| UniProt ID | TYW4_HUMAN | |
|---|---|---|
| UniProt AC | O60294 | |
| Protein Name | tRNA wybutosine-synthesizing protein 4 | |
| Gene Name | LCMT2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 686 | |
| Subcellular Localization | ||
| Protein Description | Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.. | |
| Protein Sequence | MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRARAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNSPLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWHLKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGHASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCWRHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLLVGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGGGNCFSFGTYFNPHTVTLDLSSLSAGQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Methylation | GPRSRERRAGAVQNT CCCCHHHHHCCCCCC | 115481911 | ||
| 16 | Phosphorylation | RAGAVQNTNDSSALS HHCCCCCCCCHHHHH | 23312004 | ||
| 19 | Phosphorylation | AVQNTNDSSALSKRS CCCCCCCHHHHHHHH | 29255136 | ||
| 20 | Phosphorylation | VQNTNDSSALSKRSL CCCCCCHHHHHHHHH | 29255136 | ||
| 23 | Phosphorylation | TNDSSALSKRSLAAR CCCHHHHHHHHHHHC | 29255136 | ||
| 24 | Ubiquitination | NDSSALSKRSLAARG CCHHHHHHHHHHHCC | 21906983 | ||
| 218 | Phosphorylation | PNALFVVYEQMRPQD CCEEEEEEEECCCCC | 25404012 | ||
| 316 | Phosphorylation | LAASRGDTLSHTLVF EEECCCCCCEEEEEE | - | ||
| 318 | Phosphorylation | ASRGDTLSHTLVFPS ECCCCCCEEEEEECC | - | ||
| 338 | Phosphorylation | RVNPASPSGVFPASV CCCCCCCCCCCCHHH | 25332170 | ||
| 356 | Ubiquitination | EGQVPNLKRYGHASV CCCCCCCCCCCCEEE | 21906983 | ||
| 358 | Phosphorylation | QVPNLKRYGHASVFL CCCCCCCCCCEEEEE | 22468782 | ||
| 362 | Phosphorylation | LKRYGHASVFLSPDV CCCCCCEEEEECCCE | 22468782 | ||
| 372 | Phosphorylation | LSPDVILSAGGFGEQ ECCCEEEECCCCCCC | 22468782 | ||
| 401 | Ubiquitination | RDCDSEWKGSQIGSC CCCCCCCCCCCCCCC | 21963094 | ||
| 410 | Phosphorylation | SQIGSCGTGVQWDGR CCCCCCCCCCEECCH | 28555341 | ||
| 426 | Phosphorylation | YHTMTRLSESRVLVL EEEEECCCCCEEEEE | - | ||
| 428 | Phosphorylation | TMTRLSESRVLVLGG EEECCCCCEEEEECC | - | ||
| 438 | Phosphorylation | LVLGGRLSPVSPALG EEECCCCCCCCHHHH | - | ||
| 441 | Phosphorylation | GGRLSPVSPALGVLQ CCCCCCCCHHHHHHE | - | ||
| 453 | Sumoylation | VLQLHFFKSEDNNTE HHEEEEEECCCCCCC | - | ||
| 454 | Phosphorylation | LQLHFFKSEDNNTED HEEEEEECCCCCCCE | - | ||
| 459 | Phosphorylation | FKSEDNNTEDLKVTI EECCCCCCCEEEEEE | - | ||
| 463 | Ubiquitination | DNNTEDLKVTITKAG CCCCCEEEEEEEECC | 21906983 | ||
| 463 | Acetylation | DNNTEDLKVTITKAG CCCCCEEEEEEEECC | 23954790 | ||
| 465 | O-linked_Glycosylation | NTEDLKVTITKAGRK CCCEEEEEEEECCCC | 30379171 | ||
| 467 | Phosphorylation | EDLKVTITKAGRKDD CEEEEEEEECCCCCC | - | ||
| 468 | Ubiquitination | DLKVTITKAGRKDDS EEEEEEEECCCCCCC | 22817900 | ||
| 472 | Ubiquitination | TITKAGRKDDSTLCC EEEECCCCCCCCEEE | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TYW4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TYW4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBAC1_HUMAN | UBAC1 | physical | 28514442 | |
| RN123_HUMAN | RNF123 | physical | 28514442 | |
| DNJC7_HUMAN | DNAJC7 | physical | 28514442 | |
| TCPB_HUMAN | CCT2 | physical | 28514442 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00149 | L-Leucine |
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