K1C16_HUMAN - dbPTM
K1C16_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K1C16_HUMAN
UniProt AC P08779
Protein Name Keratin, type I cytoskeletal 16
Gene Name KRT16
Organism Homo sapiens (Human).
Sequence Length 473
Subcellular Localization
Protein Description Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance..
Protein Sequence MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationTTCSRQFTSSSSMKG
CCCCCCCCCCCCCCC		21.2525106551
10PhosphorylationTCSRQFTSSSSMKGS
CCCCCCCCCCCCCCC		29.5225394399
11PhosphorylationCSRQFTSSSSMKGSC
CCCCCCCCCCCCCCC		24.3123927012
12PhosphorylationSRQFTSSSSMKGSCG
CCCCCCCCCCCCCCC		33.9325394399
13PhosphorylationRQFTSSSSMKGSCGI
CCCCCCCCCCCCCCC		26.8525394399
15MethylationFTSSSSMKGSCGIGG
CCCCCCCCCCCCCCC		50.01-
17PhosphorylationSSSSMKGSCGIGGGI
CCCCCCCCCCCCCCC		12.0323927012
28PhosphorylationGGGIGGGSSRISSVL
CCCCCCCCCCCCHHH		21.5125394399
29PhosphorylationGGIGGGSSRISSVLA
CCCCCCCCCCCHHHC		36.5927251275
32PhosphorylationGGGSSRISSVLAGGS
CCCCCCCCHHHCCCC		17.1825394399
33PhosphorylationGGSSRISSVLAGGSC
CCCCCCCHHHCCCCC		20.8325394399
39PhosphorylationSSVLAGGSCRAPSTY
CHHHCCCCCCCCCCC		10.2625394399
44PhosphorylationGGSCRAPSTYGGGLS
CCCCCCCCCCCCCCE		33.0228355574
45PhosphorylationGSCRAPSTYGGGLSV
CCCCCCCCCCCCCEE		25.7321406692
46PhosphorylationSCRAPSTYGGGLSVS
CCCCCCCCCCCCEEC		20.3621406692
51PhosphorylationSTYGGGLSVSSRFSS
CCCCCCCEECCCCCC		24.1921406692
53PhosphorylationYGGGLSVSSRFSSGG
CCCCCEECCCCCCCC		16.6621406692
54PhosphorylationGGGLSVSSRFSSGGA
CCCCEECCCCCCCCC		34.8821406692
55MethylationGGLSVSSRFSSGGAC
CCCEECCCCCCCCCC		28.14-
130PhosphorylationNLNDRLASYLDKVRA
CHHHHHHHHHHHHHH		30.7125106551
131PhosphorylationLNDRLASYLDKVRAL
HHHHHHHHHHHHHHH		17.2021082442
134UbiquitinationRLASYLDKVRALEEA
HHHHHHHHHHHHHHH		30.9021987572
134AcetylationRLASYLDKVRALEEA
HHHHHHHHHHHHHHH		30.9022640249
153PhosphorylationEVKIRDWYQRQRPSE
CHHHHHHHHHHCCHH		9.71-
162AcetylationRQRPSEIKDYSPYFK
HHCCHHHCCCCCCCC		46.7188141
165PhosphorylationPSEIKDYSPYFKTIE
CHHHCCCCCCCCCHH		24.21-
167PhosphorylationEIKDYSPYFKTIEDL
HHCCCCCCCCCHHHH		16.27-
169UbiquitinationKDYSPYFKTIEDLRN
CCCCCCCCCHHHHHH		42.6323503661
169AcetylationKDYSPYFKTIEDLRN
CCCCCCCCCHHHHHH		42.6388145
204PhosphorylationLAADDFRTKYEHELA
ECHHHHHHHHHHHHH		37.66-
206PhosphorylationADDFRTKYEHELALR
HHHHHHHHHHHHHHH		23.16-
215PhosphorylationHELALRQTVEADVNG
HHHHHHHHHHHHHHH		17.55-
231PhosphorylationRRVLDELTLARTDLE
HHHHHHHHHHCCCHH		19.1424719451
235PhosphorylationDELTLARTDLEMQIE
HHHHHHCCCHHHHHH		39.0520068231
245UbiquitinationEMQIEGLKEELAYLR
HHHHHHHHHHHHHHH		61.0622817900
250PhosphorylationGLKEELAYLRKNHEE
HHHHHHHHHHHCCHH		21.4720068231
283PhosphorylationAAPGVDLSRILNEMR
CCCCCCHHHHHHHHH		16.8922468782
293PhosphorylationLNEMRDQYEQMAEKN
HHHHHHHHHHHHHHH		16.65-
311UbiquitinationAETWFLSKTEELNKE
HHHHHHHHHHHHHHH		63.2023503661
317UbiquitinationSKTEELNKEVASNSE
HHHHHHHHHHHCCHH		67.2123503661
321PhosphorylationELNKEVASNSELVQS
HHHHHHHCCHHHHHC		46.1722817900
329PhosphorylationNSELVQSSRSEVTEL
CHHHHHCCHHHHHHH		23.80-
349PhosphorylationGLEIELQSQLSMKAS
HHHHHHHHHHHHHHH		45.7924043423
352PhosphorylationIELQSQLSMKASLEN
HHHHHHHHHHHHHHH		15.5924043423
356PhosphorylationSQLSMKASLENSLEE
HHHHHHHHHHHHHHH		30.6022985185
360PhosphorylationMKASLENSLEETKGR
HHHHHHHHHHHHCCC		27.9927966365
365UbiquitinationENSLEETKGRYCMQL
HHHHHHHCCCHHHHH		44.67-
381PhosphorylationQIQGLIGSVEEQLAQ
HHHHHHHCHHHHHHH		21.2524043423
407UbiquitinationYQILLDVKTRLEQEI
HHHHHHHHHHHHHHH		27.82-
416PhosphorylationRLEQEIATYRRLLEG
HHHHHHHHHHHHHCC		24.19-
417PhosphorylationLEQEIATYRRLLEGE
HHHHHHHHHHHHCCC		5.6821253578
434PhosphorylationHLSSQQASGQSYSSR
CCCCCCCCCCCCCCC		32.7826356563
437PhosphorylationSQQASGQSYSSREVF
CCCCCCCCCCCCEEC		30.4326356563
438PhosphorylationQQASGQSYSSREVFT
CCCCCCCCCCCEECC		11.6326356563
439PhosphorylationQASGQSYSSREVFTS
CCCCCCCCCCEECCC		28.3226356563
440PhosphorylationASGQSYSSREVFTSS
CCCCCCCCCEECCCC		24.9926356563
445PhosphorylationYSSREVFTSSSSSSS
CCCCEECCCCCCCCC		32.6424719451
446PhosphorylationSSREVFTSSSSSSSR
CCCEECCCCCCCCCC		19.4325463755
447PhosphorylationSREVFTSSSSSSSRQ
CCEECCCCCCCCCCC		31.0525463755
448PhosphorylationREVFTSSSSSSSRQT
CEECCCCCCCCCCCC		33.7221815630
449PhosphorylationEVFTSSSSSSSRQTR
EECCCCCCCCCCCCH		35.8726657352
450PhosphorylationVFTSSSSSSSRQTRP
ECCCCCCCCCCCCHH		33.9920639409
451PhosphorylationFTSSSSSSSRQTRPI
CCCCCCCCCCCCHHH		31.3320639409
452PhosphorylationTSSSSSSSRQTRPIL
CCCCCCCCCCCHHHH		30.2923090842
460MethylationRQTRPILKEQSSSSF
CCCHHHHCHHCCCCC		55.19115971629
463PhosphorylationRPILKEQSSSSFSQG
HHHHCHHCCCCCCCC		33.0221955146
464PhosphorylationPILKEQSSSSFSQGQ
HHHCHHCCCCCCCCC		29.6921955146
465PhosphorylationILKEQSSSSFSQGQS
HHCHHCCCCCCCCCC		40.4221955146
466PhosphorylationLKEQSSSSFSQGQSS
HCHHCCCCCCCCCCC		30.7521955146
468PhosphorylationEQSSSSFSQGQSS--
HHCCCCCCCCCCC--		35.0421955146
472PhosphorylationSSFSQGQSS------
CCCCCCCCC------		44.8523090842
473PhosphorylationSFSQGQSS-------
CCCCCCCC-------		36.0323090842
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K1C16_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K1C16_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K1C16_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K1C16_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
167200Pachyonychia congenita 1 (PC1)
613000Keratoderma, palmoplantar, non-epidermolytic, focal (FNEPPK)
144200Unilateral palmoplantar verrucous nevus (UPVN)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K1C16_HUMAN

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Related Literatures of Post-Translational Modification

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