SCO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCO1_HUMAN
• UniProt AC: O75880
• Protein Name: Protein SCO1 homolog, mitochondrial
• Gene Name: SCO1
• Organism: Homo sapiens (Human).
• Sequence Length: 301
• Subcellular Localization: Mitochondrion . Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. [PubMed: 15659396]
• Protein Sequence: MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGYCLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Ubiquitination	LGGQLWRFLPRGLEF CCHHHHHHCCCCCCC	8.13	21890473
60	Phosphorylation	RASGRPGYCLGTRPL HHCCCCCCCCCCCCC	6.28	-
89	Ubiquitination	GDSTRPSKPGPVSWK CCCCCCCCCCCCCHH	57.59	22817900
89	Malonylation	GDSTRPSKPGPVSWK CCCCCCCCCCCCCHH	57.59	26320211
119	Acetylation	MKHVKKEKAEKLEKE HHHHHHHHHHHHHHH	71.39	30592243
133	Acetylation	ERQRHIGKPLLGGPF HHHHHCCCCCCCCCC	31.71	26051181
133	Ubiquitination	ERQRHIGKPLLGGPF HHHHHCCCCCCCCCC	31.71	22817900
141	Phosphorylation	PLLGGPFSLTTHTGE CCCCCCCCCEECCCC	28.12	20860994
143	Phosphorylation	LGGPFSLTTHTGERK CCCCCCCEECCCCCC	18.48	20860994
144	Phosphorylation	GGPFSLTTHTGERKT CCCCCCEECCCCCCC	23.80	28348404
146	Phosphorylation	PFSLTTHTGERKTDK CCCCEECCCCCCCCC	38.35	20860994
189	Phosphorylation	QVVDEIDSITTLPDL HHHHHHHHCCCCCCC	27.74	24275569
191	Phosphorylation	VDEIDSITTLPDLTP HHHHHHCCCCCCCCE	26.65	24275569
210	2-Hydroxyisobutyrylation	IDPERDTKEAIANYV ECCCCCHHHHHHHHH	49.81	-
210	Ubiquitination	IDPERDTKEAIANYV ECCCCCHHHHHHHHH	49.81	29901268
216	Phosphorylation	TKEAIANYVKEFSPK HHHHHHHHHHHHCHH	12.13	-
218	Ubiquitination	EAIANYVKEFSPKLV HHHHHHHHHHCHHHH	42.56	32015554
221	Phosphorylation	ANYVKEFSPKLVGLT HHHHHHHCHHHHCCC	23.40	24719451
223	Ubiquitination	YVKEFSPKLVGLTGT HHHHHCHHHHCCCCC	55.39	29967540
223	2-Hydroxyisobutyrylation	YVKEFSPKLVGLTGT HHHHHCHHHHCCCCC	55.39	-
228	Phosphorylation	SPKLVGLTGTREEVD CHHHHCCCCCHHHHH	30.49	21406692
230	Phosphorylation	KLVGLTGTREEVDQV HHHCCCCCHHHHHHH	29.67	21406692
246	Phosphorylation	RAYRVYYSPGPKDED HHHEEEECCCCCCCC	12.99	-
283	Ubiquitination	YFGQNKRKGEIAASI HHCCCCCCHHHHHHH	63.61	-
289	Phosphorylation	RKGEIAASIATHMRP CCHHHHHHHHHHCCC	12.06	20068231
292	Phosphorylation	EIAASIATHMRPYRK HHHHHHHHHCCCCCC	17.97	20068231
297	Phosphorylation	IATHMRPYRKKS--- HHHHCCCCCCCC---	25.38	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCO1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SCO1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 220110: Mitochondrial complex IV deficiency (MT-C4D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.