K1C10_HUMAN - dbPTM
K1C10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K1C10_HUMAN
UniProt AC P13645
Protein Name Keratin, type I cytoskeletal 10
Gene Name KRT10
Organism Homo sapiens (Human).
Sequence Length 584
Subcellular Localization Secreted, extracellular space . Localized on the surface of desquamated nasal epithelial cells.
Protein Description Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization..
Protein Sequence MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGIFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSVRYSSSK
------CCCCCCCCC		18.46-
11PhosphorylationRYSSSKHYSSSRSGG
CCCCCCCCCCCCCCC		17.6229083192
12PhosphorylationYSSSKHYSSSRSGGG
CCCCCCCCCCCCCCC		22.8929083192
13PhosphorylationSSSKHYSSSRSGGGG
CCCCCCCCCCCCCCC		23.7021712546
14PhosphorylationSSKHYSSSRSGGGGG
CCCCCCCCCCCCCCC		25.2429083192
16PhosphorylationKHYSSSRSGGGGGGG
CCCCCCCCCCCCCCC		43.6823927012
32PhosphorylationCGGGGGVSSLRISSS
CCCCCCCCCEEEECC		27.2523927012
33PhosphorylationGGGGGVSSLRISSSK
CCCCCCCCEEEECCC		21.1823927012
37PhosphorylationGVSSLRISSSKGSLG
CCCCEEEECCCCCCC		23.3323186163
38PhosphorylationVSSLRISSSKGSLGG
CCCEEEECCCCCCCC		33.4327966365
39PhosphorylationSSLRISSSKGSLGGG
CCEEEECCCCCCCCC		33.9627966365
42PhosphorylationRISSSKGSLGGGFSS
EEECCCCCCCCCCCC		27.8121082442
48PhosphorylationGSLGGGFSSGGFSGG
CCCCCCCCCCCCCCC		31.2029083192
49PhosphorylationSLGGGFSSGGFSGGS
CCCCCCCCCCCCCCC		40.4530087585
53PhosphorylationGFSSGGFSGGSFSRG
CCCCCCCCCCCCCCC		45.5821815630
56PhosphorylationSGGFSGGSFSRGSSG
CCCCCCCCCCCCCCC		24.4721815630
56O-linked_GlycosylationSGGFSGGSFSRGSSG
CCCCCCCCCCCCCCC		24.4726853435
58O-linked_GlycosylationGFSGGSFSRGSSGGG
CCCCCCCCCCCCCCC		37.1126853435
58PhosphorylationGFSGGSFSRGSSGGG
CCCCCCCCCCCCCCC		37.1129083192
61PhosphorylationGGSFSRGSSGGGCFG
CCCCCCCCCCCCCCC		25.3827966365
62PhosphorylationGSFSRGSSGGGCFGG
CCCCCCCCCCCCCCC		44.2621815630
70PhosphorylationGGGCFGGSSGGYGGL
CCCCCCCCCCCCCCC		26.6225247763
71PhosphorylationGGCFGGSSGGYGGLG
CCCCCCCCCCCCCCC		39.2423927012
74PhosphorylationFGGSSGGYGGLGGFG
CCCCCCCCCCCCCCC		16.1427251275
84PhosphorylationLGGFGGGSFRGSYGS
CCCCCCCCCCCCCCC		18.2923186163
159PhosphorylationNLNDRLASYLDKVRA
CHHHHHHHHHHHHHH		30.7125106551
160PhosphorylationLNDRLASYLDKVRAL
HHHHHHHHHHHHHHH		17.2026356563
163AcetylationRLASYLDKVRALEES
HHHHHHHHHHHHHHC		30.9019608861
163UbiquitinationRLASYLDKVRALEES
HHHHHHHHHHHHHHC		30.9019608861
170PhosphorylationKVRALEESNYELEGK
HHHHHHHCCCCCCHH		35.027512983
172PhosphorylationRALEESNYELEGKIK
HHHHHCCCCCCHHHH		31.0422817900
188PhosphorylationWYEKHGNSHQGEPRD
HHHHHCCCCCCCCCC		23.0624719451
199PhosphorylationEPRDYSKYYKTIDDL
CCCCHHHHHHHHHHH		12.3122817900
200PhosphorylationPRDYSKYYKTIDDLK
CCCHHHHHHHHHHHH		12.8522817900
238PhosphorylationADDFRLKYENEVALR
CCHHHHHHHCHHHHH		28.6922817900
277PhosphorylationEMQIESLTEELAYLK
HHHHHHHHHHHHHHH		36.37-
282PhosphorylationSLTEELAYLKKNHEE
HHHHHHHHHHHCCHH		31.51-
284SumoylationTEELAYLKKNHEEEM
HHHHHHHHHCCHHHH		38.56-
284UbiquitinationTEELAYLKKNHEEEM
HHHHHHHHHCCHHHH		38.5622817900
284SumoylationTEELAYLKKNHEEEM
HHHHHHHHHCCHHHH		38.56-
285UbiquitinationEELAYLKKNHEEEMK
HHHHHHHHCCHHHHH		62.0222817900
298PhosphorylationMKDLRNVSTGDVNVE
HHHHCCCCCCCCCCC		30.1618691976
299PhosphorylationKDLRNVSTGDVNVEM
HHHCCCCCCCCCCCC		32.8723186163
325PhosphorylationLNNMRSQYEQLAEQN
HHHHHHHHHHHHHHH		13.5922817900
334UbiquitinationQLAEQNRKDAEAWFN
HHHHHHHHHHHHHHH		69.6922817900
343UbiquitinationAEAWFNEKSKELTTE
HHHHHHHHHHHHHHH		68.8529967540
344PhosphorylationEAWFNEKSKELTTEI
HHHHHHHHHHHHHHC		25.78-
348PhosphorylationNEKSKELTTEIDNNI
HHHHHHHHHHCHHCH		24.3929083192
349PhosphorylationEKSKELTTEIDNNIE
HHHHHHHHHCHHCHH		43.5029083192
363PhosphorylationEQISSYKSEITELRR
HHHHHCHHHHHHHHH		26.4623403867
392PhosphorylationLKQSLEASLAETEGR
HHHHHHHHHHHHCCC		20.8021815630
430PhosphorylationAETECQNTEYQQLLD
HHHHHCCHHHHHHHH		15.36-
451PhosphorylationNEIQTYRSLLEGEGS
HHHHHHHHHHCCCCC		27.2223186163
458PhosphorylationSLLEGEGSSGGGGRG
HHHCCCCCCCCCCCC		22.8521815630
459PhosphorylationLLEGEGSSGGGGRGG
HHCCCCCCCCCCCCC		52.9221815630
535PhosphorylationGGYGGGSSGGGGGGY
CCCCCCCCCCCCCCC		44.74-
546PhosphorylationGGGYGGGSSGGGSSS
CCCCCCCCCCCCCCC		29.14-
557PhosphorylationGSSSGGGYGGGSSSG
CCCCCCCCCCCCCCC		18.84-
568PhosphorylationSSSGGHKSSSSGSVG
CCCCCCCCCCCCCCC		29.7629083192
569PhosphorylationSSGGHKSSSSGSVGE
CCCCCCCCCCCCCCC		33.0729083192
570PhosphorylationSGGHKSSSSGSVGES
CCCCCCCCCCCCCCC		45.8924719451
571PhosphorylationGGHKSSSSGSVGESS
CCCCCCCCCCCCCCC		36.7121815630
573PhosphorylationHKSSSSGSVGESSSK
CCCCCCCCCCCCCCC		28.9721815630
577PhosphorylationSSGSVGESSSKGPRY
CCCCCCCCCCCCCCC		33.7024532841
578PhosphorylationSGSVGESSSKGPRY-
CCCCCCCCCCCCCC-		31.59-
579PhosphorylationGSVGESSSKGPRY--
CCCCCCCCCCCCC--		51.41-
584PhosphorylationSSSKGPRY-------
CCCCCCCC-------		26.49-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K1C10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K1C10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K1C10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AKT1_HUMANAKT1physical
11585925
KPCZ_HUMANPRKCZphysical
11585925
K2C1_HUMANKRT1physical
22939629
K22E_HUMANKRT2physical
22939629
K1C16_HUMANKRT16physical
26344197
K2C1B_HUMANKRT77physical
26344197
TRY1_HUMANPRSS1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
113800Epidermolytic hyperkeratosis (EHK)
607602Ichthyosis annular epidermolytic (AEI)
609165Erythroderma, ichthyosiform, congenital reticular (CRIE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K1C10_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-42, AND MASSSPECTROMETRY.

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