dbPTM

UBP25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP25_HUMAN
UniProt AC	Q9UHP3
Protein Name	Ubiquitin carboxyl-terminal hydrolase 25
Gene Name	USP25
Organism	Homo sapiens (Human).
Sequence Length	1055
Subcellular Localization	Cytoplasm . Isoform USP25m: Cytoplasm. Nucleus. Some transient punctuate nuclear location in myotubes during myocyte development..
Protein Description	Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function..
Protein Sequence	MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVEQNVLQ ------CCHHHHHHH	44.01	24043423
11	Phosphorylation	EQNVLQQSAAQKHQQ HHHHHHHHHHHHHHH	16.77	24043423
14	Ubiquitination	VLQQSAAQKHQQTFL HHHHHHHHHHHHHHH	43.40	21890473
15	Ubiquitination	LQQSAAQKHQQTFLN HHHHHHHHHHHHHHH	38.36	21890473
15	Ubiquitination	LQQSAAQKHQQTFLN HHHHHHHHHHHHHHH	38.36	32015554
19	Phosphorylation	AAQKHQQTFLNQLRE HHHHHHHHHHHHHHH	24.42	24043423
29	Ubiquitination	NQLREITGINDTQIL HHHHHHHCCCHHHHH	23.51	23000965
33	Ubiquitination	EITGINDTQILQQAL HHHCCCHHHHHHHHH	17.02	23000965
40	Ubiquitination	TQILQQALKDSNGNL HHHHHHHHHCCCCCH	5.71	23000965
47	Ubiquitination	LKDSNGNLELAVAFL HHCCCCCHHHEEEHH	6.38	21890473
48	Ubiquitination	KDSNGNLELAVAFLT HCCCCCHHHEEEHHH	38.39	22817900
49	Ubiquitination	DSNGNLELAVAFLTA CCCCCHHHEEEHHHH	5.38	21890473
50	Ubiquitination	SNGNLELAVAFLTAK CCCCHHHEEEHHHHC	4.92	21963094
57	Ubiquitination	AVAFLTAKNAKTPQQ EEEHHHHCCCCCCCC	52.80	21890473
57	Ubiquitination	AVAFLTAKNAKTPQQ EEEHHHHCCCCCCCC	52.80	21906983
57 (in isoform 1)	Ubiquitination	-	52.80	21890473
57 (in isoform 2)	Ubiquitination	-	52.80	21890473
60	Ubiquitination	FLTAKNAKTPQQEET HHHHCCCCCCCCCCC	70.86	21906983
60 (in isoform 1)	Ubiquitination	-	70.86	21890473
60 (in isoform 2)	Ubiquitination	-	70.86	21890473
61	Phosphorylation	LTAKNAKTPQQEETT HHHCCCCCCCCCCCC	24.74	29978859
67	Phosphorylation	KTPQQEETTYYQTAL CCCCCCCCCEEEECC	21.24	28796482
67 (in isoform 3)	Phosphorylation	-	21.24	27642862
68	Phosphorylation	TPQQEETTYYQTALP CCCCCCCCEEEECCC	24.42	28796482
68 (in isoform 3)	Phosphorylation	-	24.42	27642862
69	Phosphorylation	PQQEETTYYQTALPG CCCCCCCEEEECCCC	10.86	28796482
69 (in isoform 3)	Phosphorylation	-	10.86	27642862
70	Phosphorylation	QQEETTYYQTALPGN CCCCCCEEEECCCCC	9.41	28796482
70 (in isoform 3)	Phosphorylation	-	9.41	27642862
71	Ubiquitination	QEETTYYQTALPGND CCCCCEEEECCCCCC	15.19	33845483
72	Phosphorylation	EETTYYQTALPGNDR CCCCEEEECCCCCCC	17.65	28796482
80	Phosphorylation	ALPGNDRYISVGSQA CCCCCCCEEEECCCC	10.62	28674151
80 (in isoform 3)	Phosphorylation	-	10.62	27642862
82	Phosphorylation	PGNDRYISVGSQADT CCCCCEEEECCCCCC	16.10	23186163
85	Phosphorylation	DRYISVGSQADTNVI CCEEEECCCCCCCEE	21.75	23186163
89	Ubiquitination	SVGSQADTNVIDLTG EECCCCCCCEEECCC	34.11	22817900
91	Ubiquitination	GSQADTNVIDLTGDD CCCCCCCEEECCCCC	3.80	33845483
92	Ubiquitination	SQADTNVIDLTGDDK CCCCCCEEECCCCCH	3.79	21890473
93	Ubiquitination	QADTNVIDLTGDDKD CCCCCEEECCCCCHH	33.62	21890473
99	Sumoylation	IDLTGDDKDDLQRAI EECCCCCHHHHHHHH	58.86	-
99	Sumoylation	IDLTGDDKDDLQRAI EECCCCCHHHHHHHH	58.86	19440361
99	Ubiquitination	IDLTGDDKDDLQRAI EECCCCCHHHHHHHH	58.86	22817900
99 (in isoform 1)	Ubiquitination	-	58.86	21890473
99 (in isoform 2)	Ubiquitination	-	58.86	21890473
113	Phosphorylation	IALSLAESNRAFRET HHHHHHHHHHHHHHH	26.47	27251275
116	Ubiquitination	SLAESNRAFRETGIT HHHHHHHHHHHHCCC	16.46	21890473
128	Ubiquitination	GITDEEQAISRVLEA CCCCHHHHHHHHHHH	12.66	21890473
136	Phosphorylation	ISRVLEASIAENKAC HHHHHHHHHHCCHHH	16.98	26270265
141	Sumoylation	EASIAENKACLKRTP HHHHHCCHHHHHCCC	31.79	-
141	Sumoylation	EASIAENKACLKRTP HHHHHCCHHHHHCCC	31.79	-
145	Ubiquitination	AENKACLKRTPTEVW HCCHHHHHCCCHHHH	54.85	21890473
147	Phosphorylation	NKACLKRTPTEVWRD CHHHHHCCCHHHHHC	32.73	25159151
149	Phosphorylation	ACLKRTPTEVWRDSR HHHHCCCHHHHHCCC	42.42	28450419
166	Ubiquitination	YDRKRQDKAPVGLKN CCCCCCCCCCCCCCC	46.37	29967540
171	Ubiquitination	QDKAPVGLKNVGNTC CCCCCCCCCCCCCCH	3.57	21890473
180	Ubiquitination	NVGNTCWFSAVIQSL CCCCCHHHHHHHHHH	3.50	23000965
191	Ubiquitination	IQSLFNLLEFRRLVL HHHHHHHHHHHHHHH	6.49	22053931
200	Phosphorylation	FRRLVLNYKPPSNAQ HHHHHHHCCCCCCCC	22.25	26074081
201	Ubiquitination	RRLVLNYKPPSNAQD HHHHHHCCCCCCCCC	49.75	21890473
201	Ubiquitination	RRLVLNYKPPSNAQD HHHHHHCCCCCCCCC	49.75	22053931
201 (in isoform 1)	Ubiquitination	-	49.75	21890473
201 (in isoform 2)	Ubiquitination	-	49.75	21890473
204	Phosphorylation	VLNYKPPSNAQDLPR HHHCCCCCCCCCCCC	54.01	26074081
221	Ubiquitination	KEHRNLPFMRELRYL HHHCCCHHHHHHHHH	8.98	21890473
223	Ubiquitination	HRNLPFMRELRYLFA HCCCHHHHHHHHHHH	39.93	23000965
226	Ubiquitination	LPFMRELRYLFALLV CHHHHHHHHHHHHHH	22.73	23000965
239	Phosphorylation	LVGTKRKYVDPSRAV HHCCCCCCCCHHHHH	17.70	30576142
240	Ubiquitination	VGTKRKYVDPSRAVE HCCCCCCCCHHHHHH	11.07	21890473
244	Ubiquitination	RKYVDPSRAVEILKD CCCCCHHHHHHHHHH	48.30	23000965
250	Ubiquitination	SRAVEILKDAFKSND HHHHHHHHHHHHCCC	53.31	21890473
250	Ubiquitination	SRAVEILKDAFKSND HHHHHHHHHHHHCCC	53.31	23000965
250 (in isoform 1)	Ubiquitination	-	53.31	21890473
250 (in isoform 2)	Ubiquitination	-	53.31	21890473
250 (in isoform 3)	Ubiquitination	-	53.31	-
254	Ubiquitination	EILKDAFKSNDSQQQ HHHHHHHHCCCHHCC	50.50	21890473
254	Ubiquitination	EILKDAFKSNDSQQQ HHHHHHHHCCCHHCC	50.50	23000965
254 (in isoform 1)	Ubiquitination	-	50.50	21890473
254 (in isoform 2)	Ubiquitination	-	50.50	21890473
256	Ubiquitination	LKDAFKSNDSQQQDV HHHHHHCCCHHCCCH	54.25	21890473
265	Ubiquitination	SQQQDVSEFTHKLLD HHCCCHHHHHHHHHH	55.18	22053931
281	Ubiquitination	LEDAFQMKAEEETDE HHHHHHHHHHHCCCC	41.69	32015554
285	Ubiquitination	FQMKAEEETDEEKPK HHHHHHHCCCCCCCC	53.73	21890473
292	Ubiquitination	ETDEEKPKNPMVELF CCCCCCCCCCCHHHH	82.08	33845483
294	Ubiquitination	DEEKPKNPMVELFYG CCCCCCCCCHHHHHH	34.03	21890473
299	Ubiquitination	KNPMVELFYGRFLAV CCCCHHHHHHCHHHH	3.73	21890473
302	Ubiquitination	MVELFYGRFLAVGVL CHHHHHHCHHHHEEE	16.42	22817900
303	Ubiquitination	VELFYGRFLAVGVLE HHHHHHCHHHHEEEC	4.45	21890473
306	Ubiquitination	FYGRFLAVGVLEGKK HHHCHHHHEEECCCC	6.23	21963094
311	Ubiquitination	LAVGVLEGKKFENTE HHHEEECCCCEECCC	34.00	21963094
312	Ubiquitination	AVGVLEGKKFENTEM HHEEECCCCEECCCC	44.93	21906983
312 (in isoform 1)	Ubiquitination	-	44.93	21890473
312 (in isoform 2)	Ubiquitination	-	44.93	21890473
313	Ubiquitination	VGVLEGKKFENTEMF HEEECCCCEECCCCC	69.62	21890473
313	Ubiquitination	VGVLEGKKFENTEMF HEEECCCCEECCCCC	69.62	21890473
313 (in isoform 1)	Ubiquitination	-	69.62	21890473
313 (in isoform 2)	Ubiquitination	-	69.62	21890473
317	Ubiquitination	EGKKFENTEMFGQYP CCCCEECCCCCCCCC	22.94	21890473
320	Ubiquitination	KFENTEMFGQYPLQV CEECCCCCCCCCCEE	4.49	21890473
331	Ubiquitination	PLQVNGFKDLHECLE CCEECCCCCHHHHHH	61.86	23000965
363	Ubiquitination	KSGQEHWFTELPPVL CCCCCEECCCCCCEE	4.03	22053931
366	Ubiquitination	QEHWFTELPPVLTFE CCEECCCCCCEEEEE	5.44	23000965
370	Ubiquitination	FTELPPVLTFELSRF CCCCCCEEEEEEEHH	5.83	22053931
378	Ubiquitination	TFELSRFEFNQALGR EEEEEHHHHHHHHCC	42.45	32015554
382	Ubiquitination	SRFEFNQALGRPEKI EHHHHHHHHCCCHHH	17.06	21890473
388	Ubiquitination	QALGRPEKIHNKLEF HHHCCCHHHHCCCCC	52.53	29967540
392	Ubiquitination	RPEKIHNKLEFPQVL CCHHHHCCCCCCCHH	34.92	21890473
392	Ubiquitination	RPEKIHNKLEFPQVL CCHHHHCCCCCCCHH	34.92	21890473
392 (in isoform 1)	Ubiquitination	-	34.92	21890473
392 (in isoform 2)	Ubiquitination	-	34.92	21890473
399	Ubiquitination	KLEFPQVLYLDRYMH CCCCCCHHHHHHHHH	2.71	21890473
404	Phosphorylation	QVLYLDRYMHRNREI CHHHHHHHHHHCCCC	9.28	-
405	Ubiquitination	VLYLDRYMHRNREIT HHHHHHHHHHCCCCH	2.20	22053931
409	Ubiquitination	DRYMHRNREITRIKR HHHHHHCCCCHHHCH	36.33	23000965
411	Ubiquitination	YMHRNREITRIKREE HHHHCCCCHHHCHHH	2.57	21890473
416	Ubiquitination	REITRIKREEIKRLK CCCHHHCHHHHHHHH	44.39	21890473
422	Ubiquitination	KREEIKRLKDYLTVL CHHHHHHHHHHHHHH	4.15	21890473
425	Phosphorylation	EIKRLKDYLTVLQQR HHHHHHHHHHHHHHH	11.59	24719451
427	Phosphorylation	KRLKDYLTVLQQRLE HHHHHHHHHHHHHHH	16.97	24719451
434	Ubiquitination	TVLQQRLERYLSYGS HHHHHHHHHHHHCCC	41.28	21890473
444	Ubiquitination	LSYGSGPKRFPLVDV HHCCCCCCCCCHHHH	70.92	21890473
444	Ubiquitination	LSYGSGPKRFPLVDV HHCCCCCCCCCHHHH	70.92	23000965
444 (in isoform 1)	Ubiquitination	-	70.92	21890473
444 (in isoform 2)	Ubiquitination	-	70.92	21890473
444 (in isoform 3)	Ubiquitination	-	70.92	-
446	Ubiquitination	YGSGPKRFPLVDVLQ CCCCCCCCCHHHHHH	7.38	21890473
448	Ubiquitination	SGPKRFPLVDVLQYA CCCCCCCHHHHHHHH	4.77	22053931
451	Ubiquitination	KRFPLVDVLQYALEF CCCCHHHHHHHHHHH	2.53	21890473
457	Ubiquitination	DVLQYALEFASSKPV HHHHHHHHHHHCCCC	30.87	21890473
469	Ubiquitination	KPVCTSPVDDIDASS CCCCCCCCCCCCCCC	11.78	23503661
477	Ubiquitination	DDIDASSPPSGSIPS CCCCCCCCCCCCCCC	25.28	21890473
489	Ubiquitination	IPSQTLPSTTEQQGA CCCCCCCCCCCCCCC	51.58	21963094
494	Ubiquitination	LPSTTEQQGALSSEL CCCCCCCCCCCCCCC	32.66	21963094
500	Ubiquitination	QQGALSSELPSTSPS CCCCCCCCCCCCCHH	62.41	21890473
510	Ubiquitination	STSPSSVAAISSRSV CCCHHHHHHHHCCCC	10.88	21890473
520	Ubiquitination	SSRSVIHKPFTQSRI HCCCCCCCCCCCCCC	30.60	21890473
520	Ubiquitination	SSRSVIHKPFTQSRI HCCCCCCCCCCCCCC	30.60	21890473
520 (in isoform 1)	Ubiquitination	-	30.60	21890473
520 (in isoform 2)	Ubiquitination	-	30.60	21890473
539	Ubiquitination	PMHPAPRHITEEELS CCCCCCCCCCHHHHH	30.20	23503661
561	Ubiquitination	RWRTEIENDTRDLQE HHHHHHHHCCHHHHH	62.71	32015554
574	Ubiquitination	QESISRIHRTIELMY HHHHHHHHHHHHHHH	21.52	21890473
582	Phosphorylation	RTIELMYSDKSMIQV HHHHHHHCCCCCCCC	25.29	23663014
584	Ubiquitination	IELMYSDKSMIQVPY HHHHHCCCCCCCCCE	35.66	21890473
584	Ubiquitination	IELMYSDKSMIQVPY HHHHHCCCCCCCCCE	35.66	22053931
584 (in isoform 1)	Ubiquitination	-	35.66	21890473
584 (in isoform 2)	Ubiquitination	-	35.66	21890473
585	Phosphorylation	ELMYSDKSMIQVPYR HHHHCCCCCCCCCEE	26.55	23663014
591	Phosphorylation	KSMIQVPYRLHAVLV CCCCCCCEEEEEEEE	27.27	23663014
620	Ubiquitination	FDHRESRWMKYNDIA EECCCCCCCCCCCEE	9.26	23000965
622	Ubiquitination	HRESRWMKYNDIAVT CCCCCCCCCCCEEEE	33.66	-
630	Ubiquitination	YNDIAVTKSSWEELV CCCEEEEHHHHHHHH	35.57	21890473
630	Ubiquitination	YNDIAVTKSSWEELV CCCEEEEHHHHHHHH	35.57	23000965
630 (in isoform 1)	Ubiquitination	-	35.57	21890473
630 (in isoform 2)	Ubiquitination	-	35.57	21890473
630 (in isoform 3)	Ubiquitination	-	35.57	-
644	Ubiquitination	VRDSFGGYRNASAYC HHHHCCCCCCCCEEE	10.90	23503661
652	Ubiquitination	RNASAYCLMYINDKA CCCCEEEEEHHCHHH	1.58	23503661
659	Ubiquitination	LMYINDKAQFLIQEE EEHHCHHHHHHHHHH	14.28	22053931
669	Ubiquitination	LIQEEFNKETGQPLV HHHHHHHHCCCCCCE	63.07	21906983
669 (in isoform 1)	Ubiquitination	-	63.07	21890473
669 (in isoform 2)	Ubiquitination	-	63.07	21890473
679	Ubiquitination	GQPLVGIETLPPDLR CCCCEEEEECCCCHH	38.06	23503661
680	Phosphorylation	QPLVGIETLPPDLRD CCCEEEEECCCCHHH	42.52	-
688	Ubiquitination	LPPDLRDFVEEDNQR CCCCHHHHHHHHHHH	6.35	21890473
698	Ubiquitination	EDNQRFEKELEEWDA HHHHHHHHHHHHHHH	65.96	21890473
698	Ubiquitination	EDNQRFEKELEEWDA HHHHHHHHHHHHHHH	65.96	6983
698 (in isoform 1)	Ubiquitination	-	65.96	21890473
698 (in isoform 2)	Ubiquitination	-	65.96	21890473
700	Ubiquitination	NQRFEKELEEWDAQL HHHHHHHHHHHHHHH	12.23	21890473
705	Ubiquitination	KELEEWDAQLAQKAL HHHHHHHHHHHHHHH	13.83	21890473
710	Ubiquitination	WDAQLAQKALQEKLL HHHHHHHHHHHHHHH	45.52	21890473
710	Ubiquitination	WDAQLAQKALQEKLL HHHHHHHHHHHHHHH	45.52	21906983
710 (in isoform 1)	Ubiquitination	-	45.52	21890473
710 (in isoform 2)	Ubiquitination	-	45.52	21890473
711	Ubiquitination	DAQLAQKALQEKLLA HHHHHHHHHHHHHHH	11.46	21890473
715	Ubiquitination	AQKALQEKLLASQKL HHHHHHHHHHHCHHH	35.52	21890473
715	Ubiquitination	AQKALQEKLLASQKL HHHHHHHHHHHCHHH	35.52	21963094
715 (in isoform 1)	Ubiquitination	-	35.52	21890473
715 (in isoform 2)	Ubiquitination	-	35.52	21890473
715 (in isoform 3)	Ubiquitination	-	35.52	-
721	Ubiquitination	EKLLASQKLRESETS HHHHHCHHHHHCCCC	47.20	21890473
721	Ubiquitination	EKLLASQKLRESETS HHHHHCHHHHHCCCC	47.20	27667366
721 (in isoform 1)	Ubiquitination	-	47.20	21890473
721 (in isoform 2)	Ubiquitination	-	47.20	21890473
722	Ubiquitination	KLLASQKLRESETSV HHHHCHHHHHCCCCH	5.95	23503661
725	Phosphorylation	ASQKLRESETSVTTA HCHHHHHCCCCHHHH	39.48	29978859
727	Phosphorylation	QKLRESETSVTTAQA HHHHHCCCCHHHHHH	37.46	29978859
728	Phosphorylation	KLRESETSVTTAQAA HHHHCCCCHHHHHHH	17.26	29978859
730	Phosphorylation	RESETSVTTAQAAGD HHCCCCHHHHHHHCC	19.04	29978859
731	Phosphorylation	ESETSVTTAQAAGDP HCCCCHHHHHHHCCH	18.02	29978859
740	Phosphorylation	QAAGDPEYLEQPSRS HHHCCHHHHCCCCCC	22.41	29978859
745	Phosphorylation	PEYLEQPSRSDFSKH HHHHCCCCCCHHHHH	44.07	29978859
772 (in isoform 1)	Phosphorylation	-	40.05	24043423
775 (in isoform 1)	Phosphorylation	-	29.87	24043423
779 (in isoform 1)	Phosphorylation	-	28.00	24043423
782	Ubiquitination	TVLQSAIKLEYARLV HHHHHHHHHHHHHHH	34.68	32015554
783 (in isoform 1)	Phosphorylation	-	5.07	24043423
835	Phosphorylation	QFGDRNLSFDERCHN HHCCCCCCHHHHHHH	33.91	28857561
845	Ubiquitination	ERCHNIMKVAQAKLE HHHHHHHHHHHHHHH	30.53	29967540
850	Ubiquitination	IMKVAQAKLEMIKPE HHHHHHHHHHHCCHH	32.66	29967540
873	Ubiquitination	EWHQDYRKFRETTMY HHHHHHHHHHHHHHH	42.41	23503661
877	Ubiquitination	DYRKFRETTMYLIIG HHHHHHHHHHHHEEC	16.77	29967540
882	Ubiquitination	RETTMYLIIGLENFQ HHHHHHHEECCCHHC	0.98	29967540
905	Ubiquitination	LFLICAYQNNKELLS HHHHHHHHCCHHHHH	28.61	23503661
905 (in isoform 1)	Ubiquitination	-	28.61	-
912	Phosphorylation	QNNKELLSKGLYRGH HCCHHHHHCCCCCCC	36.98	-
915	Ubiquitination	KELLSKGLYRGHDEE HHHHHCCCCCCCCHH	2.79	29967540
916	Phosphorylation	ELLSKGLYRGHDEEL HHHHCCCCCCCCHHH	24.18	17924679
920	Ubiquitination	KGLYRGHDEELISHY CCCCCCCCHHHHHHH	54.62	29967540
933	Ubiquitination	HYRRECLLKLNEQAA HHHHHHHHHHHHHHH	10.04	23503661
943	Ubiquitination	NEQAAELFESGEDRE HHHHHHHHHCCCCCC	5.45	23503661
948	Phosphorylation	ELFESGEDREVNNGL HHHHCCCCCCCCCCE	56.41	17924679
1006	Phosphorylation	PHLQEKLTDFLPKLL HHHHHHHHHHHHHHH	35.45	22210691
1011	Ubiquitination	KLTDFLPKLLDCSME HHHHHHHHHHHCCCH	64.92	29967540
1043	Ubiquitination	LCERFARIMLSLSRT HHHHHHHHHHHHHCC	2.67	29967540
1046	Phosphorylation	RFARIMLSLSRTPAD HHHHHHHHHHCCCCC	13.61	24719451
1048	Phosphorylation	ARIMLSLSRTPADGR HHHHHHHHCCCCCCC	30.63	17081983
1081	Ubiquitination	--------------------------------- ---------------------------------		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
680	T	Phosphorylation	Kinase	VRK2	Q86Y07	PSP
727	T	Phosphorylation	Kinase	VRK2	Q86Y07	PSP
745	S	Phosphorylation	Kinase	VRK2	Q86Y07	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANXA1_HUMAN	ANXA1	physical	19615732
LYSC_HUMAN	LYZ	physical	19615732
MYO6_HUMAN	MYO6	physical	19615732
NEDD8_HUMAN	NEDD8	physical	19615732
PIP_HUMAN	PIP	physical	19615732
KLHL9_HUMAN	KLHL9	physical	19615732
WRIP1_HUMAN	WRNIP1	physical	19615732
UBP28_HUMAN	USP28	physical	19615732
BACD3_HUMAN	KCTD10	physical	19615732
BTBD9_HUMAN	BTBD9	physical	19615732
ZG16B_HUMAN	ZG16B	physical	19615732
BACD1_HUMAN	KCTD13	physical	19615732
MT2_HUMAN	MT2A	physical	16501887
G3P_HUMAN	GAPDH	physical	16501887
MYPC1_HUMAN	MYBPC1	physical	16501887
ACTS_HUMAN	ACTA1	physical	16501887
FLNC_HUMAN	FLNC	physical	16501887
UBP25_HUMAN	USP25	physical	19440361
KSYK_HUMAN	SYK	physical	19909739
SUMO1_HUMAN	SUMO1	physical	18538659
SUMO3_HUMAN	SUMO3	physical	18538659
SUMO2_HUMAN	SUMO2	physical	18538659
UBC_HUMAN	UBC	physical	22195557
K1468_HUMAN	KIAA1468	physical	22863883
UBC_HUMAN	UBC	physical	18538659
ZN426_HUMAN	ZNF426	physical	25416956
A4_HUMAN	APP	physical	25740315
KSYK_HUMAN	SYK	physical	21516116
BACD1_HUMAN	KCTD13	physical	28514442
BACD2_HUMAN	TNFAIP1	physical	28514442
BTBD9_HUMAN	BTBD9	physical	28514442
UBB_HUMAN	UBB	physical	28514442
BACD3_HUMAN	KCTD10	physical	28514442
UBP28_HUMAN	USP28	physical	28514442
APBP2_HUMAN	APPBP2	physical	28514442
SUMO1_HUMAN	SUMO1	physical	28538147
UBC_HUMAN	UBC	physical	28538147
UBC_HUMAN	UBC	physical	29131570
UBC_HUMAN	UBC	physical	28327663

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP25_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-916, AND MASSSPECTROMETRY.	17924679 [Abstract]
Sumoylation
Reference	PubMed
"The UBA-UIM domains of the USP25 regulate the enzyme ubiquitinationstate and modulate substrate recognition."; Denuc A., Bosch-Comas A., Gonzalez-Duarte R., Marfany G.; PLoS ONE 4:E5571-E5571(2009). Cited for: UBIQUITINATION AT LYS-99, DEUBIQUITINATION, ACTIVE SITE AT CYS-178,ACETYLATION, PHOSPHORYLATION, SUMOYLATION, FUNCTION, SUBCELLULARLOCATION, SUBUNIT, AND MUTAGENESIS OF LYS-99 AND CYS-178.	19440361 [Abstract]
"Mechanism and consequences for paralog-specific sumoylation ofubiquitin-specific protease 25."; Meulmeester E., Kunze M., Hsiao H.H., Urlaub H., Melchior F.; Mol. Cell 30:610-619(2008). Cited for: SUMOYLATION AT LYS-99, FUNCTION, INTERACTION WITH SUMO1; SUMO3 ANDUBIQUITIN, MASS SPECTROMETRY, AND MUTAGENESIS OF VAL-91; ILE-92 ANDLYS-99.	18538659 [Abstract]