dbPTM

ILF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ILF2_HUMAN
UniProt AC	Q12905
Protein Name	Interleukin enhancer-binding factor 2
Gene Name	ILF2
Organism	Homo sapiens (Human).
Sequence Length	390
Subcellular Localization	Nucleus, nucleolus. Cytoplasm. Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein Description	Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus..
Protein Sequence	MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	GRGGRFGSRGGPGGG CCCCCCCCCCCCCCC	25.66	-
16	Asymmetric dimethylarginine	RGGRFGSRGGPGGGF CCCCCCCCCCCCCCC	55.24	-
16	Methylation	RGGRFGSRGGPGGGF CCCCCCCCCCCCCCC	55.24	24129315
24	Dimethylation	GGPGGGFRPFVPHIP CCCCCCCCCCCCCCC	27.33	-
24	Methylation	GGPGGGFRPFVPHIP CCCCCCCCCCCCCCC	27.33	24129315
45	Sumoylation	EMAFPRVKPAPDETS HHHCCCCCCCCCCCC	36.42	-
45	Sumoylation	EMAFPRVKPAPDETS HHHCCCCCCCCCCCC	36.42	-
45	Ubiquitination	EMAFPRVKPAPDETS HHHCCCCCCCCCCCC	36.42	21906983
45	Acetylation	EMAFPRVKPAPDETS HHHCCCCCCCCCCCC	36.42	26051181
51	Phosphorylation	VKPAPDETSFSEALL CCCCCCCCCHHHHHH	42.31	30266825
52	Phosphorylation	KPAPDETSFSEALLK CCCCCCCCHHHHHHH	25.40	30266825
54	Phosphorylation	APDETSFSEALLKRN CCCCCCHHHHHHHHC	23.02	30266825
59	2-Hydroxyisobutyrylation	SFSEALLKRNQDLAP CHHHHHHHHCCCCCC	50.59	-
59	Ubiquitination	SFSEALLKRNQDLAP CHHHHHHHHCCCCCC	50.59	21906983
59	Methylation	SFSEALLKRNQDLAP CHHHHHHHHCCCCCC	50.59	24625217
59	Acetylation	SFSEALLKRNQDLAP CHHHHHHHHCCCCCC	50.59	23749302
68	Phosphorylation	NQDLAPNSAEQASIL CCCCCCCHHHHHHHH	31.93	29255136
73	Phosphorylation	PNSAEQASILSLVTK CCHHHHHHHHHHHHH	24.61	29255136
76	Phosphorylation	AEQASILSLVTKINN HHHHHHHHHHHHHHH	21.08	25850435
79	Phosphorylation	ASILSLVTKINNVID HHHHHHHHHHHHHHH	31.34	21406692
107	Phosphorylation	EEVRQVGSYKKGTMT EEEEECCCCCCCCCC	34.62	23828894
109	2-Hydroxyisobutyrylation	VRQVGSYKKGTMTTG EEECCCCCCCCCCCC	46.56	-
109	Ubiquitination	VRQVGSYKKGTMTTG EEECCCCCCCCCCCC	46.56	-
110	Ubiquitination	RQVGSYKKGTMTTGH EECCCCCCCCCCCCC	51.92	-
141	Ubiquitination	AVAALGNKVVESLRA HHHHCCHHHHHHHHC	45.95	21906983
186	Sumoylation	TVPPNLRKLDPELHL CCCCCHHCCCHHHHH	61.48	28112733
186	Sumoylation	TVPPNLRKLDPELHL CCCCCHHCCCHHHHH	61.48	-
186	Ubiquitination	TVPPNLRKLDPELHL CCCCCHHCCCHHHHH	61.48	21906983
186	Acetylation	TVPPNLRKLDPELHL CCCCCHHCCCHHHHH	61.48	26051181
196	Ubiquitination	PELHLDIKVLQSALA HHHHHCHHHHHHHHH	36.24	21906983
200	Phosphorylation	LDIKVLQSALAAIRH HCHHHHHHHHHHHHH	22.53	24850871
218	Phosphorylation	FEENASQSTVKVLIR HHHCCCHHHHHHHHH	32.45	23186163
219	Phosphorylation	EENASQSTVKVLIRL HHCCCHHHHHHHHHH	19.40	21815630
221	Ubiquitination	NASQSTVKVLIRLLK CCCHHHHHHHHHHHH	31.26	21906983
322	Phosphorylation	QTLVRILSHGGFRKI HHHHHHHHCCCHHHH	20.09	23312004
328	Ubiquitination	LSHGGFRKILGQEGD HHCCCHHHHHCCCCC	39.77	21906983
338	Phosphorylation	GQEGDASYLASEIST CCCCCHHHHHHHHCC	14.17	-
352	Phosphorylation	TWDGVIVTPSEKAYE CCCCEEECCCHHHCC	15.24	-
356	Ubiquitination	VIVTPSEKAYEKPPE EEECCCHHHCCCCCC	61.68	21906983
358	Phosphorylation	VTPSEKAYEKPPEKK ECCCHHHCCCCCCCC	35.24	27642862
360	Ubiquitination	PSEKAYEKPPEKKEG CCHHHCCCCCCCCCC	53.87	-
360	Acetylation	PSEKAYEKPPEKKEG CCHHHCCCCCCCCCC	53.87	25953088
364	Sumoylation	AYEKPPEKKEGEEEE HCCCCCCCCCCCCCC	63.00	28112733
364	Ubiquitination	AYEKPPEKKEGEEEE HCCCCCCCCCCCCCC	63.00	-
364	2-Hydroxyisobutyrylation	AYEKPPEKKEGEEEE HCCCCCCCCCCCCCC	63.00	-
364	Acetylation	AYEKPPEKKEGEEEE HCCCCCCCCCCCCCC	63.00	26051181
365	Ubiquitination	YEKPPEKKEGEEEEE CCCCCCCCCCCCCCC	70.10	-
365	Acetylation	YEKPPEKKEGEEEEE CCCCCCCCCCCCCCC	70.10	26051181
374	Phosphorylation	GEEEEENTEEPPQGE CCCCCCCCCCCCCCC	45.03	30576142
385	Phosphorylation	PQGEEEESMETQE-- CCCCHHHHHCCCC--	25.79	29507054
388	Phosphorylation	EEEESMETQE----- CHHHHHCCCC-----	29.38	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ILF2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ILF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ILF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKDC_HUMAN	PRKDC	physical	9442054
ILF3_HUMAN	ILF3	physical	17389650
XRCC6_HUMAN	XRCC6	physical	17389650
XRCC5_HUMAN	XRCC5	physical	17389650
PRKDC_HUMAN	PRKDC	physical	17389650
ILF3_HUMAN	ILF3	physical	21969602
BIRC2_HUMAN	BIRC2	physical	19893574
ILF3_HUMAN	ILF3	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL17_HUMAN	RPL17	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
SF3B1_HUMAN	SF3B1	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RL11_HUMAN	RPL11	physical	22939629
RL10A_HUMAN	RPL10A	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RL21_HUMAN	RPL21	physical	22939629
RL18_HUMAN	RPL18	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
RL10_HUMAN	RPL10	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
MOV10_HUMAN	MOV10	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
SF3B4_HUMAN	SF3B4	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
SRSF5_HUMAN	SRSF5	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
TRA2B_HUMAN	TRA2B	physical	22939629
SRSF3_HUMAN	SRSF3	physical	22939629
PUF60_HUMAN	PUF60	physical	22939629
SPT5H_HUMAN	SUPT5H	physical	22939629
OST48_HUMAN	DDOST	physical	22939629
RCN1_HUMAN	RCN1	physical	22939629
PTBP3_HUMAN	PTBP3	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
RBP2_HUMAN	RANBP2	physical	22939629
SON_HUMAN	SON	physical	22939629
P5CS_HUMAN	ALDH18A1	physical	22939629
TIM13_HUMAN	TIMM13	physical	22939629
SYSM_HUMAN	SARS2	physical	22939629
RM21_HUMAN	MRPL21	physical	22939629
RHOB_HUMAN	RHOB	physical	22939629
PYC_HUMAN	PC	physical	22939629
SYIM_HUMAN	IARS2	physical	22939629
RT26_HUMAN	MRPS26	physical	22939629
TBD2A_HUMAN	TBC1D2	physical	22939629
NENF_HUMAN	NENF	physical	22939629
SSRD_HUMAN	SSR4	physical	22939629
TRI56_HUMAN	TRIM56	physical	22939629
RBM14_HUMAN	RBM14	physical	22939629
SNP23_HUMAN	SNAP23	physical	22939629
SPTN1_HUMAN	SPTAN1	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
MYOF_HUMAN	MYOF	physical	22939629
CAVN3_HUMAN	PRKCDBP	physical	22939629
RM50_HUMAN	MRPL50	physical	22939629
MI4GD_HUMAN	MIF4GD	physical	22939629
SCFD1_HUMAN	SCFD1	physical	22939629
ZBT8B_HUMAN	ZBTB8B	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
EMC1_HUMAN	EMC1	physical	22939629
PPT2_HUMAN	PPT2	physical	22939629
RM17_HUMAN	MRPL17	physical	22939629
MPH6_HUMAN	MPHOSPH6	physical	22939629
LBR_HUMAN	LBR	physical	22939629
RM24_HUMAN	MRPL24	physical	22939629
SND1_HUMAN	SND1	physical	22939629
TOM22_HUMAN	TOMM22	physical	22939629
RM28_HUMAN	MRPL28	physical	22939629
CAVN1_HUMAN	PTRF	physical	22939629
RM55_HUMAN	MRPL55	physical	22939629
SFXN2_HUMAN	SFXN2	physical	22939629
RM38_HUMAN	MRPL38	physical	22939629
TPM4_HUMAN	TPM4	physical	22939629
PYRD1_HUMAN	PYROXD1	physical	22939629
WDR44_HUMAN	WDR44	physical	22939629
RT34_HUMAN	MRPS34	physical	22939629
SOAT1_HUMAN	SOAT1	physical	22939629
METH_HUMAN	MTR	physical	22939629
LAMP1_HUMAN	LAMP1	physical	22939629
THIOM_HUMAN	TXN2	physical	22939629
YES_HUMAN	YES1	physical	22939629
SFXN1_HUMAN	SFXN1	physical	22939629
LTOR3_HUMAN	LAMTOR3	physical	22939629
RAB6C_HUMAN	RAB6C	physical	22939629
PLAK_HUMAN	JUP	physical	22939629
MFN1_HUMAN	MFN1	physical	22939629
RAP1B_HUMAN	RAP1B	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
HNRPU_HUMAN	HNRNPU	physical	22863883
IF2B3_HUMAN	IGF2BP3	physical	22863883
MRE11_HUMAN	MRE11A	physical	22863883
PTBP1_HUMAN	PTBP1	physical	22863883
CCDB1_HUMAN	CCNDBP1	physical	25416956
ILF3_HUMAN	ILF3	physical	20808282
EP300_HUMAN	EP300	physical	20808282
PRKDC_HUMAN	PRKDC	physical	20808282
MCM2_HUMAN	MCM2	physical	20808282
MCM3_HUMAN	MCM3	physical	20808282
MCM4_HUMAN	MCM4	physical	20808282
MCM5_HUMAN	MCM5	physical	20808282
MCM6_HUMAN	MCM6	physical	20808282
MCM7_HUMAN	MCM7	physical	20808282
RAD50_HUMAN	RAD50	physical	20808282
MRE11_HUMAN	MRE11A	physical	20808282
RUVB2_HUMAN	RUVBL2	physical	20808282
ORC2_HUMAN	ORC2	physical	20808282
ORC3_HUMAN	ORC3	physical	20808282
EF1A1_HUMAN	EEF1A1	physical	20808282
GLYM_HUMAN	SHMT2	physical	20808282
NIP7_HUMAN	NIP7	physical	26186194
KNOP1_HUMAN	KNOP1	physical	26186194
RBM28_HUMAN	RBM28	physical	26186194
SPB1_HUMAN	FTSJ3	physical	26186194
F120A_HUMAN	FAM120A	physical	26186194
ILF3_HUMAN	ILF3	physical	26186194
STRBP_HUMAN	STRBP	physical	26186194
RENT1_HUMAN	UPF1	physical	26186194
RL10A_HUMAN	RPL10A	physical	26186194
STAU2_HUMAN	STAU2	physical	26186194
STAU1_HUMAN	STAU1	physical	26186194
HNRPR_HUMAN	HNRNPR	physical	26186194
ZFR_HUMAN	ZFR	physical	26186194
PABP4_HUMAN	PABPC4	physical	26186194
SRP72_HUMAN	SRP72	physical	26186194
DHX30_HUMAN	DHX30	physical	26186194
ELAV2_HUMAN	ELAVL2	physical	26186194
GLYR1_HUMAN	GLYR1	physical	26186194
PUM2_HUMAN	PUM2	physical	26186194
MOV10_HUMAN	MOV10	physical	26186194
MBB1A_HUMAN	MYBBP1A	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
MTEF3_HUMAN	MTERF3	physical	26186194
CDC5L_HUMAN	CDC5L	physical	26186194
TAP26_HUMAN	CCDC59	physical	26186194
RRP8_HUMAN	RRP8	physical	26186194
H2AX_HUMAN	H2AFX	physical	26186194
SRRM1_HUMAN	SRRM1	physical	26186194
ZCHC3_HUMAN	ZCCHC3	physical	26186194
LARP1_HUMAN	LARP1	physical	26186194
LYAR_HUMAN	LYAR	physical	26186194
RRP1B_HUMAN	RRP1B	physical	26186194
CEBPZ_HUMAN	CEBPZ	physical	26186194
NOP2_HUMAN	NOP2	physical	26186194
BRX1_HUMAN	BRIX1	physical	26186194
DDX18_HUMAN	DDX18	physical	26186194
NOG1_HUMAN	GTPBP4	physical	26186194
RL15_HUMAN	RPL15	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
HNRPC_HUMAN	HNRNPC	physical	26186194
DDX31_HUMAN	DDX31	physical	26186194
NVL_HUMAN	NVL	physical	26186194
YTDC1_HUMAN	YTHDC1	physical	26186194
RALY_HUMAN	RALY	physical	26186194
DICER_HUMAN	DICER1	physical	26186194
RPF2_HUMAN	RPF2	physical	26186194
ANM6_HUMAN	PRMT6	physical	26186194
NOC2L_HUMAN	NOC2L	physical	26186194
RMXL1_HUMAN	RBMXL1	physical	26186194
CENPV_HUMAN	CENPV	physical	26186194
PTCD1_HUMAN	PTCD1	physical	26186194
PAIP1_HUMAN	PAIP1	physical	26186194
IMP4_HUMAN	IMP4	physical	26186194
PRKRA_HUMAN	PRKRA	physical	26186194
ZNF22_HUMAN	ZNF22	physical	26186194
TRBP2_HUMAN	TARBP2	physical	26186194
PRP17_HUMAN	CDC40	physical	26186194
LAGE3_HUMAN	LAGE3	physical	26344197
SPTN2_HUMAN	SPTBN2	physical	26344197
TRI27_HUMAN	TRIM27	physical	21516116
ZFR_HUMAN	ZFR	physical	28514442
ILF3_HUMAN	ILF3	physical	28514442
RMXL1_HUMAN	RBMXL1	physical	28514442
PUM2_HUMAN	PUM2	physical	28514442
HNRPR_HUMAN	HNRNPR	physical	28514442
PRKRA_HUMAN	PRKRA	physical	28514442
ANM6_HUMAN	PRMT6	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
HNRPC_HUMAN	HNRNPC	physical	28514442
CENPV_HUMAN	CENPV	physical	28514442
RALY_HUMAN	RALY	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
IF2B3_HUMAN	IGF2BP3	physical	28514442
TRBP2_HUMAN	TARBP2	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
ZCHC3_HUMAN	ZCCHC3	physical	28514442
KNOP1_HUMAN	KNOP1	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
IMP4_HUMAN	IMP4	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	26472337
ILF3_HUMAN	ILF3	physical	26472337

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ILF2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-388, AND MASSSPECTROMETRY.	17525332 [Abstract]