K2C1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C1B_HUMAN
• UniProt AC: Q7Z794
• Protein Name: Keratin, type II cytoskeletal 1b
• Gene Name: KRT77
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Protein Sequence: MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRCGGGGYGIHGRGFGSRSLYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQTSTNTSHRRILE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHQFSSQS ------CCCCCCCHH	26.46	24043423
6	Phosphorylation	--MSHQFSSQSAFSS --CCCCCCCHHHHHH	22.39	24043423
7	Phosphorylation	-MSHQFSSQSAFSSM -CCCCCCCHHHHHHH	29.46	24043423
9	Phosphorylation	SHQFSSQSAFSSMSR CCCCCCHHHHHHHCC	32.98	24043423
12	Phosphorylation	FSSQSAFSSMSRRVY CCCHHHHHHHCCCEE	25.50	24043423
13	Phosphorylation	SSQSAFSSMSRRVYS CCHHHHHHHCCCEEE	17.83	24043423
15	Phosphorylation	QSAFSSMSRRVYSTS HHHHHHHCCCEEECC	20.91	24043423
23	Phosphorylation	RRVYSTSSSAGSGGG CCEEECCCCCCCCCC	25.05	30576142
24	Phosphorylation	RVYSTSSSAGSGGGS CEEECCCCCCCCCCC	36.09	30576142
27	Phosphorylation	STSSSAGSGGGSPAV ECCCCCCCCCCCCCC	33.70	24719451
31	Phosphorylation	SAGSGGGSPAVGSVC CCCCCCCCCCCCEEE	16.98	30576142
60	Phosphorylation	GRGFGSRSLYNLGGS CCCCCCCCCEECCCC	36.58	26657352
69	Phosphorylation	YNLGGSRSISINLMG EECCCCCEEEEEECC	23.53	23312004
71	Phosphorylation	LGGSRSISINLMGRS CCCCCEEEEEECCCC	13.48	22985185
78	Phosphorylation	SINLMGRSTSGFCQG EEEECCCCCCCCCCC	22.61	27251275
79	Phosphorylation	INLMGRSTSGFCQGG EEECCCCCCCCCCCC	31.35	27251275
80	Phosphorylation	NLMGRSTSGFCQGGG EECCCCCCCCCCCCC	30.99	21082442
95	Methylation	VGGFGGGRGFGVGST CCCCCCCCCCCCCCC	40.31	-
174	Ubiquitination	QIMVLNNKFASFIDK HEEECCHHHHHHHHH	41.03	-
177	Phosphorylation	VLNNKFASFIDKVRF ECCHHHHHHHHHHHH	26.35	28355574
181	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	19608861
181	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21906983
250	Phosphorylation	MQDVVEDYKSKYEDE HHHHHHHHHHHHHHH	12.03	21082442
253	Ubiquitination	VVEDYKSKYEDEINK HHHHHHHHHHHHHHH	48.81	-
328	Phosphorylation	LSMDNNRSLDLDSII EEECCCCCCCHHHHH	28.49	20166139
361	Phosphorylation	EALYQTKYQELQITA HHHHHHHHHHHHHCC	15.59	26657352
465	Phosphorylation	SLDVEIATYRQLLEG EEEEEHHHHHHHHCC	25.54	28348404
466	Phosphorylation	LDVEIATYRQLLEGE EEEEHHHHHHHHCCC	6.32	28348404
475	Phosphorylation	QLLEGEESRMSGELQ HHHCCCHHHCCCCCE	29.05	21815630
478	Phosphorylation	EGEESRMSGELQSHV CCCHHHCCCCCEECE	28.18	24043423
483	Phosphorylation	RMSGELQSHVSISVQ HCCCCCEECEEEEEE	38.18	24043423
486	Phosphorylation	GELQSHVSISVQNSQ CCCEECEEEEEECCE	12.06	24043423
488	Phosphorylation	LQSHVSISVQNSQVS CEECEEEEEECCEEE	15.33	24043423
492	Phosphorylation	VSISVQNSQVSVNGG EEEEEECCEEEECCC	18.18	24043423
495	Phosphorylation	SVQNSQVSVNGGAGG EEECCEEEECCCCCC	11.39	24043423
505	Phosphorylation	GGAGGGGSYGSGGYG CCCCCCCCCCCCCCC	29.60	24043423
506	Phosphorylation	GAGGGGSYGSGGYGG CCCCCCCCCCCCCCC	20.70	24043423
508	Phosphorylation	GGGGSYGSGGYGGGS CCCCCCCCCCCCCCC	22.32	24043423
511	Phosphorylation	GSYGSGGYGGGSGGG CCCCCCCCCCCCCCC	19.00	24043423
515	Phosphorylation	SGGYGGGSGGGYGGG CCCCCCCCCCCCCCC	37.22	24043423
519	Phosphorylation	GGGSGGGYGGGRSYR CCCCCCCCCCCCCCC	18.84	24043423
523	Methylation	GGGYGGGRSYRGGGA CCCCCCCCCCCCCCC	33.51	-
534	Phosphorylation	GGGARGRSGGGYGSG CCCCCCCCCCCCCCC	44.61	-
549	Phosphorylation	CGGGGGSYGGSGRSG CCCCCCCCCCCCCCC	28.87	-
552	Phosphorylation	GGGSYGGSGRSGRGS CCCCCCCCCCCCCCC	27.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C1B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C1B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.