dbPTM

ELAV2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ELAV2_HUMAN
UniProt AC	Q12926
Protein Name	ELAV-like protein 2
Gene Name	ELAVL2
Organism	Homo sapiens (Human).
Sequence Length	359
Subcellular Localization
Protein Description	Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR..
Protein Sequence	METQLSNGPTCNNTANGPTTINNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--METQLSNGPTCNN --CCCCCCCCCCCCC	29.89	22210691
10	Phosphorylation	TQLSNGPTCNNTANG CCCCCCCCCCCCCCC	29.30	28348404
14	Phosphorylation	NGPTCNNTANGPTTI CCCCCCCCCCCCCEE	13.91	28348404
19	Phosphorylation	NNTANGPTTINNNCS CCCCCCCCEECCCCC	41.53	22210691
20	Phosphorylation	NTANGPTTINNNCSS CCCCCCCEECCCCCC	25.49	22210691
26	Phosphorylation	TTINNNCSSPVDSGN CEECCCCCCCCCCCC	39.54	28348404
27	Phosphorylation	TINNNCSSPVDSGNT EECCCCCCCCCCCCC	31.01	28348404
51	Phosphorylation	NYLPQNMTQEELKSL ECCCCCCCHHHHHHH	40.14	-
74 (in isoform 2)	Ubiquitination	-	31.44	21890473
74	Ubiquitination	SCKLVRDKITGQSLG HCEEECCCCCCCCCC	31.44	-
74 (in isoform 1)	Ubiquitination	-	31.44	21890473
95	Ubiquitination	IDPKDAEKAINTLNG CCHHHHHHHHHHHHC	57.18	-
95 (in isoform 1)	Ubiquitination	-	57.18	21890473
95 (in isoform 2)	Ubiquitination	-	57.18	21890473
99	Phosphorylation	DAEKAINTLNGLRLQ HHHHHHHHHHCCEEE	18.58	-
111	Ubiquitination	RLQTKTIKVSYARPS EEEEEEEEEEEECCC	30.29	-
113	Phosphorylation	QTKTIKVSYARPSSA EEEEEEEEEECCCCC	14.20	24117733
114	Phosphorylation	TKTIKVSYARPSSAS EEEEEEEEECCCCCC	15.04	-
118	Phosphorylation	KVSYARPSSASIRDA EEEEECCCCCCCCCC	32.74	24117733
119	Phosphorylation	VSYARPSSASIRDAN EEEECCCCCCCCCCC	28.81	24117733
121	Phosphorylation	YARPSSASIRDANLY EECCCCCCCCCCCEE	21.80	24117733
135	Phosphorylation	YVSGLPKTMTQKELE EECCCCCCCCHHHHH	24.42	30631047
137	Phosphorylation	SGLPKTMTQKELEQL CCCCCCCCHHHHHHH	41.54	30622161
146	Phosphorylation	KELEQLFSQYGRIIT HHHHHHHHHHHHHHH	30.96	30622161
148	Phosphorylation	LEQLFSQYGRIITSR HHHHHHHHHHHHHHH	13.74	30622161
153	Phosphorylation	SQYGRIITSRILVDQ HHHHHHHHHHHHHHH	15.02	24719451
154	Phosphorylation	QYGRIITSRILVDQV HHHHHHHHHHHHHHH	13.60	24719451
162	Phosphorylation	RILVDQVTGISRGVG HHHHHHHHCCCCCCC	24.14	21406692
165	Phosphorylation	VDQVTGISRGVGFIR HHHHHCCCCCCCEEE	25.07	24719451
209	Ubiquitination	FANNPSQKTNQAILS ECCCCCHHHHHHHHH	54.50	2189047
209 (in isoform 1)	Ubiquitination	-	54.50	21890473
209 (in isoform 2)	Ubiquitination	-	54.50	21890473
216	Phosphorylation	KTNQAILSQLYQSPN HHHHHHHHHHHCCCC	16.42	21406692
219	Phosphorylation	QAILSQLYQSPNRRY HHHHHHHHCCCCCCC	10.17	21406692
221	Phosphorylation	ILSQLYQSPNRRYPG HHHHHHCCCCCCCCC	15.58	7972035
315	Ubiquitination	IRDFNTNKCKGFGFV EEECCCCCCCCEEEE	34.97	-
323	Phosphorylation	CKGFGFVTMTNYDEA CCCEEEEEECCHHHH	18.93	-
336	Phosphorylation	EAAMAIASLNGYRLG HHHHHHHHHCCCCCC	19.09	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ELAV2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ELAV2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ELAV2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROAA_HUMAN	HNRNPAB	physical	20211142
HXC9_HUMAN	HOXC9	physical	20211142
NR2E3_HUMAN	NR2E3	physical	20211142
RFOX2_HUMAN	RBFOX2	physical	20211142
ELAV3_HUMAN	ELAVL3	physical	28514442
RMXL1_HUMAN	RBMXL1	physical	28514442
RPC8_HUMAN	POLR3H	physical	28514442
RBM45_HUMAN	RBM45	physical	28514442
PUM2_HUMAN	PUM2	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
HNRC1_HUMAN	HNRNPCL1	physical	28514442
SAFB2_HUMAN	SAFB2	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
YBOX2_HUMAN	YBX2	physical	28514442
ZC11A_HUMAN	ZC3H11A	physical	28514442
RALY_HUMAN	RALY	physical	28514442
GCFC2_HUMAN	GCFC2	physical	28514442
ABC3F_HUMAN	APOBEC3F	physical	28514442
YTDC1_HUMAN	YTHDC1	physical	28514442
CLK2_HUMAN	CLK2	physical	28514442
RBMS2_HUMAN	RBMS2	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
PUM1_HUMAN	PUM1	physical	28514442
CARF_HUMAN	CDKN2AIP	physical	28514442
PAI2B_HUMAN	PAIP2B	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
AQR_HUMAN	AQR	physical	28514442
SUV3_HUMAN	SUPV3L1	physical	28514442
CASC3_HUMAN	CASC3	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
C19L1_HUMAN	CWF19L1	physical	28514442
ABC3B_HUMAN	APOBEC3B	physical	28514442
CCDC9_HUMAN	CCDC9	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442
PHAX_HUMAN	PHAX	physical	28514442
SRSF8_HUMAN	SRSF8	physical	28514442
HNRPC_HUMAN	HNRNPC	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
CLK3_HUMAN	CLK3	physical	28514442
ZFR_HUMAN	ZFR	physical	28514442
LAR1B_HUMAN	LARP1B	physical	28514442
SUGP2_HUMAN	SUGP2	physical	28514442
ATX2_HUMAN	ATXN2	physical	28514442
IREB2_HUMAN	IREB2	physical	28514442
ILF2_HUMAN	ILF2	physical	28514442
PAIP1_HUMAN	PAIP1	physical	28514442
NCBP3_HUMAN	C17orf85	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
PININ_HUMAN	PNN	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
ZCH18_HUMAN	ZC3H18	physical	28514442
ZN346_HUMAN	ZNF346	physical	28514442
HNRL2_HUMAN	HNRNPUL2	physical	28514442
GTPB3_HUMAN	GTPBP3	physical	28514442
ZCHC3_HUMAN	ZCCHC3	physical	28514442
IF2B3_HUMAN	IGF2BP3	physical	28514442
ZN326_HUMAN	ZNF326	physical	28514442
SAFB1_HUMAN	SAFB	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
HNRPR_HUMAN	HNRNPR	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
PABP4_HUMAN	PABPC4	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
RBMX_HUMAN	RBMX	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442
RO60_HUMAN	TROVE2	physical	28514442
PRKRA_HUMAN	PRKRA	physical	28514442
SRSF1_HUMAN	SRSF1	physical	28514442
MKRN2_HUMAN	MKRN2	physical	28514442
IF2B1_HUMAN	IGF2BP1	physical	28514442
TRA2B_HUMAN	TRA2B	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
ALG13_HUMAN	ALG13	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
PABP1_HUMAN	PABPC1	physical	28514442
MATR3_HUMAN	MATR3	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
IF2B2_HUMAN	IGF2BP2	physical	28514442
RNPS1_HUMAN	RNPS1	physical	28514442
HNRPL_HUMAN	HNRNPL	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
SRS10_HUMAN	SRSF10	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442
HNRPQ_HUMAN	SYNCRIP	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ELAV2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND MASSSPECTROMETRY.	18669648 [Abstract]