| UniProt ID | GARS_HUMAN | |
|---|---|---|
| UniProt AC | P41250 | |
| Protein Name | Glycine--tRNA ligase | |
| Gene Name | GARS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 739 | |
| Subcellular Localization | Cytoplasm . Cell projection, axon . Secreted . Secreted, exosome . Secreted by motor neuron, possibly through the exosome pathway (By similarity). In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). | |
| Protein Description | Catalyzes the ligation of glycine to the 3'-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.. | |
| Protein Sequence | MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCPPISLPAAASRSSMDGAGAEEVLAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVEARYPLFEGQETGKKETIEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | PRLLARPSLLLRRSL HHHHCCHHHHHHHCC | 26434776 | ||
| 35 | Phosphorylation | PSLLLRRSLSAASCP HHHHHHHCCCCCCCC | 28450419 | ||
| 37 | Phosphorylation | LLLRRSLSAASCPPI HHHHHCCCCCCCCCC | 28450419 | ||
| 40 | Phosphorylation | RRSLSAASCPPISLP HHCCCCCCCCCCCCC | 28450419 | ||
| 53 | Phosphorylation | LPAAASRSSMDGAGA CCCHHCCCCCCCCCH | 20068231 | ||
| 54 | Phosphorylation | PAAASRSSMDGAGAE CCHHCCCCCCCCCHH | 20068231 | ||
| 55 | Sulfoxidation | AAASRSSMDGAGAEE CHHCCCCCCCCCHHH | 21406390 | ||
| 80 | Ubiquitination | QQGDLVRKLKEDKAP HHCHHHHHHHCCCCC | - | ||
| 82 | Malonylation | GDLVRKLKEDKAPQV CHHHHHHHCCCCCCC | 26320211 | ||
| 82 | Sumoylation | GDLVRKLKEDKAPQV CHHHHHHHCCCCCCC | - | ||
| 82 | Ubiquitination | GDLVRKLKEDKAPQV CHHHHHHHCCCCCCC | 21906983 | ||
| 85 | 2-Hydroxyisobutyrylation | VRKLKEDKAPQVDVD HHHHHCCCCCCCCHH | - | ||
| 85 | Acetylation | VRKLKEDKAPQVDVD HHHHHCCCCCCCCHH | 26051181 | ||
| 85 | Ubiquitination | VRKLKEDKAPQVDVD HHHHHCCCCCCCCHH | - | ||
| 93 | 2-Hydroxyisobutyrylation | APQVDVDKAVAELKA CCCCCHHHHHHHHHH | - | ||
| 93 | Acetylation | APQVDVDKAVAELKA CCCCCHHHHHHHHHH | 23236377 | ||
| 93 | Malonylation | APQVDVDKAVAELKA CCCCCHHHHHHHHHH | 26320211 | ||
| 93 | Ubiquitination | APQVDVDKAVAELKA CCCCCHHHHHHHHHH | 21906983 | ||
| 99 | Acetylation | DKAVAELKARKRVLE HHHHHHHHHHHHHHH | 23749302 | ||
| 99 | Malonylation | DKAVAELKARKRVLE HHHHHHHHHHHHHHH | 26320211 | ||
| 99 | Ubiquitination | DKAVAELKARKRVLE HHHHHHHHHHHHHHH | 21906983 | ||
| 108 | 2-Hydroxyisobutyrylation | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | - | ||
| 108 | Acetylation | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | 23749302 | ||
| 108 | Malonylation | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | 26320211 | ||
| 108 | Ubiquitination | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | 21890473 | ||
| 115 | Acetylation | KELALQPKDDIVDRA HHHHCCCCCCCCCHH | 26051181 | ||
| 115 | Malonylation | KELALQPKDDIVDRA HHHHCCCCCCCCCHH | 26320211 | ||
| 115 | Succinylation | KELALQPKDDIVDRA HHHHCCCCCCCCCHH | 23954790 | ||
| 115 | Ubiquitination | KELALQPKDDIVDRA HHHHCCCCCCCCCHH | - | ||
| 123 | Ubiquitination | DDIVDRAKMEDTLKR CCCCCHHHHHHHHHH | - | ||
| 129 | Acetylation | AKMEDTLKRRFFYDQ HHHHHHHHHHHHHHH | 25953088 | ||
| 129 | Ubiquitination | AKMEDTLKRRFFYDQ HHHHHHHHHHHHHHH | - | ||
| 141 | Phosphorylation | YDQAFAIYGGVSGLY HHHHHHHHCCCCCCC | - | ||
| 145 | Phosphorylation | FAIYGGVSGLYDFGP HHHHCCCCCCCCCCH | - | ||
| 148 | Phosphorylation | YGGVSGLYDFGPVGC HCCCCCCCCCCHHHH | 22817900 | ||
| 191 | Phosphorylation | TPEPVLKTSGHVDKF CCCCCCCCCCCHHHH | - | ||
| 192 | Phosphorylation | PEPVLKTSGHVDKFA CCCCCCCCCCHHHHH | - | ||
| 197 | 2-Hydroxyisobutyrylation | KTSGHVDKFADFMVK CCCCCHHHHHHEEEE | - | ||
| 197 | Acetylation | KTSGHVDKFADFMVK CCCCCHHHHHHEEEE | 25038526 | ||
| 197 | Malonylation | KTSGHVDKFADFMVK CCCCCHHHHHHEEEE | 26320211 | ||
| 197 | Ubiquitination | KTSGHVDKFADFMVK CCCCCHHHHHHEEEE | 21890473 | ||
| 202 | Sulfoxidation | VDKFADFMVKDVKNG HHHHHHEEEEECCCC | 21406390 | ||
| 204 | 2-Hydroxyisobutyrylation | KFADFMVKDVKNGEC HHHHEEEEECCCCCC | - | ||
| 204 | Acetylation | KFADFMVKDVKNGEC HHHHEEEEECCCCCC | 19608861 | ||
| 204 | Succinylation | KFADFMVKDVKNGEC HHHHEEEEECCCCCC | 23954790 | ||
| 204 | Ubiquitination | KFADFMVKDVKNGEC HHHHEEEEECCCCCC | 21906983 | ||
| 207 | 2-Hydroxyisobutyrylation | DFMVKDVKNGECFRA HEEEEECCCCCCCCH | - | ||
| 207 | Malonylation | DFMVKDVKNGECFRA HEEEEECCCCCCCCH | 26320211 | ||
| 207 | Ubiquitination | DFMVKDVKNGECFRA HEEEEECCCCCCCCH | - | ||
| 219 | 2-Hydroxyisobutyrylation | FRADHLLKAHLQKLM CCHHHHHHHHHHHHH | - | ||
| 219 | Acetylation | FRADHLLKAHLQKLM CCHHHHHHHHHHHHH | 23236377 | ||
| 219 | Malonylation | FRADHLLKAHLQKLM CCHHHHHHHHHHHHH | 26320211 | ||
| 219 | Ubiquitination | FRADHLLKAHLQKLM CCHHHHHHHHHHHHH | - | ||
| 224 | Acetylation | LLKAHLQKLMSDKKC HHHHHHHHHHCCCCC | 23236377 | ||
| 224 | Malonylation | LLKAHLQKLMSDKKC HHHHHHHHHHCCCCC | 26320211 | ||
| 224 | Ubiquitination | LLKAHLQKLMSDKKC HHHHHHHHHHCCCCC | - | ||
| 265 | Phosphorylation | FVNYNVKSPITGNDL HHHCCCCCCCCCCCC | 28102081 | ||
| 268 | Phosphorylation | YNVKSPITGNDLSPP CCCCCCCCCCCCCCC | 28102081 | ||
| 273 | Phosphorylation | PITGNDLSPPVSFNL CCCCCCCCCCEEEEE | 30576142 | ||
| 277 | Phosphorylation | NDLSPPVSFNLMFKT CCCCCCEEEEEEEEE | 30576142 | ||
| 281 | Sulfoxidation | PPVSFNLMFKTFIGP CCEEEEEEEEEEECC | 30846556 | ||
| 292 | Sulfoxidation | FIGPGGNMPGYLRPE EECCCCCCCCCCCHH | 30846556 | ||
| 309 | Acetylation | QGIFLNFKRLLEFNQ CCCEECHHHHHHHCC | 130509 | ||
| 309 | Ubiquitination | QGIFLNFKRLLEFNQ CCCEECHHHHHHHCC | - | ||
| 318 | Acetylation | LLEFNQGKLPFAAAQ HHHHCCCCCCCCHHH | 25953088 | ||
| 318 | Ubiquitination | LLEFNQGKLPFAAAQ HHHHCCCCCCCCHHH | 21890473 | ||
| 329 | Phosphorylation | AAAQIGNSFRNEISP CHHHHCHHHCCCCCC | 28102081 | ||
| 335 | Phosphorylation | NSFRNEISPRSGLIR HHHCCCCCCCCCEEE | 22199227 | ||
| 348 | Sulfoxidation | IRVREFTMAEIEHFV EEEEEEEHHHEECCC | 30846556 | ||
| 360 | Acetylation | HFVDPSEKDHPKFQN CCCCCCCCCCCCCCC | 25953088 | ||
| 374 | Phosphorylation | NVADLHLYLYSAKAQ CHHHHHHHHHHHCCC | 28152594 | ||
| 376 | Phosphorylation | ADLHLYLYSAKAQVS HHHHHHHHHHCCCCC | 28152594 | ||
| 377 | Phosphorylation | DLHLYLYSAKAQVSG HHHHHHHHHCCCCCC | 28152594 | ||
| 379 | Ubiquitination | HLYLYSAKAQVSGQS HHHHHHHCCCCCCCC | 21890473 | ||
| 383 | Phosphorylation | YSAKAQVSGQSARKM HHHCCCCCCCCHHHC | 20860994 | ||
| 414 | Phosphorylation | GYFIGRIYLYLTKVG HHHHHHHHHHHHHCC | 25367160 | ||
| 416 | Phosphorylation | FIGRIYLYLTKVGIS HHHHHHHHHHHCCCC | 25367160 | ||
| 419 | Succinylation | RIYLYLTKVGISPDK HHHHHHHHCCCCHHH | 23954790 | ||
| 419 | Ubiquitination | RIYLYLTKVGISPDK HHHHHHHHCCCCHHH | 21890473 | ||
| 423 | Phosphorylation | YLTKVGISPDKLRFR HHHHCCCCHHHHHHH | 21815630 | ||
| 426 | Acetylation | KVGISPDKLRFRQHM HCCCCHHHHHHHHHH | 26822725 | ||
| 426 | Ubiquitination | KVGISPDKLRFRQHM HCCCCHHHHHHHHHH | - | ||
| 433 | Sulfoxidation | KLRFRQHMENEMAHY HHHHHHHHHHHHHHH | 30846556 | ||
| 437 | Sulfoxidation | RQHMENEMAHYACDC HHHHHHHHHHHHHCC | 30846556 | ||
| 451 | Phosphorylation | CWDAESKTSYGWIEI CCCCCCCCCCCEEEE | 28442448 | ||
| 452 | Phosphorylation | WDAESKTSYGWIEIV CCCCCCCCCCEEEEE | 28442448 | ||
| 453 | Phosphorylation | DAESKTSYGWIEIVG CCCCCCCCCEEEEEE | 28152594 | ||
| 465 | Phosphorylation | IVGCADRSCYDLSCH EEEECCCCEECCCCC | 28152594 | ||
| 466 | S-nitrosocysteine | VGCADRSCYDLSCHA EEECCCCEECCCCCC | - | ||
| 467 | Phosphorylation | GCADRSCYDLSCHAR EECCCCEECCCCCCC | 28152594 | ||
| 470 | Phosphorylation | DRSCYDLSCHARATK CCCEECCCCCCCCCC | 28152594 | ||
| 471 | S-nitrosocysteine | RSCYDLSCHARATKV CCEECCCCCCCCCCC | - | ||
| 477 | Malonylation | SCHARATKVPLVAEK CCCCCCCCCCEEEEC | 26320211 | ||
| 484 | Acetylation | KVPLVAEKPLKEPKT CCCEEEECCCCCCCE | 23954790 | ||
| 484 | Ubiquitination | KVPLVAEKPLKEPKT CCCEEEECCCCCCCE | - | ||
| 487 | Acetylation | LVAEKPLKEPKTVNV EEEECCCCCCCEEEE | 25953088 | ||
| 487 | Malonylation | LVAEKPLKEPKTVNV EEEECCCCCCCEEEE | 26320211 | ||
| 487 | Ubiquitination | LVAEKPLKEPKTVNV EEEECCCCCCCEEEE | - | ||
| 500 | Phosphorylation | NVVQFEPSKGAIGKA EEEEEECCCCCCCHH | 28348404 | ||
| 501 | 2-Hydroxyisobutyrylation | VVQFEPSKGAIGKAY EEEEECCCCCCCHHH | - | ||
| 501 | Acetylation | VVQFEPSKGAIGKAY EEEEECCCCCCCHHH | 19608861 | ||
| 501 | Malonylation | VVQFEPSKGAIGKAY EEEEECCCCCCCHHH | 26320211 | ||
| 501 | Ubiquitination | VVQFEPSKGAIGKAY EEEEECCCCCCCHHH | 21906983 | ||
| 506 | Acetylation | PSKGAIGKAYKKDAK CCCCCCCHHHHHHHH | 25953088 | ||
| 506 | Ubiquitination | PSKGAIGKAYKKDAK CCCCCCCHHHHHHHH | - | ||
| 518 | Phosphorylation | DAKLVMEYLAICDEC HHHHHHHHHHHCCCC | - | ||
| 544 | Phosphorylation | KGEFTIETEGKTFQL CCCEEEEECCEEEEE | - | ||
| 547 | Ubiquitination | FTIETEGKTFQLTKD EEEEECCEEEEEEHH | 21890473 | ||
| 548 | Phosphorylation | TIETEGKTFQLTKDM EEEECCEEEEEEHHH | 20068231 | ||
| 552 | Phosphorylation | EGKTFQLTKDMINVK CCEEEEEEHHHHCHH | 20068231 | ||
| 553 | Succinylation | GKTFQLTKDMINVKR CEEEEEEHHHHCHHH | 23954790 | ||
| 553 | Ubiquitination | GKTFQLTKDMINVKR CEEEEEEHHHHCHHH | - | ||
| 559 | 2-Hydroxyisobutyrylation | TKDMINVKRFQKTLY EHHHHCHHHHHEEEE | - | ||
| 559 | Acetylation | TKDMINVKRFQKTLY EHHHHCHHHHHEEEE | 26051181 | ||
| 559 | Malonylation | TKDMINVKRFQKTLY EHHHHCHHHHHEEEE | 26320211 | ||
| 559 | Ubiquitination | TKDMINVKRFQKTLY EHHHHCHHHHHEEEE | - | ||
| 563 | Ubiquitination | INVKRFQKTLYVEEV HCHHHHHEEEEEEEC | 21890473 | ||
| 585 | Sulfoxidation | SFGLGRIMYTVFEHT CCCCCHHHEEEEEEE | 30846556 | ||
| 596 | Methylation | FEHTFHVREGDEQRT EEEEEECCCCCCCCE | - | ||
| 606 | Phosphorylation | DEQRTFFSFPAVVAP CCCCEEEECCEEECC | - | ||
| 628 | Sulfoxidation | LSQNQEFMPFVKELS CCCCCCHHHHHHHHH | 21406390 | ||
| 646 | Succinylation | TRHGVSHKVDDSSGS HHHCCCCCCCCCCCC | 27452117 | ||
| 646 | Ubiquitination | TRHGVSHKVDDSSGS HHHCCCCCCCCCCCC | 21906983 | ||
| 650 | Phosphorylation | VSHKVDDSSGSIGRR CCCCCCCCCCCCCCC | 26699800 | ||
| 651 | Phosphorylation | SHKVDDSSGSIGRRY CCCCCCCCCCCCCCC | 29255136 | ||
| 653 | Phosphorylation | KVDDSSGSIGRRYAR CCCCCCCCCCCCCEE | 29255136 | ||
| 687 | Methylation | TPHTATLRDRDSMRQ CCCCCCCCCHHHHHH | - | ||
| 700 | Phosphorylation | RQIRAEISELPSIVQ HHHHHHHHHCHHHHH | - | ||
| 704 | Phosphorylation | AEISELPSIVQDLAN HHHHHCHHHHHHHHC | 25338102 | ||
| 731 | Phosphorylation | PLFEGQETGKKETIE CCCCCCCCCCCCCCC | 23186163 | ||
| 733 | 2-Hydroxyisobutyrylation | FEGQETGKKETIEE- CCCCCCCCCCCCCC- | - | ||
| 733 | Acetylation | FEGQETGKKETIEE- CCCCCCCCCCCCCC- | 23236377 | ||
| 733 | Malonylation | FEGQETGKKETIEE- CCCCCCCCCCCCCC- | 26320211 | ||
| 733 | Ubiquitination | FEGQETGKKETIEE- CCCCCCCCCCCCCC- | 2190698 | ||
| 734 | Ubiquitination | EGQETGKKETIEE-- CCCCCCCCCCCCC-- | 21890473 | ||
| 736 | Phosphorylation | QETGKKETIEE---- CCCCCCCCCCC---- | 7962006 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GARS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GARS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GARS_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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