dbPTM

CENPE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CENPE_HUMAN
UniProt AC	Q02224
Protein Name	Centromere-associated protein E
Gene Name	CENPE
Organism	Homo sapiens (Human).
Sequence Length	2701
Subcellular Localization	Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere . Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarde
Protein Description	Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. [PubMed: 7889940]
Protein Sequence	MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	PLNSREESLGETAQV ECCCCCCHHCCCEEE	36.60	19007248
26	Phosphorylation	REESLGETAQVYWKT CCCHHCCCEEEEEEC	22.16	28122231
30	Phosphorylation	LGETAQVYWKTDNNV HCCCEEEEEECCCCE	6.79	28122231
45	Ubiquitination	IYQVDGSKSFNFDRV EEEECCCCCCCCEEE	65.67	29967540
46	Phosphorylation	YQVDGSKSFNFDRVF EEECCCCCCCCEEEE	27.41	24702127
130	Phosphorylation	REFLLRVSYMEIYNE HHHHHHHHHHHHCCC	16.60	-
131	Phosphorylation	EFLLRVSYMEIYNET HHHHHHHHHHHCCCH	8.91	-
146	Phosphorylation	ITDLLCGTQKMKPLI HHHHHHCCCCCCEEE	24.82	-
163	Phosphorylation	EDVNRNVYVADLTEE CCCCCCEEEEECCCC	8.09	-
173	Phosphorylation	DLTEEVVYTSEMALK ECCCCEEEEHHHHHH	15.10	-
191	Phosphorylation	KGEKSRHYGETKMNQ CCCCCCCCCCCCCCH	18.62	-
194	Phosphorylation	KSRHYGETKMNQRSS CCCCCCCCCCCHHHH	31.09	-
227	Ubiquitination	SNCEGSVKVSHLNLV CCCCCCEEEEEEEEE	39.45	29967540
253	Ubiquitination	GAAGVRLKEGCNINR CCCCCCCCCCCCCCH	41.31	29967540
271	Ubiquitination	ILGQVIKKLSDGQVG HHHHHHHHCCCCCCC	41.94	29967540
273	Phosphorylation	GQVIKKLSDGQVGGF HHHHHHCCCCCCCEE	48.88	22817900
283	Phosphorylation	QVGGFINYRDSKLTR CCCEEEECCHHHHHH	15.81	25884760
301	Ubiquitination	NSLGGNAKTRIICTI HHCCCCCCCEEEEEE	42.19	29967540
312	Phosphorylation	ICTITPVSFDETLTA EEEECCCCCCHHHHH	28.34	-
316	Phosphorylation	TPVSFDETLTALQFA CCCCCCHHHHHHHHH	31.11	-
328	Phosphorylation	QFASTAKYMKNTPYV HHHHHHHHHCCCCCC	15.74	-
334	Phosphorylation	KYMKNTPYVNEVSTD HHHCCCCCCCCCCCC	17.54	-
346	Ubiquitination	STDEALLKRYRKEIM CCCHHHHHHHHHHHH	48.51	29967540
348	Phosphorylation	DEALLKRYRKEIMDL CHHHHHHHHHHHHHH	25.17	-
356	Acetylation	RKEIMDLKKQLEEVS HHHHHHHHHHHHHCC	33.92	30587587
357	Ubiquitination	KEIMDLKKQLEEVSL HHHHHHHHHHHHCCH	68.37	-
373	Ubiquitination	TRAQAMEKDQLAQLL HHHHHHHHHHHHHHH	37.38	29967540
383	Ubiquitination	LAQLLEEKDLLQKVQ HHHHHHHHHHHHHHH	44.28	29967540
388	Ubiquitination	EEKDLLQKVQNEKIE HHHHHHHHHHHHHHH	45.84	29967540
393	Ubiquitination	LQKVQNEKIENLTRM HHHHHHHHHHHHHHH	63.97	29967540
398	Phosphorylation	NEKIENLTRMLVTSS HHHHHHHHHHHHHCC	26.14	22210691
403	Phosphorylation	NLTRMLVTSSSLTLQ HHHHHHHHCCCCCHH	20.94	22210691
422	Phosphorylation	AKRKRRVTWCLGKIN HHHHHHHHHHHHHHH	14.51	20860994
432	Ubiquitination	LGKINKMKNSNYADQ HHHHHHCCCCCCHHH	59.85	29967540
436	Phosphorylation	NKMKNSNYADQFNIP HHCCCCCCHHHCCCC	16.04	28555341
449	Ubiquitination	IPTNITTKTHKLSIN CCCCCCCCCCCCCHH	39.73	29967540
454	Phosphorylation	TTKTHKLSINLLREI CCCCCCCCHHHHHHC	17.77	20860994
514	Phosphorylation	YDNLVLDYEQLRTEK HHHHHHCHHHHHCHH	11.04	27642862
531	Ubiquitination	MELKLKEKNDLDEFE HHHHHHHCCCHHHHH	54.92	29967540
544	Phosphorylation	FEALERKTKKDQEMQ HHHHHHHCHHHHHHH	49.93	17081983
544 (in isoform 3)	Phosphorylation	-	49.93	17081983
555	Ubiquitination	QEMQLIHEISNLKNL HHHHHHHHHHHHHHH	40.91	29967540
564	Ubiquitination	SNLKNLVKHAEVYNQ HHHHHHHHHHHHHCH	40.02	29967540
577	Ubiquitination	NQDLENELSSKVELL CHHHHHHHHHHHHHH	12.05	29967540
580	Ubiquitination	LENELSSKVELLREK HHHHHHHHHHHHHHH	36.03	29967540
602	Ubiquitination	QEYIDSQKLENIKMD HHHHHHHHHHHCCCC	62.82	29967540
611	Phosphorylation	ENIKMDLSYSLESIE HHCCCCCHHCCHHCC	14.38	21712546
612	Phosphorylation	NIKMDLSYSLESIED HCCCCCHHCCHHCCC	25.27	27251275
613	Phosphorylation	IKMDLSYSLESIEDP CCCCCHHCCHHCCCH	23.45	23186163
613	Ubiquitination	IKMDLSYSLESIEDP CCCCCHHCCHHCCCH	23.45	29967540
638	Ubiquitination	ETVALDAKRESAFLR HHHHHHHHHHHHHHH	57.26	29967540
641	Phosphorylation	ALDAKRESAFLRSEN HHHHHHHHHHHHHCC	28.49	28555341
682	Ubiquitination	QLEAKKKMQVDLEKE HHHHHHHHCCCHHHH	6.88	29967540
692	Phosphorylation	DLEKELQSAFNEITK CHHHHHHHHHHHHHH	47.67	24532841
698	Phosphorylation	QSAFNEITKLTSLID HHHHHHHHHHHHHHC	17.52	-
702	Phosphorylation	NEITKLTSLIDGKVP HHHHHHHHHHCCCCC	33.49	-
707	Ubiquitination	LTSLIDGKVPKDLLC HHHHHCCCCCHHHHH	52.17	29967540
751	Phosphorylation	ILLSELKSLPSEVER HHHHHHHCCHHHHHH	59.13	27050516
779	Ubiquitination	IITSEKDKLFSEVVH EECCCHHHHHHHHHC	63.60	-
901	Phosphorylation	EQLENRDSTLQTVER HHHHCCHHHHHHHHH	27.99	20860994
902	Phosphorylation	QLENRDSTLQTVERE HHHCCHHHHHHHHHH	27.46	29083192
905	Phosphorylation	NRDSTLQTVEREKTL CCHHHHHHHHHHHHH	27.70	29083192
961	Ubiquitination	DTVNMNIDTQEQLRN HHHCCCCCHHHHHHH	37.02	29967540
979	Phosphorylation	SLKQHQETINTLKSK HHHHHHHHHHHHHHH	16.98	21406692
982	Phosphorylation	QHQETINTLKSKISE HHHHHHHHHHHHHHH	31.54	21406692
985	Phosphorylation	ETINTLKSKISEEVS HHHHHHHHHHHHHHH	38.03	21406692
986	Ubiquitination	TINTLKSKISEEVSR HHHHHHHHHHHHHHH	48.98	29967540
1026	Phosphorylation	QDLEAKNTQTLTADV HCHHHCCCCEEECCC	23.40	19007248
1088	Ubiquitination	IENQEELRLLGDELK HCCHHHHHHCHHHHH	31.01	16196087
1096	Ubiquitination	LLGDELKKQQEIVAQ HCHHHHHHHHHHHHH	70.60	16196087
1105	Ubiquitination	QEIVAQEKNHAIKKE HHHHHHHHHHHHHHH	41.79	-
1110	Ubiquitination	QEKNHAIKKEGELSR HHHHHHHHHHCHHHH	45.62	-
1131	Ubiquitination	EVEEKLKEKSQQLQE HHHHHHHHHHHHHHH	69.26	16196087
1139	Ubiquitination	KSQQLQEKQQQLLNV HHHHHHHHHHHHHHH	40.21	16196087
1151	Phosphorylation	LNVQEEMSEMQKKIN HHHHHHHHHHHHHHH	32.95	30576142
1156	Ubiquitination	EMSEMQKKINEIENL HHHHHHHHHHHHHHH	33.59	16196087
1162	Ubiquitination	KKINEIENLKNELKN HHHHHHHHHHHHHHC	63.07	29967540
1164	Ubiquitination	INEIENLKNELKNKE HHHHHHHHHHHHCCC	61.02	16196087
1179	Phosphorylation	LTLEHMETERLELAQ CCHHHHHHHHHHHHH	20.87	-
1187	Ubiquitination	ERLELAQKLNENYEE HHHHHHHHHHHCHHH	47.90	29967540
1192	Phosphorylation	AQKLNENYEEVKSIT HHHHHHCHHHHHHHH	13.79	28796482
1211	Phosphorylation	VLKELQKSFETERDH HHHHHHHHHHHCHHH	18.49	25159151
1214	Phosphorylation	ELQKSFETERDHLRG HHHHHHHHCHHHHHH	34.02	29449344
1236	Ubiquitination	TGLQTKEELKIAHIH CCCCCHHHHHEEEEE	57.85	29967540
1261	Ubiquitination	LRRSVSEKTAQIINT HHHHHHHHHHHHHCH	41.47	29967540
1262	Phosphorylation	RRSVSEKTAQIINTQ HHHHHHHHHHHHCHH	21.53	28555341
1268	Phosphorylation	KTAQIINTQDLEKSH HHHHHHCHHHHHHHC	17.04	22817900
1274	Phosphorylation	NTQDLEKSHTKLQEE CHHHHHHHCHHHHHH	27.32	27690223
1276	Phosphorylation	QDLEKSHTKLQEEIP HHHHHHCHHHHHHCC	40.31	27690223
1301	Phosphorylation	NVKEVSETQETMNEL CCCHHHHHHHHHHHH	24.97	30576142
1311	Ubiquitination	TMNELELLTEQSTTK HHHHHHHHHHCCCCC	3.46	29967540
1312	Phosphorylation	MNELELLTEQSTTKD HHHHHHHHHCCCCCC	44.60	30576142
1315	Phosphorylation	LELLTEQSTTKDSTT HHHHHHCCCCCCCCH	31.63	30576142
1316	Phosphorylation	ELLTEQSTTKDSTTL HHHHHCCCCCCCCHH	37.24	-
1321	Phosphorylation	QSTTKDSTTLARIEM CCCCCCCCHHHHHHH	35.64	-
1336	Ubiquitination	ERLRLNEKFQESQEE HHHHHHHHHHHCHHH	51.80	29967540
1340	Phosphorylation	LNEKFQESQEEIKSL HHHHHHHCHHHHHHH	31.91	23911959
1342	Ubiquitination	EKFQESQEEIKSLTK HHHHHCHHHHHHHHH	71.60	27667366
1344	Ubiquitination	FQESQEEIKSLTKER HHHCHHHHHHHHHHH	3.46	29967540
1369	Ubiquitination	EVKHDQLKEHIRETL HCCHHHHHHHHHHHH	41.43	29967540
1385	Ubiquitination	KIQESQSKQEQSLNM HHHHHHHHHHHHCCC	50.66	27667366
1399	Phosphorylation	MKEKDNETTKIVSEM CCHHCCHHHHHHHHH	39.38	29052541
1400	Phosphorylation	KEKDNETTKIVSEME CHHCCHHHHHHHHHH	16.76	29052541
1410	Ubiquitination	VSEMEQFKPKDSALL HHHHHHCCCCCCHHH	51.34	27667366
1439	Phosphorylation	ESHDEMKSVAKEKDD HCHHHHHHHHHHHHH	26.46	26074081
1444	Acetylation	MKSVAKEKDDLQRLQ HHHHHHHHHHHHHHH	56.70	25953088
1478	Ubiquitination	KHLETEEELKVAHCC HHCCCHHHHHHHHHH	47.89	23503661
1483	Ubiquitination	EEELKVAHCCLKEQE HHHHHHHHHHHHCHH	13.05	23503661
1484	Ubiquitination	EELKVAHCCLKEQEE HHHHHHHHHHHCHHH	1.78	23503661
1492	Phosphorylation	CLKEQEETINELRVN HHHCHHHHHHHHHCC	28.49	30108239
1501	Phosphorylation	NELRVNLSEKETEIS HHHHCCCCHHHHHHH	41.22	20860994
1505	Phosphorylation	VNLSEKETEISTIQK CCCCHHHHHHHHHHH	50.08	20860994
1508	Phosphorylation	SEKETEISTIQKQLE CHHHHHHHHHHHHHH	17.15	30576142
1521	Ubiquitination	LEAINDKLQNKIQEI HHHHHHHHHHHHHHH	8.28	23503661
1526	Ubiquitination	DKLQNKIQEIYEKEE HHHHHHHHHHHHHHH	32.42	23503661
1529	Phosphorylation	QNKIQEIYEKEEQFN HHHHHHHHHHHHHCC	21.86	30576142
1546	Ubiquitination	QISEVQEKVNELKQF HHHHHHHHHHHHHHH	33.01	23503661
1546 (in isoform 2)	Ubiquitination	-	33.01	-
1551	Ubiquitination	QEKVNELKQFKEHRK HHHHHHHHHHHHHHH	47.73	23503661
1558	Ubiquitination	KQFKEHRKAKDSALQ HHHHHHHHHHHHHHH	62.79	23503661
1564	Ubiquitination	RKAKDSALQSIESKM HHHHHHHHHHHHHHH	4.80	23503661
1601	Ubiquitination	EMKRVQEALQIERDQ HHHHHHHHHHHCHHH	6.41	23503661
1607	Ubiquitination	EALQIERDQLKENTK HHHHHCHHHHHHHHH	45.43	23503661
1626	Ubiquitination	KMKESQEKEYQFLKM HHHHHHHHHHHHHHH	54.83	23503661
1628	Phosphorylation	KESQEKEYQFLKMTA HHHHHHHHHHHHHHC	18.68	27642862
1632	Ubiquitination	EKEYQFLKMTAVNET HHHHHHHHHHCCCHH	35.18	23503661
1632 (in isoform 2)	Ubiquitination	-	35.18	-
1657	Ubiquitination	KEQFETQKLNLENIE HHHHHHCCCCCCCCH	46.92	29967540
1681	Ubiquitination	LHENLEEMRSVTKER HHHCHHHHHHHCCCH	2.56	29967540
1706	Ubiquitination	KVERDQLKENLRETI HHCHHHHHHHHHHHH	38.63	29967540
1714	Phosphorylation	ENLRETITRDLEKQE HHHHHHHHHHHHHHH	26.08	20860994
1714	Ubiquitination	ENLRETITRDLEKQE HHHHHHHHHHHHHHH	26.08	29967540
1739	Ubiquitination	EHQETIDKLRGIVSE HHHHHHHHHHHHHHH	35.91	29967540
1745	Phosphorylation	DKLRGIVSEKTNEIS HHHHHHHHHHHHHHH	31.30	20860994
1752	Phosphorylation	SEKTNEISNMQKDLE HHHHHHHHHHHHHHH	21.77	20860994
1786	Ubiquitination	AHMHLKEQQETIDKL HHHHHHHHHHHHHHH	44.84	22817900
1789	Ubiquitination	HLKEQQETIDKLRGI HHHHHHHHHHHHHHH	30.09	22817900
1794	Ubiquitination	QETIDKLRGIVSEKT HHHHHHHHHHHHHHH	38.23	22817900
1801	Phosphorylation	RGIVSEKTDKLSNMQ HHHHHHHHHHHHHHH	34.02	-
1814	Phosphorylation	MQKDLENSNAKLQEK HHHHHHHHHHHHHHH	28.87	29978859
1866	Ubiquitination	QSLTLSKLEIENLNL HCCCCHHHHHHCCHH	7.82	22817900
1869	Ubiquitination	TLSKLEIENLNLAQK CCHHHHHHCCHHHHH	46.41	22817900
1874	Ubiquitination	EIENLNLAQKLHENL HHHCCHHHHHHHHCH	11.91	22817900
1881	Ubiquitination	AQKLHENLEEMKSVM HHHHHHCHHHHHHHH	5.55	22817900
1884	Ubiquitination	LHENLEEMKSVMKER HHHCHHHHHHHHHHH	2.60	22817900
1886	Phosphorylation	ENLEEMKSVMKERDN HCHHHHHHHHHHHHH	26.57	-
1889	Ubiquitination	EEMKSVMKERDNLRR HHHHHHHHHHHHHHH	47.65	22817900
1909	Ubiquitination	KLERDQLKESLQETK HHCHHHHHHHHHHHH	39.36	22817900
1912	Ubiquitination	RDQLKESLQETKARD HHHHHHHHHHHHHHH	5.82	22817900
1917	Ubiquitination	ESLQETKARDLEIQQ HHHHHHHHHHHHHHH	20.03	22817900
1934	Ubiquitination	KTARMLSKEHKETVD HHHHHHCHHHHHHHH	60.93	22817900
1937	Ubiquitination	RMLSKEHKETVDKLR HHHCHHHHHHHHHHH	57.05	22817900
1942	Ubiquitination	EHKETVDKLREKISE HHHHHHHHHHHHHHH	45.14	22817900
1951	O-linked_Glycosylation	REKISEKTIQISDIQ HHHHHHCCCCHHHHH	17.67	30379171
1951	Phosphorylation	REKISEKTIQISDIQ HHHHHHCCCCHHHHH	17.67	28555341
2005	Ubiquitination	EMEQLKKQFEAQNLS HHHHHHHHHHHCCCC	39.56	29967540
2024	Phosphorylation	RMDNFQLTKKLHESL HCCCHHHHHHHHHHH	18.49	29083192
2061	Phosphorylation	ERDQFIATLREMIAR HHHHHHHHHHHHHHH	22.87	29083192
2083	Phosphorylation	KPEKRLLSDGQQHLT CCHHHHCCHHHHHHH	44.26	29978859
2090	Phosphorylation	SDGQQHLTESLREKC CHHHHHHHHHHHHHH	22.77	23186163
2092	Phosphorylation	GQQHLTESLREKCSR HHHHHHHHHHHHHHH	27.73	21815630
2107	Phosphorylation	IKELLKRYSEMDDHY HHHHHHHHHCCCCHH	13.85	26074081
2108	Phosphorylation	KELLKRYSEMDDHYE HHHHHHHHCCCCHHH	30.40	26074081
2109	Ubiquitination	ELLKRYSEMDDHYEC HHHHHHHCCCCHHHH	37.38	29967540
2114	Phosphorylation	YSEMDDHYECLNRLS HHCCCCHHHHHHHHC	18.48	26074081
2126	Ubiquitination	RLSLDLEKEIEFQKE HHCCCHHHHHHHHHH	71.88	29967540
2143	Phosphorylation	MRVKANLSLPYLQTK HHHHHCCCCCHHCHH	27.40	-
2163	Ubiquitination	FTANQRCSMEFHRIM HHHCHHHHHHHHHHH	24.44	29967540
2229	Ubiquitination	PSRELRDLKLNQNMD CCHHHHHCCCCCCCC	5.70	29967540
2230	Ubiquitination	SRELRDLKLNQNMDL CHHHHHCCCCCCCCC	50.08	29967540
2253	Ubiquitination	FSESEFPSIKTEFQQ CCCCCCCCHHHHHHH	41.88	23503661
2255	Ubiquitination	ESEFPSIKTEFQQVL CCCCCCHHHHHHHHH	46.47	23503661
2256	Ubiquitination	SEFPSIKTEFQQVLS CCCCCHHHHHHHHHH	40.12	23503661
2258	Ubiquitination	FPSIKTEFQQVLSNR CCCHHHHHHHHHHCH	8.13	23503661
2259	Ubiquitination	PSIKTEFQQVLSNRK CCHHHHHHHHHHCHH	26.66	23503661
2261	Ubiquitination	IKTEFQQVLSNRKEM HHHHHHHHHHCHHHH	4.38	33845483
2270	Ubiquitination	SNRKEMTQFLEEWLN HCHHHHHHHHHHHHH	39.35	23503661
2272	Ubiquitination	RKEMTQFLEEWLNTR HHHHHHHHHHHHHCC	4.13	23503661
2274	Ubiquitination	EMTQFLEEWLNTRFD HHHHHHHHHHHCCCC	60.45	23503661
2276	Ubiquitination	TQFLEEWLNTRFDIE HHHHHHHHHCCCCHH	5.47	23503661
2280	Ubiquitination	EEWLNTRFDIEKLKN HHHHHCCCCHHHHHH	11.90	23503661
2282	Ubiquitination	WLNTRFDIEKLKNGI HHHCCCCHHHHHHCC	4.65	23503661
2284	Ubiquitination	NTRFDIEKLKNGIQK HCCCCHHHHHHCCCC	66.16	29967540
2285	Ubiquitination	TRFDIEKLKNGIQKE CCCCHHHHHHCCCCC	3.19	23503661
2288	Ubiquitination	DIEKLKNGIQKENDR CHHHHHHCCCCCCCC	23.32	23503661
2299	Ubiquitination	ENDRICQVNNFFNNR CCCCEEEECHHHCCC	5.69	23503661
2303	Ubiquitination	ICQVNNFFNNRIIAI EEEECHHHCCCEEEE	9.59	23503661
2306	Ubiquitination	VNNFFNNRIIAIMNE ECHHHCCCEEEECCC	23.85	23503661
2307	Ubiquitination	NNFFNNRIIAIMNES CHHHCCCEEEECCCC	2.44	23503661
2309	Ubiquitination	FFNNRIIAIMNESTE HHCCCEEEECCCCCC	7.81	23503661
2310	Ubiquitination	FNNRIIAIMNESTEF HCCCEEEECCCCCCH	1.83	23503661
2312	Ubiquitination	NRIIAIMNESTEFEE CCEEEECCCCCCHHH	33.67	23503661
2313	Ubiquitination	RIIAIMNESTEFEER CEEEECCCCCCHHHH	41.48	23503661
2323	Ubiquitination	EFEERSATISKEWEQ CHHHHHCCCCHHHHH	27.34	23503661
2324	Ubiquitination	FEERSATISKEWEQD HHHHHCCCCHHHHHH	5.76	23503661
2327	Ubiquitination	RSATISKEWEQDLKS HHCCCCHHHHHHHHH	49.83	23503661
2328	Ubiquitination	SATISKEWEQDLKSL HCCCCHHHHHHHHHH	16.58	23503661
2330	Ubiquitination	TISKEWEQDLKSLKE CCCHHHHHHHHHHHH	63.51	29967540
2333	Ubiquitination	KEWEQDLKSLKEKNE HHHHHHHHHHHHHHH	63.13	23503661
2334	Ubiquitination	EWEQDLKSLKEKNEK HHHHHHHHHHHHHHH	52.55	23503661
2335	Ubiquitination	WEQDLKSLKEKNEKL HHHHHHHHHHHHHHH	8.75	23503661
2338	Ubiquitination	DLKSLKEKNEKLFKN HHHHHHHHHHHHHHH	69.67	23503661
2341	Ubiquitination	SLKEKNEKLFKNYQT HHHHHHHHHHHHHHH	69.49	23503661
2346	Phosphorylation	NEKLFKNYQTLKTSL HHHHHHHHHHHHHHH	11.94	29496907
2350	Ubiquitination	FKNYQTLKTSLASGA HHHHHHHHHHHHCCC	39.18	23503661
2352	Phosphorylation	NYQTLKTSLASGAQV HHHHHHHHHHCCCCC	21.98	25137130
2352	Ubiquitination	NYQTLKTSLASGAQV HHHHHHHHHHCCCCC	21.98	23503661
2353	Ubiquitination	YQTLKTSLASGAQVN HHHHHHHHHCCCCCC	5.49	23503661
2356	Ubiquitination	LKTSLASGAQVNPTT HHHHHHCCCCCCCCC	17.89	23503661
2362	Phosphorylation	SGAQVNPTTQDNKNP CCCCCCCCCCCCCCC	31.70	25137130
2362	Ubiquitination	SGAQVNPTTQDNKNP CCCCCCCCCCCCCCC	31.70	23503661
2363	Phosphorylation	GAQVNPTTQDNKNPH CCCCCCCCCCCCCCC	34.87	18491316
2367	Ubiquitination	NPTTQDNKNPHVTSR CCCCCCCCCCCCCCH	78.95	23503661
2371	Ubiquitination	QDNKNPHVTSRATQL CCCCCCCCCCHHHHH	5.69	23503661
2373	Phosphorylation	NKNPHVTSRATQLTT CCCCCCCCHHHHHCH	20.87	25137130
2373 (in isoform 2)	Ubiquitination	-	20.87	-
2377	Ubiquitination	HVTSRATQLTTEKIR CCCCHHHHHCHHHHH	35.51	23503661
2378	Ubiquitination	VTSRATQLTTEKIRE CCCHHHHHCHHHHHH	5.78	23503661
2381	Ubiquitination	RATQLTTEKIRELEN HHHHHCHHHHHHHHH	41.05	23503661
2382	Ubiquitination	ATQLTTEKIRELENS HHHHCHHHHHHHHHH	45.00	33845483
2384	Ubiquitination	QLTTEKIRELENSLH HHCHHHHHHHHHHHH	54.22	23503661
2384 (in isoform 2)	Ubiquitination	-	54.22	-
2388 (in isoform 2)	Ubiquitination	-	63.60	-
2389	Phosphorylation	KIRELENSLHEAKES HHHHHHHHHHHHHHH	23.02	25159151
2395	Ubiquitination	NSLHEAKESAMHKES HHHHHHHHHHHHHHH	51.26	23503661
2399	Ubiquitination	EAKESAMHKESKIIK HHHHHHHHHHHHHHH	30.37	23503661
2403	Ubiquitination	SAMHKESKIIKMQKE HHHHHHHHHHHHHHH	49.93	23503661
2405	Ubiquitination	MHKESKIIKMQKELE HHHHHHHHHHHHHHH	3.32	23503661
2406	Ubiquitination	HKESKIIKMQKELEV HHHHHHHHHHHHHHH	38.46	23503661
2409	Ubiquitination	SKIIKMQKELEVTND HHHHHHHHHHHHCHH	61.85	23503661
2420	Ubiquitination	VTNDIIAKLQAKVHE HCHHHHHHHHHHHHH	30.62	23503661
2424	Ubiquitination	IIAKLQAKVHESNKC HHHHHHHHHHHCCHH	31.03	23503661
2430	Ubiquitination	AKVHESNKCLEKTKE HHHHHCCHHHHHHHH	49.85	23503661
2451	Ubiquitination	DKVALGAKPYKEEIE HHHHCCCCCCHHHHH	47.27	29967540
2457	Ubiquitination	AKPYKEEIEDLKMKL CCCCHHHHHHHHHHH	5.39	23503661
2459	Ubiquitination	PYKEEIEDLKMKLVK CCHHHHHHHHHHHHH	58.20	23503661
2460	Ubiquitination	YKEEIEDLKMKLVKI CHHHHHHHHHHHHHH	3.66	23503661
2462	Ubiquitination	EEIEDLKMKLVKIDL HHHHHHHHHHHHHCH	5.43	23503661
2483	Phosphorylation	KEFEKEISATKATVE HHHHHHHHCCHHHHH	30.86	22210691
2486	Ubiquitination	EKEISATKATVEYQK HHHHHCCHHHHHHHH	41.60	23503661
2489	Ubiquitination	ISATKATVEYQKEVI HHCCHHHHHHHHHHH	8.45	23503661
2510	Ubiquitination	LRRSQQAQDTSVISE HHHHHHHHHCCHHCC	50.61	23503661
2511	Ubiquitination	RRSQQAQDTSVISEH HHHHHHHHCCHHCCC	43.92	23503661
2513	Phosphorylation	SQQAQDTSVISEHTD HHHHHHCCHHCCCCC	26.24	19007248
2513	Ubiquitination	SQQAQDTSVISEHTD HHHHHHCCHHCCCCC	26.24	23503661
2514	Ubiquitination	QQAQDTSVISEHTDP HHHHHCCHHCCCCCC	6.40	23503661
2520	Ubiquitination	SVISEHTDPQPSNKP CHHCCCCCCCCCCCC	41.57	33845483
2539	Ubiquitination	GGSGIVQNTKALILK CCCCHHCCCCCHHHH	32.43	23503661
2542	Ubiquitination	GIVQNTKALILKSEH CHHCCCCCHHHHHHH	9.59	23503661
2554	Ubiquitination	SEHIRLEKEISKLKQ HHHHHHHHHHHHHHH	66.01	23503661
2557	Ubiquitination	IRLEKEISKLKQQNE HHHHHHHHHHHHHHH	32.78	23503661
2570	Phosphorylation	NEQLIKQKNELLSNN HHHHHHHHHHHHHCC	47.60	9744883
2571 (in isoform 2)	Ubiquitination	-	42.53	-
2581	Phosphorylation	LSNNQHLSNEVKTWK HHCCHHHHHHHHHHH	28.90	25159151
2582	Ubiquitination	SNNQHLSNEVKTWKE HCCHHHHHHHHHHHH	65.52	23503661
2585	Ubiquitination	QHLSNEVKTWKERTL HHHHHHHHHHHHHHH	42.35	23503661
2586	Phosphorylation	HLSNEVKTWKERTLK HHHHHHHHHHHHHHH	47.12	24719451
2601	Phosphorylation	REAHKQVTCENSPKS HHHHHHCCCCCCCCC	16.17	18669648
2605	Phosphorylation	KQVTCENSPKSPKVT HHCCCCCCCCCCCCC	16.06	25159151
2607	Ubiquitination	VTCENSPKSPKVTGT CCCCCCCCCCCCCCC	78.27	23503661
2608	Phosphorylation	TCENSPKSPKVTGTA CCCCCCCCCCCCCCC	33.08	25159151
2609	Phosphorylation	CENSPKSPKVTGTAS CCCCCCCCCCCCCCC	41.06	18669648
2610	Ubiquitination	ENSPKSPKVTGTASK CCCCCCCCCCCCCCC	60.56	23503661
2612	Phosphorylation	SPKSPKVTGTASKKK CCCCCCCCCCCCCCC	34.63	-
2613	Phosphorylation	PKSPKVTGTASKKKQ CCCCCCCCCCCCCCC	23.44	16565220
2616	Phosphorylation	PKVTGTASKKKQITP CCCCCCCCCCCCCCH	44.86	16565220
2622	Phosphorylation	ASKKKQITPSQCKER CCCCCCCCHHHHHHC	17.88	22199227
2624	Phosphorylation	KKKQITPSQCKERNL CCCCCCHHHHHHCCC	39.29	22199227
2639	Phosphorylation	QDPVPKESPKSCFFD CCCCCCCCCCCCCCC	43.69	23401153
2641	Ubiquitination	PVPKESPKSCFFDSR CCCCCCCCCCCCCCC	69.96	33845483
2642	Phosphorylation	VPKESPKSCFFDSRS CCCCCCCCCCCCCCC	21.38	27174698
2647	Phosphorylation	PKSCFFDSRSKSLPS CCCCCCCCCCCCCCC	33.04	21815630
2649	Phosphorylation	SCFFDSRSKSLPSPH CCCCCCCCCCCCCCC	30.46	25159151
2651	Phosphorylation	FFDSRSKSLPSPHPV CCCCCCCCCCCCCCC	46.92	25159151
2654	Phosphorylation	SRSKSLPSPHPVRYF CCCCCCCCCCCCCCC	40.93	25159151
2664	Phosphorylation	PVRYFDNSSLGLCPE CCCCCCCCCCCCCHH	28.87	-
2698	Farnesylation	SGKDVPECKTQ---- CCCCCCCCCCC----	4.78	10852915
2698	Farnesylation	SGKDVPECKTQ---- CCCCCCCCCCC----	4.78	10852915
2698	Methylation	SGKDVPECKTQ---- CCCCCCCCCCC----	4.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
422	T	Phosphorylation	Kinase	AURKA	O14965	GPS
2605	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
2608	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
2639	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
2654	S	Phosphorylation	Kinase	MAPK1	P28482	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CENPE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CENPE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRC1_HUMAN	PRC1	physical	15297875
MK01_HUMAN	MAPK1	physical	9744883
SEPT7_HUMAN	SEPT7	physical	19779646
CUL1_HUMAN	CUL1	physical	19779646
NUF2_HUMAN	NUF2	physical	19779646
FANCA_HUMAN	FANCA	physical	19779646
TRAF4_HUMAN	TRAF4	physical	19779646
DNJB1_HUMAN	DNAJB1	physical	19779646
CENPE_HUMAN	CENPE	physical	19779646
SKP1_HUMAN	SKP1	physical	16682006
TPM4_HUMAN	TPM4	physical	26344197
TSN_HUMAN	TSN	physical	26344197
RED2_HUMAN	ADARB2	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
CLAP2_HUMAN	CLASP2	physical	26496610
RM24_HUMAN	MRPL24	physical	26496610
MISP_HUMAN	MISP	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616051	Microcephaly 13, primary, autosomal recessive (MCPH13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CENPE_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2639 AND SER-2647, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; THR-1026; SER-2389;SER-2513 AND SER-2639, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-422; SER-454; SER-611;SER-1211; THR-1268; SER-2639; SER-2651 AND SER-2654, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544, AND MASSSPECTROMETRY.	17081983 [Abstract]
Prenylation
Reference	PubMed
"Farnesyl transferase inhibitors block the farnesylation of CENP-E andCENP-F and alter the association of CENP-E with the microtubules."; Ashar H.R., James L., Gray K., Carr D., Black S., Armstrong L.,Bishop W.R., Kirschmeier P.; J. Biol. Chem. 275:30451-30457(2000). Cited for: ISOPRENYLATION AT CYS-2698.	10852915 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1937, AND MASSSPECTROMETRY.	17370265 [Abstract]