KLH15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH15_HUMAN
• UniProt AC: Q96M94
• Protein Name: Kelch-like protein 15
• Gene Name: KLHL15
• Organism: Homo sapiens (Human).
• Sequence Length: 604
• Subcellular Localization: Nucleus .
• Protein Description: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. [PubMed: 14528312 Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits]
• Protein Sequence: MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	LLATQSDYFRIMFTA HHHCCCCEEEEEEEC	10.45	-
217	Phosphorylation	RRWRHTDTIIQNIRF HHHCCHHHHHHHHHH	22.57	-
237	Ubiquitination	TSVFEKVKTSEFYRY CHHHHHHCHHHHHHH	58.35	-
271	Ubiquitination	QQPLLDMKSSRIRSA CCCCCCCCCHHHHCC	44.97	21906983
279	Ubiquitination	SSRIRSAKPQTTVFR CHHHHCCCCCCEECC	38.62	-
282	Phosphorylation	IRSAKPQTTVFRGMI HHCCCCCCEECCHHC	33.19	29759185
283	Phosphorylation	RSAKPQTTVFRGMIG HCCCCCCEECCHHCC	16.64	29759185
292	Phosphorylation	FRGMIGHSMVNSKIL CCHHCCHHHHCCEEE	21.15	29759185
296	Phosphorylation	IGHSMVNSKILLLKK CCHHHHCCEEEEEEC	15.06	29759185
358	Phosphorylation	RYDPRQNSWLQMADM EECCCCCCEEHHCCC	22.33	-
366	Phosphorylation	WLQMADMSVPRSEFA EEHHCCCCCCHHHHH	29.53	30631047
392	Phosphorylation	AGRTRDETFYSTERY HCCCCCCCCCCCEEE	31.96	-
396	Phosphorylation	RDETFYSTERYDITN CCCCCCCCEEEECCC	17.07	-
405	Ubiquitination	RYDITNDKWEFVDPY EEECCCCCEEECCCC	51.17	2190698
450	Ubiquitination	VCVFDPSKEGTIEQR EEEECCCCCCCHHHH	66.60	-
458	Phosphorylation	EGTIEQRTRRTQVVT CCCHHHHHHCEEEEE	24.97	28555341
471	Ubiquitination	VTNCWENKSKMNYAR EECHHCCCCCCCHHH	39.68	-
473	Ubiquitination	NCWENKSKMNYARCF CHHCCCCCCCHHHHH	32.54	-
581	Ubiquitination	EYPRMPCKLDGLQVC CCCCCCCCCCCEEEE	43.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2ABB_HUMAN	PPP2R2B	physical	23135275
KLH15_HUMAN	KLHL15	physical	23135275
PP2AA_HUMAN	PPP2CA	physical	23135275
2AAA_HUMAN	PPP2R1A	physical	23135275
ELP5_HUMAN	ELP5	physical	28514442
CACB1_HUMAN	CACNB1	physical	28514442
CUL3_HUMAN	CUL3	physical	27561354
CTIP_HUMAN	RBBP8	physical	27561354

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.