GLE1_HUMAN - dbPTM
GLE1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLE1_HUMAN
UniProt AC Q53GS7
Protein Name Nucleoporin GLE1
Gene Name GLE1
Organism Homo sapiens (Human).
Sequence Length 698
Subcellular Localization Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658).
Isoform 1: Cytoplasm . Nucleus, nuclear pore complex . Shuttles between the nucleus a
Protein Description Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC)..
Protein Sequence MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHMQENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKEGMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12MethylationGRCWETLKALRSSDK
CCHHHHHHHHHCCCC		53.44-
12UbiquitinationGRCWETLKALRSSDK
CCHHHHHHHHHCCCC		53.44-
16PhosphorylationETLKALRSSDKGRLC
HHHHHHHCCCCCCHH		43.6820068231
17PhosphorylationTLKALRSSDKGRLCY
HHHHHHCCCCCCHHH		36.5920068231
41PhosphorylationDVLEECMSLPKLSSY
HHHHHHHCCCCHHHC		53.8530108239
67PhosphorylationMQENQPLSETSPSST
HHCCCCCCCCCCCCC		45.5728348404
69PhosphorylationENQPLSETSPSSTSA
CCCCCCCCCCCCCCC		42.4326074081
70PhosphorylationNQPLSETSPSSTSAS
CCCCCCCCCCCCCCH		20.8026074081
72PhosphorylationPLSETSPSSTSASAL
CCCCCCCCCCCCHHH		46.1226074081
73PhosphorylationLSETSPSSTSASALD
CCCCCCCCCCCHHHC		29.7526074081
74PhosphorylationSETSPSSTSASALDQ
CCCCCCCCCCHHHCC		32.4226074081
75PhosphorylationETSPSSTSASALDQP
CCCCCCCCCHHHCCC		23.3626074081
77PhosphorylationSPSSTSASALDQPSF
CCCCCCCHHHCCCCC		29.1826074081
83PhosphorylationASALDQPSFVPKSPD
CHHHCCCCCCCCCCC		32.9926074081
88PhosphorylationQPSFVPKSPDASSAF
CCCCCCCCCCCHHCC		23.1830266825
92PhosphorylationVPKSPDASSAFSPAS
CCCCCCCHHCCCCCC		29.5830266825
93PhosphorylationPKSPDASSAFSPASP
CCCCCCHHCCCCCCC		34.7530266825
96PhosphorylationPDASSAFSPASPATP
CCCHHCCCCCCCCCC		21.1930266825
99PhosphorylationSSAFSPASPATPNGT
HHCCCCCCCCCCCCC		20.6030266825
102PhosphorylationFSPASPATPNGTKGK
CCCCCCCCCCCCCCC		22.2230266825
106PhosphorylationSPATPNGTKGKDESQ
CCCCCCCCCCCCHHH		43.1730266825
107UbiquitinationPATPNGTKGKDESQH
CCCCCCCCCCCHHHH		66.42-
109UbiquitinationTPNGTKGKDESQHTE
CCCCCCCCCHHHHHH		60.9321906983
109 (in isoform 1)Ubiquitination-60.9321906983
109 (in isoform 2)Ubiquitination-60.9321906983
112PhosphorylationGTKGKDESQHTESMV
CCCCCCHHHHHHHHH		37.0828555341
117PhosphorylationDESQHTESMVLQSSR
CHHHHHHHHHHHHCC		18.4928555341
127AcetylationLQSSRGIKVEGCVRM
HHHCCCCCCCHHHHH		36.7426051181
127UbiquitinationLQSSRGIKVEGCVRM
HHHCCCCCCCHHHHH		36.74-
135PhosphorylationVEGCVRMYELVHRMK
CCHHHHHHHHHHHHC		8.7827642862
142UbiquitinationYELVHRMKGTEGLRL
HHHHHHHCCCHHHHH		63.74-
157AcetylationWQEEQERKVQALSEM
HHHHHHHHHHHHHHH		37.647679277
157UbiquitinationWQEEQERKVQALSEM
HHHHHHHHHHHHHHH		37.64-
162PhosphorylationERKVQALSEMASEQL
HHHHHHHHHHHHHHH		28.4823403867
166PhosphorylationQALSEMASEQLKRFD
HHHHHHHHHHHHCHH		25.2723403867
170UbiquitinationEMASEQLKRFDEWKE
HHHHHHHHCHHHHHH		51.1921906983
170 (in isoform 1)Ubiquitination-51.1921906983
170 (in isoform 2)Ubiquitination-51.1921906983
176AcetylationLKRFDEWKELKQHKE
HHCHHHHHHHHHCHH		51.637679287
176UbiquitinationLKRFDEWKELKQHKE
HHCHHHHHHHHHCHH		51.6321906983
176 (in isoform 1)Ubiquitination-51.6321906983
176 (in isoform 2)Ubiquitination-51.6321906983
179UbiquitinationFDEWKELKQHKEFQD
HHHHHHHHHCHHHHH		51.99-
182UbiquitinationWKELKQHKEFQDLRE
HHHHHHCHHHHHHHH		58.70-
193UbiquitinationDLREVMEKSSREALG
HHHHHHHHHHHHHHC		35.32-
204UbiquitinationEALGHQEKLKAEHRH
HHHCCHHHHHHHHHH		49.03-
214AcetylationAEHRHRAKILNLKLR
HHHHHHHHHHHHHHH		47.9127452117
214UbiquitinationAEHRHRAKILNLKLR
HHHHHHHHHHHHHHH		47.91-
219AcetylationRAKILNLKLREAEQQ
HHHHHHHHHHHHHHH		44.4126051181
229UbiquitinationEAEQQRVKQAEQERL
HHHHHHHHHHHHHHH		46.08-
238UbiquitinationAEQERLRKEEGQIRL
HHHHHHHHHHHHHHH		65.79-
269UbiquitinationLDASEQHKALLKVDL
CCHHHHHHHHHHHHH		40.19-
273UbiquitinationEQHKALLKVDLAAFQ
HHHHHHHHHHHHHHH		34.26-
297PhosphorylationISGIIRASSESSYPT
HHHHHHHCCCCCCCC		25.4520068231
298PhosphorylationSGIIRASSESSYPTA
HHHHHHCCCCCCCCH		40.2820068231
300PhosphorylationIIRASSESSYPTAES
HHHHCCCCCCCCHHH		36.8020068231
301PhosphorylationIRASSESSYPTAESQ
HHHCCCCCCCCHHHH		30.9520068231
302PhosphorylationRASSESSYPTAESQA
HHCCCCCCCCHHHHH		17.5520068231
304PhosphorylationSSESSYPTAESQAEA
CCCCCCCCHHHHHHH		34.5220068231
307PhosphorylationSSYPTAESQAEAERA
CCCCCHHHHHHHHHH		32.0220068231
330PhosphorylationMNLGQEITRACEDKR
HHHHHHHHHHHHHHH		16.0922210691
361UbiquitinationQQGPEAHKEPPAPSQ
HHCCHHHCCCCCCCC		78.0921906983
361 (in isoform 1)Ubiquitination-78.0921906983
361 (in isoform 2)Ubiquitination-78.0921906983
373UbiquitinationPSQGPGGKQNEDLQV
CCCCCCCCCCCCCCC		56.7321906983
373 (in isoform 1)Ubiquitination-56.7321906983
373 (in isoform 2)Ubiquitination-56.7321906983
386PhosphorylationQVKVQDITMQWYQQL
CCHHHHHHHHHHHHH		16.1724043423
390PhosphorylationQDITMQWYQQLQDAS
HHHHHHHHHHHHHCC		3.0224043423
397PhosphorylationYQQLQDASMQCVLTF
HHHHHHCCCCCEEEE		20.0624043423
403PhosphorylationASMQCVLTFEGLTNS
CCCCCEEEEECCCCC		10.1524043423
408PhosphorylationVLTFEGLTNSKDSQA
EEEEECCCCCCCHHH		48.5824043423
410PhosphorylationTFEGLTNSKDSQAKK
EEECCCCCCCHHHHH		32.3824043423
419UbiquitinationDSQAKKIKMDLQKAA
CHHHHHHCHHHHHHC		34.93-
424UbiquitinationKIKMDLQKAATIPVS
HHCHHHHHHCCCCHH		47.4921906983
424 (in isoform 1)Ubiquitination-47.4921906983
424 (in isoform 2)Ubiquitination-47.4921906983
427PhosphorylationMDLQKAATIPVSQIS
HHHHHHCCCCHHHHH		30.5822468782
431PhosphorylationKAATIPVSQISTIAG
HHCCCCHHHHHHHCC		19.2225599653
434PhosphorylationTIPVSQISTIAGSKL
CCCHHHHHHHCCHHH		13.2125599653
435PhosphorylationIPVSQISTIAGSKLK
CCHHHHHHHCCHHHH		19.2425599653
439PhosphorylationQISTIAGSKLKEIFD
HHHHHCCHHHHHHHH		26.2825599653
440UbiquitinationISTIAGSKLKEIFDK
HHHHCCHHHHHHHHH		63.76-
442UbiquitinationTIAGSKLKEIFDKIH
HHCCHHHHHHHHHHH		53.12-
447UbiquitinationKLKEIFDKIHSLLSG
HHHHHHHHHHHHHCC		31.41-
450PhosphorylationEIFDKIHSLLSGKPV
HHHHHHHHHHCCCCC		34.18-
455UbiquitinationIHSLLSGKPVQSGGR
HHHHHCCCCCCCCCE		38.3421906983
455 (in isoform 1)Ubiquitination-38.3421906983
455 (in isoform 2)Ubiquitination-38.3421906983
459PhosphorylationLSGKPVQSGGRSVSV
HCCCCCCCCCEEEEE		43.3720068231
463PhosphorylationPVQSGGRSVSVTLNP
CCCCCCEEEEEEECC		23.2420068231
465PhosphorylationQSGGRSVSVTLNPQG
CCCCEEEEEEECCCC		15.6120068231
467PhosphorylationGGRSVSVTLNPQGLD
CCEEEEEEECCCCCC		17.2020068231
478PhosphorylationQGLDFVQYKLAEKFV
CCCCHHHHHHHHHHH		11.5820068231
479UbiquitinationGLDFVQYKLAEKFVK
CCCHHHHHHHHHHHH		24.9121906983
479 (in isoform 1)Ubiquitination-24.9121906983
479 (in isoform 2)Ubiquitination-24.9121906983
483UbiquitinationVQYKLAEKFVKQGEE
HHHHHHHHHHHHCHH		50.26-
486UbiquitinationKLAEKFVKQGEEEVA
HHHHHHHHHCHHHHH		56.57-
526UbiquitinationLILAHLHKKCPYSVP
HHHHHHHHHCCCCCC		63.5321906983
526 (in isoform 1)Ubiquitination-63.5321906983
526 (in isoform 2)Ubiquitination-63.5321906983
527UbiquitinationILAHLHKKCPYSVPF
HHHHHHHHCCCCCCC		29.69-
539UbiquitinationVPFYPTFKEGMALED
CCCCCCCCCCCCHHH		56.70-
556UbiquitinationRMLGYQVKDSKVEQQ
HHHCCCCCCCHHHHH		40.5321906983
556 (in isoform 1)Ubiquitination-40.5321906983
556 (in isoform 2)Ubiquitination-40.5321906983
559UbiquitinationGYQVKDSKVEQQDNF
CCCCCCCHHHHHHHH		60.9821906983
559 (in isoform 1)Ubiquitination-60.9821906983
559 (in isoform 2)Ubiquitination-60.9821906983
568UbiquitinationEQQDNFLKRMSGMIR
HHHHHHHHHHHHHHH		41.7521906983
568 (in isoform 1)Ubiquitination-41.7521906983
568 (in isoform 2)Ubiquitination-41.7521906983
652PhosphorylationLILIKEDYFPRIEAI
HHHHCCCCCCCCEEE		19.3022817900
660PhosphorylationFPRIEAITSSGQMGS
CCCCEEECCCCCCCH		24.7220068231
661PhosphorylationPRIEAITSSGQMGSF
CCCEEECCCCCCCHH		26.7620068231
672UbiquitinationMGSFIRLKQFLEKCL
CCHHHHHHHHHHHHH		29.202190698
672 (in isoform 1)Ubiquitination-29.2021906983
677UbiquitinationRLKQFLEKCLQHKDI
HHHHHHHHHHCCCCC		42.25-
682UbiquitinationLEKCLQHKDIPVPKG
HHHHHCCCCCCCCCC		44.38-
688UbiquitinationHKDIPVPKGFLTSSF
CCCCCCCCCCCCHHH		63.63-
694PhosphorylationPKGFLTSSFWRS---
CCCCCCHHHCCC---		24.4828857561
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
88SPhosphorylationKinaseJNK1P45983
PSP
88SPhosphorylationKinaseGSK3BP49841
PSP
88SPhosphorylationKinaseERK2P28482
PSP
88SPhosphorylationKinaseERK1P27361
PSP
92SPhosphorylationKinaseGSK3BP49841
PSP
92SPhosphorylationKinaseJNK1P45983
PSP
92SPhosphorylationKinaseERK2P28482
PSP
92SPhosphorylationKinaseERK1P27361
PSP
93SPhosphorylationKinaseGSK3BP49841
PSP
93SPhosphorylationKinaseJNK1P45983
PSP
93SPhosphorylationKinaseERK2P28482
PSP
93SPhosphorylationKinaseERK1P27361
PSP
99SPhosphorylationKinaseERK1P27361
PSP
99SPhosphorylationKinaseJNK1P45983
PSP
99SPhosphorylationKinaseGSK3BP49841
PSP
99SPhosphorylationKinaseERK2P28482
PSP
102TPhosphorylationKinaseERK1P27361
PSP
102TPhosphorylationKinaseJNK1P45983
PSP
102TPhosphorylationKinaseERK2P28482
PSP
102TPhosphorylationKinaseGSK3BP49841
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLE1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLE1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NU155_HUMANNUP155physical
14645504
K1C10_HUMANKRT10physical
14645504
UXT_HUMANUXTphysical
14645504
EIF3F_HUMANEIF3Fphysical
18724935
GLE1_HUMANGLE1physical
24243016
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
253310Lethal congenital contracture syndrome 1 (LCCS1)
611890Lethal arthrogryposis with anterior horn cell disease (LAAHD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLE1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, AND MASSSPECTROMETRY.

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