| UniProt ID | YBOX3_HUMAN | |
|---|---|---|
| UniProt AC | P16989 | |
| Protein Name | Y-box-binding protein 3 | |
| Gene Name | YBX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 372 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity).. | |
| Protein Sequence | MSEAGEATTTTTTTLPQAPTEAAAAAPQDPAPKSPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNYAGEEEEEGSGSSEGFDPPATDRQFSGARNQLRRPQYRPQYRQRRFPPYHVGQTFDRRSRVLPHPNRIQAGEIGEMKDGVPEGAQLQGPVHRNPTYRPRYRSRGPPRPRPAPAVGEAEDKENQQATSGPNQPSVRRGYRRPYNYRRRPRPPNAPSQDGKEAKAGEAPTENPAPPTQQSSAE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEAGEATT ------CCCCCCCCC | 19413330 | ||
| 2 | Phosphorylation | ------MSEAGEATT ------CCCCCCCCC | 29255136 | ||
| 8 | Phosphorylation | MSEAGEATTTTTTTL CCCCCCCCCCCCCCC | 29255136 | ||
| 9 | Phosphorylation | SEAGEATTTTTTTLP CCCCCCCCCCCCCCC | 29255136 | ||
| 10 | Phosphorylation | EAGEATTTTTTTLPQ CCCCCCCCCCCCCCC | 28464451 | ||
| 11 | Phosphorylation | AGEATTTTTTTLPQA CCCCCCCCCCCCCCC | 29255136 | ||
| 12 | Phosphorylation | GEATTTTTTTLPQAP CCCCCCCCCCCCCCC | 28464451 | ||
| 13 | Phosphorylation | EATTTTTTTLPQAPT CCCCCCCCCCCCCCC | 28464451 | ||
| 14 | Phosphorylation | ATTTTTTTLPQAPTE CCCCCCCCCCCCCCH | 29255136 | ||
| 20 | Phosphorylation | TTLPQAPTEAAAAAP CCCCCCCCHHHHHCC | 20068231 | ||
| 34 | Phosphorylation | PQDPAPKSPVGSGAP CCCCCCCCCCCCCCC | 29255136 | ||
| 38 | Phosphorylation | APKSPVGSGAPQAAA CCCCCCCCCCCCCCC | 29255136 | ||
| 65 | Phosphorylation | GDAAPAATGTAAAAS CCCCCCHHHHHHHHH | 29255136 | ||
| 67 | Phosphorylation | AAPAATGTAAAASLA CCCCHHHHHHHHHHH | 23927012 | ||
| 72 | Phosphorylation | TGTAAAASLATAAGS HHHHHHHHHHHHHCC | 29255136 | ||
| 75 | Phosphorylation | AAAASLATAAGSEDA HHHHHHHHHHCCHHH | 29255136 | ||
| 79 | Phosphorylation | SLATAAGSEDAEKKV HHHHHHCCHHHHHHH | 29255136 | ||
| 84 | Ubiquitination | AGSEDAEKKVLATKV HCCHHHHHHHHHHHH | 21906983 | ||
| 84 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 84 | Acetylation | AGSEDAEKKVLATKV HCCHHHHHHHHHHHH | 26051181 | ||
| 84 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 84 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 90 | Ubiquitination | EKKVLATKVLGTVKW HHHHHHHHHHCEEEE | 21890473 | ||
| 90 | Acetylation | EKKVLATKVLGTVKW HHHHHHHHHHCEEEE | 25953088 | ||
| 90 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 90 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 90 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 96 | Acetylation | TKVLGTVKWFNVRNG HHHHCEEEEEECCCC | 25825284 | ||
| 96 | Ubiquitination | TKVLGTVKWFNVRNG HHHHCEEEEEECCCC | 21890473 | ||
| 96 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 96 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 96 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 104 | Phosphorylation | WFNVRNGYGFINRND EEECCCCEEEECCCC | 28152594 | ||
| 112 | Phosphorylation | GFINRNDTKEDVFVH EEECCCCCCCCEEEE | 27050516 | ||
| 113 | Acetylation | FINRNDTKEDVFVHQ EECCCCCCCCEEEEH | 26051181 | ||
| 113 | Ubiquitination | FINRNDTKEDVFVHQ EECCCCCCCCEEEEH | 21890473 | ||
| 113 | 2-Hydroxyisobutyrylation | FINRNDTKEDVFVHQ EECCCCCCCCEEEEH | - | ||
| 113 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 113 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 113 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 121 | Phosphorylation | EDVFVHQTAIKKNNP CCEEEEHHHHHCCCH | 25159151 | ||
| 124 | Ubiquitination | FVHQTAIKKNNPRKY EEEHHHHHCCCHHHH | 21890473 | ||
| 124 | 2-Hydroxyisobutyrylation | FVHQTAIKKNNPRKY EEEHHHHHCCCHHHH | - | ||
| 124 | Acetylation | FVHQTAIKKNNPRKY EEEHHHHHCCCHHHH | 25953088 | ||
| 124 | Methylation | FVHQTAIKKNNPRKY EEEHHHHHCCCHHHH | 23748837 | ||
| 124 | Succinylation | FVHQTAIKKNNPRKY EEEHHHHHCCCHHHH | 23954790 | ||
| 124 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 124 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 124 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 125 | Ubiquitination | VHQTAIKKNNPRKYL EEHHHHHCCCHHHHH | 21890473 | ||
| 125 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 125 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 125 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 131 | Phosphorylation | KKNNPRKYLRSVGDG HCCCHHHHHEECCCC | 28450419 | ||
| 133 | Methylation | NNPRKYLRSVGDGET CCHHHHHEECCCCCE | - | ||
| 134 | Phosphorylation | NPRKYLRSVGDGETV CHHHHHEECCCCCEE | 19664994 | ||
| 140 | Phosphorylation | RSVGDGETVEFDVVE EECCCCCEEEEEEEC | 30266825 | ||
| 150 | Ubiquitination | FDVVEGEKGAEAANV EEEECCCCCCCCCCC | 21906983 | ||
| 150 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 150 | Acetylation | FDVVEGEKGAEAANV EEEECCCCCCCCCCC | 26051181 | ||
| 150 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 150 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 158 | Phosphorylation | GAEAANVTGPDGVPV CCCCCCCCCCCCCCC | 28555341 | ||
| 168 | Phosphorylation | DGVPVEGSRYAADRR CCCCCCCCCHHHHHH | 28857561 | ||
| 169 | Methylation | GVPVEGSRYAADRRR CCCCCCCCHHHHHHH | - | ||
| 174 | Methylation | GSRYAADRRRYRRGY CCCHHHHHHHHHCCC | - | ||
| 175 | Methylation | SRYAADRRRYRRGYY CCHHHHHHHHHCCCC | - | ||
| 176 | Methylation | RYAADRRRYRRGYYG CHHHHHHHHHCCCCC | - | ||
| 179 | Methylation | ADRRRYRRGYYGRRR HHHHHHHCCCCCCCC | - | ||
| 182 | Phosphorylation | RRYRRGYYGRRRGPP HHHHCCCCCCCCCCC | - | ||
| 192 | Phosphorylation | RRGPPRNYAGEEEEE CCCCCCCCCCCCCCC | 23927012 | ||
| 199 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 201 | Phosphorylation | GEEEEEGSGSSEGFD CCCCCCCCCCCCCCC | 23927012 | ||
| 203 | Phosphorylation | EEEEGSGSSEGFDPP CCCCCCCCCCCCCCC | 23927012 | ||
| 204 | Phosphorylation | EEEGSGSSEGFDPPA CCCCCCCCCCCCCCC | 23927012 | ||
| 212 | Phosphorylation | EGFDPPATDRQFSGA CCCCCCCCHHCCCCH | 23927012 | ||
| 217 | Phosphorylation | PATDRQFSGARNQLR CCCHHCCCCHHHHHC | 26699800 | ||
| 220 | Dimethylation | DRQFSGARNQLRRPQ HHCCCCHHHHHCCCC | - | ||
| 220 | Methylation | DRQFSGARNQLRRPQ HHCCCCHHHHHCCCC | - | ||
| 225 | Methylation | GARNQLRRPQYRPQY CHHHHHCCCCCCHHH | - | ||
| 228 | Phosphorylation | NQLRRPQYRPQYRQR HHHCCCCCCHHHHHH | - | ||
| 229 | Methylation | QLRRPQYRPQYRQRR HHCCCCCCHHHHHHC | - | ||
| 232 | Phosphorylation | RPQYRPQYRQRRFPP CCCCCHHHHHHCCCC | - | ||
| 233 | Methylation | PQYRPQYRQRRFPPY CCCCHHHHHHCCCCC | - | ||
| 235 | Methylation | YRPQYRQRRFPPYHV CCHHHHHHCCCCCCC | - | ||
| 236 | Methylation | RPQYRQRRFPPYHVG CHHHHHHCCCCCCCC | - | ||
| 240 | Phosphorylation | RQRRFPPYHVGQTFD HHHCCCCCCCCCCCC | 28555341 | ||
| 242 (in isoform 2) | Ubiquitination | - | - | ||
| 245 | Phosphorylation | PPYHVGQTFDRRSRV CCCCCCCCCCCCCCC | 24173317 | ||
| 250 | Phosphorylation | GQTFDRRSRVLPHPN CCCCCCCCCCCCCCC | 26434776 | ||
| 251 | Methylation | QTFDRRSRVLPHPNR CCCCCCCCCCCCCCC | 24129315 | ||
| 258 | Methylation | RVLPHPNRIQAGEIG CCCCCCCCCCCCCCC | - | ||
| 267 | Sulfoxidation | QAGEIGEMKDGVPEG CCCCCCCCCCCCCCC | 21406390 | ||
| 268 | Ubiquitination | AGEIGEMKDGVPEGA CCCCCCCCCCCCCCC | 21906983 | ||
| 268 | Acetylation | AGEIGEMKDGVPEGA CCCCCCCCCCCCCCC | 26051181 | ||
| 268 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 268 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 283 | Methylation | QLQGPVHRNPTYRPR CCCCCCCCCCCCCCC | - | ||
| 284 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 286 | Phosphorylation | GPVHRNPTYRPRYRS CCCCCCCCCCCCCHH | 28857561 | ||
| 287 | Phosphorylation | PVHRNPTYRPRYRSR CCCCCCCCCCCCHHC | 23312004 | ||
| 288 | Methylation | VHRNPTYRPRYRSRG CCCCCCCCCCCHHCC | - | ||
| 290 | Methylation | RNPTYRPRYRSRGPP CCCCCCCCCHHCCCC | - | ||
| 291 | Phosphorylation | NPTYRPRYRSRGPPR CCCCCCCCHHCCCCC | 27282143 | ||
| 292 | Methylation | PTYRPRYRSRGPPRP CCCCCCCHHCCCCCC | - | ||
| 293 | Phosphorylation | TYRPRYRSRGPPRPR CCCCCCHHCCCCCCC | 25159151 | ||
| 294 | Methylation | YRPRYRSRGPPRPRP CCCCCHHCCCCCCCC | - | ||
| 298 | Methylation | YRSRGPPRPRPAPAV CHHCCCCCCCCCCCC | - | ||
| 300 | Methylation | SRGPPRPRPAPAVGE HCCCCCCCCCCCCCC | - | ||
| 311 | Ubiquitination | AVGEAEDKENQQATS CCCCCCCHHHHHCCC | - | ||
| 311 | Acetylation | AVGEAEDKENQQATS CCCCCCCHHHHHCCC | 23236377 | ||
| 317 | Phosphorylation | DKENQQATSGPNQPS CHHHHHCCCCCCCHH | 23401153 | ||
| 318 | Phosphorylation | KENQQATSGPNQPSV HHHHHCCCCCCCHHH | 29255136 | ||
| 324 | Phosphorylation | TSGPNQPSVRRGYRR CCCCCCHHHHCCCCC | 23401153 | ||
| 326 | Dimethylation | GPNQPSVRRGYRRPY CCCCHHHHCCCCCCC | - | ||
| 326 | Methylation | GPNQPSVRRGYRRPY CCCCHHHHCCCCCCC | 24129315 | ||
| 327 | Dimethylation | PNQPSVRRGYRRPYN CCCHHHHCCCCCCCC | - | ||
| 327 | Methylation | PNQPSVRRGYRRPYN CCCHHHHCCCCCCCC | - | ||
| 330 | Dimethylation | PSVRRGYRRPYNYRR HHHHCCCCCCCCCCC | - | ||
| 330 | Methylation | PSVRRGYRRPYNYRR HHHHCCCCCCCCCCC | - | ||
| 331 | Dimethylation | SVRRGYRRPYNYRRR HHHCCCCCCCCCCCC | - | ||
| 331 | Methylation | SVRRGYRRPYNYRRR HHHCCCCCCCCCCCC | - | ||
| 333 | Phosphorylation | RRGYRRPYNYRRRPR HCCCCCCCCCCCCCC | - | ||
| 336 | Methylation | YRRPYNYRRRPRPPN CCCCCCCCCCCCCCC | - | ||
| 337 | Methylation | RRPYNYRRRPRPPNA CCCCCCCCCCCCCCC | - | ||
| 338 | Methylation | RPYNYRRRPRPPNAP CCCCCCCCCCCCCCC | - | ||
| 340 | Methylation | YNYRRRPRPPNAPSQ CCCCCCCCCCCCCCC | - | ||
| 346 | Phosphorylation | PRPPNAPSQDGKEAK CCCCCCCCCCCCCCC | 30266825 | ||
| 350 | Ubiquitination | NAPSQDGKEAKAGEA CCCCCCCCCCCCCCC | - | ||
| 353 | Ubiquitination | SQDGKEAKAGEAPTE CCCCCCCCCCCCCCC | 2190698 | ||
| 353 | Acetylation | SQDGKEAKAGEAPTE CCCCCCCCCCCCCCC | 26051181 | ||
| 353 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 359 | Phosphorylation | AKAGEAPTENPAPPT CCCCCCCCCCCCCCC | 23403867 | ||
| 366 | Phosphorylation | TENPAPPTQQSSAE- CCCCCCCCCCCCCC- | 30266825 | ||
| 366 | O-linked_Glycosylation | TENPAPPTQQSSAE- CCCCCCCCCCCCCC- | 31373491 | ||
| 369 | Phosphorylation | PAPPTQQSSAE---- CCCCCCCCCCC---- | 30266825 | ||
| 370 | Phosphorylation | APPTQQSSAE----- CCCCCCCCCC----- | 30266825 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 112 | T | Phosphorylation | Kinase | CHEK1 | O14757 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of YBOX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of YBOX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NDUBA_HUMAN | NDUFB10 | physical | 22939629 | |
| IL7RA_HUMAN | IL7R | physical | 23151878 | |
| ABCF1_HUMAN | ABCF1 | physical | 22863883 | |
| CN166_HUMAN | C14orf166 | physical | 22863883 | |
| RTCB_HUMAN | RTCB | physical | 22863883 | |
| NELFB_HUMAN | NELFB | physical | 22863883 | |
| HNRPU_HUMAN | HNRNPU | physical | 22863883 | |
| IF2B3_HUMAN | IGF2BP3 | physical | 22863883 | |
| ILF2_HUMAN | ILF2 | physical | 22863883 | |
| MAP7_HUMAN | MAP7 | physical | 22863883 | |
| MRE11_HUMAN | MRE11A | physical | 22863883 | |
| NMT1_HUMAN | NMT1 | physical | 22863883 | |
| PTBP1_HUMAN | PTBP1 | physical | 22863883 | |
| RFC4_HUMAN | RFC4 | physical | 22863883 | |
| ABCB7_HUMAN | ABCB7 | physical | 26344197 | |
| VA0D1_HUMAN | ATP6V0D1 | physical | 26344197 | |
| COX5A_HUMAN | COX5A | physical | 26344197 | |
| NDUA9_HUMAN | NDUFA9 | physical | 26344197 | |
| PELO_HUMAN | PELO | physical | 26344197 | |
| SK2L2_HUMAN | SKIV2L2 | physical | 26344197 | |
| CDK4_HUMAN | CDK4 | physical | 10100871 | |
| CDK5_HUMAN | CDK5 | physical | 10100871 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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