LPPRC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LPPRC_HUMAN
• UniProt AC: P42704
• Protein Name: Leucine-rich PPR motif-containing protein, mitochondrial
• Gene Name: LRPPRC
• Organism: Homo sapiens (Human).
• Sequence Length: 1394
• Subcellular Localization: Mitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Seems to be predominantly mitochondrial.
• Protein Description: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity)..
• Protein Sequence: MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFEFYAQQLRKLRENSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAALLRSARWLLRA -CHHHHHHHHHHHHC	23.35	24043423
23	Phosphorylation	AAPRLPLSLRLLPGG CCCCCCEEEEECCCC	14.98	-
38	Phosphorylation	PGRLHAASYLPAARA CCCCCHHHCCCHHHC	28.17	28787133
54	Phosphorylation	PVAGGLLSPARLYAI CCCCCCCCHHHHHHH	22.89	21815630
66	2-Hydroxyisobutyrylation	YAIAAKEKDIQEEST HHHHHHHCCCCCCCC	60.47	-
66	Acetylation	YAIAAKEKDIQEEST HHHHHHHCCCCCCCC	60.47	26051181
66	Ubiquitination	YAIAAKEKDIQEEST HHHHHHHCCCCCCCC	60.47	-
72	Phosphorylation	EKDIQEESTFSSRKI HCCCCCCCCCCCHHH	33.72	20068231
73	Phosphorylation	KDIQEESTFSSRKIS CCCCCCCCCCCHHHH	30.71	30108239
75	Phosphorylation	IQEESTFSSRKISNQ CCCCCCCCCHHHHHH	29.35	30108239
76	Phosphorylation	QEESTFSSRKISNQF CCCCCCCCHHHHHHH	33.14	30108239
80	Phosphorylation	TFSSRKISNQFDWAL CCCCHHHHHHHHHHH	27.84	29978859
107	Acetylation	IPKKLLQKVFNDTCR CCHHHHHHHHHCHHH	49.08	25825284
107	Malonylation	IPKKLLQKVFNDTCR CCHHHHHHHHHCHHH	49.08	26320211
107	Succinylation	IPKKLLQKVFNDTCR CCHHHHHHHHHCHHH	49.08	27452117
107	Ubiquitination	IPKKLLQKVFNDTCR CCHHHHHHHHHCHHH	49.08	-
112	O-linked_Glycosylation	LQKVFNDTCRSGGLG HHHHHHCHHHCCCCC	15.78	23301498
115	Phosphorylation	VFNDTCRSGGLGGSH HHHCHHHCCCCCHHH	39.08	20068231
121	Phosphorylation	RSGGLGGSHALLLLR HCCCCCHHHHHHHHH	12.09	26546556
128	Methylation	SHALLLLRSCGSLLP HHHHHHHHHCCHHCC	29.85	115482313
130	Glutathionylation	ALLLLRSCGSLLPEL HHHHHHHCCHHCCCC	3.29	22555962
138	2-Hydroxyisobutyrylation	GSLLPELKLEERTEF CHHCCCCCHHHHHHH	52.79	-
138	Acetylation	GSLLPELKLEERTEF CHHCCCCCHHHHHHH	52.79	26051181
155	Acetylation	RIWDTLQKLGAVYDV HHHHHHHHHCCEECH	52.59	19608861
155	Ubiquitination	RIWDTLQKLGAVYDV HHHHHHHHHCCEECH	52.59	21890473
160	Phosphorylation	LQKLGAVYDVSHYNA HHHHCCEECHHHHHH	15.30	-
165	Phosphorylation	AVYDVSHYNALLKVY CEECHHHHHHHHHHH	8.47	-
172	Phosphorylation	YNALLKVYLQNEYKF HHHHHHHHHCCCCCC	10.86	28152594
177	Phosphorylation	KVYLQNEYKFSPTDF HHHHCCCCCCCHHHH	25.53	28152594
178	2-Hydroxyisobutyrylation	VYLQNEYKFSPTDFL HHHCCCCCCCHHHHH	32.94	-
178	Acetylation	VYLQNEYKFSPTDFL HHHCCCCCCCHHHHH	32.94	26051181
178	Ubiquitination	VYLQNEYKFSPTDFL HHHCCCCCCCHHHHH	32.94	-
180	Phosphorylation	LQNEYKFSPTDFLAK HCCCCCCCHHHHHHH	23.80	21712546
187	Acetylation	SPTDFLAKMEEANIQ CHHHHHHHHHHCCCC	49.33	19608861
187	Succinylation	SPTDFLAKMEEANIQ CHHHHHHHHHHCCCC	49.33	23954790
187	Ubiquitination	SPTDFLAKMEEANIQ CHHHHHHHHHHCCCC	49.33	-
188	Sulfoxidation	PTDFLAKMEEANIQP HHHHHHHHHHCCCCC	4.71	21406390
197	Methylation	EANIQPNRVTYQRLI HCCCCCCCCHHHHHH	28.92	115482305
206	Phosphorylation	TYQRLIASYCNVGDI HHHHHHHHHCCCCCC	24.19	28152594
207	Phosphorylation	YQRLIASYCNVGDIE HHHHHHHHCCCCCCC	4.49	28152594
217	Phosphorylation	VGDIEGASKILGFMK CCCCCCHHHHHCCCC	30.96	28152594
224	Acetylation	SKILGFMKTKDLPVT HHHHCCCCCCCCCCH	50.60	25953088
224	Malonylation	SKILGFMKTKDLPVT HHHHCCCCCCCCCCH	50.60	26320211
226	Acetylation	ILGFMKTKDLPVTEA HHCCCCCCCCCCHHH	52.31	-
236	Phosphorylation	PVTEAVFSALVTGHA CCHHHHHHHHHHCCC	17.69	-
248	Sulfoxidation	GHARAGDMENAENIL CCCCCCCCCCHHHHH	4.12	21406390
269	Phosphorylation	GIEPGPDTYLALLNA CCCCCHHHHHHHHHH	24.46	-
270	Phosphorylation	IEPGPDTYLALLNAY CCCCHHHHHHHHHHH	9.43	-
277	Phosphorylation	YLALLNAYAEKGDID HHHHHHHHHHHCCHH	17.77	-
280	2-Hydroxyisobutyrylation	LLNAYAEKGDIDHVK HHHHHHHHCCHHHHH	54.43	-
280	Ubiquitination	LLNAYAEKGDIDHVK HHHHHHHHCCHHHHH	54.43	-
287	2-Hydroxyisobutyrylation	KGDIDHVKQTLEKVE HCCHHHHHHHHHHHH	33.86	-
287	Acetylation	KGDIDHVKQTLEKVE HCCHHHHHHHHHHHH	33.86	26822725
287	Ubiquitination	KGDIDHVKQTLEKVE HCCHHHHHHHHHHHH	33.86	-
292	Acetylation	HVKQTLEKVEKSELH HHHHHHHHHHHHHHH	59.82	19608861
295	Acetylation	QTLEKVEKSELHLMD HHHHHHHHHHHHCCC	52.82	26822725
295	Malonylation	QTLEKVEKSELHLMD HHHHHHHHHHHHCCC	52.82	26320211
311	Phosphorylation	DLLQIIFSFSKAGYP HHHHHHHHHHCCCCH	20.43	24719451
317	Phosphorylation	FSFSKAGYPQYVSEI HHHHCCCCHHHHHHH	7.63	28152594
320	Phosphorylation	SKAGYPQYVSEILEK HCCCCHHHHHHHHHH	11.05	28152594
322	Phosphorylation	AGYPQYVSEILEKVT CCCHHHHHHHHHHHC	17.62	28152594
327	Acetylation	YVSEILEKVTCERRY HHHHHHHHHCCCHHC	39.12	26051181
334	Phosphorylation	KVTCERRYIPDAMNL HHCCCHHCCCHHHHH	24.03	-
370	Phosphorylation	VSKEDGPSVFGSFFL CCCCCCCCHHHHHHH	35.29	21406692
374	Phosphorylation	DGPSVFGSFFLQHCV CCCCHHHHHHHHHHH	11.02	21406692
382	Phosphorylation	FFLQHCVTMNTPVEK HHHHHHHHCCCCHHH	15.31	21406692
385	Phosphorylation	QHCVTMNTPVEKLTD HHHHHCCCCHHHHHH	20.21	21406692
395	Acetylation	EKLTDYCKKLKEVQM HHHHHHHHHHHHCCC	55.71	25953088
396	Acetylation	KLTDYCKKLKEVQMH HHHHHHHHHHHCCCC	62.32	7704389
398	Acetylation	TDYCKKLKEVQMHSF HHHHHHHHHCCCCCC	65.79	26051181
424	2-Hydroxyisobutyrylation	ANKTDLAKALMKAVK CCCHHHHHHHHHHHH	49.72	-
424	Acetylation	ANKTDLAKALMKAVK CCCHHHHHHHHHHHH	49.72	25953088
428	2-Hydroxyisobutyrylation	DLAKALMKAVKEEGF HHHHHHHHHHHHHCC	51.37	-
428	Acetylation	DLAKALMKAVKEEGF HHHHHHHHHHHHHCC	51.37	25953088
431	Acetylation	KALMKAVKEEGFPIR HHHHHHHHHHCCCCC	55.71	26051181
453	2-Hydroxyisobutyrylation	LVGRRKEKNVQGIIE HCCCCCCCCHHHHHH	66.51	-
453	Acetylation	LVGRRKEKNVQGIIE HCCCCCCCCHHHHHH	66.51	25953088
453	Ubiquitination	LVGRRKEKNVQGIIE HCCCCCCCCHHHHHH	66.51	21890473
463	Acetylation	QGIIEILKGMQELGV HHHHHHHHHHHHHCC	58.98	-
502	Phosphorylation	LQENGCLSDSDMFSQ HHHCCCCCCHHHHHH	38.86	28348404
506	Sulfoxidation	GCLSDSDMFSQAGLR CCCCCHHHHHHHHHH	3.94	21406390
526	Phosphorylation	GNLDFVLSFLKSNTL CCHHHHHHHHHCCCC	24.19	24719451
530	Phosphorylation	FVLSFLKSNTLPISL HHHHHHHCCCCCCCH	36.87	21712546
532	Phosphorylation	LSFLKSNTLPISLQS HHHHHCCCCCCCHHH	40.79	21712546
536	Phosphorylation	KSNTLPISLQSIRSS HCCCCCCCHHHHHHH	20.58	30108239
539	Phosphorylation	TLPISLQSIRSSLLL CCCCCHHHHHHHHHH	25.84	30108239
542	Phosphorylation	ISLQSIRSSLLLGFR CCHHHHHHHHHHHHH	24.54	21406692
543	Phosphorylation	SLQSIRSSLLLGFRR CHHHHHHHHHHHHHH	17.12	30108239
593	Phosphorylation	YNLIDSMSDSEVQAK HHHHHHCCHHHHHHH	41.77	-
605	Methylation	QAKEEHLRQYFHQLE HHHHHHHHHHHHHHH	30.94	115482289
607	Phosphorylation	KEEHLRQYFHQLEKM HHHHHHHHHHHHHHC	9.15	-
613	Acetylation	QYFHQLEKMNVKIPE HHHHHHHHCCCCCCH	44.35	19608861
613	Malonylation	QYFHQLEKMNVKIPE HHHHHHHHCCCCCCH	44.35	26320211
613	Ubiquitination	QYFHQLEKMNVKIPE HHHHHHHHCCCCCCH	44.35	21890473
617	2-Hydroxyisobutyrylation	QLEKMNVKIPENIYR HHHHCCCCCCHHHHH	47.76	-
617	Sumoylation	QLEKMNVKIPENIYR HHHHCCCCCCHHHHH	47.76	-
617	Ubiquitination	QLEKMNVKIPENIYR HHHHCCCCCCHHHHH	47.76	21890473
623	Phosphorylation	VKIPENIYRGIRNLL CCCCHHHHHHHHHHH	17.86	-
632	Phosphorylation	GIRNLLESYHVPELI HHHHHHHHCCHHHHH	22.10	28152594
633	Phosphorylation	IRNLLESYHVPELIK HHHHHHHCCHHHHHH	9.47	28152594
640	2-Hydroxyisobutyrylation	YHVPELIKDAHLLVE CCHHHHHHHHHHHHH	62.58	-
649	Acetylation	AHLLVESKNLDFQKT HHHHHHCCCCCHHHH	48.28	23749302
649	Ubiquitination	AHLLVESKNLDFQKT HHHHHHCCCCCHHHH	48.28	21890473
655	Ubiquitination	SKNLDFQKTVQLTSS CCCCCHHHHEEECHH	51.13	-
656	Phosphorylation	KNLDFQKTVQLTSSE CCCCHHHHEEECHHH	11.60	29116813
660	Phosphorylation	FQKTVQLTSSELEST HHHHEEECHHHHHHH	17.08	29116813
661	Phosphorylation	QKTVQLTSSELESTL HHHEEECHHHHHHHH	30.33	28348404
662	Phosphorylation	KTVQLTSSELESTLE HHEEECHHHHHHHHH	40.75	29116813
666	Phosphorylation	LTSSELESTLETLKA ECHHHHHHHHHHHHH	51.41	-
672	Acetylation	ESTLETLKAENQPIR HHHHHHHHHCCCCHH	62.16	26051181
702	Acetylation	MQKALELKAKYESDM HHHHHHHHHHHHHHH	33.19	25953088
705	Phosphorylation	ALELKAKYESDMVTG HHHHHHHHHHHHHCH	26.06	24144214
707	Phosphorylation	ELKAKYESDMVTGGY HHHHHHHHHHHCHHH	28.10	24144214
711	Phosphorylation	KYESDMVTGGYAALI HHHHHHHCHHHHHHH	20.46	24144214
714	Phosphorylation	SDMVTGGYAALINLC HHHHCHHHHHHHHHH	7.05	24144214
726	2-Hydroxyisobutyrylation	NLCCRHDKVEDALNL HHHHCCCCHHHHHCC	41.20	-
726	Acetylation	NLCCRHDKVEDALNL HHHHCCCCHHHHHCC	41.20	19608861
734	2-Hydroxyisobutyrylation	VEDALNLKEEFDRLD HHHHHCCHHHHHHCC	54.87	-
734	Acetylation	VEDALNLKEEFDRLD HHHHHCCHHHHHHCC	54.87	26822725
739	Methylation	NLKEEFDRLDSSAVL CCHHHHHHCCCCCCC	45.79	115482281
742	Phosphorylation	EEFDRLDSSAVLDTG HHHHHCCCCCCCCCC	25.45	25627689
743	Phosphorylation	EFDRLDSSAVLDTGK HHHHCCCCCCCCCCC	23.28	25627689
750	2-Hydroxyisobutyrylation	SAVLDTGKYVGLVRV CCCCCCCCHHHHHHH	38.56	-
750	Acetylation	SAVLDTGKYVGLVRV CCCCCCCCHHHHHHH	38.56	19608861
750	Succinylation	SAVLDTGKYVGLVRV CCCCCCCCHHHHHHH	38.56	27452117
751	Phosphorylation	AVLDTGKYVGLVRVL CCCCCCCHHHHHHHH	10.90	23882029
763	2-Hydroxyisobutyrylation	RVLAKHGKLQDAINI HHHHHCCCHHHHHHH	42.57	-
763	Acetylation	RVLAKHGKLQDAINI HHHHHCCCHHHHHHH	42.57	23236377
772	2-Hydroxyisobutyrylation	QDAINILKEMKEKDV HHHHHHHHHHHHCCC	52.55	-
772	Acetylation	QDAINILKEMKEKDV HHHHHHHHHHHHCCC	52.55	26051181
772	Succinylation	QDAINILKEMKEKDV HHHHHHHHHHHHCCC	52.55	23954790
777	2-Hydroxyisobutyrylation	ILKEMKEKDVLIKDT HHHHHHHCCCEECCC	47.85	-
777	Acetylation	ILKEMKEKDVLIKDT HHHHHHHCCCEECCC	47.85	7695359
851	2-Hydroxyisobutyrylation	VAIDCYEKYKVLPRI HHHHHHHHHCCHHHH	24.73	-
851	Acetylation	VAIDCYEKYKVLPRI HHHHHHHHHCCHHHH	24.73	26822725
864	2-Hydroxyisobutyrylation	RIHDVLCKLVEKGET HHHHHHHHHHHCCCH	51.94	-
864	Acetylation	RIHDVLCKLVEKGET HHHHHHHHHHHCCCH	51.94	23954790
864	Malonylation	RIHDVLCKLVEKGET HHHHHHHHHHHCCCH	51.94	26320211
868	2-Hydroxyisobutyrylation	VLCKLVEKGETDLIQ HHHHHHHCCCHHHHH	55.35	-
868	Acetylation	VLCKLVEKGETDLIQ HHHHHHHCCCHHHHH	55.35	23954790
868	Malonylation	VLCKLVEKGETDLIQ HHHHHHHCCCHHHHH	55.35	26320211
868	Succinylation	VLCKLVEKGETDLIQ HHHHHHHCCCHHHHH	55.35	27452117
882	Phosphorylation	QKAMDFVSQEQGEMV HHHHHHHCHHHCCHH	28.17	17322306
892	Phosphorylation	QGEMVMLYDLFFAFL HCCHHHHHHHHHHHH	7.78	28787133
901	Phosphorylation	LFFAFLQTGNYKEAK HHHHHHHHCCHHHHH	29.55	28787133
903	Phosphorylation	FAFLQTGNYKEAKKI HHHHHHCCHHHHHHH	48.36	17322306
904	Phosphorylation	AFLQTGNYKEAKKII HHHHHCCHHHHHHHH	16.14	28787133
909	Malonylation	GNYKEAKKIIETPGI CCHHHHHHHHCCCCC	56.83	26320211
913	Phosphorylation	EAKKIIETPGIRARS HHHHHHCCCCCCCCH	19.19	-
920	Phosphorylation	TPGIRARSARLQWFC CCCCCCCHHHHHHHH	19.43	24670416
929	Methylation	RLQWFCDRCVANNQV HHHHHHHHHHHCCHH	20.28	115482297
930	S-nitrosocysteine	LQWFCDRCVANNQVE HHHHHHHHHHCCHHH	1.85	-
930	S-nitrosylation	LQWFCDRCVANNQVE HHHHHHHHHHCCHHH	1.85	22178444
941	Acetylation	NQVETLEKLVELTQK CHHHHHHHHHHHHHH	62.03	23236377
958	Phosphorylation	ECDRDQMYYNLLKLY HCCHHHHHHHHHHHH	5.42	28509920
959	Phosphorylation	CDRDQMYYNLLKLYK CCHHHHHHHHHHHHH	8.26	28122231
966	2-Hydroxyisobutyrylation	YNLLKLYKINGDWQR HHHHHHHHCCCCHHH	39.88	-
966	Acetylation	YNLLKLYKINGDWQR HHHHHHHHCCCCHHH	39.88	25953088
966	Succinylation	YNLLKLYKINGDWQR HHHHHHHHCCCCHHH	39.88	23954790
980	2-Hydroxyisobutyrylation	RADAVWNKIQEENVI HHHHHHHHHHHCCCC	30.01	-
980	Acetylation	RADAVWNKIQEENVI HHHHHHHHHHHCCCC	30.01	23236377
980	Ubiquitination	RADAVWNKIQEENVI HHHHHHHHHHHCCCC	30.01	21890473
1016	Phosphorylation	FDVPELWYEDEKHSL CCCCCHHCCCCCCCC	26.57	-
1022	Phosphorylation	WYEDEKHSLNSSSAS HCCCCCCCCCCCCCC	40.07	25159151
1025	Phosphorylation	DEKHSLNSSSASTTE CCCCCCCCCCCCCCC	30.85	29255136
1026	Phosphorylation	EKHSLNSSSASTTEP CCCCCCCCCCCCCCC	28.93	29255136
1027	Phosphorylation	KHSLNSSSASTTEPD CCCCCCCCCCCCCCC	26.51	29255136
1029	Phosphorylation	SLNSSSASTTEPDFQ CCCCCCCCCCCCCHH	37.50	25849741
1030	Phosphorylation	LNSSSASTTEPDFQK CCCCCCCCCCCCHHH	34.59	29255136
1031	Phosphorylation	NSSSASTTEPDFQKD CCCCCCCCCCCHHHH	42.92	29255136
1037	2-Hydroxyisobutyrylation	TTEPDFQKDILIACR CCCCCHHHHHHHHHH	46.89	-
1037	Acetylation	TTEPDFQKDILIACR CCCCCHHHHHHHHHH	46.89	26822725
1049	2-Hydroxyisobutyrylation	ACRLNQKKGAYDIFL HHHHCCCCCCCEEEE	38.72	-
1049	Malonylation	ACRLNQKKGAYDIFL HHHHCCCCCCCEEEE	38.72	26320211
1052	Phosphorylation	LNQKKGAYDIFLNAK HCCCCCCCEEEECCC	20.45	28152594
1070	Phosphorylation	IVFNAETYSNLIKLL EEEEHHHHHHHHHHH	6.25	-
1082	Phosphorylation	KLLMSEDYFTQAMEV HHHHCCCHHHHHHHH	12.41	29083192
1084	Phosphorylation	LMSEDYFTQAMEVKA HHCCCHHHHHHHHHH	14.80	29083192
1098	2-Hydroxyisobutyrylation	AFAETHIKGFTLNDA HHHHHHCCCEECCHH	40.13	-
1098	Acetylation	AFAETHIKGFTLNDA HHHHHHCCCEECCHH	40.13	26051181
1098	Ubiquitination	AFAETHIKGFTLNDA HHHHHHCCCEECCHH	40.13	21890473
1113	O-linked_Glycosylation	ANSRLIITQVRRDYL HHCCEEEEHHHHHHH	17.64	23301498
1121	2-Hydroxyisobutyrylation	QVRRDYLKEAVTTLK HHHHHHHHHHHHHHH	37.08	-
1121	Acetylation	QVRRDYLKEAVTTLK HHHHHHHHHHHHHHH	37.08	26051181
1121	Malonylation	QVRRDYLKEAVTTLK HHHHHHHHHHHHHHH	37.08	26320211
1121	Succinylation	QVRRDYLKEAVTTLK HHHHHHHHHHHHHHH	37.08	23954790
1128	2-Hydroxyisobutyrylation	KEAVTTLKTVLDQQQ HHHHHHHHHHHHCCC	34.20	-
1128	Acetylation	KEAVTTLKTVLDQQQ HHHHHHHHHHHHCCC	34.20	25953088
1136	Phosphorylation	TVLDQQQTPSRLAVT HHHHCCCCHHHHHHH	20.92	26471730
1138	Phosphorylation	LDQQQTPSRLAVTRV HHCCCCHHHHHHHHH	43.23	21712546
1151	Sulfoxidation	RVIQALAMKGDVENI HHHHHHHHCCCHHHH	5.32	21406390
1152	2-Hydroxyisobutyrylation	VIQALAMKGDVENIE HHHHHHHCCCHHHHH	46.48	-
1163	Ubiquitination	ENIEVVQKMLNGLED HHHHHHHHHHCCCHH	33.47	-
1164	Sulfoxidation	NIEVVQKMLNGLEDS HHHHHHHHHCCCHHH	1.64	28183972
1171	Phosphorylation	MLNGLEDSIGLSKMV HHCCCHHHCCCCHHH	14.80	20068231
1175	Phosphorylation	LEDSIGLSKMVFINN CHHHCCCCHHHHCCC	17.31	20068231
1177	Sulfoxidation	DSIGLSKMVFINNIA HHCCCCHHHHCCCCH	2.40	28183972
1203	Sulfoxidation	AIENIENMLTSENKV HHHHHHHHHHCCCCC	2.54	21406390
1205	Phosphorylation	ENIENMLTSENKVIE HHHHHHHHCCCCCCC	24.19	28102081
1206	Phosphorylation	NIENMLTSENKVIEP HHHHHHHCCCCCCCH	34.90	28102081
1215	Phosphorylation	NKVIEPQYFGLAYLF CCCCCHHHHHHHHHH	15.44	-
1220	Phosphorylation	PQYFGLAYLFRKVIE HHHHHHHHHHHHHHH	16.06	-
1224	Acetylation	GLAYLFRKVIEEQLE HHHHHHHHHHHHHHH	39.98	26051181
1224	Malonylation	GLAYLFRKVIEEQLE HHHHHHHHHHHHHHH	39.98	26320211
1224	Succinylation	GLAYLFRKVIEEQLE HHHHHHHHHHHHHHH	39.98	23954790
1236	2-Hydroxyisobutyrylation	QLEPAVEKISIMAER HHHHHHHHHHHHHHH	34.84	-
1251	Phosphorylation	LANQFAIYKPVTDFF HHHCCCCCCCCCHHH	13.05	20860994
1266	2-Hydroxyisobutyrylation	LQLVDAGKVDDARAL HHHHHCCCHHHHHHH	44.18	-
1302	Phosphorylation	SRKQGKASTVKSVLE CCCCCCHHHHHHHHH	36.90	24702127
1303	Phosphorylation	RKQGKASTVKSVLEL CCCCCHHHHHHHHHH	36.49	24702127
1306	Phosphorylation	GKASTVKSVLELIPE CCHHHHHHHHHHHHH	27.83	24719451
1317	2-Hydroxyisobutyrylation	LIPELNEKEEAYNSL HHHHHCHHHHHHHHH	60.83	-
1317	Acetylation	LIPELNEKEEAYNSL HHHHHCHHHHHHHHH	60.83	23954790
1321	Nitration	LNEKEEAYNSLMKSY HCHHHHHHHHHHHHH	14.47	-
1321	Phosphorylation	LNEKEEAYNSLMKSY HCHHHHHHHHHHHHH	14.47	-
1323	Phosphorylation	EKEEAYNSLMKSYVS HHHHHHHHHHHHHCC	19.71	24719451
1326	2-Hydroxyisobutyrylation	EAYNSLMKSYVSEKD HHHHHHHHHHCCCCC	43.88	-
1326	Acetylation	EAYNSLMKSYVSEKD HHHHHHHHHHCCCCC	43.88	26822725
1326	Succinylation	EAYNSLMKSYVSEKD HHHHHHHHHHCCCCC	43.88	23954790
1327	Phosphorylation	AYNSLMKSYVSEKDV HHHHHHHHHCCCCCC	19.46	23663014
1328	Phosphorylation	YNSLMKSYVSEKDVT HHHHHHHHCCCCCCC	11.50	21406692
1330	Phosphorylation	SLMKSYVSEKDVTSA HHHHHHCCCCCCCHH	30.60	21406692
1332	2-Hydroxyisobutyrylation	MKSYVSEKDVTSAKA HHHHCCCCCCCHHHH	50.41	-
1332	Acetylation	MKSYVSEKDVTSAKA HHHHCCCCCCCHHHH	50.41	23954790
1332	Malonylation	MKSYVSEKDVTSAKA HHHHCCCCCCCHHHH	50.41	26320211
1332	Succinylation	MKSYVSEKDVTSAKA HHHHCCCCCCCHHHH	50.41	27452117
1335	Phosphorylation	YVSEKDVTSAKALYE HCCCCCCCHHHHHHH	32.85	21406692
1336	Phosphorylation	VSEKDVTSAKALYEH CCCCCCCHHHHHHHH	27.85	21406692
1338	2-Hydroxyisobutyrylation	EKDVTSAKALYEHLT CCCCCHHHHHHHHHH	38.40	-
1341	Phosphorylation	VTSAKALYEHLTAKN CCHHHHHHHHHHCCC	13.23	28152594
1345	Phosphorylation	KALYEHLTAKNTKLD HHHHHHHHCCCCCHH	37.18	28152594
1347	Acetylation	LYEHLTAKNTKLDDL HHHHHHCCCCCHHHH	60.97	25953088
1350	2-Hydroxyisobutyrylation	HLTAKNTKLDDLFLK HHHCCCCCHHHHHHH	60.35	-
1350	Ubiquitination	HLTAKNTKLDDLFLK HHHCCCCCHHHHHHH	60.35	21890473
1357	2-Hydroxyisobutyrylation	KLDDLFLKRYASLLK CHHHHHHHHHHHHHH	35.71	-
1357	Acetylation	KLDDLFLKRYASLLK CHHHHHHHHHHHHHH	35.71	26051181
1357	Succinylation	KLDDLFLKRYASLLK CHHHHHHHHHHHHHH	35.71	23954790
1361	Phosphorylation	LFLKRYASLLKYAGE HHHHHHHHHHHHCCC	25.87	24719451
1382	Phosphorylation	PPESFEFYAQQLRKL CCHHHHHHHHHHHHH	9.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LPPRC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LPPRC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LPPRC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UXT_HUMAN	UXT	physical	11827465
MAP1S_HUMAN	MAP1S	physical	11827465
CECR2_HUMAN	CECR2	physical	11827465
HEBP2_HUMAN	HEBP2	physical	11827465
PRGC1_HUMAN	PPARGC1A	physical	17050673
FOXO1_HUMAN	FOXO1	physical	17050673
RT35_HUMAN	MRPS35	physical	22939629
SC23A_HUMAN	SEC23A	physical	22939629
LMAN1_HUMAN	LMAN1	physical	26344197
LSMD1_HUMAN	NAA38	physical	26344197
CENPE_HUMAN	CENPE	physical	26496610
ERCC5_HUMAN	ERCC5	physical	26496610
ETFB_HUMAN	ETFB	physical	26496610
FEN1_HUMAN	FEN1	physical	26496610
HSP7C_HUMAN	HSPA8	physical	26496610
ICT1_HUMAN	ICT1	physical	26496610
ITPR3_HUMAN	ITPR3	physical	26496610
SCO1_HUMAN	SCO1	physical	26496610
WASP_HUMAN	WAS	physical	26496610
STK24_HUMAN	STK24	physical	26496610
LONM_HUMAN	LONP1	physical	26496610
SIR1_HUMAN	SIRT1	physical	26496610
C1TM_HUMAN	MTHFD1L	physical	26496610
TIDC1_HUMAN	TIMMDC1	physical	26496610
SPC25_HUMAN	SPC25	physical	26496610
ZC3HE_HUMAN	ZC3H14	physical	26496610
EDEM3_HUMAN	EDEM3	physical	26496610
SLIRP_HUMAN	SLIRP	physical	26496610
E2AK4_HUMAN	EIF2AK4	physical	26496610

Drug and Disease Associations

• Kegg Disease
• H00072: Pyruvate dehydrogenase complex deficiency, including: Leigh syndrome; Pyruvate dehydrogenase phospha
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• 220111: Leigh syndrome French-Canadian type (LSFC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-155; LYS-187; LYS-292;LYS-613; LYS-726; LYS-750 AND LYS-864, AND MASS SPECTROMETRY.
PubMed: 19608861