PSME1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSME1_HUMAN
• UniProt AC: Q06323
• Protein Name: Proteasome activator complex subunit 1
• Gene Name: PSME1
• Organism: Homo sapiens (Human).
• Sequence Length: 249
• Protein Description: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome..
• Protein Sequence: MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKPRGETKGMIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	VQPEAQAKVDVFRED CCHHHHHHHHHHHHH	27.21	-
13	Ubiquitination	VQPEAQAKVDVFRED CCHHHHHHHHHHHHH	27.21	-
13	Acetylation	VQPEAQAKVDVFRED CCHHHHHHHHHHHHH	27.21	23749302
13	Ubiquitination	VQPEAQAKVDVFRED CCHHHHHHHHHHHHH	27.21	-
23	Phosphorylation	VFREDLCTKTENLLG HHHHHHHHHHHHHHH	48.58	29255136
24	Ubiquitination	FREDLCTKTENLLGS HHHHHHHHHHHHHHH	53.50	-
24	Ubiquitination	FREDLCTKTENLLGS HHHHHHHHHHHHHHH	53.50	-
24	Acetylation	FREDLCTKTENLLGS HHHHHHHHHHHHHHH	53.50	26051181
25	Phosphorylation	REDLCTKTENLLGSY HHHHHHHHHHHHHHH	16.38	29255136
31	Phosphorylation	KTENLLGSYFPKKIS HHHHHHHHHCCCCHH	24.46	29255136
32	Phosphorylation	TENLLGSYFPKKISE HHHHHHHHCCCCHHH	23.31	25849741
35	Ubiquitination	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	21890473
35	Acetylation	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	23954790
35	Ubiquitination	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	21890473
35	Succinylation	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	23954790
35	Ubiquitination	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	21890473
35	Ubiquitination	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	-
35	Acetylation	LLGSYFPKKISELDA HHHHHCCCCHHHHHH	53.49	-
36	Ubiquitination	LGSYFPKKISELDAF HHHHCCCCHHHHHHH	52.26	-
36	Ubiquitination	LGSYFPKKISELDAF HHHHCCCCHHHHHHH	52.26	-
38	Phosphorylation	SYFPKKISELDAFLK HHCCCCHHHHHHHHC	40.77	28258704
45	Ubiquitination	SELDAFLKEPALNEA HHHHHHHCCHHCCCC	56.02	-
55	Phosphorylation	ALNEANLSNLKAPLD HCCCCCHHCCCCCCC	39.67	25159151
58	Sumoylation	EANLSNLKAPLDIPV CCCHHCCCCCCCCCC	52.81	-
58	Ubiquitination	EANLSNLKAPLDIPV CCCHHCCCCCCCCCC	52.81	-
70	Acetylation	IPVPDPVKEKEKEER CCCCCCCCHHHHHHH	69.34	25953088
90	Acetylation	KEDKDEKKKGEDEDK HHHHHHHHCCCCCCC	65.05	8270215
91	Acetylation	EDKDEKKKGEDEDKG HHHHHHHCCCCCCCC	77.82	25953088
97	Acetylation	KKGEDEDKGPPCGPV HCCCCCCCCCCCCCC	71.86	26051181
109	Ubiquitination	GPVNCNEKIVVLLQR CCCCCCHHHHHHHHH	27.15	-
155	Ubiquitination	FGVAVQEKVFELMTS CCHHHHHHHHHHHHH	34.82	-
172	Phosphorylation	TKLEGFHTQISKYFS HHHHHHHHHHHHHHH	25.90	28348404
175	Phosphorylation	EGFHTQISKYFSERG HHHHHHHHHHHHHHC	16.10	28348404
176	Ubiquitination	GFHTQISKYFSERGD HHHHHHHHHHHHHCH	52.52	21890473
176	Ubiquitination	GFHTQISKYFSERGD HHHHHHHHHHHHHCH	52.52	21890473
176	Ubiquitination	GFHTQISKYFSERGD HHHHHHHHHHHHHCH	52.52	21890473
176	Acetylation	GFHTQISKYFSERGD HHHHHHHHHHHHHCH	52.52	27452117
177	Phosphorylation	FHTQISKYFSERGDA HHHHHHHHHHHHCHH	12.92	28270605
179	Phosphorylation	TQISKYFSERGDAVT HHHHHHHHHHCHHHH	24.24	28270605
186	Phosphorylation	SERGDAVTKAAKQPH HHHCHHHHHHHHCCC	19.38	23532336
187	Acetylation	ERGDAVTKAAKQPHV HHCHHHHHHHHCCCC	39.48	25953088
187	Ubiquitination	ERGDAVTKAAKQPHV HHCHHHHHHHHCCCC	39.48	-
190	Ubiquitination	DAVTKAAKQPHVGDY HHHHHHHHCCCCCCH	70.04	-
190	Acetylation	DAVTKAAKQPHVGDY HHHHHHHHCCCCCCH	70.04	25953088
209	Phosphorylation	HELDEAEYRDIRLMV HHCCHHHHHHHHHHH	22.19	-
213	Methylation	EAEYRDIRLMVMEIR HHHHHHHHHHHHHHH	22.48	115372757
213	Dimethylation	EAEYRDIRLMVMEIR HHHHHHHHHHHHHHH	22.48	-
215	Sulfoxidation	EYRDIRLMVMEIRNA HHHHHHHHHHHHHHH	1.61	21406390
220	Dimethylation	RLMVMEIRNAYAVLY HHHHHHHHHHHHHHH	14.39	-
220	Methylation	RLMVMEIRNAYAVLY HHHHHHHHHHHHHHH	14.39	115372763
227	Phosphorylation	RNAYAVLYDIILKNF HHHHHHHHHHHHHCH	9.86	20068231
232	Acetylation	VLYDIILKNFEKLKK HHHHHHHHCHHHHCC	49.54	156757
238	Phosphorylation	LKNFEKLKKPRGETK HHCHHHHCCCCCCCC	72.33	-
238 (in isoform 2)	Phosphorylation	-	72.33	-
245	Ubiquitination	KKPRGETKGMIY--- CCCCCCCCCCCC---	42.03	-
249	Phosphorylation	GETKGMIY------- CCCCCCCC-------	12.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSME1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSME1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSME1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSME2_HUMAN	PSME2	physical	16189514
PSME1_HUMAN	PSME1	physical	16169070
VINC_HUMAN	VCL	physical	16169070
VIME_HUMAN	VIM	physical	16169070
CHD3_HUMAN	CHD3	physical	16169070
PSME1_HUMAN	PSME1	physical	9403698
PSME2_HUMAN	PSME2	physical	8663520
PRS8_HUMAN	PSMC5	physical	10799514
PSA1_HUMAN	PSMA1	physical	10799514
PRS8_HUMAN	PSMC5	physical	9620878
PSME2_HUMAN	PSME2	physical	19017543
PSME1_HUMAN	PSME1	physical	9385652
PSME2_HUMAN	PSME2	physical	9346951
PSME1_HUMAN	PSME1	physical	9346951
PSB9_HUMAN	PSMB9	physical	11745344
PSB6_HUMAN	PSMB6	physical	11745344
PSA4_HUMAN	PSMA4	physical	11745344
PSMD6_HUMAN	PSMD6	physical	11745344
PSB7_HUMAN	PSMB7	physical	11745344
PSB8_HUMAN	PSMB8	physical	11745344
PSB10_HUMAN	PSMB10	physical	11745344
A4_HUMAN	APP	physical	21832049
PSME2_HUMAN	PSME2	physical	22939629
RBBP6_HUMAN	RBBP6	physical	22939629
UBL7_HUMAN	UBL7	physical	22939629
SCOT1_HUMAN	OXCT1	physical	22939629
PSRC1_HUMAN	PSRC1	physical	22939629
UBP5_HUMAN	USP5	physical	22939629
XPO2_HUMAN	CSE1L	physical	22939629
PSA1_HUMAN	PSMA1	physical	24429290
PSDE_HUMAN	PSMD14	physical	24429290
ADRM1_HUMAN	ADRM1	physical	24429290
PSME1_HUMAN	PSME1	physical	9325261
PSME2_HUMAN	PSME2	physical	9325261
PSME1_HUMAN	PSME1	physical	25416956
GARS_HUMAN	GARS	physical	26344197
PAK2_HUMAN	PAK2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.