BACD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BACD1_HUMAN
• UniProt AC: Q8WZ19
• Protein Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 {ECO:0000303|PubMed:19782033}
• Gene Name: KCTD13
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Nucleus .
• Protein Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. [PubMed: 19782033 The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome]
• Protein Sequence: MSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKRETLSPLCLIPMVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGAGGAGRGEDEENREHRVRRIHVRRHITHDERPHGQQIVFKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Ubiquitination	APSLEAPKPSGLEPG CCCCCCCCCCCCCCC	59.88	-
34	Ubiquitination	GPAAYGLKPLTPNSK CCCCCCCCCCCCCCC	33.35	21890473
41	Ubiquitination	KPLTPNSKYVKLNVG CCCCCCCCEEEEECC	61.78	21890473
67	Ubiquitination	TGQDTMLKAMFSGRV CCCHHHHHHHHCCCE	27.30	-
71	Phosphorylation	TMLKAMFSGRVEVLT HHHHHHHCCCEEEEE	16.77	22210691
78	Phosphorylation	SGRVEVLTDAGGWVL CCCEEEEEECCCEEE	29.04	22210691
89	Phosphorylation	GWVLIDRSGRHFGTI CEEEEECCCCCHHHH	36.11	22210691
140	Ubiquitination	CQLALQQKRETLSPL HHHHHHHCHHHCCHH	38.96	-
168	Ubiquitination	QLLASTSKPVVKLLH HHHHCCCCCHHHHHH	41.75	21906983
172	Ubiquitination	STSKPVVKLLHNRSN CCCCCHHHHHHCCCC	45.63	-
181	Ubiquitination	LHNRSNNKYSYTSTS HHCCCCCCEEEEECC	39.56	21890473
194	Ubiquitination	TSDDNLLKNIELFDK CCCCCHHHHHHHHHH	60.07	21890473
201	Ubiquitination	KNIELFDKLALRFHG HHHHHHHHHHHHHHC	28.46	-
250	Phosphorylation	YATEKKQTKVEFPEA HHCCCCCCCCCCCHH	46.03	-
251	Ubiquitination	ATEKKQTKVEFPEAR HCCCCCCCCCCCHHH	36.95	-
269	Phosphorylation	ETLNILIYETPRGPD HHHHEEEEECCCCCC	15.42	-
294	Methylation	AGAGGAGRGEDEENR CCCCCCCCCCCCCHH	44.81	115480865

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BACD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BACD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BACD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPOD2_HUMAN	POLD2	physical	11593007
PCNA_HUMAN	PCNA	physical	11593007
PLEC_HUMAN	PLEC	physical	19615732
BACD2_HUMAN	TNFAIP1	physical	19615732
SRPX_HUMAN	SRPX	physical	19615732
LAMB4_HUMAN	LAMB4	physical	19615732
BACD3_HUMAN	KCTD10	physical	19615732
SPRTN_HUMAN	SPRTN	physical	22902628
PPARG_HUMAN	PPARG	physical	16239304
RHOA_HUMAN	RHOA	physical	19782033
BACD1_HUMAN	KCTD13	physical	25416956
HS71L_HUMAN	HSPA1L	physical	26186194
FLNC_HUMAN	FLNC	physical	26186194
BACD2_HUMAN	TNFAIP1	physical	26186194
BACD3_HUMAN	KCTD10	physical	26186194
HSPB8_HUMAN	HSPB8	physical	26186194
BACD2_HUMAN	TNFAIP1	physical	21516116
RHOA_HUMAN	RHOA	physical	26100637
BACD2_HUMAN	TNFAIP1	physical	28514442
CUL3_HUMAN	CUL3	physical	28514442
BACD3_HUMAN	KCTD10	physical	28514442
FLNC_HUMAN	FLNC	physical	28514442
HSPB8_HUMAN	HSPB8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.