dbPTM

WDR74_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR74_HUMAN
UniProt AC	Q6RFH5
Protein Name	WD repeat-containing protein 74
Gene Name	WDR74
Organism	Homo sapiens (Human).
Sequence Length	385
Subcellular Localization	Nucleus, nucleolus .
Protein Description
Protein Sequence	MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLVGCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKLSGLEQPQGALQTRRRKKKRPGSTSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	GTETGILKGVNLQRK ECCCCCCCCCCCCHH	59.91	29967540
21	Sumoylation	GTETGILKGVNLQRK ECCCCCCCCCCCCHH	59.91	-
21	Acetylation	GTETGILKGVNLQRK ECCCCCCCCCCCCHH	59.91	26051181
21	Sumoylation	GTETGILKGVNLQRK ECCCCCCCCCCCCHH	59.91	-
28	Ubiquitination	KGVNLQRKQAANFTA CCCCCCHHHHHCCCC	31.18	22505724
52	Phosphorylation	VSALCWGTGGETQML HHHHHCCCCCHHHEE	19.95	-
68	Acetylation	GCADRTVKHFSTEDG ECCCCCEEEEECCCC	38.02	26051181
68	2-Hydroxyisobutyrylation	GCADRTVKHFSTEDG ECCCCCEEEEECCCC	38.02	-
68 (in isoform 1)	Ubiquitination	-	38.02	21890473
68 (in isoform 2)	Ubiquitination	-	38.02	21890473
68	Ubiquitination	GCADRTVKHFSTEDG ECCCCCEEEEECCCC	38.02	22817900
71	Phosphorylation	DRTVKHFSTEDGIFQ CCCEEEEECCCCCCC	30.52	24719451
115	Ubiquitination	ILRVWHDKDKDTSSD CEEEEECCCCCCCCC	54.51	22505724
117	Ubiquitination	RVWHDKDKDTSSDPL EEEECCCCCCCCCCC	69.51	33845483
119	Phosphorylation	WHDKDKDTSSDPLLE EECCCCCCCCCCCEE	35.55	21406692
120	Phosphorylation	HDKDKDTSSDPLLEL ECCCCCCCCCCCEEE	42.76	21406692
121	Phosphorylation	DKDKDTSSDPLLELR CCCCCCCCCCCEEEE	45.39	21406692
131	Ubiquitination	LLELRVGPGVCRMRQ CEEEEECCCCCCCCC	29.23	32015554
148	Phosphorylation	AHPHVVATGGKENAL CCCCEEECCCCCCEE	34.55	20068231
151	Acetylation	HVVATGGKENALKIW CEEECCCCCCEEEEE	49.49	26051181
151	Ubiquitination	HVVATGGKENALKIW CEEECCCCCCEEEEE	49.49	22817900
156	Sumoylation	GGKENALKIWDLQGS CCCCCEEEEECCCCC	39.06	-
156 (in isoform 2)	Ubiquitination	-	39.06	21890473
156	Sumoylation	GGKENALKIWDLQGS CCCCCEEEEECCCCC	39.06	-
156	Ubiquitination	GGKENALKIWDLQGS CCCCCEEEEECCCCC	39.06	21906983
156 (in isoform 1)	Ubiquitination	-	39.06	21890473
176	Ubiquitination	RAKNVRNDWLDLRVP EEECCCCCCCCEECC	36.43	32015554
197	Acetylation	QFLPGSQKLVTCTGY EECCCCCEEEEECCE	46.77	26051181
197	Ubiquitination	QFLPGSQKLVTCTGY EECCCCCEEEEECCE	46.77	21963094
202	Phosphorylation	SQKLVTCTGYHQVRV CCEEEEECCEEEEEE	31.26	28152594
204	Phosphorylation	KLVTCTGYHQVRVYD EEEEECCEEEEEEEC	3.21	28152594
210	Phosphorylation	GYHQVRVYDPASPQR CEEEEEEECCCCCCC	12.97	28152594
214	Phosphorylation	VRVYDPASPQRRPVL EEEECCCCCCCCCEE	27.27	25159151
224	Ubiquitination	RRPVLETTYGEYPLT CCCEEEEECCCCEEE	21.83	33845483
231	Phosphorylation	TYGEYPLTAMTLTPG ECCCCEEEEEEEECC	15.18	22210691
241	Phosphorylation	TLTPGGNSVIVGNTH EEECCCCEEEEECCC	19.25	22210691
249	Phosphorylation	VIVGNTHGQLAEIDL EEEECCCCEEEEEEC	23.35	33259812
266 (in isoform 2)	Ubiquitination	-	56.82	21890473
266	Acetylation	GRLLGCLKGLAGSVR CHHHHHHHHHHHHCC	56.82	26051181
266 (in isoform 1)	Ubiquitination	-	56.82	21890473
266	Ubiquitination	GRLLGCLKGLAGSVR CHHHHHHHHHHHHCC	56.82	21906983
280	Ubiquitination	RGLQCHPSKPLLASC CCCCCCCCCHHHHHC	24.20	32015554
280	Phosphorylation	RGLQCHPSKPLLASC CCCCCCCCCHHHHHC	24.20	24719451
281	Ubiquitination	GLQCHPSKPLLASCG CCCCCCCCHHHHHCC	44.10	22505724
281	Acetylation	GLQCHPSKPLLASCG CCCCCCCCHHHHHCC	44.10	26051181
286	Phosphorylation	PSKPLLASCGLDRVL CCCHHHHHCCHHHEE	14.53	21406692
307	Ubiquitination	NPRGLEHKVYLKSQL CCCCCCCEEEHHHHH	24.17	22817900
307	Acetylation	NPRGLEHKVYLKSQL CCCCCCCEEEHHHHH	24.17	26051181
311	Ubiquitination	LEHKVYLKSQLNCLL CCCEEEHHHHHHEEE	20.61	21963094
311	Methylation	LEHKVYLKSQLNCLL CCCEEEHHHHHHEEE	20.61	24129315
312	Phosphorylation	EHKVYLKSQLNCLLL CCEEEHHHHHHEEEC	36.99	21406692
318	Ubiquitination	KSQLNCLLLSGRDNW HHHHHEEECCCCCCC	3.79	22817900
320	Phosphorylation	QLNCLLLSGRDNWED HHHEEECCCCCCCCC	31.58	21406692
325	Ubiquitination	LLSGRDNWEDEPQEP ECCCCCCCCCCCCCC	20.78	32015554
337	Ubiquitination	QEPQEPNKVPLEDTE CCCCCCCCCCCCCCC	56.81	21906983
337 (in isoform 1)	Ubiquitination	-	56.81	21890473
337	Sumoylation	QEPQEPNKVPLEDTE CCCCCCCCCCCCCCC	56.81	-
338	Ubiquitination	EPQEPNKVPLEDTET CCCCCCCCCCCCCCH	9.21	22817900
340	Ubiquitination	QEPNKVPLEDTETDE CCCCCCCCCCCCHHH	11.86	27667366
340 (in isoform 2)	Ubiquitination	-	11.86	21890473
345	O-linked_Glycosylation	VPLEDTETDELWASL CCCCCCCHHHHHHHH	36.54	55821225
351	O-linked_Glycosylation	ETDELWASLEAAAKR CHHHHHHHHHHHHHH	18.37	55821231
357	Ubiquitination	ASLEAAAKRKLSGLE HHHHHHHHHHHCCCC	45.39	21906983
357 (in isoform 1)	Ubiquitination	-	45.39	21890473
359	Sumoylation	LEAAAKRKLSGLEQP HHHHHHHHHCCCCCC	46.42	-
359	Sumoylation	LEAAAKRKLSGLEQP HHHHHHHHHCCCCCC	46.42	-
359 (in isoform 1)	Ubiquitination	-	46.42	21890473
359	Ubiquitination	LEAAAKRKLSGLEQP HHHHHHHHHCCCCCC	46.42	27667366
361	Phosphorylation	AAAKRKLSGLEQPQG HHHHHHHCCCCCCCC	44.35	23927012
365	Phosphorylation	RKLSGLEQPQGALQT HHHCCCCCCCCHHHH	40.43	33259812
372	Phosphorylation	QPQGALQTRRRKKKR CCCCHHHHHHHCCCC	27.30	28555341
373	Ubiquitination	PQGALQTRRRKKKRP CCCHHHHHHHCCCCC	24.36	33845483
382	Phosphorylation	RKKKRPGSTSP---- HCCCCCCCCCC----	28.52	30266825
383	Phosphorylation	KKKRPGSTSP----- CCCCCCCCCC-----	51.43	30266825
384	Phosphorylation	KKRPGSTSP------ CCCCCCCCC------	30.24	30266825
398	Phosphorylation	-------------------- --------------------		33259812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WDR74_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR74_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR74_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX47_HUMAN	DDX47	physical	26344197
DHX37_HUMAN	DHX37	physical	26344197
NOG2_HUMAN	GNL2	physical	26344197
RRS1_HUMAN	RRS1	physical	26344197
ZC3HF_HUMAN	ZC3H15	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR74_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, AND MASSSPECTROMETRY.	18669648 [Abstract]