CSN9_HUMANMYEOV2physical
21145461
ACTS_HUMANACTA1physical
21145461
RS3A_HUMANRPS3Aphysical
21145461
ODP2_HUMANDLATphysical
21145461
PSA6_HUMANPSMA6physical
21145461
RL35_HUMANRPL35physical
21145461
SYTC_HUMANTARSphysical
21145461
G3BP1_HUMANG3BP1physical
21145461
PSA7_HUMANPSMA7physical
21145461
CAH2_HUMANCA2physical
21145461
DBNL_HUMANDBNLphysical
21145461
ACOXL_HUMANACOXLphysical
21145461
ATS17_HUMANADAMTS17physical
21145461
BAT1_HUMANSLC7A9physical
21145461
BMP8B_HUMANBMP8Bphysical
21145461
CC146_HUMANCCDC146physical
21145461
ESIP1_HUMANEPSTI1physical
21145461
MUT7_HUMANEXD3physical
21145461
GBRB1_HUMANGABRB1physical
21145461
LEG8_HUMANLGALS8physical
21145461
KMT2E_HUMANKMT2Ephysical
21145461
MYPC3_HUMANMYBPC3physical
21145461
NP1L2_HUMANNAP1L2physical
21145461
NEXN_HUMANNEXNphysical
21145461
NUDT7_HUMANNUDT7physical
21145461
POMP_HUMANPOMPphysical
21145461
PEPL_HUMANPPLphysical
21145461
PRD10_HUMANPRDM10physical
21145461
PSB4_HUMANPSMB4physical
21145461
PSMG1_HUMANPSMG1physical
21145461
PSMG3_HUMANPSMG3physical
21145461
RGAP1_HUMANRACGAP1physical
21145461
RXRG_HUMANRXRGphysical
21145461
RYR3_HUMANRYR3physical
21145461
ZBT46_HUMANZBTB46physical
21145461
SPTB2_HUMANSPTBN1physical
21145461
AKP8L_HUMANAKAP8Lphysical
21145461
RT26_HUMANMRPS26physical
21145461
NEDD8_HUMANNEDD8physical
21145461
UBP11_HUMANUSP11physical
21145461
FXL17_HUMANFBXL17physical
21145461
G3BP2_HUMANG3BP2physical
21145461
WWP2_HUMANWWP2physical
21145461
SPTN1_HUMANSPTAN1physical
21145461
CAC1C_HUMANCACNA1Cphysical
21145461
CPN2_HUMANCPN2physical
21145461
KIF5C_HUMANKIF5Cphysical
21145461
PDE6D_HUMANPDE6Dphysical
21145461
PSA3_HUMANPSMA3physical
21145461
POP1_HUMANPOP1physical
21145461
CLH1_HUMANCLTCphysical
21145461
RS11_HUMANRPS11physical
21145461
DPOD1_HUMANPOLD1physical
21145461
DOCK1_HUMANDOCK1physical
21145461
FXL12_HUMANFBXL12physical
21145461
RM19_HUMANMRPL19physical
21145461
MYH10_HUMANMYH10physical
21145461
SCRB1_HUMANSCARB1physical
21145461
SNX18_HUMANSNX18physical
21145461
TFG_HUMANTFGphysical
21145461
RL28_HUMANRPL28physical
21145461
CUL3_HUMANCUL3physical
21145461
DNJC9_HUMANDNAJC9physical
21145461
GNL3_HUMANGNL3physical
21145461
SYMC_HUMANMARSphysical
21145461
MYH3_HUMANMYH3physical
21145461
ML12B_HUMANMYL12Bphysical
21145461
MYL6_HUMANMYL6physical
21145461
MYL6B_HUMANMYL6Bphysical
21145461
MYO1A_HUMANMYO1Aphysical
21145461
MYO1E_HUMANMYO1Ephysical
21145461
PSB6_HUMANPSMB6physical
21145461
RL36_HUMANRPL36physical
21145461
DHPR_HUMANQDPRphysical
21145461
CBX3_HUMANCBX3physical
21145461
RACK1_HUMANGNB2L1physical
21145461
NOP2_HUMANNOP2physical
21145461
PSA5_HUMANPSMA5physical
21145461
RL34_HUMANRPL34physical
21145461
RS27_HUMANRPS27physical
21145461
CDK4_HUMANCDK4physical
21145461
DDX56_HUMANDDX56physical
21145461
DHX9_HUMANDHX9physical
21145461
EF2_HUMANEEF2physical
21145461
EIF3L_HUMANEIF3Lphysical
21145461
IF4A3_HUMANEIF4A3physical
21145461
SYEP_HUMANEPRSphysical
21145461
GYS1_HUMANGYS1physical
21145461
HNRL1_HUMANHNRNPUL1physical
21145461
HSP7C_HUMANHSPA8physical
21145461
K2C1_HUMANKRT1physical
21145461
K1C10_HUMANKRT10physical
21145461
RM11_HUMANMRPL11physical
21145461
NCBP2_HUMANNCBP2physical
21145461
PHS_HUMANPCBD1physical
21145461
RAE1L_HUMANRAE1physical
21145461
RCBT1_HUMANRCBTB1physical
21145461
STAU1_HUMANSTAU1physical
21145461
TUT4_HUMANZCCHC11physical
21145461
DDB1_HUMANDDB1physical
21145461
DHX30_HUMANDHX30physical
21145461
EF1D_HUMANEEF1Dphysical
21145461
RT22_HUMANMRPS22physical
21145461
RT27_HUMANMRPS27physical
21145461
MBB1A_HUMANMYBBP1Aphysical
21145461
NUCL_HUMANNCLphysical
21145461
PSA4_HUMANPSMA4physical
21145461
RBBP6_HUMANRBBP6physical
21145461
MCES_HUMANRNMTphysical
21145461
SORL_HUMANSORL1physical
21145461
GDE_HUMANAGLphysical
21145461
PABP1_HUMANPABPC1physical
21145461
PWP2_HUMANPWP2physical
21145461
RBM3_HUMANRBM3physical
21145461
RL26L_HUMANRPL26L1physical
21145461
1433E_HUMANYWHAEphysical
21145461
AIMP1_HUMANAIMP1physical
21145461
CN166_HUMANC14orf166physical
21145461
CLH2_HUMANCLTCL1physical
21145461
ENOA_HUMANENO1physical
21145461
EWS_HUMANEWSR1physical
21145461
H2B1L_HUMANHIST1H2BLphysical
21145461
ROA2_HUMANHNRNPA2B1physical
21145461
GRP75_HUMANHSPA9physical
21145461
K22E_HUMANKRT2physical
21145461
K1C9_HUMANKRT9physical
21145461
MYH9_HUMANMYH9physical
21145461
PRDX6_HUMANPRDX6physical
21145461
PWP1_HUMANPWP1physical
21145461
RBM39_HUMANRBM39physical
21145461
MRM3_HUMANRNMTL1physical
21145461
RL6_HUMANRPL6physical
21145461
RS19_HUMANRPS19physical
21145461
RS9_HUMANRPS9physical
21145461
SK2L2_HUMANSKIV2L2physical
21145461
S2543_HUMANSLC25A43physical
21145461
TBB4B_HUMANTUBB4Bphysical
21145461
WDR5_HUMANWDR5physical
21145461
DHX15_HUMANDHX15physical
21145461
FUS_HUMANFUSphysical
21145461
GRSF1_HUMANGRSF1physical
21145461
GRP78_HUMANHSPA5physical
21145461
KCNH2_HUMANKCNH2physical
21145461
IMA5_HUMANKPNA1physical
21145461
MPP2_HUMANMPP2physical
21145461
RM12_HUMANMRPL12physical
21145461
NPM_HUMANNPM1physical
21145461
PRP19_HUMANPRPF19physical
21145461
PSB5_HUMANPSMB5physical
21145461
RL10A_HUMANRPL10Aphysical
21145461
RL18A_HUMANRPL18Aphysical
21145461
RS17_HUMANRPS17physical
21145461
RS3_HUMANRPS3physical
21145461
RS4X_HUMANRPS4Xphysical
21145461
RS5_HUMANRPS5physical
21145461
RS7_HUMANRPS7physical
21145461
SRSF6_HUMANSRSF6physical
21145461
THOC4_HUMANALYREFphysical
21145461
DDX5_HUMANDDX5physical
21145461
GRWD1_HUMANGRWD1physical
21145461
TF3C5_HUMANGTF3C5physical
21145461
H1X_HUMANH1FXphysical
21145461
ROA3_HUMANHNRNPA3physical
21145461
HNRH1_HUMANHNRNPH1physical
21145461
IF2B1_HUMANIGF2BP1physical
21145461
ILF2_HUMANILF2physical
21145461
ILF3_HUMANILF3physical
21145461
RM49_HUMANMRPL49physical
21145461
SSF1_HUMANPPANphysical
21145461
PURA_HUMANPURAphysical
21145461
RL21_HUMANRPL21physical
21145461
RL27_HUMANRPL27physical
21145461
RL3_HUMANRPL3physical
21145461
RL30_HUMANRPL30physical
21145461
RL4_HUMANRPL4physical
21145461
RL5_HUMANRPL5physical
21145461
RL7L_HUMANRPL7L1physical
21145461
RL9_HUMANRPL9physical
21145461
RLA0_HUMANRPLP0physical
21145461
RS21_HUMANRPS21physical
21145461
SRSF3_HUMANSRSF3physical
21145461
SMD2_HUMANSNRPD2physical
21145461
HNRPQ_HUMANSYNCRIPphysical
21145461
XRN2_HUMANXRN2physical
21145461
ACTA_HUMANACTA2physical
21145461
ACTB_HUMANACTBphysical
21145461
CBR1_HUMANCBR1physical
21145461
CIRBP_HUMANCIRBPphysical
21145461
DDX1_HUMANDDX1physical
21145461
DDX3X_HUMANDDX3Xphysical
21145461
HNRPD_HUMANHNRNPDphysical
21145461
HNRPK_HUMANHNRNPKphysical
21145461
HNRPM_HUMANHNRNPMphysical
21145461
HS90A_HUMANHSP90AA1physical
21145461
SYK_HUMANKARSphysical
21145461
IMA1_HUMANKPNA2physical
21145461
LYAR_HUMANLYARphysical
21145461
NKRF_HUMANNKRFphysical
21145461
TIRR_HUMANNUDT16L1physical
21145461
PABP4_HUMANPABPC4physical
21145461
PP1G_HUMANPPP1CCphysical
21145461
PP2AA_HUMANPPP2CAphysical
21145461
PTBP1_HUMANPTBP1physical
21145461
RL12_HUMANRPL12physical
21145461
RL23_HUMANRPL23physical
21145461
RS15A_HUMANRPS15Aphysical
21145461
RS18_HUMANRPS18physical
21145461
RS2_HUMANRPS2physical
21145461
RS6_HUMANRPS6physical
21145461
RL1D1_HUMANRSL1D1physical
21145461
SRSF1_HUMANSRSF1physical
21145461
SREK1_HUMANSREK1physical
21145461
GLYM_HUMANSHMT2physical
21145461
RU17_HUMANSNRNP70physical
21145461
RSMB_HUMANSNRPBphysical
21145461
SMD1_HUMANSNRPD1physical
21145461
LA_HUMANSSBphysical
21145461
SSBP_HUMANSSBP1physical
21145461
SPF27_HUMANBCAS2physical
21145461
C1QBP_HUMANC1QBPphysical
21145461
IF6_HUMANEIF6physical
21145461
SYFA_HUMANFARSAphysical
21145461
H12_HUMANHIST1H1Cphysical
21145461
ROAA_HUMANHNRNPABphysical
21145461
HNRPF_HUMANHNRNPFphysical
21145461
HNRPR_HUMANHNRNPRphysical
21145461
HNRDL_HUMANHNRNPDLphysical
21145461
HP1B3_HUMANHP1BP3physical
21145461
ENPL_HUMANHSP90B1physical
21145461
HS71L_HUMANHSPA1Lphysical
21145461
HSP76_HUMANHSPA6physical
21145461
K1C16_HUMANKRT16physical
21145461
LG3BP_HUMANLGALS3BPphysical
21145461
NSUN2_HUMANNSUN2physical
21145461
8ODP_HUMANNUDT1physical
21145461
PIMT_HUMANPCMT1physical
21145461
SYQ_HUMANQARSphysical
21145461
RBM14_HUMANRBM14physical
21145461
RBM4_HUMANRBM4physical
21145461
RBM28_HUMANRBM28physical
21145461
RNPS1_HUMANRNPS1physical
21145461
RL10L_HUMANRPL10Lphysical
21145461
RL13A_HUMANRPL13Aphysical
21145461
RL15_HUMANRPL15physical
21145461
HNRH2_HUMANHNRNPH2physical
21145461
RLA2_HUMANRPLP2physical
21145461
RS10_HUMANRPS10physical
21145461
RS12_HUMANRPS12physical
21145461
RS13_HUMANRPS13physical
21145461
RS14_HUMANRPS14physical
21145461
RS16_HUMANRPS16physical
21145461
RS23_HUMANRPS23physical
21145461
RS24_HUMANRPS24physical
21145461
RS25_HUMANRPS25physical
21145461
RS8_HUMANRPS8physical
21145461
SF3B4_HUMANSF3B4physical
21145461
SRSF5_HUMANSRSF5physical
21145461
SRP14_HUMANSRP14physical
21145461
TIAR_HUMANTIAL1physical
21145461
TRA2B_HUMANTRA2Bphysical
21145461
TBA4A_HUMANTUBA4Aphysical
21145461
TBB5_HUMANTUBBphysical
21145461
THIL_HUMANACAT1physical
21145461
FBF1_HUMANFBF1physical
21145461
BRX1_HUMANBRIX1physical
21145461
CG050_HUMANC7orf50physical
21145461
KCRB_HUMANCKBphysical
21145461
YBOX3_HUMANYBX3physical
21145461
SYDC_HUMANDARSphysical
21145461
DAZP1_HUMANDAZAP1physical
21145461
DJC10_HUMANDNAJC10physical
21145461
EBP2_HUMANEBNA1BP2physical
21145461
EF1B_HUMANEEF1B2physical
21145461
AGO2_HUMANAGO2physical
21145461
ELAV1_HUMANELAVL1physical
21145461
ROA1_HUMANHNRNPA1physical
21145461
HNRPC_HUMANHNRNPCphysical
21145461
HNRH3_HUMANHNRNPH3physical
21145461
K1C13_HUMANKRT13physical
21145461
K1C14_HUMANKRT14physical
21145461
K2C6B_HUMANKRT6Bphysical
21145461
LARP1_HUMANLARP1physical
21145461
MATR3_HUMANMATR3physical
21145461
RT23_HUMANMRPS23physical
21145461
NAT10_HUMANNAT10physical
21145461
NXF1_HUMANNXF1physical
21145461
PCBP2_HUMANPCBP2physical
21145461
PCNA_HUMANPCNAphysical
21145461
PDIA6_HUMANPDIA6physical
21145461
PDXK_HUMANPDXKphysical
21145461
KPYM_HUMANPKMphysical
21145461
PLOD1_HUMANPLOD1physical
21145461
PPIA_HUMANPPIAphysical
21145461
PRDX3_HUMANPRDX3physical
21145461
QPCT_HUMANQPCTphysical
21145461
SYRC_HUMANRARSphysical
21145461
RL19_HUMANRPL19physical
21145461
RL23A_HUMANRPL23Aphysical
21145461
RL31_HUMANRPL31physical
21145461
RL35A_HUMANRPL35Aphysical
21145461
RL37A_HUMANRPL37Aphysical
21145461
RS15_HUMANRPS15physical
21145461
RS20_HUMANRPS20physical
21145461
RRP12_HUMANRRP12physical
21145461
SDHB_HUMANSDHBphysical
21145461
SC23A_HUMANSEC23Aphysical
21145461
SF3B1_HUMANSF3B1physical
21145461
SRSF2_HUMANSRSF2physical
21145461
SNRPA_HUMANSNRPAphysical
21145461
RUXE_HUMANSNRPEphysical
21145461
RUXG_HUMANSNRPGphysical
21145461
STRBP_HUMANSTRBPphysical
21145461
RBP56_HUMANTAF15physical
21145461
TIA1_HUMANTIA1physical
21145461
TIM13_HUMANTIMM13physical
21145461
TIF1B_HUMANTRIM28physical
21145461
U2AF1_HUMANU2AF1physical
21145461
U2AF2_HUMANU2AF2physical
21145461
YBOX1_HUMANYBX1physical
21145461
ACTZ_HUMANACTR1Aphysical
21145461
ATD3A_HUMANATAD3Aphysical
21145461
BAG4_HUMANBAG4physical
21145461
RTCB_HUMANRTCBphysical
21145461
DFFB_HUMANDFFBphysical
21145461
KAT3_HUMANCCBL2physical
21145461
CDC5L_HUMANCDC5Lphysical
21145461
LC7L3_HUMANLUC7L3physical
21145461
DDX18_HUMANDDX18physical
21145461
EF1A1_HUMANEEF1A1physical
21145461
EF1G_HUMANEEF1Gphysical
21145461
IF4A1_HUMANEIF4A1physical
21145461
FA98A_HUMANFAM98Aphysical
21145461
H2B2E_HUMANHIST2H2BEphysical
21145461
ROA0_HUMANHNRNPA0physical
21145461
HNRC1_HUMANHNRNPCL1physical
21145461
HCD2_HUMANHSD17B10physical
21145461
HSP74_HUMANHSPA4physical
21145461
K2C5_HUMANKRT5physical
21145461
K2C6A_HUMANKRT6Aphysical
21145461
NP1L1_HUMANNAP1L1physical
21145461
PDCD6_HUMANPDCD6physical
21145461
RL11_HUMANRPL11physical
21145461
RL13_HUMANRPL13physical
21145461
RL18_HUMANRPL18physical
21145461
RL22_HUMANRPL22physical
21145461
RL24_HUMANRPL24physical
21145461
RL38_HUMANRPL38physical
21145461
RL8_HUMANRPL8physical
21145461
RLA1_HUMANRPLP1physical
21145461
SDHA_HUMANSDHAphysical
21145461
PAIRB_HUMANSERBP1physical
21145461
SRSF4_HUMANSRSF4physical
21145461
SRSF7_HUMANSRSF7physical
21145461
RU1C_HUMANSNRPCphysical
21145461
SR140_HUMANU2SURPphysical
21145461
TIM50_HUMANTIMM50physical
21145461
TNR6B_HUMANTNRC6Bphysical
21145461
TOP1_HUMANTOP1physical
21145461
TPIS_HUMANTPI1physical
21145461
TBA1C_HUMANTUBA1Cphysical
21145461
TBB1_HUMANTUBB1physical
21145461
TBB4A_HUMANTUBB4Aphysical
21145461
UBC_HUMANUBCphysical
21145461
UGGG1_HUMANUGGT1physical
21145461
1433Z_HUMANYWHAZphysical
21145461
SAHH_HUMANAHCYphysical
21145461
AIFM1_HUMANAIFM1physical
21145461
AMPD1_HUMANAMPD1physical
21145461
ATPA_HUMANATP5A1physical
21145461
CARM1_HUMANCARM1physical
21145461
TCPB_HUMANCCT2physical
21145461
PYRG1_HUMANCTPS1physical
21145461
DLGP3_HUMANDLGAP3physical
21145461
DDX17_HUMANDDX17physical
21145461
DNJA1_HUMANDNAJA1physical
21145461
EF1A2_HUMANEEF1A2physical
21145461
ENOG_HUMANENO2physical
21145461
UBIM_HUMANFAUphysical
21145461
SPB1_HUMANFTSJ3physical
21145461
HNRPL_HUMANHNRNPLphysical
21145461
HS90B_HUMANHSP90AB1physical
21145461
IRS4_HUMANIRS4physical
21145461
FUBP2_HUMANKHSRPphysical
21145461
K1C24_HUMANKRT24physical
21145461
K2C6C_HUMANKRT6Cphysical
21145461
K2C75_HUMANKRT75physical
21145461
NP1L4_HUMANNAP1L4physical
21145461
NCBP1_HUMANNCBP1physical
21145461
PABP2_HUMANPABPN1physical
21145461
PRDX1_HUMANPRDX1physical
21145461
RMXL2_HUMANRBMXL2physical
21145461
RSSA_HUMANRPSAphysical
21145461
ADT2_HUMANSLC25A5physical
21145461
ADT3_HUMANSLC25A6physical
21145461
RU2B_HUMANSNRPB2physical
21145461
SMD3_HUMANSNRPD3physical
21145461
VIME_HUMANVIMphysical
21145461
ACTBL_HUMANACTBL2physical
21145461
TCPQ_HUMANCCT8physical
21145461
G3P_HUMANGAPDHphysical
21145461
ILK_HUMANILKphysical
21145461
TCPD_HUMANCCT4physical
21145461
PRDX2_HUMANPRDX2physical
21145461
RL14_HUMANRPL14physical
21145461
RUVB2_HUMANRUVBL2physical
21145461
SF3B3_HUMANSF3B3physical
21145461
THIO_HUMANTXNphysical
21145461
H2A1B_HUMANHIST1H2AEphysical
21145461
H2A1J_HUMANHIST1H2AJphysical
21145461
H2A1_HUMANHIST1H2AIphysical
21145461
NEDD8_HUMANNEDD8physical
22474075
SKP1_HUMANSKP1physical
22474075
DDB1_HUMANDDB1physical
22474075
RBX1_HUMANRBX1physical
22474075
CASA1_HUMANCSN1S1physical
22474075
CSN6_HUMANCOPS6physical
22474075
CSN5_HUMANCOPS5physical
22474075
CAND1_HUMANCAND1physical
22474075
SKP1_HUMANSKP1physical
9663463
SKP2_HUMANSKP2physical
9663463
CCNA1_HUMANCCNA1physical
9663463
RBX1_MOUSERbx1physical
16275325
SKP1_HUMANSKP1physical
9636170
PSB4_HUMANPSMB4physical
9636170
SKP2_HUMANSKP2physical
9636170
SKP1_YEASTSKP1physical
9636170
CDC4_YEASTCDC4physical
9636170
RBX1_HUMANRBX1physical
11027288
SKP1_HUMANSKP1physical
11027288
IKBA_HUMANNFKBIAphysical
11027288
CAND1_HUMANCAND1physical
12504025
RBX1_HUMANRBX1physical
12504025
SKP1_HUMANSKP1physical
12504025
CAND1_HUMANCAND1physical
23019411
DCNL1_HUMANDCUN1D1physical
21247897
CSN5_HUMANCOPS5physical
22959436
CSN8_HUMANCOPS8physical
22959436
LTP_EBVB9BPLF1physical
20190741
SENP8_HUMANSENP8physical
20190741
DPTOR_HUMANDEPTORphysical
22017875
SKP1_MOUSESkp1aphysical
12417738
SKP2_MOUSESkp2physical
12417738
RBX1_MOUSERbx1physical
12417738
FXL20_HUMANFBXL20physical
22939629
SKP2_HUMANSKP2physical
9736735
SKP1_HUMANSKP1physical
9736735
CCND1_HUMANCCND1physical
9736735
CDN1A_HUMANCDKN1Aphysical
9736735
FBXW7_HUMANFBXW7physical
23453757
BRAP_HUMANBRAPphysical
23554956
SCNND_HUMANSCNN1Dphysical
23589227
RBX1_HUMANRBX1physical
21765416
UBC12_YEASTUBC12physical
21765416
CCD22_HUMANCCDC22physical
23563313
SF3B3_HUMANSF3B3physical
23951410
CAND2_HUMANCAND2physical
23951410
SKP1_HUMANSKP1physical
23951410
SKP2_HUMANSKP2physical
23951410
RBP2_HUMANRANBP2physical
21988832
FZR1_HUMANFZR1physical
23972993
RHG07_HUMANDLC1physical
24082123
SWP70_HUMANSWAP70physical
22863883
TRI47_HUMANTRIM47physical
22863883
MTSS1_HUMANMTSS1physical
24318128
EZH2_HUMANEZH2physical
24469040
MS18B_HUMANOIP5physical
24269809
RBX1_HUMANRBX1physical
19942853
ESR1_HUMANESR1physical
23770852
SKP2_HUMANSKP2physical
23770852
SKP1_HUMANSKP1physical
23770852
RBX1_HUMANRBX1physical
23770852
EF2_MOUSEEef2physical
11337588
CSN2_MOUSECops2physical
11337588
FBX3_MOUSEFbxo3physical
11337588
CSN3_MOUSECops3physical
11337588
CSN4_MOUSECops4physical
11337588
CSN5_MOUSECops5physical
11337588
CSN6_MOUSECops6physical
11337588
CSN7A_MOUSECops7aphysical
11337588
CSN7B_MOUSECops7bphysical
11337588
CSN8_MOUSECops8physical
11337588
RBX1_MOUSERbx1physical
11337588
SKP1_MOUSESkp1aphysical
11337588
FBX6_MOUSEFbxo6physical
11337588
RBX1_HUMANRBX1physical
17452440
RBX1_HUMANRBX1physical
12565873
FBW1A_HUMANBTRCphysical
10713156
LTP_EBVB9BPLF1physical
22474075
LTP_HHV8PORF64physical
22474075
TERA_HUMANVCPphysical
22466964
RBX1_HUMANRBX1physical
18805092
CDN1B_HUMANCDKN1Bphysical
22959436
PDE12_HUMANPDE12physical
26344197
PSD12_HUMANPSMD12physical
26344197
RBX1_HUMANRBX1physical
26344197
SGTA_HUMANSGTAphysical
26344197
FBW1B_HUMANFBXW11physical
25241761
GHR_HUMANGHRphysical
25505247
MAGC2_HUMANMAGEC2physical
26540345
SKP1_HUMANSKP1physical
26540345
RBX1_HUMANRBX1physical
26540345
KDM2B_HUMANKDM2Bphysical
26725323
RBX1_HUMANRBX1physical
26725323
SKP1_HUMANSKP1physical
26725323
UBC_HUMANUBCphysical
27001857
TRIB2_HUMANTRIB2physical
24211582
CUL1_HUMANCUL1physical
17254749
CAND1_HUMANCAND1physical
27542266
SKP2_HUMANSKP2physical
27542266
DCNL3_HUMANDCUN1D3physical
27542266
COMD1_HUMANCOMMD1physical
27677741
CSN2_HUMANCOPS2physical
26976604
HUTH_HUMANHALphysical
28514442
GNS_HUMANGNSphysical
28514442
CYTM_HUMANCST6physical
28514442
NFH_HUMANNEFHphysical
28514442
SPA12_HUMANSERPINA12physical
28514442
ECM1_HUMANECM1physical
28514442
FBX32_HUMANFBXO32physical
26753747
SKP1_HUMANSKP1physical
26753747
FBW1A_HUMANBTRCphysical
27910872
RBX2_HUMANRNF7physical
27910872
RBX1_HUMANRBX1physical
27910872
FBXW7_HUMANFBXW7physical
28007894
SKP1_HUMANSKP1physical
28007894
CAND1_HUMANCAND1physical
28715492
BZLF1_EBVB9BZLF1physical
28715492
RBX2_HUMANRNF7physical
27591266
RBX1_HUMANRBX1physical
27591266
UBC12_HUMANUBE2Mphysical
27591266

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CUL1_HUMAN

loading...

Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-708 AND LYS-720, AND MASSSPECTROMETRY.

TOP