PSB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB6_HUMAN
• UniProt AC: P28072
• Protein Name: Proteasome subunit beta type-6
• Gene Name: PSMB6
• Organism: Homo sapiens (Human).
• Sequence Length: 239
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues..
• Protein Sequence: MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATLLAAR ------CHHHHHHHC	14.78	22814378
9	Methylation	AATLLAARGAGPAPA HHHHHHHCCCCCCCC	29.86	115384965
23	Phosphorylation	AWGPEAFTPDWESRE CCCCCCCCCCCHHCC	27.64	-
54	Phosphorylation	VLGADSRTTTGSYIA EEECCCCCCCCCHHH	32.44	26437602
55	Phosphorylation	LGADSRTTTGSYIAN EECCCCCCCCCHHHH	28.22	24719451
56	Phosphorylation	GADSRTTTGSYIANR ECCCCCCCCCHHHHH	24.42	28152594
58	Phosphorylation	DSRTTTGSYIANRVT CCCCCCCCHHHHHHC	15.98	28152594
59	Phosphorylation	SRTTTGSYIANRVTD CCCCCCCHHHHHHCC	12.85	28152594
59	Nitration	SRTTTGSYIANRVTD CCCCCCCHHHHHHCC	12.85	-
63	Methylation	TGSYIANRVTDKLTP CCCHHHHHHCCCCCC	24.56	115489425
65	Phosphorylation	SYIANRVTDKLTPIH CHHHHHHCCCCCCCC	24.95	23403867
67	Acetylation	IANRVTDKLTPIHDR HHHHHCCCCCCCCCC	44.91	25953088
67	2-Hydroxyisobutyrylation	IANRVTDKLTPIHDR HHHHHCCCCCCCCCC	44.91	-
67	Ubiquitination	IANRVTDKLTPIHDR HHHHHCCCCCCCCCC	44.91	21906983
69	Phosphorylation	NRVTDKLTPIHDRIF HHHCCCCCCCCCCEE	26.41	23403867
74	Methylation	KLTPIHDRIFCCRSG CCCCCCCCEEEECCC	15.10	115489417
115	Phosphorylation	PLVHTAASLFKEMCY CHHHHHHHHHHHHHH	31.69	24719451
118	Acetylation	HTAASLFKEMCYRYR HHHHHHHHHHHHHHH	50.24	155859
158	Phosphorylation	GGMMVRQSFAIGGSG CCEEEEEEEEECCCC	13.19	22817900
177	Phosphorylation	YGYVDATYREGMTKE EEEEECCCCCCCCHH	14.37	22817900
183	Ubiquitination	TYREGMTKEECLQFT CCCCCCCHHHHHHHH	42.49	-
190	Phosphorylation	KEECLQFTANALALA HHHHHHHHHHHHHHH	13.17	20363803
203	Phosphorylation	LAMERDGSSGGVIRL HHHHCCCCCCCEEHH	30.05	20363803
204	Phosphorylation	AMERDGSSGGVIRLA HHHCCCCCCCEEHHH	45.13	20363803
216	Phosphorylation	RLAAIAESGVERQVL HHHHHHHHCCEEEEE	38.83	21712546
230	Ubiquitination	LLGDQIPKFAVATLP ECCCCCCCEEEECCC	47.81	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSB7_HUMAN	PSMB7	physical	14733938
POMP_HUMAN	POMP	physical	14733938
PSB3_HUMAN	PSMB3	physical	17948026
PSB7_HUMAN	PSMB7	physical	17948026
PSA7L_HUMAN	PSMA8	physical	17948026
POMP_HUMAN	POMP	physical	17948026
PSA6_HUMAN	PSMA6	physical	17948026
PSB9_HUMAN	PSMB9	physical	11745344
PSB10_HUMAN	PSMB10	physical	11745344
PSB8_HUMAN	PSMB8	physical	11745344
PSB7_HUMAN	PSMB7	physical	11745344
PSB5_HUMAN	PSMB5	physical	11745344
PSME1_HUMAN	PSME1	physical	11745344
PSME2_HUMAN	PSME2	physical	11745344
PSB7_HUMAN	PSMB7	physical	22939629
PSB8_HUMAN	PSMB8	physical	22939629
PSD12_HUMAN	PSMD12	physical	22939629
PSMD7_HUMAN	PSMD7	physical	22939629
PSMD1_HUMAN	PSMD1	physical	22939629
PSMD3_HUMAN	PSMD3	physical	22939629
PSMD6_HUMAN	PSMD6	physical	22939629
PSDE_HUMAN	PSMD14	physical	22939629
PSMD2_HUMAN	PSMD2	physical	22939629
PSMD4_HUMAN	PSMD4	physical	22939629
PSMD8_HUMAN	PSMD8	physical	22939629
PSD13_HUMAN	PSMD13	physical	22939629
ZCHC8_HUMAN	ZCCHC8	physical	22939629
PSA2_HUMAN	PSMA2	physical	22863883
PSA4_HUMAN	PSMA4	physical	22863883
PSA5_HUMAN	PSMA5	physical	22863883
PSB1_HUMAN	PSMB1	physical	22863883
PSB2_HUMAN	PSMB2	physical	22863883
PSB3_HUMAN	PSMB3	physical	22863883
PSB5_HUMAN	PSMB5	physical	22863883
GDE_HUMAN	AGL	physical	26344197
ASNA_HUMAN	ASNA1	physical	26344197
CAZA2_HUMAN	CAPZA2	physical	26344197
CPSF2_HUMAN	CPSF2	physical	26344197
DCTN1_HUMAN	DCTN1	physical	26344197
DCTN2_HUMAN	DCTN2	physical	26344197
ELP6_HUMAN	ELP6	physical	26344197
NELFE_HUMAN	NELFE	physical	26344197
PDCD4_HUMAN	PDCD4	physical	26344197
PSA3_HUMAN	PSMA3	physical	26344197
PSA4_HUMAN	PSMA4	physical	26344197
PSB2_HUMAN	PSMB2	physical	26344197
PSB3_HUMAN	PSMB3	physical	26344197
PRS4_HUMAN	PSMC1	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
PRS6A_HUMAN	PSMC3	physical	26344197
PRS6B_HUMAN	PSMC4	physical	26344197
PRS8_HUMAN	PSMC5	physical	26344197
PSD13_HUMAN	PSMD13	physical	26344197
PSMD2_HUMAN	PSMD2	physical	26344197
PSMG2_HUMAN	PSMG2	physical	26344197
SAE1_HUMAN	SAE1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.