| UniProt ID | ELP5_HUMAN | |
|---|---|---|
| UniProt AC | Q8TE02 | |
| Protein Name | Elongator complex protein 5 | |
| Gene Name | ELP5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 316 | |
| Subcellular Localization | Nucleus. Cytoplasm. | |
| Protein Description | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.. | |
| Protein Sequence | MTPSEGARAGTGRELEMLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTPSEGARA ------CCCCHHCCC | 20860994 | ||
| 4 | Phosphorylation | ----MTPSEGARAGT ----CCCCHHCCCCC | 20068231 | ||
| 40 | Phosphorylation | SVEWEGRSLLKALVK CCCCCCHHHHHHHHH | 24719451 | ||
| 48 | Ubiquitination | LLKALVKKSALCGEQ HHHHHHHHHHHCCCE | 29967540 | ||
| 48 (in isoform 4) | Ubiquitination | - | - | ||
| 94 | Ubiquitination | RDPLNWSKTEEAFPG CCCCCHHHCCCCCCC | 21963094 | ||
| 94 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 94 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 94 (in isoform 3) | Ubiquitination | - | 21906983 | ||
| 94 (in isoform 4) | Ubiquitination | - | 21906983 | ||
| 268 | Phosphorylation | KEREARDSLILPFQF HHHHHHHCEEECCCC | 14702039 | ||
| 276 | Phosphorylation | LILPFQFSSEKQQAL EEECCCCCCHHHHHH | 22199227 | ||
| 277 | Phosphorylation | ILPFQFSSEKQQALL EECCCCCCHHHHHHH | 22199227 | ||
| 279 | Ubiquitination | PFQFSSEKQQALLRP CCCCCCHHHHHHHCC | 29967540 | ||
| 302 | Phosphorylation | IFYEPDAYDDLDQED EEECCCCCCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ELP5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ELP5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ELP5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ELP5_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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