dbPTM

ANKH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANKH1_HUMAN
UniProt AC	Q8IWZ3
Protein Name	Ankyrin repeat and KH domain-containing protein 1
Gene Name	ANKHD1
Organism	Homo sapiens (Human).
Sequence Length	2542
Subcellular Localization	Cytoplasm .
Protein Description	May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases..
Protein Sequence	MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTAASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVTSTCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSASNSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTDAQQIWPGTWAPHIGNMHLKYVN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLTDSGGG -------CCCCCCCC	40.43	22814378
3	Phosphorylation	-----MLTDSGGGGT -----CCCCCCCCCC	39.72	28464451
5	Phosphorylation	---MLTDSGGGGTSF ---CCCCCCCCCCCH	33.82	25627689
10	Phosphorylation	TDSGGGGTSFEEDLD CCCCCCCCCHHHHHH	33.25	29507054
11	Phosphorylation	DSGGGGTSFEEDLDS CCCCCCCCHHHHHHH	33.66	25159151
18	Phosphorylation	SFEEDLDSVAPRSAP CHHHHHHHCCCCCCC	27.72	26074081
23	Phosphorylation	LDSVAPRSAPAGASE HHHCCCCCCCCCCCC	37.23	29978859
29	Phosphorylation	RSAPAGASEPPPPGG CCCCCCCCCCCCCCC	50.12	28555341
43	Phosphorylation	GVGLGIRTVRLFGEA CCCCCCEEEEECCCC	14.20	-
54	Phosphorylation	FGEAGPASGVGSSGG CCCCCCCCCCCCCCC	36.83	22210691
58	Phosphorylation	GPASGVGSSGGGGSG CCCCCCCCCCCCCCC	24.33	25159151
59	Phosphorylation	PASGVGSSGGGGSGS CCCCCCCCCCCCCCC	35.21	25159151
64	Phosphorylation	GSSGGGGSGSGTGGG CCCCCCCCCCCCCCC	32.82	25159151
66	Phosphorylation	SGGGGSGSGTGGGDA CCCCCCCCCCCCCHH	34.57	25159151
86	Phosphorylation	LAAAVLRTGGGGGAS HHHHHHHCCCCCCCC	35.70	30278072
93	Phosphorylation	TGGGGGASGSDEDEV CCCCCCCCCCCHHHH	41.95	26503892
95	Phosphorylation	GGGGASGSDEDEVSE CCCCCCCCCHHHHHH	35.02	26503892
101	Phosphorylation	GSDEDEVSEVESFIL CCCHHHHHHHHHHCC	33.60	28102081
105	Phosphorylation	DEVSEVESFILDQED HHHHHHHHHCCCHHH	23.82	28674151
120	Phosphorylation	LDNPVLKTTSEIFLS CCCCCHHCHHHHHHH	31.24	28348404
121	Phosphorylation	DNPVLKTTSEIFLSS CCCCHHCHHHHHHHC	23.83	28348404
122	Phosphorylation	NPVLKTTSEIFLSST CCCHHCHHHHHHHCC	33.65	28348404
136	Methylation	TAEGADLRTVDPETQ CCCCCCCCCCCHHHH	33.00	-
157	Ubiquitination	LEAAGIGKLSTADGK HHHCCCCCCCCCCCH	37.03	29967540
164	Ubiquitination	KLSTADGKAFADPEV CCCCCCCHHCCCHHH	40.66	21890473
164	Ubiquitination	KLSTADGKAFADPEV CCCCCCCHHCCCHHH	40.66	22817900
164 (in isoform 1)	Ubiquitination	-	40.66	21890473
164 (in isoform 2)	Ubiquitination	-	40.66	21890473
164 (in isoform 4)	Ubiquitination	-	40.66	21890473
164 (in isoform 5)	Ubiquitination	-	40.66	21890473
173	Methylation	FADPEVLRRLTSSVS CCCHHHHHHHHHHHH	36.42	-
176	Phosphorylation	PEVLRRLTSSVSCAL HHHHHHHHHHHHHHH	19.69	28450419
177	Phosphorylation	EVLRRLTSSVSCALD HHHHHHHHHHHHHHH	33.08	28450419
178	Phosphorylation	VLRRLTSSVSCALDE HHHHHHHHHHHHHHH	16.89	28450419
180	Phosphorylation	RRLTSSVSCALDEAA HHHHHHHHHHHHHHH	8.81	28450419
181	S-nitrosylation	RLTSSVSCALDEAAA HHHHHHHHHHHHHHH	4.01	24105792
183	Ubiquitination	TSSVSCALDEAAAAL HHHHHHHHHHHHHHH	7.78	24816145
191	Phosphorylation	DEAAAALTRMKAENS HHHHHHHHHHHHHCC	24.80	-
194	Ubiquitination	AAALTRMKAENSHNA HHHHHHHHHHCCCCC	49.62	24816145
198	Phosphorylation	TRMKAENSHNAGQVD HHHHHHCCCCCCCCC	15.04	25159151
208	Phosphorylation	AGQVDTRSLAEACSD CCCCCHHHHHHHCCC	33.74	20873877
212	Ubiquitination	DTRSLAEACSDGDVN CHHHHHHHCCCCCHH	7.78	24816145
213	S-nitrosylation	TRSLAEACSDGDVNA HHHHHHHCCCCCHHH	2.61	24105792
223	Ubiquitination	GDVNAVRKLLDEGRS CCHHHHHHHHHCCCC	46.96	24816145
270	Ubiquitination	NVEDRGNKGDITPLM CCHHCCCCCCCHHHH	61.86	-
361	Ubiquitination	ARVLLDHGAGINTHS HHHHHHCCCCCCCCC	25.76	29967540
371	Ubiquitination	INTHSNEFKESALTL CCCCCHHHHHHHHHH	14.40	29967540
372	Ubiquitination	NTHSNEFKESALTLA CCCCHHHHHHHHHHH	44.58	29967540
380	S-nitrosylation	ESALTLACYKGHLDM HHHHHHHHHHCHHHH	3.97	24105792
382	Ubiquitination	ALTLACYKGHLDMVR HHHHHHHHCHHHHHH	39.47	29967540
535	S-nitrosylation	GADIELGCSTPLMEA CCCEEECCCCCCHHH	6.82	24105792
557	Phosphorylation	LVKYLLASGANVHAT HHHHHHHCCCCEEEE	38.11	-
567	Phosphorylation	NVHATTATGDTALTY CEEEEECCCCHHHHH	33.23	-
590	Ubiquitination	VADVLLQAGADLEHE HHHHHHHCCCCCCCC	18.34	29967540
600	Ubiquitination	DLEHESEGGRTPLMK CCCCCCCCCCCHHHH	39.91	29967540
601	Ubiquitination	LEHESEGGRTPLMKA CCCCCCCCCCHHHHH	26.66	29967540
607	Ubiquitination	GGRTPLMKAARAGHL CCCCHHHHHHHHCCE	46.72	27667366
611	Ubiquitination	PLMKAARAGHLCTVQ HHHHHHHHCCEEEEH	12.67	29967540
622	O-linked_Glycosylation	CTVQFLISKGANVNR EEEHHHHHCCCCCCC	27.47	30059200
666	Ubiquitination	ADPTHRLKDGSTMLI CCCCCCCCCCCEEEE	61.06	29967540
735	Phosphorylation	PPQEPDRTSQENSPA CCCCCCCCCCCCCCC	41.99	25159151
736	Phosphorylation	PQEPDRTSQENSPAL CCCCCCCCCCCCCCC	36.07	25159151
740	Phosphorylation	DRTSQENSPALLGVQ CCCCCCCCCCCCCCC	15.70	25159151
748	Ubiquitination	PALLGVQKGTSKQKS CCCCCCCCCCCCCCC	62.85	29967540
772	Phosphorylation	LLPSFHPYQPLECIV CCCCCCCCCCCEEEE	17.75	-
794	Phosphorylation	NELGQRISAIEKAQL HHHHHHHHHHHHHHH	25.94	28555341
798	Ubiquitination	QRISAIEKAQLKSLE HHHHHHHHHHHHHCH	35.01	29967540
802	Ubiquitination	AIEKAQLKSLELIQG HHHHHHHHHCHHHCC	40.70	29967540
803	Phosphorylation	IEKAQLKSLELIQGE HHHHHHHHCHHHCCC	35.35	29507054
832	Acetylation	EEQVQKKKKILKELQ HHHHHHHHHHHHHHH	52.67	-
848	Ubiquitination	VERQLQMKTQQQFTK HHHHHHHHHHHHHHH	30.16	29967540
855	Ubiquitination	KTQQQFTKEYLETKG HHHHHHHHHHHHHCC	45.72	29967540
857	Phosphorylation	QQQFTKEYLETKGQK HHHHHHHHHHHCCCC	16.05	-
874	Phosphorylation	VSLHQQCSHRGVFPE EEHHHHHCCCCCCCC	16.33	28857561
887	Phosphorylation	PEGEGDGSLPEDHFS CCCCCCCCCCCCCCC	45.55	25159151
894	Phosphorylation	SLPEDHFSELPQVDT CCCCCCCCCCCCCCE	34.50	27732954
901	Phosphorylation	SELPQVDTILFKDND CCCCCCCEEEECCCC	22.26	27732954
931	Phosphorylation	FVPVQPLSSPQCNFS EEECCCCCCCCCCCC	46.81	26074081
932	Phosphorylation	VPVQPLSSPQCNFSS EECCCCCCCCCCCCC	27.03	26074081
938	Phosphorylation	SSPQCNFSSDLGSNG CCCCCCCCCCCCCCC	14.67	26074081
939	Phosphorylation	SPQCNFSSDLGSNGT CCCCCCCCCCCCCCC	32.49	26074081
1118	Phosphorylation	GGDIEAQSERTKDTP CCCCCCCCCCCCCCC	35.77	28122231
1122	Ubiquitination	EAQSERTKDTPLSLA CCCCCCCCCCCCEEE	66.86	24816145
1185	Phosphorylation	GAEINSRTGSKLGIS CCCCCCCCCCCCCCC	45.70	46163925
1187	Phosphorylation	EINSRTGSKLGISPL CCCCCCCCCCCCCHH	24.88	23612710
1192	Phosphorylation	TGSKLGISPLMLAAM CCCCCCCCHHHHHHH	15.35	46163883
1241	Phosphorylation	QGRAEVVSLLLDRKA HCCHHHHHHHHCCCC	20.62	21406692
1255	Ubiquitination	ANVEHRAKTGLTPLM CCHHHHHHHCCHHHH	42.98	29967540
1256	Phosphorylation	NVEHRAKTGLTPLME CHHHHHHHCCHHHHH	36.12	20068231
1259	Phosphorylation	HRAKTGLTPLMEAAS HHHHHCCHHHHHHHC	18.74	20068231
1266	Phosphorylation	TPLMEAASGGYAEVG HHHHHHHCCCCCCHH	39.54	22210691
1269	Phosphorylation	MEAASGGYAEVGRVL HHHHCCCCCCHHHEE	11.78	22210691
1279	Ubiquitination	VGRVLLDKGADVNAP HHHEEEECCCCCCCC	56.84	29967540
1290	Phosphorylation	VNAPPVPSSRDTALT CCCCCCCCCHHHEEE	37.93	21406692
1291	Phosphorylation	NAPPVPSSRDTALTI CCCCCCCCHHHEEEE	28.27	21406692
1302	Ubiquitination	ALTIAADKGHYKFCE EEEEEECCCCHHHHH	42.75	21890473
1302	Ubiquitination	ALTIAADKGHYKFCE EEEEEECCCCHHHHH	42.75	21890473
1302 (in isoform 1)	Ubiquitination	-	42.75	21890473
1302 (in isoform 4)	Ubiquitination	-	42.75	21890473
1305	Phosphorylation	IAADKGHYKFCELLI EEECCCCHHHHHHHE	17.90	18083107
1306	Ubiquitination	AADKGHYKFCELLIH EECCCCHHHHHHHEE	37.55	22817900
1364	O-linked_Glycosylation	RKITPLMSAFRKGHV CCCHHHHHHHHCCCH	31.75	30059200
1372	Ubiquitination	AFRKGHVKVVQYLVK HHHCCCHHHHHHHHH	30.89	29967540
1398	Phosphorylation	MRYIATITDKELLKK HHHHHHCCCHHHHHH	36.34	21815630
1400	Ubiquitination	YIATITDKELLKKCH HHHHCCCHHHHHHHH	41.43	33845483
1405	Ubiquitination	TDKELLKKCHQCVET CCHHHHHHHHHHHHH	36.60	29967540
1426	Ubiquitination	QQAAEANKNASILLK HHHHHHHHCHHHHHH	62.02	29967540
1429	Phosphorylation	AEANKNASILLKELD HHHHHCHHHHHHHHC	24.14	21815630
1433	Ubiquitination	KNASILLKELDLEKS HCHHHHHHHHCHHHC	53.43	32015554
1446	Ubiquitination	KSREESRKQALAAKR HCHHHHHHHHHHHHH	49.56	24816145
1452	Acetylation	RKQALAAKREKRKEK HHHHHHHHHHHHHHH	56.32	-
1468	Ubiquitination	KKKKEEQKRKQEEDE HHHHHHHHHHHHHHH	65.91	24816145
1537	Phosphorylation	KKRANVVTTPSTNRK CCCCCEECCCCCCCC	28.80	23403867
1538	Phosphorylation	KRANVVTTPSTNRKN CCCCEECCCCCCCCC	12.02	25159151
1540	Phosphorylation	ANVVTTPSTNRKNKK CCEECCCCCCCCCCC	35.90	25159151
1541	Phosphorylation	NVVTTPSTNRKNKKN CEECCCCCCCCCCCC	40.00	25159151
1546	Acetylation	PSTNRKNKKNKTKET CCCCCCCCCCCCCCC	61.84	-
1549	Acetylation	NRKNKKNKTKETPPT CCCCCCCCCCCCCCC	70.61	-
1550	Phosphorylation	RKNKKNKTKETPPTA CCCCCCCCCCCCCCC	43.43	28450419
1551	Acetylation	KNKKNKTKETPPTAH CCCCCCCCCCCCCCE	62.29	-
1553	Phosphorylation	KKNKTKETPPTAHLI CCCCCCCCCCCCEEE	35.80	25159151
1556	Phosphorylation	KTKETPPTAHLILPE CCCCCCCCCEEECHH	28.10	28450419
1591	Phosphorylation	GGGAGGNSDSDNLDS CCCCCCCCCCCCCCC	41.59	30278072
1593	Phosphorylation	GAGGNSDSDNLDSTD CCCCCCCCCCCCCCC	28.37	30278072
1598	Phosphorylation	SDSDNLDSTDCNSES CCCCCCCCCCCCCCC	29.34	23927012
1599	Phosphorylation	DSDNLDSTDCNSESS CCCCCCCCCCCCCCC	44.21	28985074
1603	Phosphorylation	LDSTDCNSESSSGGK CCCCCCCCCCCCCCC	45.23	23927012
1606	Phosphorylation	TDCNSESSSGGKSQE CCCCCCCCCCCCCCE	29.02	22468782
1607	Phosphorylation	DCNSESSSGGKSQEL CCCCCCCCCCCCCEE	61.93	21815630
1611	Phosphorylation	ESSSGGKSQELNFVM CCCCCCCCCEEEEEE	31.96	20068231
1622	Phosphorylation	NFVMDVNSSKYPSLL EEEEECCCCCCCCEE	28.23	22210691
1625	Phosphorylation	MDVNSSKYPSLLLHS EECCCCCCCCEEEEC	10.45	-
1627	Phosphorylation	VNSSKYPSLLLHSQE CCCCCCCCEEEECCC	28.67	28555341
1632	Phosphorylation	YPSLLLHSQEEKTST CCCEEEECCCCCCCC	38.98	28985074
1653	Phosphorylation	TRLEGEVTPNSLSTS EEEECEECCCCCCCC	16.67	10470851
1656	O-linked_Glycosylation	EGEVTPNSLSTSYKT ECEECCCCCCCCEEE	25.54	30059200
1656	Phosphorylation	EGEVTPNSLSTSYKT ECEECCCCCCCCEEE	25.54	29978859
1658	Phosphorylation	EVTPNSLSTSYKTVS EECCCCCCCCEEEEE	18.35	29978859
1659	Phosphorylation	VTPNSLSTSYKTVSL ECCCCCCCCEEEEEC	41.17	29978859
1660	Phosphorylation	TPNSLSTSYKTVSLP CCCCCCCCEEEEECC	22.66	29978859
1661	Phosphorylation	PNSLSTSYKTVSLPL CCCCCCCEEEEECCC	15.69	29978859
1662	Ubiquitination	NSLSTSYKTVSLPLS CCCCCCEEEEECCCC	42.07	29967540
1663	Phosphorylation	SLSTSYKTVSLPLSS CCCCCEEEEECCCCC	13.70	29978859
1665	Phosphorylation	STSYKTVSLPLSSPN CCCEEEEECCCCCCC	29.51	28176443
1669	Phosphorylation	KTVSLPLSSPNIKLN EEEECCCCCCCEEEE	41.64	23401153
1670	Phosphorylation	TVSLPLSSPNIKLNL EEECCCCCCCEEEEC	29.64	25159151
1678	Phosphorylation	PNIKLNLTSPKRGQK CCEEEECCCCCCCCC	41.74	30266825
1679	Phosphorylation	NIKLNLTSPKRGQKR CEEEECCCCCCCCCH	31.43	22167270
1681	Acetylation	KLNLTSPKRGQKREE EEECCCCCCCCCHHH	69.77	-
1685	Acetylation	TSPKRGQKREEGWKE CCCCCCCCHHHHHHH	65.68	-
1691	Ubiquitination	QKREEGWKEVVRRSK CCHHHHHHHHHHHHC	52.03	29967540
1701	Phosphorylation	VRRSKKLSVPASVVS HHHHCCCCCCHHHHH	34.63	20068231
1705	Phosphorylation	KKLSVPASVVSRIMG CCCCCCHHHHHHHHC	19.58	20873877
1708	Phosphorylation	SVPASVVSRIMGRGG CCCHHHHHHHHCCCC	17.59	20068231
1713	Methylation	VVSRIMGRGGCNITA HHHHHHCCCCCCEEE	22.43	-
1733	Ubiquitination	GAHIDVDKQKDKNGE CCCCCCCCCCCCCCC	60.13	29967540
1744	Phosphorylation	KNGERMITIRGGTES CCCCEEEEEECCCHH	8.69	-
1746	Methylation	GERMITIRGGTESTR CCEEEEEECCCHHHH	28.92	-
1776	Ubiquitination	ELEDLIPKNHIRTPA HHHHHCCCCCCCCCC	54.91	29967540
1781	Phosphorylation	IPKNHIRTPASTKSI CCCCCCCCCCCCCCE	23.70	25159151
1784	Phosphorylation	NHIRTPASTKSIHAN CCCCCCCCCCCEEEE	37.26	25159151
1785	Phosphorylation	HIRTPASTKSIHANF CCCCCCCCCCEEEEC	30.80	17081983
1786	Ubiquitination	IRTPASTKSIHANFS CCCCCCCCCEEEECC	44.94	29967540
1787	Phosphorylation	RTPASTKSIHANFSS CCCCCCCCEEEECCC	21.50	28857561
1793	O-linked_Glycosylation	KSIHANFSSGVGTTA CCEEEECCCCCCCCC	26.45	30059200
1794	O-linked_Glycosylation	SIHANFSSGVGTTAA CEEEECCCCCCCCCC	33.10	30059200
1794	Phosphorylation	SIHANFSSGVGTTAA CEEEECCCCCCCCCC	33.10	28555341
1798	O-linked_Glycosylation	NFSSGVGTTAASSKN ECCCCCCCCCCCCCC	15.74	30059200
1799	O-linked_Glycosylation	FSSGVGTTAASSKNA CCCCCCCCCCCCCCC	17.81	30059200
1802	O-linked_Glycosylation	GVGTTAASSKNAFPL CCCCCCCCCCCCCCC	39.11	30059200
1803	O-linked_Glycosylation	VGTTAASSKNAFPLG CCCCCCCCCCCCCCC	25.79	30059200
1813	O-linked_Glycosylation	AFPLGAPTLVTSQAT CCCCCCCEEEECCCC	33.07	30059200
1816	O-linked_Glycosylation	LGAPTLVTSQATTLS CCCCEEEECCCCCCC	20.45	30059200
1817	O-linked_Glycosylation	GAPTLVTSQATTLST CCCEEEECCCCCCCC	15.44	30059200
1820	O-linked_Glycosylation	TLVTSQATTLSTFQP EEEECCCCCCCCCCC	22.19	30059200
1821	O-linked_Glycosylation	LVTSQATTLSTFQPA EEECCCCCCCCCCCC	23.02	30059200
1823	O-linked_Glycosylation	TSQATTLSTFQPANK ECCCCCCCCCCCCCC	25.69	30059200
1824	O-linked_Glycosylation	SQATTLSTFQPANKL CCCCCCCCCCCCCCC	29.42	30059200
1830	Ubiquitination	STFQPANKLNKNVPT CCCCCCCCCCCCCCC	56.39	22505724
1830 (in isoform 4)	Ubiquitination	-	56.39	-
1833	Ubiquitination	QPANKLNKNVPTNVR CCCCCCCCCCCCCCH	70.52	22505724
1833 (in isoform 4)	Ubiquitination	-	70.52	-
1837	O-linked_Glycosylation	KLNKNVPTNVRSSFP CCCCCCCCCCHHCCC	41.90	30059200
1840	Methylation	KNVPTNVRSSFPVSL CCCCCCCHHCCCCCC	28.75	-
1846	O-linked_Glycosylation	VRSSFPVSLPLAYPH CHHCCCCCCCCCCCC	25.22	30059200
1884	Phosphorylation	FGGTFSPSPNTWGPF CCCCCCCCCCCCCCC	29.59	30576142
1887	Phosphorylation	TFSPSPNTWGPFPVR CCCCCCCCCCCCCCC	34.87	30576142
1901	Phosphorylation	RPVNPGNTNSSPKHN CCCCCCCCCCCCCCC	42.25	27732954
1903	Phosphorylation	VNPGNTNSSPKHNNT CCCCCCCCCCCCCCC	46.08	27732954
1904	Phosphorylation	NPGNTNSSPKHNNTS CCCCCCCCCCCCCCC	39.78	27732954
1957	Phosphorylation	TNTRTPSSVRKQLFA CCCCCCHHHHHHHEE	27.43	23532336
1960	Ubiquitination	RTPSSVRKQLFACVP CCCHHHHHHHEECCC	49.55	27667366
2067	Phosphorylation	GAPETHPSSSPTPTS CCCCCCCCCCCCCCC	35.52	22468782
2068	Phosphorylation	APETHPSSSPTPTSS CCCCCCCCCCCCCCC	44.80	22468782
2069	Phosphorylation	PETHPSSSPTPTSSN CCCCCCCCCCCCCCC	36.81	22468782
2073	Phosphorylation	PSSSPTPTSSNTQEE CCCCCCCCCCCCCCH	47.46	22468782
2074	Phosphorylation	SSSPTPTSSNTQEEA CCCCCCCCCCCCCHH	23.85	24275569
2090	Phosphorylation	PSSVSDLSPMSMPFA CCCHHHCCCCCCCCC	24.44	26074081
2093	Phosphorylation	VSDLSPMSMPFASNS HHHCCCCCCCCCCCC	27.04	26074081
2098	O-linked_Glycosylation	PMSMPFASNSEPAPL CCCCCCCCCCCCCCC	41.07	30059200
2098	Phosphorylation	PMSMPFASNSEPAPL CCCCCCCCCCCCCCC	41.07	26074081
2100	Phosphorylation	SMPFASNSEPAPLTL CCCCCCCCCCCCCCC	42.32	26074081
2106	Phosphorylation	NSEPAPLTLTSPRMV CCCCCCCCCCCCCEE	27.25	26074081
2108	Phosphorylation	EPAPLTLTSPRMVAA CCCCCCCCCCCEEEC	31.30	26074081
2109	Phosphorylation	PAPLTLTSPRMVAAD CCCCCCCCCCEEECC	17.39	26074081
2121	Phosphorylation	AADNQDTSNLPQLAV ECCCCCCCCCCCCCC	44.66	28555341
2166	Phosphorylation	IFVTNPVTLTPPQGP EEEECCEECCCCCCC	26.60	26074081
2168	Phosphorylation	VTNPVTLTPPQGPPA EECCEECCCCCCCCC	24.45	26074081
2266	Phosphorylation	ENMHPDNSKAPGFRP HHCCCCCCCCCCCCC	37.26	26074081
2272	Methylation	NSKAPGFRPPSQRVS CCCCCCCCCCHHCCC	48.40	-
2275	Phosphorylation	APGFRPPSQRVSTSP CCCCCCCHHCCCCCC	33.05	26074081
2279	Phosphorylation	RPPSQRVSTSPVGLP CCCHHCCCCCCCCCC	25.92	28102081
2280	Phosphorylation	PPSQRVSTSPVGLPS CCHHCCCCCCCCCCC	33.91	28102081
2281	Phosphorylation	PSQRVSTSPVGLPSI CHHCCCCCCCCCCCC	15.30	21082442
2287	Phosphorylation	TSPVGLPSIDPSGSS CCCCCCCCCCCCCCC	44.67	28102081
2291	Phosphorylation	GLPSIDPSGSSPSSS CCCCCCCCCCCCCCC	47.78	28102081
2293	Phosphorylation	PSIDPSGSSPSSSSA CCCCCCCCCCCCCCC	43.33	28102081
2294	Phosphorylation	SIDPSGSSPSSSSAP CCCCCCCCCCCCCCC	32.12	30206219
2296	Phosphorylation	DPSGSSPSSSSAPLA CCCCCCCCCCCCCCH	44.81	30206219
2297	Phosphorylation	PSGSSPSSSSAPLAS CCCCCCCCCCCCCHH	31.53	30206219
2298	Phosphorylation	SGSSPSSSSAPLASF CCCCCCCCCCCCHHC	34.55	23663014
2299	Phosphorylation	GSSPSSSSAPLASFS CCCCCCCCCCCHHCC	35.53	30206219
2304	Phosphorylation	SSSAPLASFSGIPGT CCCCCCHHCCCCCCC	27.85	23663014
2306	Phosphorylation	SAPLASFSGIPGTRV CCCCHHCCCCCCCEE	33.06	23663014
2311	Phosphorylation	SFSGIPGTRVFLQGP HCCCCCCCEEEEECC	20.50	23663014
2323	Phosphorylation	QGPAPVGTPSFNRQH ECCCCCCCCCCCCCC	18.92	25159151
2325	Phosphorylation	PAPVGTPSFNRQHFS CCCCCCCCCCCCCCC	34.68	28450419
2332	Phosphorylation	SFNRQHFSPHPWTSA CCCCCCCCCCCCCCC	21.85	27251275
2340	Phosphorylation	PHPWTSASNSSTSAP CCCCCCCCCCCCCCC	36.69	24719451
2344	Phosphorylation	TSASNSSTSAPPTLG CCCCCCCCCCCCCCC	28.82	22817900
2357	O-linked_Glycosylation	LGQPKGVSASQDRKI CCCCCCCCCCCCCCC	30.76	30059200
2370	Phosphorylation	KIPPPIGTERLARIR CCCCCCCHHHHHHHH	20.74	24719451
2398	O-linked_Glycosylation	FVAPVGHSGIWSFGV EEEECCCCCCHHHHH	26.50	30059200
2539	Phosphorylation	HIGNMHLKYVN---- CCCCCCEEECC----	32.26	32142685
2539	Ubiquitination	HIGNMHLKYVN---- CCCCCCEEECC----	32.26	29967540
2595	Phosphorylation	------------------------------------------------------------ ------------------------------------------------------------		20068231
2598	Phosphorylation	--------------------------------------------------------------- ---------------------------------------------------------------		20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANKH1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANKH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANKH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
IKBE_HUMAN	NFKBIE	physical	21988832
ZN346_HUMAN	ZNF346	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANKH1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-1670, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1670 AND SER-1679, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1653, AND MASSSPECTROMETRY.	18669648 [Abstract]