VAT1_HUMAN - dbPTM
VAT1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VAT1_HUMAN
UniProt AC Q99536
Protein Name Synaptic vesicle membrane protein VAT-1 homolog
Gene Name VAT1
Organism Homo sapiens (Human).
Sequence Length 393
Subcellular Localization Cytoplasm. Mitochondrion outer membrane
Peripheral membrane protein. The majority is localized in the cytoplasm and a small amount is associated with mitochondria..
Protein Description Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2)..
Protein Sequence MSDEREVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAASPPLLRCLVLTGFGGYDKVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYDRLPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSVQTFLIPEAMTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVFGTASASKHEALKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLLKPMGKVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSGVVARLLALYNQGHIKPHIDSVWPFEKVADAMKQMQEKKNVGKVLLVPGPEKEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDEREVAE
------CCHHHHHHH		48.4523401153
2Acetylation------MSDEREVAE
------CCHHHHHHH		48.4519413330
12PhosphorylationREVAEAATGEDASSP
HHHHHHHCCCCCCCC		48.4228464451
17PhosphorylationAATGEDASSPPPKTE
HHCCCCCCCCCCCCC		56.5529255136
18PhosphorylationATGEDASSPPPKTEA
HCCCCCCCCCCCCCC		43.0529255136
22UbiquitinationDASSPPPKTEAASDP
CCCCCCCCCCCCCCC		65.85-
23O-linked_GlycosylationASSPPPKTEAASDPQ
CCCCCCCCCCCCCCC		36.31OGP
23PhosphorylationASSPPPKTEAASDPQ
CCCCCCCCCCCCCCC		36.3128464451
27PhosphorylationPPKTEAASDPQHPAA
CCCCCCCCCCCCCHH		57.8029255136
35O-linked_GlycosylationDPQHPAASEGAAAAA
CCCCCHHHHHHHHHH		38.37OGP
35PhosphorylationDPQHPAASEGAAAAA
CCCCCHHHHHHHHHH		38.3729255136
44PhosphorylationGAAAAAASPPLLRCL
HHHHHHHCCHHHHHE		23.4829255136
49MethylationAASPPLLRCLVLTGF
HHCCHHHHHEHHCCC		21.29115919765
50S-nitrosocysteineASPPLLRCLVLTGFG
HCCHHHHHEHHCCCC		2.88-
50S-nitrosylationASPPLLRCLVLTGFG
HCCHHHHHEHHCCCC		2.8819483679
54PhosphorylationLLRCLVLTGFGGYDK
HHHHEHHCCCCCCCC		24.0028555341
59PhosphorylationVLTGFGGYDKVKLQS
HHCCCCCCCCEEEEC		16.9925147952
61UbiquitinationTGFGGYDKVKLQSRP
CCCCCCCCEEEECCC		32.55-
63UbiquitinationFGGYDKVKLQSRPAA
CCCCCCEEEECCCCC		46.69-
80PhosphorylationAPGPGQLTLRLRACG
CCCCCCEEEEEEHHC		11.2723312004
94SulfoxidationGLNFADLMARQGLYD
CCCHHHHHHHCCHHH		2.7321406390
96UbiquitinationNFADLMARQGLYDRL
CHHHHHHHCCHHHCC		19.68-
100PhosphorylationLMARQGLYDRLPPLP
HHHHCCHHHCCCCCC		13.0725022875
102MethylationARQGLYDRLPPLPVT
HHCCHHHCCCCCCCC		35.22115919761
109PhosphorylationRLPPLPVTPGMEGAG
CCCCCCCCCCCCCCC		16.5229255136
116UbiquitinationTPGMEGAGVVIAVGE
CCCCCCCCEEEEECC		25.69-
117UbiquitinationPGMEGAGVVIAVGEG
CCCCCCCEEEEECCC		2.53-
121UbiquitinationGAGVVIAVGEGVSDR
CCCEEEEECCCCCCC		5.01-
126PhosphorylationIAVGEGVSDRKAGDR
EEECCCCCCCCCCCE		42.4225022875
137UbiquitinationAGDRVMVLNRSGMWQ
CCCEEEEECCCCCCC		2.08-
143UbiquitinationVLNRSGMWQEEVTVP
EECCCCCCCEEEECC		13.12-
161UbiquitinationTFLIPEAMTFEEAAA
EECCCCCCCHHHHHH		4.15-
211PhosphorylationAAVQLCRTVENVTVF
HHHHHHHCCCCEEEE		31.04-
220PhosphorylationENVTVFGTASASKHE
CCEEEEECCCCCHHH		13.1327251275
221UbiquitinationNVTVFGTASASKHEA
CEEEEECCCCCHHHH		11.95-
222PhosphorylationVTVFGTASASKHEAL
EEEEECCCCCHHHHH		32.6729507054
224PhosphorylationVFGTASASKHEALKE
EEECCCCCHHHHHHH		31.8627251275
230MalonylationASKHEALKENGVTHP
CCHHHHHHHCCCCCC		57.0626320211
230UbiquitinationASKHEALKENGVTHP
CCHHHHHHHCCCCCC		57.06-
238UbiquitinationENGVTHPIDYHTTDY
HCCCCCCCCCCCCCC		6.79-
240PhosphorylationGVTHPIDYHTTDYVD
CCCCCCCCCCCCCHH		11.2022817900
242PhosphorylationTHPIDYHTTDYVDEI
CCCCCCCCCCCHHHH		18.3522115753
243PhosphorylationHPIDYHTTDYVDEIK
CCCCCCCCCCHHHHH		16.4222115753
245PhosphorylationIDYHTTDYVDEIKKI
CCCCCCCCHHHHHHH		14.01-
248UbiquitinationHTTDYVDEIKKISPK
CCCCCHHHHHHHCCC		46.81-
2502-HydroxyisobutyrylationTDYVDEIKKISPKGV
CCCHHHHHHHCCCCC		41.84-
250UbiquitinationTDYVDEIKKISPKGV
CCCHHHHHHHCCCCC		41.8421906983
251UbiquitinationDYVDEIKKISPKGVD
CCHHHHHHHCCCCCC		54.82-
255UbiquitinationEIKKISPKGVDIVMD
HHHHHCCCCCCEEEE		65.8521890473
255UbiquitinationEIKKISPKGVDIVMD
HHHHHCCCCCCEEEE		65.8521890473
255UbiquitinationEIKKISPKGVDIVMD
HHHHHCCCCCCEEEE		65.8521906983
257UbiquitinationKKISPKGVDIVMDPL
HHHCCCCCCEEEECC		5.91-
257AcetylationKKISPKGVDIVMDPL
HHHCCCCCCEEEECC		5.91-
261SulfoxidationPKGVDIVMDPLGGSD
CCCCCEEEECCCCCC		4.4821406390
267PhosphorylationVMDPLGGSDTAKGYN
EEECCCCCCCHHCCC		29.9520068231
269PhosphorylationDPLGGSDTAKGYNLL
ECCCCCCCHHCCCCC		31.7820068231
271UbiquitinationLGGSDTAKGYNLLKP
CCCCCCHHCCCCCCC		65.11-
2712-HydroxyisobutyrylationLGGSDTAKGYNLLKP
CCCCCCHHCCCCCCC		65.11-
271AcetylationLGGSDTAKGYNLLKP
CCCCCCHHCCCCCCC		65.1112438011
277UbiquitinationAKGYNLLKPMGKVVT
HHCCCCCCCCCEEEE		35.80-
292PhosphorylationYGMANLLTGPKRNLM
HHHHHHHHCCHHHHH		55.3820068231
2952-HydroxyisobutyrylationANLLTGPKRNLMALA
HHHHHCCHHHHHHHH		56.09-
295UbiquitinationANLLTGPKRNLMALA
HHHHHCCHHHHHHHH		56.0921890473
295MalonylationANLLTGPKRNLMALA
HHHHHCCHHHHHHHH		56.0926320211
295UbiquitinationANLLTGPKRNLMALA
HHHHHCCHHHHHHHH		56.0921890473
295AcetylationANLLTGPKRNLMALA
HHHHHCCHHHHHHHH		56.097465855
295UbiquitinationANLLTGPKRNLMALA
HHHHHCCHHHHHHHH		56.0921890473
355UbiquitinationLYNQGHIKPHIDSVW
HHHCCCCCCCCCCCC		25.5221890473
355UbiquitinationLYNQGHIKPHIDSVW
HHHCCCCCCCCCCCC		25.5221906983
355UbiquitinationLYNQGHIKPHIDSVW
HHHCCCCCCCCCCCC		25.5221890473
366UbiquitinationDSVWPFEKVADAMKQ
CCCCCHHHHHHHHHH		43.00-
372UbiquitinationEKVADAMKQMQEKKN
HHHHHHHHHHHHHCC		44.3221890473
372AcetylationEKVADAMKQMQEKKN
HHHHHHHHHHHHHCC		44.3227452117
372UbiquitinationEKVADAMKQMQEKKN
HHHHHHHHHHHHHCC		44.3221890473
372MalonylationEKVADAMKQMQEKKN
HHHHHHHHHHHHHCC		44.3226320211
372UbiquitinationEKVADAMKQMQEKKN
HHHHHHHHHHHHHCC		44.3221890473
3722-HydroxyisobutyrylationEKVADAMKQMQEKKN
HHHHHHHHHHHHHCC		44.32-
382UbiquitinationQEKKNVGKVLLVPGP
HHHCCCCCEEEECCC		25.98-
391AcetylationLLVPGPEKEN-----
EEECCCCCCC-----		66.7323749302
391UbiquitinationLLVPGPEKEN-----
EEECCCCCCC-----		66.73-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VAT1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VAT1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VAT1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDR12_HUMANWDR12physical
22939629
ZFY21_HUMANZFYVE21physical
22939629
WDR74_HUMANWDR74physical
22939629
MVP_HUMANMVPphysical
22863883
S10AD_HUMANS100A13physical
22863883
TTC1_HUMANTTC1physical
22863883
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VAT1_HUMAN

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Related Literatures of Post-Translational Modification

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