LAMB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAMB4_HUMAN
• UniProt AC: A4D0S4
• Protein Name: Laminin subunit beta-4
• Gene Name: LAMB4
• Organism: Homo sapiens (Human).
• Sequence Length: 1761
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components..
• Protein Sequence: MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPGFARVLPGAGLRFAVNNIPFPVDFTIAIHYETQSAADWTVQIVVNPPGGSEHCIPKTLQSKPQSFALPAATRIMLLPTPICLEPDVQYSIDVYFSQPLQGESHAHSHVLVDSLGLIPQINSLENFCSKQDLDEYQLHNCVEIASAMGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGKFLKVKDYHDSVRRQIMQLNEQLKAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKIPDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKLLVKAKAAEKAANILLNLDKTLNQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITDLERKIQDLNLSRQAKADQLRILEDQVVAIKNEIVEQEKKYARCYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	DLLVGRNTQLMASST CEECCCCCHHHHCCC	23.01	21406692
46	Phosphorylation	RNTQLMASSTCGLSR CCCHHHHCCCCCCHH	16.53	21406692
47	Phosphorylation	NTQLMASSTCGLSRA CCHHHHCCCCCCHHH	20.41	21406692
48	Phosphorylation	TQLMASSTCGLSRAQ CHHHHCCCCCCHHHH	14.22	21406692
52	Phosphorylation	ASSTCGLSRAQKYCI HCCCCCCHHHHHHHH	15.74	21406692
57	Phosphorylation	GLSRAQKYCILSYLE CCHHHHHHHHHHHHC	3.45	21406692
61	Phosphorylation	AQKYCILSYLEGEQK HHHHHHHHHHCCCCE	14.04	21406692
62	Phosphorylation	QKYCILSYLEGEQKC HHHHHHHHHCCCCEE	12.82	21406692
169	N-linked_Glycosylation	DCATSFPNITSGQAQ HHHHCCCCCCCCCCC	48.43	UniProtKB CARBOHYD
188	Phosphorylation	IVCDSKYSDIEPSTG EEECCCCCCCCCCCC	35.53	30631047
194	Phosphorylation	YSDIEPSTGGEVVLK CCCCCCCCCCEEEEE	60.98	30631047
229	N-linked_Glycosylation	TLTNLRINFTKLHTL HHHCCCEEEEEECCH	31.91	UniProtKB CARBOHYD
246	N-linked_Glycosylation	ALLGRRQNDSLDKYY HHCCCCCCCCHHHHH	38.74	UniProtKB CARBOHYD
248	Phosphorylation	LGRRQNDSLDKYYYA CCCCCCCCHHHHHHH	46.12	-
252	Phosphorylation	QNDSLDKYYYALYEM CCCCHHHHHHHHHHH	11.02	22210691
253	Phosphorylation	NDSLDKYYYALYEMI CCCHHHHHHHHHHHH	6.49	22210691
254	Phosphorylation	DSLDKYYYALYEMIV CCHHHHHHHHHHHHH	6.24	-
257	Phosphorylation	DKYYYALYEMIVRGS HHHHHHHHHHHHHCC	8.69	-
272	Phosphorylation	CFCNGHASECRPMQK CCCCCCHHHCCCCHH	31.39	22210691
331	Phosphorylation	LQDNACRSCSCNSHS HCCCCCHHCCCCCCC	15.40	-
336	Phosphorylation	CRSCSCNSHSSRCHF CHHCCCCCCCCCCCC	29.13	-
338	Phosphorylation	SCSCNSHSSRCHFDM HCCCCCCCCCCCCCH	21.21	-
339	Phosphorylation	CSCNSHSSRCHFDMT CCCCCCCCCCCCCHH	33.24	-
667	Phosphorylation	SFALPAATRIMLLPT CCCCCCHHEEEEECC	23.88	24719451
674	Phosphorylation	TRIMLLPTPICLEPD HEEEEECCCEECCCC	25.84	26853621
843	Phosphorylation	CPCHGEVSGRRCDRC CCCCCCCCCCCCCCC	23.45	-
1016	N-linked_Glycosylation	GHYGSALNQTCRRCS CCHHHHHHHHCCCCC	34.53	UniProtKB CARBOHYD
1055	N-linked_Glycosylation	GACPCLPNVTGLACD CCCCCCCCCCCCCCC	30.91	UniProtKB CARBOHYD
1105	Phosphorylation	QCPCKLGYGGKRCSE CCCCCCCCCCCCCHH	32.89	-
1135	Phosphorylation	CDCNRAGTQKPICDP CCCCCCCCCCCCCCC	32.22	-
1154	Phosphorylation	CRCREGVSGQRCDRC CCCCCCCCCCCCCCC	39.81	-
1223	N-linked_Glycosylation	DFKDLRGNVSEIERI HHHHHCCCHHHHHHH	27.92	UniProtKB CARBOHYD
1301	N-linked_Glycosylation	DLQSSVLNASIADSS HHHHHHHHHHHCCCC	29.50	UniProtKB CARBOHYD
1314	Phosphorylation	SSENIKKYYHISSSA CCCHHHHHHCCCHHH	8.69	29083192
1315	Phosphorylation	SENIKKYYHISSSAE CCHHHHHHCCCHHHH	11.10	29083192
1318	Phosphorylation	IKKYYHISSSAEKKI HHHHHCCCHHHHHHH	12.62	29083192
1319	Phosphorylation	KKYYHISSSAEKKIN HHHHCCCHHHHHHHC	32.72	29083192
1320	Phosphorylation	KYYHISSSAEKKINE HHHCCCHHHHHHHCC	33.39	29083192
1326	N-linked_Glycosylation	SSAEKKINETSSTIN HHHHHHHCCCCCCCC	56.21	UniProtKB CARBOHYD
1329	Phosphorylation	EKKINETSSTINTSA HHHHCCCCCCCCCCC	21.21	-
1330	Phosphorylation	KKINETSSTINTSAN HHHCCCCCCCCCCCC	40.50	25332170
1333	N-linked_Glycosylation	NETSSTINTSANTRN CCCCCCCCCCCCCHH	28.24	UniProtKB CARBOHYD
1335	Phosphorylation	TSSTINTSANTRNDL CCCCCCCCCCCHHHH	18.29	25332170
1354	N-linked_Glycosylation	DTLTSKGNLSLERLK HHHHCCCCCCHHHHH	30.14	UniProtKB CARBOHYD
1469	N-linked_Glycosylation	EKLGNIRNQSDSEEE HHHCCCCCCCCCHHH	41.74	UniProtKB CARBOHYD
1517	N-linked_Glycosylation	HLPIPSQNLTDELVK ECCCCCCCCHHHHHH	49.61	UniProtKB CARBOHYD
1587	N-linked_Glycosylation	QITQGRANSTITQLT HHHCCCCCHHHHHHH	38.02	UniProtKB CARBOHYD
1596	N-linked_Glycosylation	TITQLTANITKIKKN HHHHHHHHHHHHHHH	36.91	UniProtKB CARBOHYD
1609	N-linked_Glycosylation	KNVLQAENQTREMKS HHHHHHHHHHHHHHH	52.09	UniProtKB CARBOHYD
1636	Phosphorylation	DGLSLLQTKLQRHQD HHHHHHHHHHHHHHH	33.42	-
1689	Phosphorylation	TTGLTKETLGKVKQL CCCCCHHHHHHHHHH	42.22	-
1707	Phosphorylation	AEKLAGDTEAKIRRI HHHHCCCHHHHHHHH	36.60	23403867
1725	N-linked_Glycosylation	ERKIQDLNLSRQAKA HHHHHHCCHHHHHHH	44.23	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAMB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAMB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAMB4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LAMB4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.