DPOD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOD4_HUMAN
• UniProt AC: Q9HCU8
• Protein Name: DNA polymerase delta subunit 4
• Gene Name: POLD4
• Organism: Homo sapiens (Human).
• Sequence Length: 107
• Subcellular Localization: Nucleus . Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation.
• Protein Description: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. [PubMed: 16510448]
• Protein Sequence: MGRKRLITDSYPVVKRREGPAGHSKGELAPELGEEPQPRDEEEAELELLRQFDLAWQYGPCTGITRLQRWCRAKQMGLEPPPEVWQVLKTHPGDPRFQCSLWHLYPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGRKRLITDSYPVVK CCCCCCCCCCCCEEE	24.39	18212344
10	Phosphorylation	RKRLITDSYPVVKRR CCCCCCCCCCEEECC	23.76	28555341
15	Ubiquitination	TDSYPVVKRREGPAG CCCCCEEECCCCCCC	46.07	PubMed
25	Acetylation	EGPAGHSKGELAPEL CCCCCCCCCCCCHHH	51.21	11492433
25	Ubiquitination	EGPAGHSKGELAPEL CCCCCCCCCCCCHHH	51.21	2190698
74	Ubiquitination	LQRWCRAKQMGLEPP HHHHHHHHHCCCCCC	22.82	PubMed
89	Ubiquitination	PEVWQVLKTHPGDPR HHHHHHHHCCCCCCC	46.03	PubMed

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF8	O76064	PMID:23233665
-	K	Ubiquitination	E3 ubiquitin ligase	DTL	Q9NZJ0	PMID:24022480

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPOD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPOE1_HUMAN	POLE	physical	21705323
PCNA_HUMAN	PCNA	physical	16510448
DPOD1_HUMAN	POLD1	physical	16510448
DPOD3_HUMAN	POLD3	physical	16510448
DPOD2_HUMAN	POLD2	physical	16510448
PCNA_HUMAN	PCNA	physical	24022480

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.