| UniProt ID | SPRTN_HUMAN | |
|---|---|---|
| UniProt AC | Q9H040 | |
| Protein Name | SprT-like domain-containing protein Spartan | |
| Gene Name | SPRTN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 489 | |
| Subcellular Localization | Nucleus. Chromosome. Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress. | |
| Protein Description | Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.. | |
| Protein Sequence | MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYYGYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKDKPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRPNSKIKVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIPKNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNFFIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDSIKVKSEESL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDDDLMLA -------CCHHHHHH | 22814378 | ||
| 73 | Phosphorylation | VKWSVRMTLCAGICS CCCHHEEEEEEECCC | - | ||
| 80 | Phosphorylation | TLCAGICSYEGKGGM EEEEECCCCCCCCCE | - | ||
| 84 | Ubiquitination | GICSYEGKGGMCSIR ECCCCCCCCCEEEEE | - | ||
| 98 | Ubiquitination | RLSEPLLKLRPRKDL EECCCHHHCCCCHHH | 21890473 | ||
| 98 | Ubiquitination | RLSEPLLKLRPRKDL EECCCHHHCCCCHHH | 21890473 | ||
| 98 | Ubiquitination | RLSEPLLKLRPRKDL EECCCHHHCCCCHHH | 21890473 | ||
| 98 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 98 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 136 | Ubiquitination | GHGPEFCKHMHRINS CCCHHHHHHHHHHHH | - | ||
| 145 | Phosphorylation | MHRINSLTGANITVY HHHHHHCCCCEEEEE | - | ||
| 154 | Phosphorylation | ANITVYHTFHDEVDE CEEEEEEECCHHHHH | - | ||
| 179 | Phosphorylation | PCQHRPPYYGYVKRA CCCCCCCCCCEEEEC | 24043423 | ||
| 180 | Phosphorylation | CQHRPPYYGYVKRAT CCCCCCCCCEEEECC | 24043423 | ||
| 182 | Phosphorylation | HRPPYYGYVKRATNR CCCCCCCEEEECCCC | 24043423 | ||
| 184 | Ubiquitination | PPYYGYVKRATNREP CCCCCEEEECCCCCC | - | ||
| 203 | Ubiquitination | YWWAEHQKTCGGTYI CHHHHCCCCCCCEEE | - | ||
| 211 | Ubiquitination | TCGGTYIKIKEPENY CCCCEEEEECCCCCC | - | ||
| 213 | Sumoylation | GGTYIKIKEPENYSK CCEEEEECCCCCCCC | - | ||
| 213 | Sumoylation | GGTYIKIKEPENYSK CCEEEEECCCCCCCC | - | ||
| 213 | Ubiquitination | GGTYIKIKEPENYSK CCEEEEECCCCCCCC | - | ||
| 220 | Ubiquitination | KEPENYSKKGKGKAK CCCCCCCCCCCCCCC | 21906983 | ||
| 220 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 220 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 221 | Ubiquitination | EPENYSKKGKGKAKL CCCCCCCCCCCCCCC | - | ||
| 227 | Ubiquitination | KKGKGKAKLGKEPVL CCCCCCCCCCCCCEE | - | ||
| 230 | Sumoylation | KGKAKLGKEPVLAAE CCCCCCCCCCEEEEC | - | ||
| 230 | Ubiquitination | KGKAKLGKEPVLAAE CCCCCCCCCCEEEEC | 21906983 | ||
| 230 | Sumoylation | KGKAKLGKEPVLAAE CCCCCCCCCCEEEEC | - | ||
| 230 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 230 | Acetylation | KGKAKLGKEPVLAAE CCCCCCCCCCEEEEC | 32649882 | ||
| 230 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 241 | Sumoylation | LAAENKDKPNRGEAQ EEECCCCCCCCCCCE | - | ||
| 241 | Sumoylation | LAAENKDKPNRGEAQ EEECCCCCCCCCCCE | - | ||
| 256 | Ubiquitination | LVIPFSGKGYVLGET EEEECCCCCEEEECC | - | ||
| 263 | Phosphorylation | KGYVLGETSNLPSPG CCEEEECCCCCCCCC | 29978859 | ||
| 264 | Phosphorylation | GYVLGETSNLPSPGK CEEEECCCCCCCCCC | 22167270 | ||
| 268 | Phosphorylation | GETSNLPSPGKLITS ECCCCCCCCCCEEHH | 22167270 | ||
| 271 | Ubiquitination | SNLPSPGKLITSHAI CCCCCCCCEEHHHHH | 21890473 | ||
| 271 | Acetylation | SNLPSPGKLITSHAI CCCCCCCCEEHHHHH | 25953088 | ||
| 271 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 280 | Ubiquitination | ITSHAINKTQDLLNQ EHHHHHHHHHHHHHC | - | ||
| 290 | Phosphorylation | DLLNQNHSANAVRPN HHHHCCCCCCCCCCC | 28555341 | ||
| 298 | Phosphorylation | ANAVRPNSKIKVKFE CCCCCCCCCEEEEEE | 28555341 | ||
| 303 | Sumoylation | PNSKIKVKFEQNGSS CCCCEEEEEEECCCC | - | ||
| 303 | Sumoylation | PNSKIKVKFEQNGSS CCCCEEEEEEECCCC | 28112733 | ||
| 317 | Phosphorylation | SKNSHLVSPAVSNSH CCCCEEECCCCCCCC | 28555341 | ||
| 341 | Sumoylation | RVSFANQKAFRGVNG CHHCCCCHHHCCCCC | - | ||
| 341 | Ubiquitination | RVSFANQKAFRGVNG CHHCCCCHHHCCCCC | 21890473 | ||
| 341 | Sumoylation | RVSFANQKAFRGVNG CHHCCCCHHHCCCCC | 28112733 | ||
| 341 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 349 | Phosphorylation | AFRGVNGSPRISVTV HHCCCCCCCCEEEEE | 29978859 | ||
| 353 | Phosphorylation | VNGSPRISVTVGNIP CCCCCCEEEEECCCC | 29978859 | ||
| 355 | Phosphorylation | GSPRISVTVGNIPKN CCCCEEEEECCCCCC | 29978859 | ||
| 361 | Sumoylation | VTVGNIPKNSVSSSS EEECCCCCCCCCCHH | - | ||
| 361 | Ubiquitination | VTVGNIPKNSVSSSS EEECCCCCCCCCCHH | 21890473 | ||
| 361 | Sumoylation | VTVGNIPKNSVSSSS EEECCCCCCCCCCHH | 28112733 | ||
| 361 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 363 | Phosphorylation | VGNIPKNSVSSSSQR ECCCCCCCCCCHHCC | 29978859 | ||
| 365 | Phosphorylation | NIPKNSVSSSSQRRV CCCCCCCCCHHCCCC | 29052541 | ||
| 366 | Phosphorylation | IPKNSVSSSSQRRVS CCCCCCCCHHCCCCC | 29978859 | ||
| 367 | Phosphorylation | PKNSVSSSSQRRVSS CCCCCCCHHCCCCCC | 29978859 | ||
| 368 | Phosphorylation | KNSVSSSSQRRVSSS CCCCCCHHCCCCCCC | 29978859 | ||
| 373 | Phosphorylation | SSSQRRVSSSKISLR CHHCCCCCCCCEECC | 31316063 | ||
| 374 | Phosphorylation | SSQRRVSSSKISLRN HHCCCCCCCCEECCC | 31316063 | ||
| 375 | Phosphorylation | SQRRVSSSKISLRNS HCCCCCCCCEECCCC | 21712546 | ||
| 376 | Ubiquitination | QRRVSSSKISLRNSS CCCCCCCCEECCCCC | - | ||
| 376 | Sumoylation | QRRVSSSKISLRNSS CCCCCCCCEECCCCC | 28112733 | ||
| 382 | Phosphorylation | SKISLRNSSKVTESA CCEECCCCCCCCCCE | - | ||
| 383 | Phosphorylation | KISLRNSSKVTESAS CEECCCCCCCCCCEE | 31316063 | ||
| 384 | Ubiquitination | ISLRNSSKVTESASV EECCCCCCCCCCEEE | 21906983 | ||
| 384 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 386 | Phosphorylation | LRNSSKVTESASVMP CCCCCCCCCCEEECC | - | ||
| 398 | Phosphorylation | VMPSQDVSGSEDTFP ECCCCCCCCCCCCCC | 28555341 | ||
| 407 | Ubiquitination | SEDTFPNKRPRLEDK CCCCCCCCCCCCCCC | 21890473 | ||
| 407 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 414 | Ubiquitination | KRPRLEDKTVFDNFF CCCCCCCCCEECCEE | 21890473 | ||
| 414 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 423 | Sumoylation | VFDNFFIKKEQIKSS EECCEEEEHHHHHCC | - | ||
| 423 | Ubiquitination | VFDNFFIKKEQIKSS EECCEEEEHHHHHCC | 21890473 | ||
| 423 | Sumoylation | VFDNFFIKKEQIKSS EECCEEEEHHHHHCC | 28112733 | ||
| 423 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 424 | Ubiquitination | FDNFFIKKEQIKSSG ECCEEEEHHHHHCCC | - | ||
| 424 | Sumoylation | FDNFFIKKEQIKSSG ECCEEEEHHHHHCCC | 28112733 | ||
| 428 | Sumoylation | FIKKEQIKSSGNDPK EEEHHHHHCCCCCCC | - | ||
| 428 | Ubiquitination | FIKKEQIKSSGNDPK EEEHHHHHCCCCCCC | 21906983 | ||
| 428 | Sumoylation | FIKKEQIKSSGNDPK EEEHHHHHCCCCCCC | - | ||
| 428 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 435 | Sumoylation | KSSGNDPKYSTTTAQ HCCCCCCCCCCCCCC | - | ||
| 435 | Ubiquitination | KSSGNDPKYSTTTAQ HCCCCCCCCCCCCCC | 2190698 | ||
| 435 | Sumoylation | KSSGNDPKYSTTTAQ HCCCCCCCCCCCCCC | - | ||
| 435 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 436 | Phosphorylation | SSGNDPKYSTTTAQN CCCCCCCCCCCCCCC | 29496907 | ||
| 437 | Phosphorylation | SGNDPKYSTTTAQNS CCCCCCCCCCCCCCC | - | ||
| 444 | Phosphorylation | STTTAQNSSSSSSQS CCCCCCCCCCCCCCC | - | ||
| 446 | Phosphorylation | TTAQNSSSSSSQSKM CCCCCCCCCCCCCEE | 28985074 | ||
| 451 | Phosphorylation | SSSSSSQSKMVNCPV CCCCCCCCEECCCHH | - | ||
| 484 | Sumoylation | EGDSIKVKSEESL-- CCCEEEECCCCCC-- | - | ||
| 484 | Ubiquitination | EGDSIKVKSEESL-- CCCEEEECCCCCC-- | - | ||
| 484 | Sumoylation | EGDSIKVKSEESL-- CCCEEEECCCCCC-- | 25218447 | ||
| 484 (in isoform 1) | Ubiquitination | - | 21890473 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPRTN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPRTN_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 616200 | Ruijs-Aalfs syndrome (RJALS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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