MYPC1_HUMAN - dbPTM
MYPC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYPC1_HUMAN
UniProt AC Q00872
Protein Name Myosin-binding protein C, slow-type
Gene Name MYBPC1
Organism Homo sapiens (Human).
Sequence Length 1141
Subcellular Localization
Protein Description Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role..
Protein Sequence MPEPTKKEENEVPAPAPPPEEPSKEKEAGTTPAKDWTLVETPPGEEQAKQNANSQLSILFIEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQSDENGEAAYDLPAEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30 (in isoform 2)Phosphorylation-36.3319764811
30 (in isoform 4)Phosphorylation-36.3319764811
31PhosphorylationKEKEAGTTPAKDWTL
CCCCCCCCCCCCCEE		21.9726437602
40 (in isoform 2)Phosphorylation-59.7219764811
40 (in isoform 4)Phosphorylation-59.7219764811
41PhosphorylationKDWTLVETPPGEEQA
CCCEEEECCCCHHHH		27.5726437602
43 (in isoform 2)Phosphorylation-70.9622673903
43 (in isoform 4)Phosphorylation-70.9622673903
59 (in isoform 4)Phosphorylation-2.9619764811
59 (in isoform 2)Phosphorylation-2.9619764811
62 (in isoform 2)Phosphorylation-51.8819764811
62 (in isoform 4)Phosphorylation-51.8819764811
66 (in isoform 2)Phosphorylation-42.1226437602
66 (in isoform 4)Phosphorylation-42.1226437602
120PhosphorylationKETFERHSRVYTFEM
HHHHHHHCCEEEEEE		29.6626437602
162PhosphorylationFDLEVHESTGTTPNI
EEEEEECCCCCCCCE		19.7726437602
163PhosphorylationDLEVHESTGTTPNID
EEEEECCCCCCCCEE		35.2524719451
166PhosphorylationVHESTGTTPNIDIRS
EECCCCCCCCEEHHH		18.7126437602
178PhosphorylationIRSAFKRSGEGQEDA
HHHHHHHCCCCCCCC		41.6126437602
188 (in isoform 4)Phosphorylation-8.6724719451
220PhosphorylationLLKNAKPSEYEKIAF
HHHCCCHHHHHHHHH		52.7026437602
251PhosphorylationMRREEKKSAAFAKIL
HHHHHHHHHHHHHHC		35.5826437602
286PhosphorylationPKLEVKWYKNGQEIR
CCCEEEEEECCEECC		6.72-
295PhosphorylationNGQEIRPSTKYIFEH
CCEECCCCCCEEECC		27.9026437602
296PhosphorylationGQEIRPSTKYIFEHK
CEECCCCCCEEECCC		30.4626437602
298PhosphorylationEIRPSTKYIFEHKGC
ECCCCCCEEECCCCC		15.7826437602
317PhosphorylationFINNCQMTDDSEYYV
EEECCEECCCCCEEE		15.6930576142
323PhosphorylationMTDDSEYYVTAGDEK
ECCCCCEEEEECCCC		6.3030576142
325PhosphorylationDDSEYYVTAGDEKCS
CCCCEEEEECCCCCC		14.59-
333PhosphorylationAGDEKCSTELFVREP
ECCCCCCEEEEECCC		46.2930576142
345PhosphorylationREPPIMVTKQLEDTT
CCCCEEEEEECCCCC		8.8322985185
351PhosphorylationVTKQLEDTTAYCGER
EEEECCCCCCCCCCE		12.1626437602
352PhosphorylationTKQLEDTTAYCGERV
EEECCCCCCCCCCEE		28.1425072903
354PhosphorylationQLEDTTAYCGERVEL
ECCCCCCCCCCEEEE		10.01-
366PhosphorylationVELECEVSEDDANVK
EEEEEEECCCCCCCE		17.0226437602
387PhosphorylationEIIPGPKSRYRIRVE
ECCCCCCCCEEEEEC		37.3629083192
406PhosphorylationILIIEGATKADAAEY
EEEEECCCHHHHCEE		37.3123403867
413PhosphorylationTKADAAEYSVMTTGG
CHHHHCEEEEEECCC		11.2220068231
414PhosphorylationKADAAEYSVMTTGGQ
HHHHCEEEEEECCCC		9.2720068231
417PhosphorylationAAEYSVMTTGGQSSA
HCEEEEEECCCCCCE		21.8220068231
418PhosphorylationAEYSVMTTGGQSSAK
CEEEEEECCCCCCEE		22.6320068231
422PhosphorylationVMTTGGQSSAKLSVD
EEECCCCCCEEEEEE		35.2220068231
423PhosphorylationMTTGGQSSAKLSVDL
EECCCCCCEEEEEEC		22.8726437602
427PhosphorylationGQSSAKLSVDLKPLK
CCCCEEEEEECCCCE		16.9320068231
437PhosphorylationLKPLKILTPLTDQTV
CCCCEEEEECCCCCE		21.5222673903
440PhosphorylationLKILTPLTDQTVNLG
CEEEEECCCCCEECC		27.5426437602
443PhosphorylationLTPLTDQTVNLGKEI
EEECCCCCEECCCEE		17.7422673903
474PhosphorylationNGLPVQESDRLKVVH
CCCCCCCHHCEEEEE		15.7826437602
495PhosphorylationLVIANALTEDEGDYV
EEEECCCCCCCCCEE		38.6922673903
536PhosphorylationLDADNTVTVIAGNKL
CCCCCEEEEEECCEE		12.2622673903
550PhosphorylationLRLEIPISGEPPPKA
EEEEEECCCCCCCCC		31.5828064214
570PhosphorylationDKAIMEGSGRIRTES
CCEECCCCCCEECCC		16.1626437602
594PhosphorylationDIAERDDSGVYHINL
EEEECCCCCEEEEEE		34.1522673903
597PhosphorylationERDDSGVYHINLKNE
ECCCCCEEEEEEECC		10.6622673903
611PhosphorylationEAGEAHASIKVKVVD
CCCCEEEEEEEEEEC		17.0526437602
663PhosphorylationIERKKKQSSRWMRLN
HEECCCCCCCCEECC		30.6527135362
664PhosphorylationERKKKQSSRWMRLNF
EECCCCCCCCEECCC		27.7127135362
706PhosphorylationAIGISKPSMPSRPFV
ECCCCCCCCCCCCCE		47.2418088087
725PhosphorylationTSPPTLLTVDSVTDT
CCCCEEEEEECCCCC		25.9422673903
726 (in isoform 5)Phosphorylation-5.3520068231
728PhosphorylationPTLLTVDSVTDTTVT
CEEEEEECCCCCEEE		23.6822673903
730PhosphorylationLLTVDSVTDTTVTMR
EEEEECCCCCEEEEE		31.4222673903
730 (in isoform 5)Phosphorylation-31.4220068231
732PhosphorylationTVDSVTDTTVTMRWR
EEECCCCCEEEEEEC		17.5022673903
733 (in isoform 9)Phosphorylation-19.4520068231
735 (in isoform 5)Phosphorylation-10.0320068231
737 (in isoform 9)Phosphorylation-19.5220068231
739 (in isoform 7)Phosphorylation-23.6220068231
740 (in isoform 8)Phosphorylation-31.5420068231
742 (in isoform 9)Phosphorylation-49.0320068231
743 (in isoform 7)Phosphorylation-26.5920068231
744 (in isoform 8)Phosphorylation-5.3920068231
748 (in isoform 7)Phosphorylation-24.6220068231
749 (in isoform 5)Phosphorylation-3.8620068231
749 (in isoform 8)Phosphorylation-3.8620068231
752PhosphorylationGAAGLDGYVLEYCFE
CCCCCCCEEEEEECC		11.0920068231
752 (in isoform 10)Phosphorylation-11.0920068231
752 (in isoform 3)Phosphorylation-11.0920068231
756 (in isoform 10)Phosphorylation-9.7720068231
756 (in isoform 3)Phosphorylation-9.7720068231
756 (in isoform 9)Phosphorylation-9.7720068231
761 (in isoform 10)Phosphorylation-16.4020068231
761 (in isoform 3)Phosphorylation-16.4020068231
762 (in isoform 7)Phosphorylation-43.4920068231
763 (in isoform 8)Phosphorylation-34.8620068231
775 (in isoform 10)Phosphorylation-25.6820068231
775 (in isoform 3)Phosphorylation-25.6820068231
777 (in isoform 2)Phosphorylation-2.5620068231
777 (in isoform 4)Phosphorylation-2.5620068231
781 (in isoform 2)Phosphorylation-42.3720068231
781 (in isoform 4)Phosphorylation-42.3720068231
786 (in isoform 2)Phosphorylation-27.7220068231
786 (in isoform 4)Phosphorylation-27.7220068231
793PhosphorylationNKDLIDKTKFTITGL
CHHHCCCCCEEEECC		27.8726437602
796PhosphorylationLIDKTKFTITGLPTD
HCCCCCEEEECCCCC		21.1326437602
798PhosphorylationDKTKFTITGLPTDAK
CCCCEEEECCCCCCE		29.6126437602
800 (in isoform 2)Phosphorylation-2.8620068231
800 (in isoform 4)Phosphorylation-2.8620068231
802PhosphorylationFTITGLPTDAKIFVR
EEEECCCCCCEEEEE		54.3422673903
819PhosphorylationAVNAAGASEPKYYSQ
EECCCCCCCCCCCCC		54.2226437602
823PhosphorylationAGASEPKYYSQPILV
CCCCCCCCCCCCEEE		21.0426437602
824PhosphorylationGASEPKYYSQPILVK
CCCCCCCCCCCEEEE		13.6226437602
825PhosphorylationASEPKYYSQPILVKE
CCCCCCCCCCEEEEE		26.7926437602
848PhosphorylationIPRHLKQTYIRRVGE
CCHHHHHHHHHHHHH		21.2326437602
849PhosphorylationPRHLKQTYIRRVGEA
CHHHHHHHHHHHHHH		7.0226437602
890PhosphorylationNQINIRNSETDTIIF
CCEEEECCCCCEEEE		31.8322673903
892PhosphorylationINIRNSETDTIIFIR
EEEECCCCCEEEEEE		37.9622673903
894PhosphorylationIRNSETDTIIFIRKA
EECCCCCEEEEEEEC		24.3222673903
904PhosphorylationFIRKAERSHSGKYDL
EEEECCCCCCCCCEE		17.3226437602
906PhosphorylationRKAERSHSGKYDLQV
EECCCCCCCCCEEEE		37.9226437602
921PhosphorylationKVDKFVETASIDIQI
EEEECEEEEEEEEEE		22.0221406692
923PhosphorylationDKFVETASIDIQIID
EECEEEEEEEEEEEC		28.3721406692
985PhosphorylationWFTVIEHYHRTSATI
HHHEEEHHHCCCCEE		4.72-
989PhosphorylationIEHYHRTSATITELV
EEHHHCCCCEEEEEE		24.3027732954
991PhosphorylationHYHRTSATITELVIG
HHHCCCCEEEEEEEC		28.3527732954
993PhosphorylationHRTSATITELVIGNE
HCCCCEEEEEEECCE		20.9327732954
1001PhosphorylationELVIGNEYYFRVFSE
EEEECCEEEEEEECC		16.3527732954
1002PhosphorylationLVIGNEYYFRVFSEN
EEECCEEEEEEECCC		4.4427732954
1007PhosphorylationEYYFRVFSENMCGLS
EEEEEEECCCCCCCC		25.7927732954
1014PhosphorylationSENMCGLSEDATMTK
CCCCCCCCCCCCCCH		20.7927732954
1023PhosphorylationDATMTKESAVIARDG
CCCCCHHHEEEEECC		29.4126437602
1110 (in isoform 7)Phosphorylation-38.8427251275
1114 (in isoform 5)Phosphorylation-25.2126437602
1121 (in isoform 9)Phosphorylation-7.4526437602
1128 (in isoform 8)Phosphorylation-7.0926437602
1133 (in isoform 7)Phosphorylation-34.5922673903
1134 (in isoform 7)Phosphorylation-16.1022673903
1140 (in isoform 10)Phosphorylation-16.4226437602
1165 (in isoform 4)Phosphorylation-26437602
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYPC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYPC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYPC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FHL1_HUMANFHL1physical
16407297
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614335Arthrogryposis, distal, 1B (DA1B)
614915Lethal congenital contracture syndrome 4 (LCCS4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYPC1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706, AND MASSSPECTROMETRY.

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