ELP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELP6_HUMAN
• UniProt AC: Q0PNE2
• Protein Name: Elongator complex protein 6
• Gene Name: ELP6
• Organism: Homo sapiens (Human).
• Sequence Length: 266
• Protein Description: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration..
• Protein Sequence: MFVELNNLLNTTPDRAEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALIQSFSHYSIVGQKLGVSLTMARERGQLVFLEGLKSAVDVVFQAQKEPHPLQFLREANAGNLKPLFEFVREALKPVDSGEARWTYPVLLVDDLSVLLSLGMGAVAVLDFIHYCRATVCWELKGNMVVLVHDSGDAEDEENDILLNGLSHQSHLILRAEGLATGFCRDVHGQLRILWRRPSQPAVHRDQSFTYQYKIQDKSVSFFAKGMSPAVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Ubiquitination	PDRAEQGKLTLLCDA CCHHHCCCEEEEEEC	37.68	21963094
26	Ubiquitination	GKLTLLCDAKTDGSF CCEEEEEECCCCCCH	51.58	21963094
43	Ubiquitination	HHFLSFYLKANCKVC HHHHHHHHHCCCEEE	3.88	27667366
50	Ubiquitination	LKANCKVCFVALIQS HHCCCEEEEHHHHHH	1.07	21963094
54	Ubiquitination	CKVCFVALIQSFSHY CEEEEHHHHHHCCCC	2.84	22817900
67	Ubiquitination	HYSIVGQKLGVSLTM CCCHHCHHHCCCEEE	41.08	27667366
78	Ubiquitination	SLTMARERGQLVFLE CEEEHHHHCCEEEEE	32.38	22817900
82	Ubiquitination	ARERGQLVFLEGLKS HHHHCCEEEEECHHH	3.85	21963094
96	Ubiquitination	SAVDVVFQAQKEPHP HHHHHHHHCCCCCCH	31.13	21963094
99 (in isoform 2)	Ubiquitination	-	76.00	21890473
99	Ubiquitination	DVVFQAQKEPHPLQF HHHHHCCCCCCHHHH	76.00	21906983
99 (in isoform 1)	Ubiquitination	-	76.00	21890473
110	Ubiquitination	PLQFLREANAGNLKP HHHHHHHCCCCCCHH	12.53	22817900
113	Ubiquitination	FLREANAGNLKPLFE HHHHCCCCCCHHHHH	39.55	27667366
116 (in isoform 1)	Ubiquitination	-	43.61	21890473
116	Ubiquitination	EANAGNLKPLFEFVR HCCCCCCHHHHHHHH	43.61	27667366
116 (in isoform 2)	Ubiquitination	-	43.61	21890473
124	Ubiquitination	PLFEFVREALKPVDS HHHHHHHHHHCCCCC	53.72	22817900
127 (in isoform 1)	Ubiquitination	-	50.47	21890473
127 (in isoform 2)	Ubiquitination	-	50.47	21890473
127	Ubiquitination	EFVREALKPVDSGEA HHHHHHHCCCCCCCC	50.47	21906983
131	Phosphorylation	EALKPVDSGEARWTY HHHCCCCCCCCCCCC	38.47	-
175	Ubiquitination	ATVCWELKGNMVVLV CEEEEEECCCEEEEE	36.40	21890473
179	Ubiquitination	WELKGNMVVLVHDSG EEECCCEEEEEEECC	3.32	22817900
186	Ubiquitination	VVLVHDSGDAEDEEN EEEEEECCCCCCCCC	44.18	21963094
199	Ubiquitination	ENDILLNGLSHQSHL CCCEEECCCCCCCEE	28.64	21890473
203	Ubiquitination	LLNGLSHQSHLILRA EECCCCCCCEEEHHH	29.21	22817900
210	Ubiquitination	QSHLILRAEGLATGF CCEEEHHHCCCCHHH	16.26	21963094
233	Phosphorylation	RILWRRPSQPAVHRD EEEEECCCCCCCCCC	47.16	22985185
242	Phosphorylation	PAVHRDQSFTYQYKI CCCCCCCCEEEEEEE	24.68	20873877
248	Ubiquitination	QSFTYQYKIQDKSVS CCEEEEEEECCCEEE	20.54	27667366
248 (in isoform 1)	Ubiquitination	-	20.54	21890473
252	Ubiquitination	YQYKIQDKSVSFFAK EEEEECCCEEEEEEC	36.06	22817900
256	Ubiquitination	IQDKSVSFFAKGMSP ECCCEEEEEECCCCC	6.91	21890473
259	Ubiquitination	KSVSFFAKGMSPAVL CEEEEEECCCCCCCC	50.41	21963094
260	Ubiquitination	SVSFFAKGMSPAVL- EEEEEECCCCCCCC-	20.54	22817900
267	Ubiquitination	GMSPAVL-------- CCCCCCC--------		21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANR40_HUMAN	ANKRD40	physical	22863883
IWS1_HUMAN	IWS1	physical	22863883
ELP4_HUMAN	ELP4	physical	26186194
ZBTB2_HUMAN	ZBTB2	physical	26186194
ZN639_HUMAN	ZNF639	physical	26186194
ELP5_HUMAN	ELP5	physical	26186194
ZBT25_HUMAN	ZBTB25	physical	26186194
NELFB_HUMAN	NELFB	physical	26344197
PSB8_HUMAN	PSMB8	physical	26344197
ELP4_HUMAN	ELP4	physical	28514442
ELP5_HUMAN	ELP5	physical	28514442
ZN639_HUMAN	ZNF639	physical	28514442
ZBTB2_HUMAN	ZBTB2	physical	28514442
ZBT25_HUMAN	ZBTB25	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.