dbPTM

RRS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRS1_HUMAN
UniProt AC	Q15050
Protein Name	Ribosome biogenesis regulatory protein homolog
Gene Name	RRS1
Organism	Homo sapiens (Human).
Sequence Length	365
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus..
Protein Sequence	MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPPTGLRCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYQRARDDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLGGKRKGGQRPGGKRRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGQSVEE -------CCCCCHHH	13.57	22223895
5	Phosphorylation	---MEGQSVEELLAK ---CCCCCHHHHHHH	42.21	25159151
20	Ubiquitination	AEQDEAEKLQRITVH HHHHHHHHHHHHHHC	57.90	33845483
20	Acetylation	AEQDEAEKLQRITVH HHHHHHHHHHHHHHC	57.90	25953088
52	Glutathionylation	NPPTGLRCAGPTPEA CCCCCCCCCCCCCHH	6.54	22555962
56	Phosphorylation	GLRCAGPTPEAELQA CCCCCCCCCHHHHHH	32.61	25850435
129	Phosphorylation	GIRPKKKTNLVWDEV CCCCCCCCCCCEECC	42.54	25690035
137	Phosphorylation	NLVWDEVSGQWRRRW CCCEECCCCHHHHHH	24.18	25690035
146	Phosphorylation	QWRRRWGYQRARDDT HHHHHHCCHHCCCCC	6.46	-
153	Phosphorylation	YQRARDDTKEWLIEV CHHCCCCCCCEEEEC	34.84	-
154	Sumoylation	QRARDDTKEWLIEVP HHCCCCCCCEEEECC	54.62	28112733
173	Acetylation	PLEDQFAKRIQAKKE HHHHHHHHHHHHHHH	51.85	26051181
173	Ubiquitination	PLEDQFAKRIQAKKE HHHHHHHHHHHHHHH	51.85	32015554
184	Sumoylation	AKKERVAKNELNRLR HHHHHHHHHHHHHHH	48.36	-
184	Sumoylation	AKKERVAKNELNRLR HHHHHHHHHHHHHHH	48.36	-
184	Ubiquitination	AKKERVAKNELNRLR HHHHHHHHHHHHHHH	48.36	24816145
203	Phosphorylation	AHKMQLPSAAGLHPT HHHCCCCCCCCCCCC	39.07	28555341
215	Ubiquitination	HPTGHQSKEELGRAM CCCCCCCHHHHHHHH	48.95	33845483
215	Acetylation	HPTGHQSKEELGRAM CCCCCCCHHHHHHHH	48.95	26051181
226	Sumoylation	GRAMQVAKVSTASVG HHHHHHHHHHHHHHH	37.55	28112733
228	Phosphorylation	AMQVAKVSTASVGRF HHHHHHHHHHHHHHH	19.97	28348404
229	Phosphorylation	MQVAKVSTASVGRFQ HHHHHHHHHHHHHHH	26.41	28348404
231	Phosphorylation	VAKVSTASVGRFQER HHHHHHHHHHHHHHH	25.78	25159151
265	Ubiquitination	FGDFAAEKKNQLELL HCHHHHHHHHHHHHH	52.91	32015554
265	2-Hydroxyisobutyrylation	FGDFAAEKKNQLELL HCHHHHHHHHHHHHH	52.91	-
265	Acetylation	FGDFAAEKKNQLELL HCHHHHHHHHHHHHH	52.91	26051181
266	Sumoylation	GDFAAEKKNQLELLR CHHHHHHHHHHHHHH	41.24	28112733
266	Ubiquitination	GDFAAEKKNQLELLR CHHHHHHHHHHHHHH	41.24	33845483
273	Citrullination	KNQLELLRVMNSKKP HHHHHHHHHHCCCCC	37.96	-
273	Citrullination	KNQLELLRVMNSKKP HHHHHHHHHHCCCCC	37.96	-
279	Ubiquitination	LRVMNSKKPQLDVTR HHHHCCCCCCHHHHH	37.50	33845483
290	Acetylation	DVTRATNKQMREEDQ HHHHHHHHHHHHHHH	40.91	26051181
302	Ubiquitination	EDQEEAAKRRKMSQK HHHHHHHHHHHHHHH	60.84	24816145
302	Acetylation	EDQEEAAKRRKMSQK HHHHHHHHHHHHHHH	60.84	26051181
307	Phosphorylation	AAKRRKMSQKGKRKG HHHHHHHHHHHHCCC	31.60	-
313	Acetylation	MSQKGKRKGGRQGPG HHHHHHCCCCCCCCC	70.02	7483953
322	Acetylation	GRQGPGGKRKGGPPS CCCCCCCCCCCCCCC	57.77	7483963
324	Ubiquitination	QGPGGKRKGGPPSQG CCCCCCCCCCCCCCC	72.24	-
329	Phosphorylation	KRKGGPPSQGGKRKG CCCCCCCCCCCCCCC	44.59	-
333	Acetylation	GPPSQGGKRKGGLGG CCCCCCCCCCCCCCC	58.73	26051181
335	Acetylation	PSQGGKRKGGLGGKM CCCCCCCCCCCCCCC	61.90	25953088
341	Ubiquitination	RKGGLGGKMNSGPPG CCCCCCCCCCCCCCC	32.86	24816145
341	Acetylation	RKGGLGGKMNSGPPG CCCCCCCCCCCCCCC	32.86	25953088
344	Phosphorylation	GLGGKMNSGPPGLGG CCCCCCCCCCCCCCC	49.53	25159151
352	Acetylation	GPPGLGGKRKGGQRP CCCCCCCCCCCCCCC	49.49	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRS1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF1_HUMAN	U2AF1	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
TPR_HUMAN	TPR	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
EBP2_HUMAN	EBNA1BP2	physical	26344197
MK67I_HUMAN	NIFK	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197
NOP2_HUMAN	NOP2	physical	26344197
RPF2_HUMAN	RPF2	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RRP15_HUMAN	RRP15	physical	26344197
H2A2C_HUMAN	HIST2H2AC	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
ABC3C_HUMAN	APOBEC3C	physical	28514442
PURB_HUMAN	PURB	physical	28514442
U2AF2_HUMAN	U2AF2	physical	28514442
RS2_HUMAN	RPS2	physical	28514442
RL37A_HUMAN	RPL37A	physical	28514442
RS18_HUMAN	RPS18	physical	28514442
YBOX1_HUMAN	YBX1	physical	28514442
LIN41_HUMAN	TRIM71	physical	28514442
RS16_HUMAN	RPS16	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
RLA1_HUMAN	RPLP1	physical	28514442
RLA2_HUMAN	RPLP2	physical	28514442
RS19_HUMAN	RPS19	physical	28514442
NUCL_HUMAN	NCL	physical	28514442
RL18_HUMAN	RPL18	physical	28514442
CDK12_HUMAN	CDK12	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
RS5_HUMAN	RPS5	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
NPM_HUMAN	NPM1	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
MKRN1_HUMAN	MKRN1	physical	28514442
RS10_HUMAN	RPS10	physical	28514442
RS25_HUMAN	RPS25	physical	28514442
RS28_HUMAN	RPS28	physical	28514442
RS9_HUMAN	RPS9	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
RS24_HUMAN	RPS24	physical	28514442
RL8_HUMAN	RPL8	physical	28514442
RL7A_HUMAN	RPL7A	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
RL6_HUMAN	RPL6	physical	28514442
RBMS1_HUMAN	RBMS1	physical	28514442
RS20_HUMAN	RPS20	physical	28514442
RM52_HUMAN	MRPL52	physical	28514442
ZCRB1_HUMAN	ZCRB1	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
RS14_HUMAN	RPS14	physical	28514442
RL34_HUMAN	RPL34	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
SREK1_HUMAN	SREK1	physical	28514442
RL35A_HUMAN	RPL35A	physical	28514442
RBM4_HUMAN	RBM4	physical	28514442
MK67I_HUMAN	NIFK	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
GLE1_HUMAN	GLE1	physical	28514442
RL23A_HUMAN	RPL23A	physical	28514442
SRSF5_HUMAN	SRSF5	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RLA0_HUMAN	RPLP0	physical	28514442
SF3B4_HUMAN	SF3B4	physical	28514442
RL31_HUMAN	RPL31	physical	28514442
RS13_HUMAN	RPS13	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
RL13A_HUMAN	RPL13A	physical	28514442
RSSA_HUMAN	RPSA	physical	28514442
RL14_HUMAN	RPL14	physical	28514442
BMS1_HUMAN	BMS1	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
RT16_HUMAN	MRPS16	physical	28514442
RS17_HUMAN	RPS17	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
CH033_HUMAN	C8orf33	physical	28514442
NOP56_HUMAN	NOP56	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
RL35_HUMAN	RPL35	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
IF2B1_HUMAN	IGF2BP1	physical	28514442
RS8_HUMAN	RPS8	physical	28514442
RL32_HUMAN	RPL32	physical	28514442
RS12_HUMAN	RPS12	physical	28514442
YBOX3_HUMAN	YBX3	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
RL29_HUMAN	RPL29	physical	28514442
RL27_HUMAN	RPL27	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
RL17_HUMAN	RPL17	physical	28514442
MPP10_HUMAN	MPHOSPH10	physical	28514442
PURA_HUMAN	PURA	physical	28514442
RL9_HUMAN	RPL9	physical	28514442
NOP53_HUMAN	GLTSCR2	physical	28514442
RL13_HUMAN	RPL13	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
KRR1_HUMAN	KRR1	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
KNOP1_HUMAN	KNOP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRS1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, AND MASSSPECTROMETRY.	19007248 [Abstract]