RN123_HUMAN - dbPTM
RN123_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RN123_HUMAN
UniProt AC Q5XPI4
Protein Name E3 ubiquitin-protein ligase RNF123
Gene Name RNF123
Organism Homo sapiens (Human).
Sequence Length 1314
Subcellular Localization Cytoplasm .
Protein Description Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle..
Protein Sequence MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALRYYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPAPDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASKGAGMS
------CCCCCCCCC		31.1122814378
3Phosphorylation-----MASKGAGMSF
-----CCCCCCCCCC		43.4024043423
4Acetylation----MASKGAGMSFS
----CCCCCCCCCCC		60.8930591959
4Ubiquitination----MASKGAGMSFS
----CCCCCCCCCCC		60.89-
4 (in isoform 2)Ubiquitination-60.89-
9PhosphorylationASKGAGMSFSRKSYR
CCCCCCCCCCCCEEE		21.1025159151
11PhosphorylationKGAGMSFSRKSYRLT
CCCCCCCCCCEEECC		31.3424043423
13AcetylationAGMSFSRKSYRLTSD
CCCCCCCCEEECCCH		51.127409425
14PhosphorylationGMSFSRKSYRLTSDA
CCCCCCCEEECCCHH		17.8625159151
15PhosphorylationMSFSRKSYRLTSDAE
CCCCCCEEECCCHHH		16.8126074081
18PhosphorylationSRKSYRLTSDAEKSR
CCCEEECCCHHHHHH		18.6326074081
19PhosphorylationRKSYRLTSDAEKSRV
CCEEECCCHHHHHHH		39.1425159151
33UbiquitinationVTGIVQEKLLNDYLN
HCHHHHHHHHHHHHH		40.98-
33 (in isoform 2)Ubiquitination-40.98-
57UbiquitinationPPAATSRKPLNFQNL
CCCCCCCCCCCCCCC		54.33-
57 (in isoform 2)Ubiquitination-54.33-
126PhosphorylationSNFGTIRSTTCVYKG
CCCCCCCCEEEEECC		24.98-
127PhosphorylationNFGTIRSTTCVYKGK
CCCCCCCEEEEECCE		17.86-
128PhosphorylationFGTIRSTTCVYKGKW
CCCCCCEEEEECCEE		10.96-
131PhosphorylationIRSTTCVYKGKWLYE
CCCEEEEECCEEHHE		19.03-
153PhosphorylationLMQIGWCTISCRFNQ
CEEEEEEEEEEECCC		14.9330631047
155PhosphorylationQIGWCTISCRFNQEE
EEEEEEEEEECCCCC		4.8930631047
180UbiquitinationYDGNRVRKWNVTTTN
ECCCCEEEEEEEECC		40.02-
180 (in isoform 2)Ubiquitination-40.02-
184PhosphorylationRVRKWNVTTTNYGKA
CEEEEEEEECCCCHH		25.3728060719
185PhosphorylationVRKWNVTTTNYGKAW
EEEEEEEECCCCHHC		14.5728060719
186PhosphorylationRKWNVTTTNYGKAWA
EEEEEEECCCCHHCC		19.6528060719
188PhosphorylationWNVTTTNYGKAWAAG
EEEEECCCCHHCCCC		20.2228060719
240PhosphorylationYFPAISLSFKESVAF
HHHHHCCCCCCCEEE		27.7324719451
244PhosphorylationISLSFKESVAFNFGS
HCCCCCCCEEECCCC		21.2422210691
251PhosphorylationSVAFNFGSRPLRYPV
CEEECCCCCCCCCCC		26.9622210691
261PhosphorylationLRYPVAGYRPLQDPP
CCCCCCCCCCCCCCC		10.1822210691
306MethylationDKESSKWRLRGQPTV
CCCCCCCHHCCCCCH		20.4624384495
384PhosphorylationCLKQLMMSLLRLYRF
HHHHHHHHHHHHHHH		15.4119845377
389PhosphorylationMMSLLRLYRFSPIVP
HHHHHHHHHHCCCCC		11.8122210691
404PhosphorylationDLGLQIHYLRLTIAI
CHHHCHHHHHHHHHH		8.6422210691
432PhosphorylationVLFDVLRSVVFFYIK
HHHHHHHHHHHHHCC		20.6224719451
437PhosphorylationLRSVVFFYIKSPLRV
HHHHHHHHCCCCCCH		8.9320068231
467UbiquitinationHCSSREGKESTEMKE
CCCCCCCCCCCCHHH		43.6821906983
467 (in isoform 1)Ubiquitination-43.6821890473
467 (in isoform 2)Ubiquitination-43.6821890473
470O-linked_GlycosylationSREGKESTEMKEETA
CCCCCCCCCHHHHHH		40.9930379171
473UbiquitinationGKESTEMKEETAEER
CCCCCCHHHHHHHHH		46.2824816145
473 (in isoform 1)Ubiquitination-46.2821890473
473 (in isoform 2)Ubiquitination-46.2821890473
515UbiquitinationLKLLLDNKDDNGGEA
HHHHHCCCCCCCCCH		67.1521906983
515 (in isoform 1)Ubiquitination-67.1521890473
515 (in isoform 2)Ubiquitination-67.1521890473
530UbiquitinationSRYIFLTKFRKFLQE
HHHHHHHHHHHHHHH		45.3722817900
530 (in isoform 1)Ubiquitination-45.3721890473
530 (in isoform 2)Ubiquitination-45.3721890473
533UbiquitinationIFLTKFRKFLQENAS
HHHHHHHHHHHHCCC		54.2622817900
533 (in isoform 1)Ubiquitination-54.2621890473
533 (in isoform 2)Ubiquitination-54.2621890473
599 (in isoform 2)Phosphorylation-11.2827642862
610PhosphorylationQRLGGLLSHLRKTLK
HHHHHHHHHHHHHHH		26.05-
614UbiquitinationGLLSHLRKTLKDDLA
HHHHHHHHHHHHHHH		65.65-
614 (in isoform 2)Ubiquitination-65.65-
617UbiquitinationSHLRKTLKDDLASKA
HHHHHHHHHHHHHHC		55.2021906983
617 (in isoform 1)Ubiquitination-55.2021890473
617 (in isoform 2)Ubiquitination-55.2021890473
674PhosphorylationLPRPGWLSSPTLGRA
CCCCCCCCCCCCHHH		27.9730266825
675PhosphorylationPRPGWLSSPTLGRAN
CCCCCCCCCCCHHHH		21.5219664994
677PhosphorylationPGWLSSPTLGRANRF
CCCCCCCCCHHHHHH		43.7430266825
683Asymmetric dimethylargininePTLGRANRFLSTAAV
CCCHHHHHHHHHHHH		32.66-
683MethylationPTLGRANRFLSTAAV
CCCHHHHHHHHHHHH		32.66-
686PhosphorylationGRANRFLSTAAVSLM
HHHHHHHHHHHHHHC		17.1828555341
691PhosphorylationFLSTAAVSLMTPRRP
HHHHHHHHHCCCCCC		14.0128555341
694PhosphorylationTAAVSLMTPRRPLST
HHHHHHCCCCCCCCC		20.9529978859
700PhosphorylationMTPRRPLSTSEKVKV
CCCCCCCCCCCCEEE		32.3526437602
702PhosphorylationPRRPLSTSEKVKVRT
CCCCCCCCCCEEEEE		31.85-
704UbiquitinationRPLSTSEKVKVRTLS
CCCCCCCCEEEEEEE		47.3127667366
709PhosphorylationSEKVKVRTLSVEQRT
CCCEEEEEEEHHHCC		26.7726699800
711PhosphorylationKVKVRTLSVEQRTRE
CEEEEEEEHHHCCHH		24.0125159151
789UbiquitinationALRDTEDKLRRCPKR
HHHCCHHHHHCCCHH		37.3529967540
798UbiquitinationRRCPKRRKDILAELT
HCCCHHHHHHHHHHH		53.8329967540
798 (in isoform 2)Ubiquitination-53.83-
805PhosphorylationKDILAELTKSQKVFS
HHHHHHHHHHHHHHH		21.8329083192
806UbiquitinationDILAELTKSQKVFSE
HHHHHHHHHHHHHHH		64.6121890473
806 (in isoform 1)Ubiquitination-64.6121890473
806 (in isoform 2)Ubiquitination-64.6121890473
807PhosphorylationILAELTKSQKVFSEK
HHHHHHHHHHHHHHH		29.9629083192
809UbiquitinationAELTKSQKVFSEKLD
HHHHHHHHHHHHHHH		52.9523000965
809 (in isoform 2)Ubiquitination-52.95-
814AcetylationSQKVFSEKLDHLSRR
HHHHHHHHHHHHHHH		59.0019821523
814UbiquitinationSQKVFSEKLDHLSRR
HHHHHHHHHHHHHHH		59.0023000965
814 (in isoform 1)Ubiquitination-59.0021890473
814 (in isoform 2)Ubiquitination-59.0021890473
875PhosphorylationSVAINSYSALKNYFG
HHHHHHHHHHHHCCC		27.2624719451
906UbiquitinationRLAAILAKHFADARI
HHHHHHHHHHCCCEE		35.4922817900
906 (in isoform 1)Ubiquitination-35.4921890473
906 (in isoform 2)Ubiquitination-35.4921890473
983PhosphorylationGCGFGYRYTRLPHLL
CCCCCHHHHCHHHHH		6.4221214269
991MethylationTRLPHLLKTKLEDAN
HCHHHHHHHHHHHCC		50.39115976769
991UbiquitinationTRLPHLLKTKLEDAN
HCHHHHHHHHHHHCC		50.3927667366
992PhosphorylationRLPHLLKTKLEDANL
CHHHHHHHHHHHCCC		40.6121214269
993MethylationLPHLLKTKLEDANLP
HHHHHHHHHHHCCCC		48.57115976777
993UbiquitinationLPHLLKTKLEDANLP
HHHHHHHHHHHCCCC		48.5727667366
1123O-linked_GlycosylationNQVLNRVTAERNLFD
HHHHHHHHHHCCCCC		21.4030379171
1131MethylationAERNLFDRVVTLRLP
HHCCCCCCEEEEECC		19.92115491381
1286UbiquitinationNQHLMNNKDCFFCKT
HHHHHCCCCCEEEEC		51.3622505724
1286 (in isoform 2)Ubiquitination-51.36-
1312PhosphorylationANTSTTSSAA-----
CCCCCCCCCC-----		26.56-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RN123_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RN123_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RN123_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBAC1_HUMANUBAC1physical
16227581
UBAC1_HUMANUBAC1physical
15746103
CDN1B_HUMANCDKN1Bphysical
15746103
UBAC1_HUMANUBAC1physical
15531880
PLOD2_HUMANPLOD2physical
22863883
NFKB1_HUMANNFKB1physical
25860612
HRSL4_HUMANRARRES3physical
27312109
IFIH1_HUMANIFIH1physical
27312109
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RN123_HUMAN

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Related Literatures of Post-Translational Modification

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