RED2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RED2_HUMAN
• UniProt AC: Q9NS39
• Protein Name: Double-stranded RNA-specific editase B2
• Gene Name: ADARB2
• Organism: Homo sapiens (Human).
• Sequence Length: 739
• Subcellular Localization: Nucleus.
• Protein Description: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA..
• Protein Sequence: MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLAPFKHLSPGITNTEDDDTLSTSSAEVKENRNVGNLAARPPPSGDRARGGAPGAKRKRPLEEGNGGHLCKLQLVWKKLSWSVAPKNALVQLHELRPGLQYRTVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMRAAELALRSFVQFPNACQAHLAMGGGPGPGTDFTSDQADFPDTLFQEFEPPAPRPGLAGGRPGDAALLSAAYGRRRLLCRALDLVGPTPATPAAPGERNPVVLLNRLRAGLRYVCLAEPAERRARSFVMAVSVDGRTFEGSGRSKKLARGQAAQAALQELFDIQMPGHAPGRARRTPMPQEFADSISQLVTQKFREVTTDLTPMHARHKALAGIVMTKGLDARQAQVVALSSGTKCISGEHLSDQGLVVNDCHAEVVARRAFLHFLYTQLELHLSKRREDSERSIFVRLKEGGYRLRENILFHLYVSTSPCGDARLHSPYEITTDLHSSKHLVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGVLLGEQLITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMSHRMEGVGQLPASYRHNRPLLSGVSDAEARQPGKSPPFSMNWVVGSADLEIINATTGRRSCGGPSRLCKHVLSARWARLYGRLSTRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKAGLGTWVRKPPEQQQFLLTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASVLGSGRG -----CCCCCCCCCC	19.31	23403867
7	Phosphorylation	-MASVLGSGRGSGGL -CCCCCCCCCCCCCC	22.58	23532336
37	Phosphorylation	SKRKDKVSILSTFLA HHHHHHHHHHHHHHH	24.45	22199227
40	Phosphorylation	KDKVSILSTFLAPFK HHHHHHHHHHHHHCC	18.55	22199227
41	Phosphorylation	DKVSILSTFLAPFKH HHHHHHHHHHHHCCC	21.15	22199227
50	Phosphorylation	LAPFKHLSPGITNTE HHHCCCCCCCCCCCC	22.31	24732914
54	Phosphorylation	KHLSPGITNTEDDDT CCCCCCCCCCCCCCC	41.84	24732914
56	Phosphorylation	LSPGITNTEDDDTLS CCCCCCCCCCCCCCC	31.94	24732914
61	Phosphorylation	TNTEDDDTLSTSSAE CCCCCCCCCCCCCHH	29.60	24732914
63	Phosphorylation	TEDDDTLSTSSAEVK CCCCCCCCCCCHHHH	28.47	24732914
64	Phosphorylation	EDDDTLSTSSAEVKE CCCCCCCCCCHHHHH	29.79	24732914
65	Phosphorylation	DDDTLSTSSAEVKEN CCCCCCCCCHHHHHH	24.95	24732914
66	Phosphorylation	DDTLSTSSAEVKENR CCCCCCCCHHHHHHC	28.65	24732914
70	Ubiquitination	STSSAEVKENRNVGN CCCCHHHHHHCCCCC	40.55	29967540
121	Phosphorylation	QLVWKKLSWSVAPKN EEEEECCCCCCCCCC	26.61	24732914
123	Phosphorylation	VWKKLSWSVAPKNAL EEECCCCCCCCCCHH	12.67	24732914
175	Ubiquitination	EGTGPTKKKAKMRAA ECCCCCHHHHHHHHH	61.51	25015289
178	Ubiquitination	GPTKKKAKMRAAELA CCCHHHHHHHHHHHH	37.49	25015289
305	Phosphorylation	PAERRARSFVMAVSV HHHHHCCEEEEEEEE	22.62	20860994
311	Phosphorylation	RSFVMAVSVDGRTFE CEEEEEEEECCCEEC	12.64	20860994
316	Phosphorylation	AVSVDGRTFEGSGRS EEEECCCEECCCCCC	31.41	29759185
320	Phosphorylation	DGRTFEGSGRSKKLA CCCEECCCCCCHHHH	24.68	50563611
323	Phosphorylation	TFEGSGRSKKLARGQ EECCCCCCHHHHHHH	37.35	50563617
612	Phosphorylation	GVGQLPASYRHNRPL CCCCCCHHHHCCCCC	22.28	46159499
634	Phosphorylation	EARQPGKSPPFSMNW HHCCCCCCCCCCCCE	43.66	46159505
638	Phosphorylation	PGKSPPFSMNWVVGS CCCCCCCCCCEEECC	19.58	46159511
696	Phosphorylation	PGDTPSMYCEAKLGA CCCCHHHCEEEECCC	7.47	50563605
719	Ubiquitination	QLFKAFQKAGLGTWV HHHHHHHHCCCCCCC	37.66	30230243
728	Ubiquitination	GLGTWVRKPPEQQQF CCCCCCCCCHHHHCE	56.13	30230243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RED2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RED2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RED2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANKH1_HUMAN	ANKHD1	physical	24778252
NOP16_HUMAN	NOP16	physical	24778252
P85B_HUMAN	PIK3R2	physical	24778252
PSME3_HUMAN	PSME3	physical	24778252

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.