SON_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SON_HUMAN
• UniProt AC: P18583
• Protein Name: Protein SON
• Gene Name: SON
• Organism: Homo sapiens (Human).
• Sequence Length: 2426
• Subcellular Localization: Nucleus speckle . Colocalizes with the pre-mRNA splicing factor SRSF2.
• Protein Description: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1. [PubMed: 27545680]
• Protein Sequence: MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSEPVDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRKGLVAVGERAQKRSGNFSAAMKDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRKHFLFRVLRNGALTRPNCMFFLNRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATNIEQIF ------CCCCHHHHH	22.21	22814378
3	Phosphorylation	-----MATNIEQIFR -----CCCCHHHHHH	48.89	20164059
10	Methylation	TNIEQIFRSFVVSKF CCHHHHHHHHHHHHH	30.71	115384383
11	Phosphorylation	NIEQIFRSFVVSKFR CHHHHHHHHHHHHHH	16.19	24719451
16	Acetylation	FRSFVVSKFREIQQE HHHHHHHHHHHHHHH	36.51	19608861
16	Ubiquitination	FRSFVVSKFREIQQE HHHHHHHHHHHHHHH	36.51	21890473
16 (in isoform 1)	Ubiquitination	-	36.51	21890473
16 (in isoform 10)	Ubiquitination	-	36.51	21890473
16 (in isoform 2)	Ubiquitination	-	36.51	21890473
16 (in isoform 3)	Ubiquitination	-	36.51	21890473
16 (in isoform 4)	Ubiquitination	-	36.51	21890473
16 (in isoform 5)	Ubiquitination	-	36.51	21890473
16 (in isoform 6)	Ubiquitination	-	36.51	21890473
16 (in isoform 7)	Ubiquitination	-	36.51	21890473
16 (in isoform 8)	Ubiquitination	-	36.51	21890473
16 (in isoform 9)	Ubiquitination	-	36.51	21890473
16	Ubiquitination	FRSFVVSKFREIQQE HHHHHHHHHHHHHHH	36.51	21890473
37	Phosphorylation	EGQLNGETNTPIEGN CCCCCCCCCCCCCCC	45.87	30108239
39	Phosphorylation	QLNGETNTPIEGNQA CCCCCCCCCCCCCCH	32.82	26462736
52	Phosphorylation	QAGDAAASARSLPNE CHHHHHHHHCCCCCH	21.35	21601212
55	Phosphorylation	DAAASARSLPNEEIV HHHHHHCCCCCHHHH	48.14	30108239
64	Sumoylation	PNEEIVQKIEEVLSG CCHHHHHHHHHHHHC	40.99	28112733
64	Ubiquitination	PNEEIVQKIEEVLSG CCHHHHHHHHHHHHC	40.99	-
75	Phosphorylation	VLSGVLDTELRYKPD HHHCCCCCCCCCCCC	32.53	28674151
80	Acetylation	LDTELRYKPDLKEGS CCCCCCCCCCCCCCC	26.14	26051181
80	Ubiquitination	LDTELRYKPDLKEGS CCCCCCCCCCCCCCC	26.14	-
80 (in isoform 5)	Ubiquitination	-	26.14	-
84	Ubiquitination	LRYKPDLKEGSRKSR CCCCCCCCCCCCCCC	68.37	-
84 (in isoform 5)	Ubiquitination	-	68.37	-
90	Phosphorylation	LKEGSRKSRCVSVQT CCCCCCCCCCEEEEC	29.78	25159151
94	Phosphorylation	SRKSRCVSVQTDPTD CCCCCCEEEECCCCC	16.48	23927012
97	Phosphorylation	SRCVSVQTDPTDEIP CCCEEEECCCCCCCC	41.62	30266825
100	Phosphorylation	VSVQTDPTDEIPTKK EEEECCCCCCCCCCH	49.42	30266825
105	Phosphorylation	DPTDEIPTKKSKKHK CCCCCCCCCHHHHHH	57.68	23403867
106	Acetylation	PTDEIPTKKSKKHKK CCCCCCCCHHHHHHH	50.09	25953088
117	Acetylation	KHKKHKNKKKKKKKE HHHHHCCHHHHHHHH	71.43	19666589
129	Phosphorylation	KKEKEKKYKRQPEES HHHHHHHHCCCCCCC	23.59	-
136	Phosphorylation	YKRQPEESESKTKSH HCCCCCCCCCCCCCC	45.57	28985074
140	Phosphorylation	PEESESKTKSHDDGN CCCCCCCCCCCCCCC	47.24	30266825
141	Ubiquitination	EESESKTKSHDDGNI CCCCCCCCCCCCCCC	49.91	-
142	Phosphorylation	ESESKTKSHDDGNID CCCCCCCCCCCCCCC	37.06	30266825
152	Phosphorylation	DGNIDLESDSFLKFD CCCCCCCCCCEEECC	45.94	25159151
154	Phosphorylation	NIDLESDSFLKFDSE CCCCCCCCEEECCCC	41.58	23927012
160	Phosphorylation	DSFLKFDSEPSAVAL CCEEECCCCCCCEEE	55.32	29255136
163	Phosphorylation	LKFDSEPSAVALELP EECCCCCCCEEEECC	31.18	28464451
171	Phosphorylation	AVALELPTRAFGPSE CEEEECCCCCCCCCC	47.45	24732914
177	Phosphorylation	PTRAFGPSETNESPA CCCCCCCCCCCCCCC	58.39	25850435
179	Phosphorylation	RAFGPSETNESPAVV CCCCCCCCCCCCCEE	48.93	25850435
182	Phosphorylation	GPSETNESPAVVLEP CCCCCCCCCCEEECC	21.89	25159151
193	Phosphorylation	VLEPPVVSMEVSEPH EECCCEEEEEECCCH	14.95	28122231
197	Phosphorylation	PVVSMEVSEPHILET CEEEEEECCCHHHHH	31.91	28122231
206	Acetylation	PHILETLKPATKTAE CHHHHHCCCCCCEEE	39.77	26051181
211	Phosphorylation	TLKPATKTAELSVVS HCCCCCCEEEEEEEE	22.47	28122231
215	Phosphorylation	ATKTAELSVVSTSVI CCCEEEEEEEEEHHC	16.39	28122231
218	Phosphorylation	TAELSVVSTSVISEQ EEEEEEEEEHHCCCC	16.89	28122231
219	Phosphorylation	AELSVVSTSVISEQS EEEEEEEEHHCCCCC	18.53	28122231
220	Phosphorylation	ELSVVSTSVISEQSE EEEEEEEHHCCCCCC	15.22	28122231
223	Phosphorylation	VVSTSVISEQSEQSV EEEEHHCCCCCCCCE	27.68	28122231
226	Phosphorylation	TSVISEQSEQSVAVM EHHCCCCCCCCEEEC	33.29	28122231
229	Phosphorylation	ISEQSEQSVAVMPEP CCCCCCCCEEECCCC	14.16	28122231
237	Phosphorylation	VAVMPEPSMTKILDS EEECCCCHHHHHHHH	37.10	28122231
239	Phosphorylation	VMPEPSMTKILDSFA ECCCCHHHHHHHHHH	21.19	28122231
244	O-linked_Glycosylation	SMTKILDSFAAAPVP HHHHHHHHHHCCCCC	17.22	20068230
252	O-linked_Glycosylation	FAAAPVPTTTLVLKS HHCCCCCEEEEEEEC	32.42	20068230
252	Phosphorylation	FAAAPVPTTTLVLKS HHCCCCCEEEEEEEC	32.42	27461979
253	O-linked_Glycosylation	AAAPVPTTTLVLKSS HCCCCCEEEEEEECC	16.44	20068230
253	Phosphorylation	AAAPVPTTTLVLKSS HCCCCCEEEEEEECC	16.44	27461979
254	O-linked_Glycosylation	AAPVPTTTLVLKSSE CCCCCEEEEEEECCC	19.83	20068230
259	Phosphorylation	TTTLVLKSSEPVVTM EEEEEEECCCCEEEE	35.45	20068231
260	O-linked_Glycosylation	TTLVLKSSEPVVTMS EEEEEECCCCEEEEE	44.31	20068230
260	Phosphorylation	TTLVLKSSEPVVTMS EEEEEECCCCEEEEE	44.31	30576142
265	O-linked_Glycosylation	KSSEPVVTMSVEYQM ECCCCEEEEEEEEHH	12.17	20068230
265	Phosphorylation	KSSEPVVTMSVEYQM ECCCCEEEEEEEEHH	12.17	30576142
267	Phosphorylation	SEPVVTMSVEYQMKS CCCEEEEEEEEHHHH	11.48	20068231
270	Phosphorylation	VVTMSVEYQMKSVLK EEEEEEEEHHHHHHH	16.26	30576142
274	Phosphorylation	SVEYQMKSVLKSVES EEEEHHHHHHHHHHC	27.60	24732914
277	Acetylation	YQMKSVLKSVESTSP EHHHHHHHHHHCCCC	50.75	25953088
277	Ubiquitination	YQMKSVLKSVESTSP EHHHHHHHHHHCCCC	50.75	-
278	Phosphorylation	QMKSVLKSVESTSPE HHHHHHHHHHCCCCC	27.27	23927012
281	Phosphorylation	SVLKSVESTSPEPSK HHHHHHHCCCCCCCC	31.84	23401153
282	Phosphorylation	VLKSVESTSPEPSKI HHHHHHCCCCCCCCE	34.49	29255136
283	Phosphorylation	LKSVESTSPEPSKIM HHHHHCCCCCCCCEE	36.22	29255136
287	Phosphorylation	ESTSPEPSKIMLVEP HCCCCCCCCEEEECC	32.90	30266825
288	Acetylation	STSPEPSKIMLVEPP CCCCCCCCEEEECCC	42.73	19608861
288	Ubiquitination	STSPEPSKIMLVEPP CCCCCCCCEEEECCC	42.73	-
303	Phosphorylation	VAKVLEPSETLVVSS CEEEECCCCEEEEEC	33.56	20068231
305	Phosphorylation	KVLEPSETLVVSSET EEECCCCEEEEECCC	29.23	29978859
309	Phosphorylation	PSETLVVSSETPTEV CCCEEEEECCCCCCC	18.25	26657352
310	Phosphorylation	SETLVVSSETPTEVY CCEEEEECCCCCCCC	33.60	29978859
312	Phosphorylation	TLVVSSETPTEVYPE EEEEECCCCCCCCCC	37.14	29978859
314	Phosphorylation	VVSSETPTEVYPEPS EEECCCCCCCCCCCC	45.57	29978859
317	Phosphorylation	SETPTEVYPEPSTST CCCCCCCCCCCCCCC	8.81	29978859
321	Phosphorylation	TEVYPEPSTSTTMDF CCCCCCCCCCCCCCC	33.07	29978859
322	Phosphorylation	EVYPEPSTSTTMDFP CCCCCCCCCCCCCCC	40.59	29978859
323	Phosphorylation	VYPEPSTSTTMDFPE CCCCCCCCCCCCCCC	26.64	29978859
324	Phosphorylation	YPEPSTSTTMDFPES CCCCCCCCCCCCCCH	26.65	29978859
325	Phosphorylation	PEPSTSTTMDFPESS CCCCCCCCCCCCCHH	17.95	29978859
331	Phosphorylation	TTMDFPESSAIEALR CCCCCCCHHHHHHHC	25.88	20068231
332	Phosphorylation	TMDFPESSAIEALRL CCCCCCHHHHHHHCC	31.44	20068231
348	Phosphorylation	EQPVDVPSEIADSSM CCCCCCCHHHCCCCC	41.29	21712546
353	Phosphorylation	VPSEIADSSMTRPQE CCHHHCCCCCCCCHH	17.00	25159151
354	O-linked_Glycosylation	PSEIADSSMTRPQEL CHHHCCCCCCCCHHC	25.39	20068230
354	Phosphorylation	PSEIADSSMTRPQEL CHHHCCCCCCCCHHC	25.39	25159151
356	Phosphorylation	EIADSSMTRPQELPE HHCCCCCCCCHHCCC	40.94	23663014
400	Phosphorylation	ELQGPPVTPVLELPG HHCCCCCCCCEECCC	17.29	26074081
442	Phosphorylation	VPELPGPSVTPVPQL CCCCCCCCCCCCCCH	44.53	26074081
444	Phosphorylation	ELPGPSVTPVPQLSQ CCCCCCCCCCCCHHH	23.94	26074081
543	Phosphorylation	LLGQPEATMVLELPG CCCCCEEEEEEECCC	13.22	22468782
555	Phosphorylation	LPGQPVATTALELPG CCCCCEEEEEEECCC	16.91	22468782
702	O-linked_Glycosylation	LVGETSVTVGVDPLM ECCCEEEEECCCCCC	16.00	20068230
738	Phosphorylation	MDSQMLASNTMDSQM CCHHHHHHCCCCHHH	28.95	20068231
748	Phosphorylation	MDSQMLASNTMDSQM CCHHHHHHCCCCHHH	28.95	20068231
763	O-linked_Glycosylation	LASSTMDSQMLATSS HHHCCCCHHHHHCCC	13.48	20068230
868	Phosphorylation	MDSQMLASGTMDSQM CCHHHHHCCCCCHHH	30.73	19007248
908	Phosphorylation	QDSAMLGSKSPDPYR CCHHHCCCCCCCHHH	26.46	26074081
910	Phosphorylation	SAMLGSKSPDPYRLA HHHCCCCCCCHHHHC	35.91	22167270
914	Phosphorylation	GSKSPDPYRLAQDPY CCCCCCHHHHCCCHH	26.16	26074081
921	Phosphorylation	YRLAQDPYRLAQDPY HHHCCCHHHHHCCCC	26.92	25839225
922	Methylation	RLAQDPYRLAQDPYR HHCCCHHHHHCCCCC	29.00	115391821
928	Phosphorylation	YRLAQDPYRLGHDPY HHHHCCCCCCCCCCC	27.10	26356563
929	Methylation	RLAQDPYRLGHDPYR HHHCCCCCCCCCCCC	39.31	80701841
935	Phosphorylation	YRLGHDPYRLGHDAY CCCCCCCCCCCCCHH	25.24	26356563
936	Methylation	RLGHDPYRLGHDAYR CCCCCCCCCCCCHHH	39.31	54559517
942	Phosphorylation	YRLGHDAYRLGQDPY CCCCCCHHHCCCCCC	16.66	-
943	Methylation	RLGHDAYRLGQDPYR CCCCCHHHCCCCCCC	33.78	54559533
949	Phosphorylation	YRLGQDPYRLGHDPY HHCCCCCCCCCCCCC	27.10	28152594
950	Methylation	RLGQDPYRLGHDPYR HCCCCCCCCCCCCCC	39.31	24129315
956	Phosphorylation	YRLGHDPYRLTPDPY CCCCCCCCCCCCCCC	25.06	23403867
957	Methylation	RLGHDPYRLTPDPYR CCCCCCCCCCCCCCC	37.16	80701849
959	Phosphorylation	GHDPYRLTPDPYRMS CCCCCCCCCCCCCCC	19.35	23401153
963	Phosphorylation	YRLTPDPYRMSPRPY CCCCCCCCCCCCCCC	26.74	23403867
964	Methylation	RLTPDPYRMSPRPYR CCCCCCCCCCCCCCC	25.21	80701833
966	Phosphorylation	TPDPYRMSPRPYRIA CCCCCCCCCCCCCCC	14.57	28555341
968	Methylation	DPYRMSPRPYRIAPR CCCCCCCCCCCCCCC	33.31	115917517
970	Phosphorylation	YRMSPRPYRIAPRSY CCCCCCCCCCCCCCC	18.87	-
971	Methylation	RMSPRPYRIAPRSYR CCCCCCCCCCCCCCC	22.67	115917521
976	Phosphorylation	PYRIAPRSYRIAPRP CCCCCCCCCCCCCCC	20.08	18669648
978	Methylation	RIAPRSYRIAPRPYR CCCCCCCCCCCCCCC	21.60	115917525
982	Methylation	RSYRIAPRPYRLAPR CCCCCCCCCCCCCCH	31.68	115917529
985	Methylation	RIAPRPYRLAPRPLM CCCCCCCCCCCHHHH	27.36	115917533
989	Dimethylation	RPYRLAPRPLMLASR CCCCCCCHHHHHHHH	31.23	-
989	Methylation	RPYRLAPRPLMLASR CCCCCCCHHHHHHHH	31.23	52718075
997	Methylation	PLMLASRRSMMMSYA HHHHHHHHHHHHHHH	26.80	54559549
998	Phosphorylation	LMLASRRSMMMSYAA HHHHHHHHHHHHHHH	19.77	23401153
1002	Phosphorylation	SRRSMMMSYAAERSM HHHHHHHHHHHHHHH	8.17	29978859
1003	Phosphorylation	RRSMMMSYAAERSMM HHHHHHHHHHHHHHH	7.61	29978859
1007	Asymmetric dimethylarginine	MMSYAAERSMMSSYE HHHHHHHHHHHHHHH	25.73	-
1007	Methylation	MMSYAAERSMMSSYE HHHHHHHHHHHHHHH	25.73	83445965
1008	Phosphorylation	MSYAAERSMMSSYER HHHHHHHHHHHHHHH	15.44	23663014
1011	Phosphorylation	AAERSMMSSYERSMM HHHHHHHHHHHHHHH	22.56	23663014
1012	Phosphorylation	AERSMMSSYERSMMS HHHHHHHHHHHHHHH	17.08	23663014
1013	Phosphorylation	ERSMMSSYERSMMSY HHHHHHHHHHHHHHH	14.19	23663014
1015	Methylation	SMMSSYERSMMSYER HHHHHHHHHHHHHHH	22.94	30761115
1016	Phosphorylation	MMSSYERSMMSYERS HHHHHHHHHHHHHHH	13.59	23663014
1019	Phosphorylation	SYERSMMSYERSMMS HHHHHHHHHHHHHCC	18.39	23663014
1020	Phosphorylation	YERSMMSYERSMMSP HHHHHHHHHHHHCCH	9.47	23663014
1022	Asymmetric dimethylarginine	RSMMSYERSMMSPMA HHHHHHHHHHCCHHH	22.94	-
1022	Methylation	RSMMSYERSMMSPMA HHHHHHHHHHCCHHH	22.94	80701825
1023	Phosphorylation	SMMSYERSMMSPMAE HHHHHHHHHCCHHHH	13.59	29255136
1026	Phosphorylation	SYERSMMSPMAERSM HHHHHHCCHHHHHHH	11.68	29255136
1031	Methylation	MMSPMAERSMMSAYE HCCHHHHHHHHHHHH	21.95	-
1032	Phosphorylation	MSPMAERSMMSAYER CCHHHHHHHHHHHHH	15.44	30108239
1035	Phosphorylation	MAERSMMSAYERSMM HHHHHHHHHHHHHHH	21.03	30108239
1037	Phosphorylation	ERSMMSAYERSMMSA HHHHHHHHHHHHHHH	12.45	17360941
1039	Methylation	SMMSAYERSMMSAYE HHHHHHHHHHHHHHH	19.71	30761121
1040	Phosphorylation	MMSAYERSMMSAYER HHHHHHHHHHHHHHH	13.59	23186163
1043	Phosphorylation	AYERSMMSAYERSMM HHHHHHHHHHHHHCC	21.03	30108239
1045	Phosphorylation	ERSMMSAYERSMMSP HHHHHHHHHHHCCCH	12.45	17360941
1047	Methylation	SMMSAYERSMMSPMA HHHHHHHHHCCCHHH	19.71	30761127
1048	Phosphorylation	MMSAYERSMMSPMAE HHHHHHHHCCCHHHH	13.59	29255136
1051	Phosphorylation	AYERSMMSPMAERSM HHHHHCCCHHHHHHH	11.68	29255136
1056	Methylation	MMSPMAERSMMSAYE CCCHHHHHHHHHHHH	21.95	-
1057	Phosphorylation	MSPMAERSMMSAYER CCHHHHHHHHHHHHH	15.44	30108239
1060	Phosphorylation	MAERSMMSAYERSMM HHHHHHHHHHHHHHH	21.03	30108239
1062	Phosphorylation	ERSMMSAYERSMMSA HHHHHHHHHHHHHHH	12.45	17360941
1064	Methylation	SMMSAYERSMMSAYE HHHHHHHHHHHHHHH	19.71	30761133
1065	Phosphorylation	MMSAYERSMMSAYER HHHHHHHHHHHHHHH	13.59	23186163
1068	Phosphorylation	AYERSMMSAYERSMM HHHHHHHHHHHHHCC	21.03	30108239
1070	Phosphorylation	ERSMMSAYERSMMSP HHHHHHHHHHHCCCC	12.45	17360941
1072	Methylation	SMMSAYERSMMSPMA HHHHHHHHHCCCCCC	19.71	30761139
1073	Phosphorylation	MMSAYERSMMSPMAD HHHHHHHHCCCCCCC	13.59	23403867
1076	Phosphorylation	AYERSMMSPMADRSM HHHHHCCCCCCCHHH	11.68	25159151
1081	Methylation	MMSPMADRSMMSMGA CCCCCCCHHHHHCCC	19.53	83435525
1082	Phosphorylation	MSPMADRSMMSMGAD CCCCCCHHHHHCCCC	21.27	23917254
1085	Phosphorylation	MADRSMMSMGADRSM CCCHHHHHCCCCHHH	12.86	22210691
1090	Methylation	MMSMGADRSMMSSYS HHHCCCCHHHHHHHH	26.39	54559525
1091	O-linked_Glycosylation	MSMGADRSMMSSYSA HHCCCCHHHHHHHHH	21.27	20068230
1091	Phosphorylation	MSMGADRSMMSSYSA HHCCCCHHHHHHHHH	21.27	21815630
1094	Phosphorylation	GADRSMMSSYSAADR CCCHHHHHHHHHHHH	19.92	28796482
1095	Phosphorylation	ADRSMMSSYSAADRS CCHHHHHHHHHHHHH	12.76	28796482
1096	Phosphorylation	DRSMMSSYSAADRSM CHHHHHHHHHHHHHH	8.60	28796482
1097	O-linked_Glycosylation	RSMMSSYSAADRSMM HHHHHHHHHHHHHHH	20.94	20068230
1097	Phosphorylation	RSMMSSYSAADRSMM HHHHHHHHHHHHHHH	20.94	28796482
1101	Methylation	SSYSAADRSMMSSYS HHHHHHHHHHHHHHH	23.02	97818467
1102	Phosphorylation	SYSAADRSMMSSYSA HHHHHHHHHHHHHHH	21.27	21815630
1105	Phosphorylation	AADRSMMSSYSAADR HHHHHHHHHHHHHHH	19.92	28796482
1106	Phosphorylation	ADRSMMSSYSAADRS HHHHHHHHHHHHHHH	12.76	28796482
1107	Phosphorylation	DRSMMSSYSAADRSM HHHHHHHHHHHHHHH	8.60	28796482
1108	Phosphorylation	RSMMSSYSAADRSMM HHHHHHHHHHHHHHH	20.94	28796482
1112	Methylation	SSYSAADRSMMSSYT HHHHHHHHHHHHHHH	23.02	83435429
1113	Phosphorylation	SYSAADRSMMSSYTA HHHHHHHHHHHHHHC	21.27	21815630
1116	Phosphorylation	AADRSMMSSYTADRS HHHHHHHHHHHCCHH	16.14	30576142
1117	Phosphorylation	ADRSMMSSYTADRSM HHHHHHHHHHCCHHH	14.49	30108239
1118	Phosphorylation	DRSMMSSYTADRSMM HHHHHHHHHCCHHHH	9.91	30108239
1119	Phosphorylation	RSMMSSYTADRSMMS HHHHHHHHCCHHHHH	24.83	30108239
1262	Phosphorylation	PESSITLTPVESAVV CCCCEEEEECCEEEE	19.35	26074081
1266	Phosphorylation	ITLTPVESAVVAEEH EEEEECCEEEEEECC	26.97	26074081
1335	Phosphorylation	SLLVPAVTTPVLAES CCCCCCCCCHHHHHH	27.73	26074081
1336	Phosphorylation	LLVPAVTTPVLAESI CCCCCCCCHHHHHHH	12.56	26074081
1378	Phosphorylation	STVTVLESSTVTVLE CEEEEEECCEEEEEC	27.44	19664994
1411	Phosphorylation	TIPVPVVSALEPSVP EECCCCEECCCCCCC	27.63	22468782
1480	Phosphorylation	ILESSIMSSHVMKGI ECHHHHHCCCCCCCC	18.67	24275569
1490	Phosphorylation	VMKGINLSSGDQNLA CCCCCCCCCCCCCCC	27.99	28555341
1491	Phosphorylation	MKGINLSSGDQNLAP CCCCCCCCCCCCCCH	49.94	25627689
1509	Phosphorylation	MQEIALHSGEEPHAE CEEHHHHCCCCCCHH	49.07	30266825
1549	Phosphorylation	AKEMEHNTVCAAGTS EHHHCCCCEEECCCC	20.90	29255136
1555	Phosphorylation	NTVCAAGTSPVGEIG CCEEECCCCCCCCCC	25.73	29255136
1556	Phosphorylation	TVCAAGTSPVGEIGE CEEECCCCCCCCCCC	19.37	29255136
1565	Acetylation	VGEIGEEKILPTSET CCCCCCCCCCCCCCC	45.28	26051181
1569	Phosphorylation	GEEKILPTSETKQRT CCCCCCCCCCCCCCE	35.43	30266825
1570	Phosphorylation	EEKILPTSETKQRTV CCCCCCCCCCCCCEE	41.13	30266825
1572	Phosphorylation	KILPTSETKQRTVLD CCCCCCCCCCCEEEE	32.04	30266825
1573	Ubiquitination	ILPTSETKQRTVLDT CCCCCCCCCCEEEEC	33.46	-
1576	Phosphorylation	TSETKQRTVLDTYPG CCCCCCCEEEECCCC	23.95	26074081
1580	Phosphorylation	KQRTVLDTYPGVSEA CCCEEEECCCCCCHH	27.70	26074081
1581	Phosphorylation	QRTVLDTYPGVSEAD CCEEEECCCCCCHHH	9.54	26074081
1585	Phosphorylation	LDTYPGVSEADAGET EECCCCCCHHHCCCC	32.74	26074081
1592	Phosphorylation	SEADAGETLSSTGPF CHHHCCCCCCCCCCC	30.90	29116813
1594	Phosphorylation	ADAGETLSSTGPFAL HHCCCCCCCCCCCCC	33.02	26074081
1595	Phosphorylation	DAGETLSSTGPFALE HCCCCCCCCCCCCCC	40.26	26074081
1596	Phosphorylation	AGETLSSTGPFALEP CCCCCCCCCCCCCCC	45.56	26074081
1606	Phosphorylation	FALEPDATGTSKGIE CCCCCCCCCCCCCEE	48.66	26074081
1608	Phosphorylation	LEPDATGTSKGIEFT CCCCCCCCCCCEEEE	23.94	26074081
1609	Phosphorylation	EPDATGTSKGIEFTT CCCCCCCCCCEEEEC	30.17	26074081
1626	Phosphorylation	TLSLVNKYDVDLSLT HHHHCCCCCCCCEEE	18.92	27251275
1631	Phosphorylation	NKYDVDLSLTTQDTE CCCCCCCEEECCCCC	21.14	20068231
1633	Phosphorylation	YDVDLSLTTQDTEHD CCCCCEEECCCCCCC	21.02	20873877
1634	Phosphorylation	DVDLSLTTQDTEHDM CCCCEEECCCCCCCE	29.73	20873877
1637	Phosphorylation	LSLTTQDTEHDMVIS CEEECCCCCCCEEEE	25.96	20873877
1644	O-linked_Glycosylation	TEHDMVISTSPSGGS CCCCEEEEECCCCCC	16.06	20068230
1644	Phosphorylation	TEHDMVISTSPSGGS CCCCEEEEECCCCCC	16.06	26657352
1645	Phosphorylation	EHDMVISTSPSGGSE CCCEEEEECCCCCCC	33.27	20873877
1646	Phosphorylation	HDMVISTSPSGGSEA CCEEEEECCCCCCCC	15.41	20873877
1648	Phosphorylation	MVISTSPSGGSEADI EEEEECCCCCCCCCC	56.40	20068231
1651	Phosphorylation	STSPSGGSEADIEGP EECCCCCCCCCCCCC	32.89	25159151
1670	Phosphorylation	DIHLDLPSNNNLVSK EEEEECCCCCCCCCC	60.53	30576142
1676	Phosphorylation	PSNNNLVSKDTEEPL CCCCCCCCCCCCCCC	28.16	24732914
1677	Acetylation	SNNNLVSKDTEEPLP CCCCCCCCCCCCCCC	62.28	26051181
1679	Phosphorylation	NNLVSKDTEEPLPVK CCCCCCCCCCCCCCC	46.08	24732914
1686	Ubiquitination	TEEPLPVKESDQTLA CCCCCCCCCCHHHHH	49.95	-
1688	Phosphorylation	EPLPVKESDQTLAAL CCCCCCCCHHHHHHH	29.33	29255136
1691	Phosphorylation	PVKESDQTLAALLSP CCCCCHHHHHHHHCC	24.29	29255136
1697	Phosphorylation	QTLAALLSPKESSGG HHHHHHHCCCCCCCC	34.47	19664994
1701	Phosphorylation	ALLSPKESSGGEKEV HHHCCCCCCCCCCCC	40.17	30266825
1702	Phosphorylation	LLSPKESSGGEKEVP HHCCCCCCCCCCCCC	52.49	23401153
1706	Acetylation	KESSGGEKEVPPPPK CCCCCCCCCCCCCCC	68.25	25953088
1715	Phosphorylation	VPPPPKETLPDSGFS CCCCCCCCCCCCCCC	50.12	26074081
1719	Phosphorylation	PKETLPDSGFSANIE CCCCCCCCCCCCCCC	39.54	26074081
1722	Phosphorylation	TLPDSGFSANIEDIN CCCCCCCCCCCCCCC	24.75	30108239
1746	Phosphorylation	PKDMERLTSLRAGIE CCHHHHHHHHHCCCC	31.75	28450419
1747	Phosphorylation	KDMERLTSLRAGIEG CHHHHHHHHHCCCCC	22.05	28450419
1759	Phosphorylation	IEGPLLASDVGRDRS CCCCCCHHHCCCCCC	32.57	29255136
1766	Phosphorylation	SDVGRDRSAASPVVS HHCCCCCCCCCCCHH	32.26	29255136
1769	Phosphorylation	GRDRSAASPVVSSMP CCCCCCCCCCHHCCC	20.24	19664994
1773	Phosphorylation	SAASPVVSSMPERAS CCCCCCHHCCCCHHC	22.58	30266825
1774	Phosphorylation	AASPVVSSMPERASE CCCCCHHCCCCHHCC	27.09	30266825
1780	Phosphorylation	SSMPERASESSSEEK HCCCCHHCCCCCCCC	44.20	23927012
1782	Phosphorylation	MPERASESSSEEKDD CCCHHCCCCCCCCCC	36.35	23927012
1783	Phosphorylation	PERASESSSEEKDDY CCHHCCCCCCCCCCE	37.40	25159151
1784	Phosphorylation	ERASESSSEEKDDYE CHHCCCCCCCCCCEE	60.08	23927012
1790	Phosphorylation	SSEEKDDYEIFVKVK CCCCCCCEEEEEEEH	22.51	23927012
1820	Phosphorylation	EKEKKRDSSLRSRSK HHHHHHHHHHHHHHH	34.99	20363803
1821	O-linked_Glycosylation	KEKKRDSSLRSRSKR HHHHHHHHHHHHHHH	31.90	20068230
1821	Phosphorylation	KEKKRDSSLRSRSKR HHHHHHHHHHHHHHH	31.90	30576142
1824	Phosphorylation	KRDSSLRSRSKRSKS HHHHHHHHHHHHHCC	46.31	20363803
1827	Acetylation	SSLRSRSKRSKSSEH HHHHHHHHHHCCHHH	60.63	11925813
1829	Phosphorylation	LRSRSKRSKSSEHKS HHHHHHHHCCHHHHH	40.40	26074081
1831	Phosphorylation	SRSKRSKSSEHKSRK HHHHHHCCHHHHHHH	42.05	26074081
1832	Phosphorylation	RSKRSKSSEHKSRKR HHHHHCCHHHHHHHH	47.67	26074081
1836	Phosphorylation	SKSSEHKSRKRTSES HCCHHHHHHHHHHHH	44.96	26074081
1840	Phosphorylation	EHKSRKRTSESRSRA HHHHHHHHHHHHHHH	39.62	26074081
1841	O-linked_Glycosylation	HKSRKRTSESRSRAR HHHHHHHHHHHHHHH	37.29	20068230
1841	Phosphorylation	HKSRKRTSESRSRAR HHHHHHHHHHHHHHH	37.29	26074081
1843	Phosphorylation	SRKRTSESRSRARKR HHHHHHHHHHHHHHH	35.01	26074081
1854 (in isoform 2)	Ubiquitination	-	41.14	21890473
1856	Phosphorylation	KRSSKSKSHRSQTRS HHHHHCHHHHHHHHH	31.09	26657352
1859	Phosphorylation	SKSKSHRSQTRSRSR HHCHHHHHHHHHHHH	30.40	26657352
1861	Phosphorylation	SKSHRSQTRSRSRSR CHHHHHHHHHHHHHH	31.68	26657352
1885	Phosphorylation	SKSRGRRSVSKEKRK HHHHCCCCCCHHHHH	29.40	26552605
1887	Phosphorylation	SRGRRSVSKEKRKRS HHCCCCCCHHHHHCC	36.02	26552605
1909	Phosphorylation	RERKRKRSSSRDNRK HHHHHHHCCCHHHHH	35.38	28509920
1910	Phosphorylation	ERKRKRSSSRDNRKT HHHHHHCCCHHHHHH	33.16	20068231
1911	Phosphorylation	RKRKRSSSRDNRKTV HHHHHCCCHHHHHHH	44.92	29759185
1922	Phosphorylation	RKTVRARSRTPSRRS HHHHHHHHCCCCHHH	39.25	26657352
1924	Phosphorylation	TVRARSRTPSRRSRS HHHHHHCCCCHHHCC	27.19	20068231
1926	Phosphorylation	RARSRTPSRRSRSHT HHHHCCCCHHHCCCC	39.45	26657352
1929	Phosphorylation	SRTPSRRSRSHTPSR HCCCCHHHCCCCCCH	36.70	20363803
1931	Phosphorylation	TPSRRSRSHTPSRRR CCCHHHCCCCCCHHH	32.72	20363803
1933	Phosphorylation	SRRSRSHTPSRRRRS CHHHCCCCCCHHHCC	24.98	29743597
1935	Phosphorylation	RSRSHTPSRRRRSRS HHCCCCCCHHHCCCC	39.30	26552605
1940	Phosphorylation	TPSRRRRSRSVGRRR CCCHHHCCCCCCCCC	27.39	20363803
1942	Phosphorylation	SRRRRSRSVGRRRSF CHHHCCCCCCCCCCC	30.12	20363803
1948	Phosphorylation	RSVGRRRSFSISPSR CCCCCCCCCCCCCCC	22.87	29255136
1950	Phosphorylation	VGRRRSFSISPSRRS CCCCCCCCCCCCCCC	24.33	29255136
1952	Phosphorylation	RRRSFSISPSRRSRT CCCCCCCCCCCCCCC	18.67	29255136
1954	Phosphorylation	RSFSISPSRRSRTPS CCCCCCCCCCCCCCC	33.27	29255136
1957	Phosphorylation	SISPSRRSRTPSRRS CCCCCCCCCCCCCCC	39.12	26657352
1959	Phosphorylation	SPSRRSRTPSRRSRT CCCCCCCCCCCCCCC	27.19	20068231
1961	Phosphorylation	SRRSRTPSRRSRTPS CCCCCCCCCCCCCCC	39.45	26657352
1964	Phosphorylation	SRTPSRRSRTPSRRS CCCCCCCCCCCCCCC	39.12	26657352
1966	Phosphorylation	TPSRRSRTPSRRSRT CCCCCCCCCCCCCCC	27.19	20068231
1968	Phosphorylation	SRRSRTPSRRSRTPS CCCCCCCCCCCCCCC	39.45	26657352
1971	Phosphorylation	SRTPSRRSRTPSRRS CCCCCCCCCCCCCCC	39.12	26657352
1973	Phosphorylation	TPSRRSRTPSRRSRT CCCCCCCCCCCCCCC	27.19	20068231
1975	Phosphorylation	SRRSRTPSRRSRTPS CCCCCCCCCCCCCCC	39.45	26657352
1978	Phosphorylation	SRTPSRRSRTPSRRS CCCCCCCCCCCCCCC	39.12	26657352
1980	Phosphorylation	TPSRRSRTPSRRSRT CCCCCCCCCCCCCCC	27.19	20068231
1982	Phosphorylation	SRRSRTPSRRSRTPS CCCCCCCCCCCCCCC	39.45	26657352
1985	Phosphorylation	SRTPSRRSRTPSRRS CCCCCCCCCCCCCCC	39.12	26657352
1987	Phosphorylation	TPSRRSRTPSRRSRT CCCCCCCCCCCCCCC	27.19	20068231
1989	Phosphorylation	SRRSRTPSRRSRTPS CCCCCCCCCCCCCCC	39.45	26657352
1992	Phosphorylation	SRTPSRRSRTPSRRR CCCCCCCCCCCCHHH	39.12	26657352
1994	Phosphorylation	TPSRRSRTPSRRRRS CCCCCCCCCCHHHHC	27.19	20068231
1996	Phosphorylation	SRRSRTPSRRRRSRS CCCCCCCCHHHHCHH	37.49	26657352
2001	Phosphorylation	TPSRRRRSRSVVRRR CCCHHHHCHHHHHHH	27.39	20363803
2003	Phosphorylation	SRRRRSRSVVRRRSF CHHHHCHHHHHHHCC	26.64	20363803
2009	Phosphorylation	RSVVRRRSFSISPVR HHHHHHHCCCCCCCC	22.87	29255136
2011	Phosphorylation	VVRRRSFSISPVRLR HHHHHCCCCCCCCCC	24.33	29255136
2013	Phosphorylation	RRRSFSISPVRLRRS HHHCCCCCCCCCCCC	19.02	29255136
2020	Phosphorylation	SPVRLRRSRTPLRRR CCCCCCCCCCCHHHH	33.79	28355574
2022	Phosphorylation	VRLRRSRTPLRRRFS CCCCCCCCCHHHHHC	28.11	28355574
2029	Phosphorylation	TPLRRRFSRSPIRRK CCHHHHHCCCCCCCC	30.00	25463755
2031	Phosphorylation	LRRRFSRSPIRRKRS HHHHHCCCCCCCCHH	24.39	22167270
2046	Phosphorylation	RSSERGRSPKRLTDL CCCCCCCCCCCCCCC	37.28	24719451
2051	Phosphorylation	GRSPKRLTDLDKAQL CCCCCCCCCCCHHHH	38.25	29214152
2055	Acetylation	KRLTDLDKAQLLEIA CCCCCCCHHHHHHHH	45.38	19608861
2055	Sumoylation	KRLTDLDKAQLLEIA CCCCCCCHHHHHHHH	45.38	28112733
2055	Ubiquitination	KRLTDLDKAQLLEIA CCCCCCCHHHHHHHH	45.38	19608861
2063	Acetylation	AQLLEIAKANAAAMC HHHHHHHHHHHHHHH	48.08	26051181
2063	Ubiquitination	AQLLEIAKANAAAMC HHHHHHHHHHHHHHH	48.08	-
2072	Ubiquitination	NAAAMCAKAGVPLPP HHHHHHHHCCCCCCC	40.52	-
2082	Acetylation	VPLPPNLKPAPPPTI CCCCCCCCCCCCCCH	45.86	26051181
2092	Sumoylation	PPPTIEEKVAKKSGG CCCCHHHHHHHHCCC	34.40	28112733
2094 (in isoform 2)	Phosphorylation	-	25.32	28450419
2096	Ubiquitination	IEEKVAKKSGGATIE HHHHHHHHCCCCCHH	44.59	-
2096 (in isoform 2)	Phosphorylation	-	44.59	28450419
2097	Phosphorylation	EEKVAKKSGGATIEE HHHHHHHCCCCCHHH	41.58	25159151
2097 (in isoform 6)	Phosphorylation	-	41.58	25159151
2099 (in isoform 2)	Phosphorylation	-	27.00	28152594
2101	Phosphorylation	AKKSGGATIEELTEK HHHCCCCCHHHHHHH	32.00	23312004
2102 (in isoform 2)	Phosphorylation	-	3.72	21815630
2106	Phosphorylation	GATIEELTEKCKQIA CCCHHHHHHHHHHHH	36.36	22817900
2108	Acetylation	TIEELTEKCKQIAQS CHHHHHHHHHHHHHC	41.31	26051181
2108	Ubiquitination	TIEELTEKCKQIAQS CHHHHHHHHHHHHHC	41.31	-
2115	Phosphorylation	KCKQIAQSKEDDDVI HHHHHHHCCCCCCEE	29.05	23403867
2129	Phosphorylation	IVNKPHVSDEEEEEP EECCCCCCCCCCCCC	35.95	22167270
2133 (in isoform 7)	Ubiquitination	-	66.66	21890473
2139	Phosphorylation	EEEEPPFYHHPFKLS CCCCCCCCCCCCCCC	12.66	22167270
2149	Acetylation	PFKLSEPKPIFFNLN CCCCCCCCCEEEEEE	46.85	26051181
2149	Sumoylation	PFKLSEPKPIFFNLN CCCCCCCCCEEEEEE	46.85	28112733
2161	Acetylation	NLNIAAAKPTPPKSQ EEEEEECCCCCCCHH	44.70	25953088
2161 (in isoform 5)	Ubiquitination	-	44.70	-
2163	Phosphorylation	NIAAAKPTPPKSQVT EEEECCCCCCCHHEE	52.06	25159151
2167	Phosphorylation	AKPTPPKSQVTLTKE CCCCCCCHHEEEEEE	35.34	26074081
2170	Phosphorylation	TPPKSQVTLTKEFPV CCCCHHEEEEEEECC	22.52	26074081
2172	O-linked_Glycosylation	PKSQVTLTKEFPVSS CCHHEEEEEEECCCC	21.11	20068230
2172	Phosphorylation	PKSQVTLTKEFPVSS CCHHEEEEEEECCCC	21.11	27174698
2173	Acetylation	KSQVTLTKEFPVSSG CHHEEEEEEECCCCC	61.54	26051181
2173	Ubiquitination	KSQVTLTKEFPVSSG CHHEEEEEEECCCCC	61.54	2189047
2173 (in isoform 1)	Ubiquitination	-	61.54	21890473
2173 (in isoform 10)	Ubiquitination	-	61.54	21890473
2173 (in isoform 3)	Ubiquitination	-	61.54	21890473
2173 (in isoform 4)	Ubiquitination	-	61.54	21890473
2173 (in isoform 5)	Ubiquitination	-	61.54	21890473
2178	Phosphorylation	LTKEFPVSSGSQHRK EEEEECCCCCCHHCC	29.26	20068231
2179	Phosphorylation	TKEFPVSSGSQHRKK EEEECCCCCCHHCCH	42.57	20068231
2181	Phosphorylation	EFPVSSGSQHRKKEA EECCCCCCHHCCHHH	25.43	20068231
2186	Ubiquitination	SGSQHRKKEADSVYG CCCHHCCHHHCCCCC	59.08	-
2190	Phosphorylation	HRKKEADSVYGEWVP HCCHHHCCCCCCEEE	25.04	28796482
2192	Phosphorylation	KKEADSVYGEWVPVE CHHHCCCCCCEEECC	17.18	28796482
2200	Ubiquitination	GEWVPVEKNGEENKD CCEEECCCCCCCCCC	71.17	-
2213 (in isoform 9)	Ubiquitination	-	17.65	21890473
2218	Phosphorylation	VFSSNLPSEPVDIST CCCCCCCCCCCCHHH	58.67	24114839
2218 (in isoform 3)	Phosphorylation	-	58.67	21815630
2224	Phosphorylation	PSEPVDISTAMSERA CCCCCCHHHHHHHHH	12.97	24114839
2225	Phosphorylation	SEPVDISTAMSERAL CCCCCHHHHHHHHHH	27.06	24114839
2228	Phosphorylation	VDISTAMSERALAQK CCHHHHHHHHHHHHH	22.82	24114839
2238	Phosphorylation	ALAQKRLSENAFDLE HHHHHHHCCCCCCHH	32.60	10470851
2247 (in isoform 3)	Phosphorylation	-	1.44	25159151
2267 (in isoform 3)	Phosphorylation	-	30.29	24719451
2268 (in isoform 3)	Phosphorylation	-	33.30	28348404
2272 (in isoform 10)	Phosphorylation	-	25.21	27732954
2274 (in isoform 10)	Phosphorylation	-	42.59	27732954
2275 (in isoform 3)	Phosphorylation	-	15.01	28348404
2281 (in isoform 10)	Phosphorylation	-	32.07	27732954
2282	Phosphorylation	GVQVLTQEQLANTGA CCEEECHHHHHHCCC	42.18	27251275
2282 (in isoform 3)	Phosphorylation	-	42.18	27174698
2285 (in isoform 3)	Phosphorylation	-	15.95	18669648
2297 (in isoform 3)	Phosphorylation	-	48.42	18669648
2299 (in isoform 3)	Phosphorylation	-	2.79	-
2305	Phosphorylation	FLRAAPVTGGMGAVL HHHHCCCCCCHHHHH	27.27	20068231
2332	Ubiquitination	GKNKEGNKEPILVDF CCCCCCCCCCEEEEE	75.60	-
2340	Ubiquitination	EPILVDFKTDRKGLV CCEEEEEECCCCCEE	45.08	-
2344	Malonylation	VDFKTDRKGLVAVGE EEEECCCCCEEEHHH	60.45	26320211
2344	Ubiquitination	VDFKTDRKGLVAVGE EEEECCCCCEEEHHH	60.45	-
2344 (in isoform 5)	Ubiquitination	-	60.45	-
2357	Phosphorylation	GERAQKRSGNFSAAM HHHHHHHCCCHHHHH	45.16	25159151
2365	Acetylation	GNFSAAMKDLSGKHP CCHHHHHHHHCCCCC	51.28	25953088
2365	Ubiquitination	GNFSAAMKDLSGKHP CCHHHHHHHHCCCCC	51.28	-
2370	Ubiquitination	AMKDLSGKHPVSALM HHHHHCCCCCHHHHH	41.16	-
2370 (in isoform 5)	Ubiquitination	-	41.16	-
2382	Ubiquitination	ALMEICNKRRWQPPE HHHHHHHCCCCCCCC	38.64	-
2382 (in isoform 5)	Ubiquitination	-	38.64	-
2402	Ubiquitination	DSGPDHRKHFLFRVL CCCHHHHHHHHHHHH	34.98	-
2402 (in isoform 5)	Ubiquitination	-	34.98	-
2410 (in isoform 9)	Ubiquitination	-	36.36	-
2413 (in isoform 5)	Phosphorylation	-	14.87	28450419
2415 (in isoform 5)	Phosphorylation	-	43.47	28450419
2418 (in isoform 5)	Phosphorylation	-	26.96	28152594
2421 (in isoform 5)	Phosphorylation	-	7.40	21815630
2422 (in isoform 9)	Ubiquitination	-	2.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SON_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SON_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SON_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF1_HUMAN	U2AF1	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
UBP25_HUMAN	USP25	physical	22939629
TFPI1_HUMAN	TFPI	physical	22939629
TRI26_HUMAN	TRIM26	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-283; SER-1556; SER-1697; SER-1769; SER-1782;SER-1783 AND SER-2129, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-16; LYS-288 AND LYS-2055,AND MASS SPECTROMETRY.
PubMed: 19608861

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2055, AND MASS SPECTROMETRY.
PubMed: 16916647

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-154; SER-283;SER-1556; SER-1697 AND SER-1782, AND MASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-283; SER-1556; SER-1697; SER-1769; SER-1782;SER-1783 AND SER-2129, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-1556; SER-1697;SER-1782; SER-1783; SER-1948; SER-1950; SER-1954; SER-2009; SER-2011AND SER-2013, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348; SER-1051; SER-1556AND SER-1697, AND MASS SPECTROMETRY.
PubMed: 18691976

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908; SER-910; SER-1051;SER-1076; SER-1697; SER-1766; SER-1769 AND THR-2163, AND MASSSPECTROMETRY.
PubMed: 19007248

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2129, AND MASSSPECTROMETRY.
PubMed: 17287340

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154; SER-283 ANDSER-1697, AND MASS SPECTROMETRY.
PubMed: 16565220

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, AND MASSSPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; SER-283; SER-1697;SER-2009; SER-2011; SER-2013; SER-2029; SER-2031 AND SER-2129, ANDMASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-910; SER-1651;SER-1697; SER-1766; SER-1769 AND SER-2013, AND MASS SPECTROMETRY.
PubMed: 15302935