dbPTM

ACINU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACINU_HUMAN
UniProt AC	Q9UKV3
Protein Name	Apoptotic chromatin condensation inducer in the nucleus
Gene Name	ACIN1
Organism	Homo sapiens (Human).
Sequence Length	1341
Subcellular Localization	Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Protein Description	Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells..
Protein Sequence	MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPAVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MWRRKHPRTSGG ---CCCCCCCCCCCC	49.76	17370265
8	Dimethylation	MWRRKHPRTSGGTRG CCCCCCCCCCCCCCC	41.04	-
8	Methylation	MWRRKHPRTSGGTRG CCCCCCCCCCCCCCC	41.04	-
9	Phosphorylation	WRRKHPRTSGGTRGV CCCCCCCCCCCCCCC	35.85	30108239
10	Phosphorylation	RRKHPRTSGGTRGVL CCCCCCCCCCCCCCC	36.18	30108239
13	Phosphorylation	HPRTSGGTRGVLSGN CCCCCCCCCCCCCCC	27.98	30108239
14	Dimethylation	PRTSGGTRGVLSGNR CCCCCCCCCCCCCCC	36.18	-
14	Methylation	PRTSGGTRGVLSGNR CCCCCCCCCCCCCCC	36.18	-
15 (in isoform 3)	Phosphorylation	-	25.26	28787133
18	Phosphorylation	GGTRGVLSGNRGVEY CCCCCCCCCCCCCEE	31.45	23312004
18 (in isoform 3)	Phosphorylation	-	31.45	28787133
29	Dimethylation	GVEYGSGRGHLGTFE CCEECCCCCCCCCCC	30.93	-
29	Methylation	GVEYGSGRGHLGTFE CCEECCCCCCCCCCC	30.93	-
65 (in isoform 3)	Ubiquitination	-	4.74	21890473
66	Phosphorylation	MAELEEVTLDGKPLQ HEEEEEEECCCCCCE	23.55	28122231
73 (in isoform 3)	Ubiquitination	-	47.05	21890473
81	Malonylation	ALRVTDLKAALEQRG EEEHHHHHHHHHHCC	34.13	26320211
81	Methylation	ALRVTDLKAALEQRG EEEHHHHHHHHHHCC	34.13	-
81	Ubiquitination	ALRVTDLKAALEQRG EEEHHHHHHHHHHCC	34.13	-
87	Methylation	LKAALEQRGLAKSGQ HHHHHHHCCCCCCCC	32.49	-
96	Phosphorylation	LAKSGQKSALVKRLK CCCCCCHHHHHHHHH	20.96	22817900
96 (in isoform 2)	Ubiquitination	-	20.96	21890473
103	Ubiquitination	SALVKRLKGALMLEN HHHHHHHHHHHHHHH	46.28	21890473
103	Methylation	SALVKRLKGALMLEN HHHHHHHHHHHHHHH	46.28	-
103	Ubiquitination	SALVKRLKGALMLEN HHHHHHHHHHHHHHH	46.28	21890473
103 (in isoform 1)	Ubiquitination	-	46.28	21890473
103 (in isoform 3)	Ubiquitination	-	46.28	21890473
104 (in isoform 2)	Ubiquitination	-	28.65	21890473
107	Sulfoxidation	KRLKGALMLENLQKH HHHHHHHHHHHHHHC	4.35	21406390
113	Trimethylation	LMLENLQKHSTPHAA HHHHHHHHCCCCCHH	42.56	-
113	Methylation	LMLENLQKHSTPHAA HHHHHHHHCCCCCHH	42.56	-
115	Phosphorylation	LENLQKHSTPHAAFQ HHHHHHCCCCCHHCC	51.15	23401153
116	Phosphorylation	ENLQKHSTPHAAFQP HHHHHCCCCCHHCCC	20.86	25159151
125	Phosphorylation	HAAFQPNSQIGEEMS CHHCCCCCHHCHHHH	29.83	23401153
132	Phosphorylation	SQIGEEMSQNSFIKQ CHHCHHHHCHHHHHH	29.50	23401153
134 (in isoform 2)	Ubiquitination	-	31.42	21890473
135	Phosphorylation	GEEMSQNSFIKQYLE CHHHHCHHHHHHHHH	22.25	23401153
138	Ubiquitination	MSQNSFIKQYLEKQQ HHCHHHHHHHHHHHH	30.77	-
143	Ubiquitination	FIKQYLEKQQELLRQ HHHHHHHHHHHHHHH	55.47	21890473
143	Trimethylation	FIKQYLEKQQELLRQ HHHHHHHHHHHHHHH	55.47	-
143	Acetylation	FIKQYLEKQQELLRQ HHHHHHHHHHHHHHH	55.47	26051181
143	Methylation	FIKQYLEKQQELLRQ HHHHHHHHHHHHHHH	55.47	-
143	Ubiquitination	FIKQYLEKQQELLRQ HHHHHHHHHHHHHHH	55.47	21890473
143 (in isoform 1)	Ubiquitination	-	55.47	21890473
166	Phosphorylation	AAELEEASAESEDEM HHHHHHHHCCCCCCC	35.53	20164059
169	Phosphorylation	LEEASAESEDEMIHP HHHHHCCCCCCCCCC	50.49	20164059
176	Phosphorylation	SEDEMIHPEGVASLL CCCCCCCCCHHHHHC	29.16	24719451
181	Phosphorylation	IHPEGVASLLPPDFQ CCCCHHHHHCCCCHH	28.21	29496963
189	Phosphorylation	LLPPDFQSSLERPEL HCCCCHHHHHCCCHH	36.56	23909892
190	Phosphorylation	LPPDFQSSLERPELE CCCCHHHHHCCCHHH	24.38	23909892
199	Phosphorylation	ERPELELSRHSPRKS CCCHHHHHCCCCCCC	20.69	23909892
202	Phosphorylation	ELELSRHSPRKSSSI HHHHHCCCCCCCCCC	25.86	26074081
206	Phosphorylation	SRHSPRKSSSISEEK HCCCCCCCCCCCCCC	30.51	23927012
207	Phosphorylation	RHSPRKSSSISEEKG CCCCCCCCCCCCCCC	34.42	23927012
208	Phosphorylation	HSPRKSSSISEEKGD CCCCCCCCCCCCCCC	36.91	23927012
210	Phosphorylation	PRKSSSISEEKGDSD CCCCCCCCCCCCCCC	41.47	23927012
216	Phosphorylation	ISEEKGDSDDEKPRK CCCCCCCCCCCCCCC	56.48	29255136
228	Phosphorylation	PRKGERRSSRVRQAR CCCCCCHHHHHHHHH	28.81	22817900
229	Phosphorylation	RKGERRSSRVRQARA CCCCCHHHHHHHHHH	32.74	22817900
238	Acetylation	VRQARAAKLSEGSQP HHHHHHHHHCCCCCC	52.11	23954790
240	Phosphorylation	QARAAKLSEGSQPAE HHHHHHHCCCCCCCC	38.92	29255136
243	Phosphorylation	AAKLSEGSQPAEEEE HHHHCCCCCCCCHHC	29.01	29255136
254	Phosphorylation	EEEEDQETPSRNLRV CHHCCCCCCCHHHHH	22.41	29255136
256	Phosphorylation	EEDQETPSRNLRVRA HCCCCCCCHHHHHHH	41.02	29255136
268	Acetylation	VRADRNLKTEEEEEE HHHHHCCCCHHHHHH	58.39	26051181
268	Sumoylation	VRADRNLKTEEEEEE HHHHHCCCCHHHHHH	58.39	25114211
269	Phosphorylation	RADRNLKTEEEEEEE HHHHCCCCHHHHHHH	52.36	21712546
295	Phosphorylation	GDDEGQKSREAPILK CCCHHHHHHCCHHHH	27.71	25159151
302	Ubiquitination	SREAPILKEFKEEGE HHCCHHHHHHHHCCC	62.92	21890473
302	Ubiquitination	SREAPILKEFKEEGE HHCCHHHHHHHHCCC	62.92	21890473
302 (in isoform 1)	Ubiquitination	-	62.92	21890473
305	Sumoylation	APILKEFKEEGEEIP CHHHHHHHHCCCCCC	56.82	28112733
315	Sumoylation	GEEIPRVKPEEMMDE CCCCCCCCHHHHCCC	48.25	-
315	Acetylation	GEEIPRVKPEEMMDE CCCCCCCCHHHHCCC	48.25	26051181
315	Sumoylation	GEEIPRVKPEEMMDE CCCCCCCCHHHHCCC	48.25	28112733
326	Phosphorylation	MMDERPKTRSQEQEV HCCCCCCCHHHHHHH	37.93	25159151
328	Phosphorylation	DERPKTRSQEQEVLE CCCCCCHHHHHHHHH	43.21	22167270
336	Methylation	QEQEVLERGGRFTRS HHHHHHHHCCCCCCC	49.02	-
341	Phosphorylation	LERGGRFTRSQEEAR HHHCCCCCCCHHHHH	28.22	26853621
343	Phosphorylation	RGGRFTRSQEEARKS HCCCCCCCHHHHHHH	38.60	23403867
350	Phosphorylation	SQEEARKSHLARQQQ CHHHHHHHHHHHHHH	20.41	29214152
359	Acetylation	LARQQQEKEMKTTSP HHHHHHHHHHCCCCC	59.79	23749302
363	Phosphorylation	QQEKEMKTTSPLEEE HHHHHHCCCCCHHHH	31.06	23401153
364	Phosphorylation	QEKEMKTTSPLEEEE HHHHHCCCCCHHHHH	23.87	29255136
365	Phosphorylation	EKEMKTTSPLEEEER HHHHCCCCCHHHHHH	32.49	19664994
375	Sumoylation	EEEEREIKSSQGLKE HHHHHHHHHHHCHHH	39.02	28112733
376	Phosphorylation	EEEREIKSSQGLKEK HHHHHHHHHHCHHHH	33.29	23898821
377	Phosphorylation	EEREIKSSQGLKEKS HHHHHHHHHCHHHHC	24.22	23403867
384	Phosphorylation	SQGLKEKSKSPSPPR HHCHHHHCCCCCCCC	39.18	23927012
386	Phosphorylation	GLKEKSKSPSPPRLT CHHHHCCCCCCCCCC	37.39	23927012
388	Phosphorylation	KEKSKSPSPPRLTED HHHCCCCCCCCCCCH	55.41	23927012
393	Phosphorylation	SPSPPRLTEDRKKAS CCCCCCCCCHHHHHE	36.80	25159151
400	Phosphorylation	TEDRKKASLVALPEQ CCHHHHHEEEECCCC	32.05	29255136
408	Phosphorylation	LVALPEQTASEEETP EEECCCCCCCCCCCC	30.41	29255136
410	Phosphorylation	ALPEQTASEEETPPP ECCCCCCCCCCCCCC	49.26	29255136
414	Phosphorylation	QTASEEETPPPLLTK CCCCCCCCCCCCCCC	44.36	29255136
420	Phosphorylation	ETPPPLLTKEASSPP CCCCCCCCCCCCCCC	34.22	29255136
424	Phosphorylation	PLLTKEASSPPPHPQ CCCCCCCCCCCCCCC	44.46	22496350
425	Phosphorylation	LLTKEASSPPPHPQL CCCCCCCCCCCCCCC	48.77	17287340
434	Phosphorylation	PPHPQLHSEEEIEPM CCCCCCCCHHHCCCC	56.12	18669648
453	Phosphorylation	PAVLIQLSPPNTDAD CEEEEECCCCCCCCC	23.18	20363803
453 (in isoform 2)	Phosphorylation	-	23.18	-
457	Phosphorylation	IQLSPPNTDADTREL EECCCCCCCCCHHHH	38.04	26074081
461	Phosphorylation	PPNTDADTRELLVSQ CCCCCCCHHHHHHHH	27.97	35585803
467	Phosphorylation	DTRELLVSQHTVQLV CHHHHHHHHHHHHCC	19.06	23927012
470	Phosphorylation	ELLVSQHTVQLVGGL HHHHHHHHHHCCCCC	11.43	30278072
478	Phosphorylation	VQLVGGLSPLSSPSD HHCCCCCCCCCCCCC	27.37	29255136
481	Phosphorylation	VGGLSPLSSPSDTKA CCCCCCCCCCCCCCC	43.52	23927012
482	Phosphorylation	GGLSPLSSPSDTKAE CCCCCCCCCCCCCCC	35.79	23927012
484	Phosphorylation	LSPLSSPSDTKAESP CCCCCCCCCCCCCCC	60.92	30266825
486	Phosphorylation	PLSSPSDTKAESPAE CCCCCCCCCCCCCCH	36.17	30266825
490	Phosphorylation	PSDTKAESPAEKVPE CCCCCCCCCCHHCCH	33.98	29255136
499	Phosphorylation	AEKVPEESVLPLVQK CHHCCHHHHHHHHHH	27.56	30278072
506	Ubiquitination	SVLPLVQKSTLADYS HHHHHHHHHHHHCHH	37.62	-
507	Phosphorylation	VLPLVQKSTLADYSA HHHHHHHHHHHCHHC	16.15	26074081
508	Phosphorylation	LPLVQKSTLADYSAQ HHHHHHHHHHCHHCC	32.76	26074081
512	Phosphorylation	QKSTLADYSAQKDLE HHHHHHCHHCCCCCC	10.57	18669648
513	Phosphorylation	KSTLADYSAQKDLEP HHHHHCHHCCCCCCC	25.44	25159151
516	Acetylation	LADYSAQKDLEPESD HHCHHCCCCCCCCCC	65.09	25953088
516	Ubiquitination	LADYSAQKDLEPESD HHCHHCCCCCCCCCC	65.09	-
522	Phosphorylation	QKDLEPESDRSAQPL CCCCCCCCCCCCCCC	49.38	30576142
524	Methylation	DLEPESDRSAQPLPL CCCCCCCCCCCCCCC	43.07	-
525	Phosphorylation	LEPESDRSAQPLPLK CCCCCCCCCCCCCCC	35.92	63708635
532	Sumoylation	SAQPLPLKIEELALA CCCCCCCCHHHHHHH	46.24	-
532	Acetylation	SAQPLPLKIEELALA CCCCCCCCHHHHHHH	46.24	25953088
532	Sumoylation	SAQPLPLKIEELALA CCCCCCCCHHHHHHH	46.24	28112733
540	Acetylation	IEELALAKGITEECL HHHHHHHCCCCHHHH	52.26	26051181
540	Ubiquitination	IEELALAKGITEECL HHHHHHHCCCCHHHH	52.26	-
546	Glutathionylation	AKGITEECLKQPSLE HCCCCHHHHHCCCCC	4.72	22555962
548	Acetylation	GITEECLKQPSLEQK CCCHHHHHCCCCCCC	72.35	26051181
548	Ubiquitination	GITEECLKQPSLEQK CCCHHHHHCCCCCCC	72.35	-
551	Phosphorylation	EECLKQPSLEQKEGR HHHHHCCCCCCCCCC	41.88	23401153
555	Acetylation	KQPSLEQKEGRRASH HCCCCCCCCCCCCHH	53.40	26051181
561	Phosphorylation	QKEGRRASHTLLPSH CCCCCCCHHCCCCHH	18.39	29255136
563	Phosphorylation	EGRRASHTLLPSHRL CCCCCHHCCCCHHHH	27.74	25463755
567	Phosphorylation	ASHTLLPSHRLKQSA CHHCCCCHHHHHCCC	22.62	24732914
581	Phosphorylation	ADSSSSRSSSSSSSS CCCCCCCCCCCCCCC	36.20	26552605
582	Phosphorylation	DSSSSRSSSSSSSSS CCCCCCCCCCCCCCC	32.88	26552605
583	Phosphorylation	SSSSRSSSSSSSSSR CCCCCCCCCCCCCCC	35.17	26552605
584	Phosphorylation	SSSRSSSSSSSSSRS CCCCCCCCCCCCCCC	35.87	30576142
585	Phosphorylation	SSRSSSSSSSSSRSR CCCCCCCCCCCCCCC	35.87	26552605
586	Phosphorylation	SRSSSSSSSSSRSRS CCCCCCCCCCCCCCC	35.87	30576142
587	Phosphorylation	RSSSSSSSSSRSRSR CCCCCCCCCCCCCCC	33.99	24260401
588	Phosphorylation	SSSSSSSSSRSRSRS CCCCCCCCCCCCCCC	31.55	30576142
589	Phosphorylation	SSSSSSSSRSRSRSP CCCCCCCCCCCCCCC	35.90	30576142
593	Phosphorylation	SSSSRSRSRSPDSSG CCCCCCCCCCCCCCC	38.05	21406692
595	Phosphorylation	SSRSRSRSPDSSGSR CCCCCCCCCCCCCCC	34.01	30242111
598	Phosphorylation	SRSRSPDSSGSRSHS CCCCCCCCCCCCCCC	39.73	20363803
599	Phosphorylation	RSRSPDSSGSRSHSP CCCCCCCCCCCCCCC	48.44	20363803
601	Phosphorylation	RSPDSSGSRSHSPLR CCCCCCCCCCCCCCH	32.34	20363803
603	Phosphorylation	PDSSGSRSHSPLRSK CCCCCCCCCCCCHHH	29.98	20363803
604 (in isoform 2)	Phosphorylation	-	32.12	-
605	Phosphorylation	SSGSRSHSPLRSKQR CCCCCCCCCCHHHHH	27.20	23927012
609	Phosphorylation	RSHSPLRSKQRDVAQ CCCCCCHHHHHHHHH	40.60	21406692
631	Phosphorylation	RGRPKMGSRSTSESR CCCCCCCCCCCCHHH	21.40	20860994
633	Phosphorylation	RPKMGSRSTSESRSR CCCCCCCCCCHHHHH	37.67	28102081
634	Phosphorylation	PKMGSRSTSESRSRS CCCCCCCCCHHHHHH	35.09	20860994
635	Phosphorylation	KMGSRSTSESRSRSR CCCCCCCCHHHHHHH	34.52	68721451
637	Phosphorylation	GSRSTSESRSRSRSR CCCCCCHHHHHHHHH	35.01	68721453
643	Phosphorylation	ESRSRSRSRSRSASS HHHHHHHHHCCCCCC	35.54	23312004
645	Phosphorylation	RSRSRSRSRSASSNS HHHHHHHCCCCCCCC	31.65	23312004
647	Phosphorylation	RSRSRSRSASSNSRK HHHHHCCCCCCCCCC	33.48	23663014
649	Phosphorylation	RSRSRSASSNSRKSL HHHCCCCCCCCCCCC	31.16	23663014
650	Phosphorylation	SRSRSASSNSRKSLS HHCCCCCCCCCCCCC	38.24	23663014
652	Phosphorylation	SRSASSNSRKSLSPG CCCCCCCCCCCCCCC	42.93	23663014
654	"N6,N6,N6-trimethyllysine"	SASSNSRKSLSPGVS CCCCCCCCCCCCCCC	56.41	-
654	Methylation	SASSNSRKSLSPGVS CCCCCCCCCCCCCCC	56.41	18438403
655	Phosphorylation	ASSNSRKSLSPGVSR CCCCCCCCCCCCCCC	32.73	29255136
657	O-linked_Glycosylation	SNSRKSLSPGVSRDS CCCCCCCCCCCCCCC	27.05	23301498
657	Phosphorylation	SNSRKSLSPGVSRDS CCCCCCCCCCCCCCC	27.05	29255136
661	O-linked_Glycosylation	KSLSPGVSRDSSTSY CCCCCCCCCCCCCCC	35.96	23301498
661	Phosphorylation	KSLSPGVSRDSSTSY CCCCCCCCCCCCCCC	35.96	30266825
664	Phosphorylation	SPGVSRDSSTSYTET CCCCCCCCCCCCEEC	34.11	25159151
665	Phosphorylation	PGVSRDSSTSYTETK CCCCCCCCCCCEECC	26.17	25159151
666	Phosphorylation	GVSRDSSTSYTETKD CCCCCCCCCCEECCC	29.70	25159151
667	Phosphorylation	VSRDSSTSYTETKDP CCCCCCCCCEECCCC	31.82	25159151
668	Phosphorylation	SRDSSTSYTETKDPS CCCCCCCCEECCCCC	14.53	21712546
669	Phosphorylation	RDSSTSYTETKDPSS CCCCCCCEECCCCCC	36.62	21712546
671	Phosphorylation	SSTSYTETKDPSSGQ CCCCCEECCCCCCCC	32.71	28102081
672	Acetylation	STSYTETKDPSSGQE CCCCEECCCCCCCCE	62.50	26051181
675	Phosphorylation	YTETKDPSSGQEVAT CEECCCCCCCCEECC	58.18	29255136
676	Phosphorylation	TETKDPSSGQEVATP EECCCCCCCCEECCC	50.30	29255136
682	Phosphorylation	SSGQEVATPPVPQLQ CCCCEECCCCCCCCE	33.05	29255136
697	Phosphorylation	VCEPKERTSTSSSSV ECCCCCCCCCCCHHH	37.13	25159151
698	Phosphorylation	CEPKERTSTSSSSVQ CCCCCCCCCCCHHHH	32.29	25159151
699	Phosphorylation	EPKERTSTSSSSVQA CCCCCCCCCCHHHHH	31.83	27794612
700	Phosphorylation	PKERTSTSSSSVQAR CCCCCCCCCHHHHHH	28.17	28450419
701	Phosphorylation	KERTSTSSSSVQARR CCCCCCCCHHHHHHH	27.07	28450419
702	Phosphorylation	ERTSTSSSSVQARRL CCCCCCCHHHHHHHH	34.00	29978859
703	Phosphorylation	RTSTSSSSVQARRLS CCCCCCHHHHHHHHC	21.87	29978859
710	Phosphorylation	SVQARRLSQPESAEK HHHHHHHCCCHHHHH	41.71	29255136
714	Phosphorylation	RRLSQPESAEKHVTQ HHHCCCHHHHHHHHH	48.70	29255136
717	Acetylation	SQPESAEKHVTQRLQ CCCHHHHHHHHHHCC	42.99	19608861
720	Phosphorylation	ESAEKHVTQRLQPER HHHHHHHHHHCCCCC	14.00	23927012
729	Phosphorylation	RLQPERGSPKKCEAE HCCCCCCCCCCCCCC	39.50	22167270
732	Sumoylation	PERGSPKKCEAEEAE CCCCCCCCCCCCCCC	40.46	28112733
733	Glutathionylation	ERGSPKKCEAEEAEP CCCCCCCCCCCCCCC	8.17	22555962
744	Phosphorylation	EAEPPAATQPQTSET CCCCCCCCCCCCCCC	42.77	24732914
748	Phosphorylation	PAATQPQTSETQTSH CCCCCCCCCCCCCCC	34.90	24732914
749	Phosphorylation	AATQPQTSETQTSHL CCCCCCCCCCCCCCC	33.14	24732914
751	Phosphorylation	TQPQTSETQTSHLPE CCCCCCCCCCCCCCH	36.59	24732914
753	Phosphorylation	PQTSETQTSHLPESE CCCCCCCCCCCCHHH	26.07	24732914
754	Phosphorylation	QTSETQTSHLPESER CCCCCCCCCCCHHHH	17.14	24732914
759	Phosphorylation	QTSHLPESERIHHTV CCCCCCHHHHCCCCC	30.18	24732914
776	Phosphorylation	KEEVTMDTSENRPEN CCCEECCCCCCCCCC	27.41	28555341
797	Phosphorylation	MPIADQVSNDDRPEG CCHHHHCCCCCCCCC	28.98	28348404
805	Phosphorylation	NDDRPEGSVEDEEKK CCCCCCCCCCHHHHH	22.22	28348404
814	Phosphorylation	EDEEKKESSLPKSFK CHHHHHHHCCCHHHH	46.16	20068231
815	Phosphorylation	DEEKKESSLPKSFKR HHHHHHHCCCHHHHH	50.19	17287340
815 (in isoform 5)	Phosphorylation	-	50.19	25849741
818	Ubiquitination	KKESSLPKSFKRKIS HHHHCCCHHHHHCEE	74.04	-
819	Phosphorylation	KESSLPKSFKRKISV HHHCCCHHHHHCEEE	33.78	23401153
823	Ubiquitination	LPKSFKRKISVVSAT CCHHHHHCEEEEEEC	39.67	21890473
823 (in isoform 1)	Ubiquitination	-	39.67	21890473
825	Phosphorylation	KSFKRKISVVSATKG HHHHHCEEEEEECCC	21.36	23927012
825 (in isoform 5)	Phosphorylation	-	21.36	30266825
828	Phosphorylation	KRKISVVSATKGVPA HHCEEEEEECCCCCC	28.23	30266825
828 (in isoform 5)	Phosphorylation	-	28.23	30266825
829 (in isoform 5)	Phosphorylation	-	11.17	23927012
830	Ubiquitination	KISVVSATKGVPAGN CEEEEEECCCCCCCC	22.33	21890473
830	Phosphorylation	KISVVSATKGVPAGN CEEEEEECCCCCCCC	22.33	30266825
831	Acetylation	ISVVSATKGVPAGNS EEEEEECCCCCCCCC	58.59	26051181
831	Ubiquitination	ISVVSATKGVPAGNS EEEEEECCCCCCCCC	58.59	21890473
831 (in isoform 1)	Ubiquitination	-	58.59	21890473
837	Phosphorylation	TKGVPAGNSDTEGGQ CCCCCCCCCCCCCCC	38.53	24719451
837 (in isoform 5)	Phosphorylation	-	38.53	25849741
838	Phosphorylation	KGVPAGNSDTEGGQP CCCCCCCCCCCCCCC	45.02	29255136
839 (in isoform 5)	Phosphorylation	-	53.42	29507054
840	Phosphorylation	VPAGNSDTEGGQPGR CCCCCCCCCCCCCCC	36.03	22167270
854	Phosphorylation	RKRRWGASTATTQKK CCCCCCCCCCCCCCC	18.03	23312004
855	Phosphorylation	KRRWGASTATTQKKP CCCCCCCCCCCCCCC	27.73	23312004
857	Phosphorylation	RWGASTATTQKKPSI CCCCCCCCCCCCCCE	29.82	23312004
858	Phosphorylation	WGASTATTQKKPSIS CCCCCCCCCCCCCEE	35.61	23312004
860	Ubiquitination	ASTATTQKKPSISIT CCCCCCCCCCCEEEE	65.64	21890473
860	Acetylation	ASTATTQKKPSISIT CCCCCCCCCCCEEEE	65.64	25953088
860	Ubiquitination	ASTATTQKKPSISIT CCCCCCCCCCCEEEE	65.64	-
861	Acetylation	STATTQKKPSISITT CCCCCCCCCCEEEEH	33.89	26051181
861	Sumoylation	STATTQKKPSISITT CCCCCCCCCCEEEEH	33.89	28112733
861	Ubiquitination	STATTQKKPSISITT CCCCCCCCCCEEEEH	33.89	21890473
861 (in isoform 1)	Ubiquitination	-	33.89	21890473
862 (in isoform 5)	Phosphorylation	-	43.88	29116813
863	Phosphorylation	ATTQKKPSISITTES CCCCCCCCEEEEHHH	37.54	25159151
864	Phosphorylation	TTQKKPSISITTESL CCCCCCCEEEEHHHH	4.72	24719451
864 (in isoform 5)	Phosphorylation	-	4.72	25627689
865	Phosphorylation	TQKKPSISITTESLK CCCCCCEEEEHHHHH	20.44	30266825
867	Phosphorylation	KKPSISITTESLKSL CCCCEEEEHHHHHHH	20.09	30266825
868	Phosphorylation	KPSISITTESLKSLI CCCEEEEHHHHHHHC	23.16	29691806
869 (in isoform 5)	Phosphorylation	-	45.48	25627689
870	O-linked_Glycosylation	SISITTESLKSLIPD CEEEEHHHHHHHCCC	38.72	23301498
870	Phosphorylation	SISITTESLKSLIPD CEEEEHHHHHHHCCC	38.72	20873877
873	Phosphorylation	ITTESLKSLIPDIKP EEHHHHHHHCCCCHH	36.50	23403867
879	Sumoylation	KSLIPDIKPLAGQEA HHHCCCCHHHCCCEE	41.16	28112733
882	Phosphorylation	IPDIKPLAGQEAVVD CCCCHHHCCCEEEEE	26.59	27251275
882 (in isoform 5)	Phosphorylation	-	26.59	25849741
885	Phosphorylation	IKPLAGQEAVVDLHA CHHHCCCEEEEECCC	42.38	24719451
885 (in isoform 5)	Phosphorylation	-	42.38	25849741
889	Phosphorylation	AGQEAVVDLHADDSR CCCEEEEECCCCCCC	26.58	27251275
895	Phosphorylation	VDLHADDSRISEDET EECCCCCCCCCCCHH	31.87	22167270
898	Phosphorylation	HADDSRISEDETERN CCCCCCCCCCHHHHC	37.57	29255136
902	Phosphorylation	SRISEDETERNGDDG CCCCCCHHHHCCCCC	53.20	30266825
910	Phosphorylation	ERNGDDGTHDKGLKI HHCCCCCCCCHHHHE	33.62	30576142
913	Acetylation	GDDGTHDKGLKICRT CCCCCCCHHHHEEEE	59.55	25953088
963	Phosphorylation	VEVALPPPAEHEVKK EEEECCCCCCCCCEE	48.63	24719451
968	Phosphorylation	PPPAEHEVKKVTLGD CCCCCCCCEEEECCC	8.63	24719451
970	Phosphorylation	PAEHEVKKVTLGDTL CCCCCCEEEECCCHH	45.70	24719451
970	Sumoylation	PAEHEVKKVTLGDTL CCCCCCEEEECCCHH	45.70	28112733
972	Phosphorylation	EHEVKKVTLGDTLTR CCCCEEEECCCHHHH	33.62	23403867
974	Phosphorylation	EVKKVTLGDTLTRRS CCEEEECCCHHHHCC	19.25	24719451
976	Phosphorylation	KKVTLGDTLTRRSIS EEEECCCHHHHCCHH	28.38	23401153
977	Phosphorylation	KVTLGDTLTRRSISQ EEECCCHHHHCCHHC	4.11	24719451
978	Phosphorylation	VTLGDTLTRRSISQQ EECCCHHHHCCHHCC	26.57	25159151
981	Phosphorylation	GDTLTRRSISQQKSG CCHHHHCCHHCCCCC	24.25	25159151
983	Phosphorylation	TLTRRSISQQKSGVS HHHHCCHHCCCCCCE	28.01	23401153
986	Ubiquitination	RRSISQQKSGVSITI HCCHHCCCCCCEEEE	41.35	-
987	Phosphorylation	RSISQQKSGVSITID CCHHCCCCCCEEEEC	39.84	30266825
990	Phosphorylation	SQQKSGVSITIDDPV HCCCCCCEEEECCCC	19.96	23401153
991	Phosphorylation	QQKSGVSITIDDPVR CCCCCCEEEECCCCE	3.48	24719451
992	Phosphorylation	QKSGVSITIDDPVRT CCCCCEEEECCCCEE	15.73	30183078
999	Phosphorylation	TIDDPVRTAQVPSPP EECCCCEECCCCCCC	22.98	23927012
1004	Phosphorylation	VRTAQVPSPPRGKIS CEECCCCCCCCCCCC	48.99	19664994
1009	Acetylation	VPSPPRGKISNIVHI CCCCCCCCCCCEEEH	44.21	25953088
1029	Ubiquitination	PFTLGQLKELLGRTG CCCHHHHHHHHCCCC	38.13	-
1047	Acetylation	EEAFWIDKIKSHCFV HHHHHHHHHHHCEEE	42.79	26051181
1047	Sumoylation	EEAFWIDKIKSHCFV HHHHHHHHHHHCEEE	42.79	28112733
1047	Ubiquitination	EEAFWIDKIKSHCFV HHHHHHHHHHHCEEE	42.79	-
1049	2-Hydroxyisobutyrylation	AFWIDKIKSHCFVTY HHHHHHHHHCEEEEE	39.63	-
1049	Malonylation	AFWIDKIKSHCFVTY HHHHHHHHHCEEEEE	39.63	26320211
1052	Glutathionylation	IDKIKSHCFVTYSTV HHHHHHCEEEEECHH	3.66	22555962
1073	Acetylation	RTALHGVKWPQSNPK HHHHCCCCCCCCCCC	58.72	26051181
1080	Acetylation	KWPQSNPKFLCADYA CCCCCCCCEEECCHH	56.04	26051181
1083	Glutathionylation	QSNPKFLCADYAEQD CCCCCEEECCHHHHC	2.81	22555962
1094	Phosphorylation	AEQDELDYHRGLLVD HHHCCCCCCCCCCCC	13.17	26074081
1104	Phosphorylation	GLLVDRPSETKTEEQ CCCCCCCCCCCCCCC	59.81	30266825
1106	Phosphorylation	LVDRPSETKTEEQGI CCCCCCCCCCCCCCC	47.83	30266825
1107	Sumoylation	VDRPSETKTEEQGIP CCCCCCCCCCCCCCC	50.30	28112733
1108	Phosphorylation	DRPSETKTEEQGIPR CCCCCCCCCCCCCCC	52.77	28122231
1159	Phosphorylation	EMERRERTRSEREWD HHHHHHHHHHHHHHH	33.52	23186163
1161	Phosphorylation	ERRERTRSEREWDRD HHHHHHHHHHHHHHH	40.15	23401153
1176	Phosphorylation	KVREGPRSRSRSRDR HHHCCCCCCHHHHHH	37.43	26074081
1178	Phosphorylation	REGPRSRSRSRDRRR HCCCCCCHHHHHHHH	35.54	20068231
1180	Phosphorylation	GPRSRSRSRDRRRKE CCCCCHHHHHHHHHH	39.52	25218447
1209	Ubiquitination	AQEEPPAKLLDDLFR HHHCCCHHHHHHHHH	56.19	2063986
1219	Acetylation	DDLFRKTKAAPCIYW HHHHHHHCCCCEEEE	45.66	26051181
1219	Phosphorylation	DDLFRKTKAAPCIYW HHHHHHHCCCCEEEE	45.66	24719451
1219	Ubiquitination	DDLFRKTKAAPCIYW HHHHHHHCCCCEEEE	45.66	-
1223	Glutathionylation	RKTKAAPCIYWLPLT HHHCCCCEEEEEECC	2.98	22555962
1225	Phosphorylation	TKAAPCIYWLPLTDS HCCCCEEEEEECCHH	13.96	28796482
1230	Phosphorylation	CIYWLPLTDSQIVQK EEEEEECCHHHHHHH	31.50	63772419
1232	Phosphorylation	YWLPLTDSQIVQKEA EEEECCHHHHHHHHH	19.30	46157711
1237	Acetylation	TDSQIVQKEAERAER CHHHHHHHHHHHHHH	48.25	26051181
1237	Ubiquitination	TDSQIVQKEAERAER CHHHHHHHHHHHHHH	48.25	-
1253	Methylation	KEREKRRKEQEEEEQ HHHHHHHHHHHHHHH	68.71	-
1284	Phosphorylation	REKRREHSRERDRER HHHHHHHHHHHHHHH	30.96	20068231
1314	Phosphorylation	ERDRERGRERDRRDT HHHHHHHHHHHHHHH	41.83	24719451
1316	Phosphorylation	DRERGRERDRRDTKR HHHHHHHHHHHHHHH	41.18	24719451
1318	Phosphorylation	ERGRERDRRDTKRHS HHHHHHHHHHHHHHH	44.59	24719451
1325	Phosphorylation	RRDTKRHSRSRSRST HHHHHHHHHHCCCCC	35.66	20068231
1327	Phosphorylation	DTKRHSRSRSRSTPV HHHHHHHHCCCCCCC	37.31	20068231
1329	Phosphorylation	KRHSRSRSRSTPVRD HHHHHHCCCCCCCCC	31.65	26055452
1331	Phosphorylation	HSRSRSRSTPVRDRG HHHHCCCCCCCCCCC	38.01	26055452
1332	Phosphorylation	SRSRSRSTPVRDRGG HHHCCCCCCCCCCCC	25.37	26055452

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1180	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
1180	S	Phosphorylation	Kinase	SRPK2	P78362	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1180	S	Phosphorylation		18559500
Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACINU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNPS1_HUMAN	RNPS1	physical	22388736
SAP18_HUMAN	SAP18	physical	22388736
SAP18_HUMAN	SAP18	physical	22939629
SPF27_HUMAN	BCAS2	physical	22939629
SMU1_HUMAN	SMU1	physical	22939629
DHX9_HUMAN	DHX9	physical	22939629
DHX15_HUMAN	DHX15	physical	22939629
DDX17_HUMAN	DDX17	physical	22939629
PRP6_HUMAN	PRPF6	physical	22939629
SF3A1_HUMAN	SF3A1	physical	22939629
PYM1_HUMAN	WIBG	physical	22939629
CGAT1_HUMAN	CSGALNACT1	physical	22939629
SEPT7_HUMAN	SEPT7	physical	22939629
SRP14_HUMAN	SRP14	physical	22939629
MIRO2_HUMAN	RHOT2	physical	22939629
BET1_HUMAN	BET1	physical	22939629
FUT8_HUMAN	FUT8	physical	22939629
DRS7B_HUMAN	DHRS7B	physical	22939629
TR112_HUMAN	TRMT112	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
RRP7A_HUMAN	RRP7A	physical	22939629
ATP7A_HUMAN	ATP7A	physical	22939629
SEPT2_HUMAN	SEPT2	physical	22939629
AP180_HUMAN	SNAP91	physical	22939629
ARMX3_HUMAN	ARMCX3	physical	22939629
CAV1_HUMAN	CAV1	physical	22939629
EVPL_HUMAN	EVPL	physical	22939629
S10A9_HUMAN	S100A9	physical	22939629
KPCA_HUMAN	PRKCA	physical	22939629
SMC1A_HUMAN	SMC1A	physical	22939629
BOP1_HUMAN	BOP1	physical	22939629
PTCD3_HUMAN	PTCD3	physical	22939629
TR150_HUMAN	THRAP3	physical	22939629
LGMN_HUMAN	LGMN	physical	22939629
NFIA_HUMAN	NFIA	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
RCC1_HUMAN	RCC1	physical	22939629
SAFB1_HUMAN	SAFB	physical	22939629
SON_HUMAN	SON	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
NDUF4_HUMAN	NDUFAF4	physical	22939629
RNPS1_HUMAN	RNPS1	physical	22365833
SRPK2_HUMAN	SRPK2	physical	22365833
RNPS1_HUMAN	RNPS1	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RS13_HUMAN	RPS13	physical	26344197
SAFB1_HUMAN	SAFB	physical	26344197
SAP18_HUMAN	SAP18	physical	26344197
4F2_HUMAN	SLC3A2	physical	26344197
SRRM2_HUMAN	SRRM2	physical	26344197
SSRP1_HUMAN	SSRP1	physical	26344197
TCP4_HUMAN	SUB1	physical	26344197
ZCH18_HUMAN	ZC3H18	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACINU_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-717, AND MASS SPECTROMETRY.	19608861 [Abstract]
Methylation
Reference	PubMed
"Protein lysine methyltransferase G9a acts on non-histone targets."; Rathert P., Dhayalan A., Murakami M., Zhang X., Tamas R.,Jurkowska R., Komatsu Y., Shinkai Y., Cheng X., Jeltsch A.; Nat. Chem. Biol. 4:344-346(2008). Cited for: METHYLATION AT LYS-654, AND MASS SPECTROMETRY.	18438403 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-243; THR-254;THR-269; SER-328; SER-365; SER-400; THR-408; SER-410; THR-414;SER-478; SER-490; SER-838; SER-987; SER-990 AND SER-1004, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; THR-408; SER-410;THR-414; SER-655; SER-657; SER-664; SER-675; SER-676; THR-682;SER-825; SER-838; THR-840 AND SER-1004, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-169; SER-216;SER-240; SER-243; THR-254; THR-269; SER-295; SER-328; SER-365;SER-384; SER-386; SER-388; THR-393; SER-410; THR-414; SER-425;SER-434; SER-453; SER-490; TYR-512; SER-561; SER-655; SER-657;THR-682; SER-710; SER-714; THR-720; SER-838 AND SER-1004, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710, AND MASSSPECTROMETRY.	19367720 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; SER-425; SER-434;SER-453; SER-895; SER-898 AND SER-1004, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Serine/arginine protein-specific kinase 2 promotes leukemia cellproliferation by phosphorylating acinus and regulating cyclin A1."; Jang S.W., Yang S.J., Ehlen A., Dong S., Khoury H., Chen J.,Persson J.L., Ye K.; Cancer Res. 68:4559-4570(2008). Cited for: FUNCTION, PHOSPHORYLATION AT SER-1180 BY SRPK2, INTERACTION WITHSRPK2, AND SUBCELLULAR LOCATION.	18559500 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; SER-365; SER-657AND SER-661, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208; SER-216; SER-228;SER-229; THR-254; SER-256; SER-384; SER-386; SER-388; SER-425;SER-561; SER-710; SER-729; SER-814; SER-815; THR-830; SER-838;THR-976; THR-978; SER-981; SER-983; SER-1176; SER-1178 AND SER-1180,AND MASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710; SER-714; SER-729AND SER-1004, AND MASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; THR-682 ANDSER-1004, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-240; SER-243;SER-328; SER-365; SER-384; SER-386; THR-393; THR-408; SER-410;SER-490; SER-655; SER-657; SER-710; SER-729; SER-1004; SER-1176;SER-1178 AND SER-1284, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-388 ANDSER-710, AND MASS SPECTROMETRY.	16083285 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-243; SER-365;SER-386; SER-388; THR-414; SER-657; SER-661; SER-676; THR-682 ANDSER-1004, AND MASS SPECTROMETRY.	15302935 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-5, AND MASS SPECTROMETRY.	17370265 [Abstract]

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