| UniProt ID | TRAF4_HUMAN | |
|---|---|---|
| UniProt AC | Q9BUZ4 | |
| Protein Name | TNF receptor-associated factor 4 | |
| Gene Name | TRAF4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 470 | |
| Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm, cytoskeleton . |
|
| Protein Description | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.. | |
| Protein Sequence | MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MPGFDYKFLEKPK --CCCCCHHHCCCCC | 11.02 | - | |
| 7 | Ubiquitination | -MPGFDYKFLEKPKR -CCCCCHHHCCCCCC | 45.37 | - | |
| 11 | Ubiquitination | FDYKFLEKPKRRLLC CCHHHCCCCCCEEEC | 58.97 | - | |
| 65 | Ubiquitination | QLPLDYAKIYPDPEL HCCCCHHHHCCCCCC | 36.22 | - | |
| 122 | Phosphorylation | NRCPMKLSRRDLPAH CCCCCCCCCCCCCHH | 21.54 | 27251275 | |
| 166 | Phosphorylation | MCPQESVYCENKCGA CCCCHHHHCCCHHHH | 11.88 | 22817900 | |
| 170 | Ubiquitination | ESVYCENKCGARMMR HHHHCCCHHHHHHHH | 16.26 | - | |
| 200 | Ubiquitination | QPCTYCTKEFVFDTI CCCCCCCCEEHHHHH | 45.66 | - | |
| 206 | Phosphorylation | TKEFVFDTIQSHQYQ CCEEHHHHHHHHCCC | 14.95 | 28152594 | |
| 209 | Phosphorylation | FVFDTIQSHQYQCPR EHHHHHHHHCCCCCC | 14.54 | 28152594 | |
| 212 | Phosphorylation | DTIQSHQYQCPRLPV HHHHHHCCCCCCCCC | 13.47 | 28152594 | |
| 229 | Phosphorylation | PNQCGVGTVAREDLP CCCCCCCCEEHHHCC | 14.48 | 24260401 | |
| 242 | Phosphorylation | LPGHLKDSCNTALVL CCCHHCCCCCCEEEE | 14.00 | 27251275 | |
| 253 | Ubiquitination | ALVLCPFKDSGCKHR EEEEECCCCCCCCCC | 35.81 | - | |
| 327 | Ubiquitination | RLQEAKAKPNLECFS HHHHHHCCCCCEECC | 33.46 | - | |
| 405 | Phosphorylation | LAKPQHVTETFHPDP CCCCCEECCCCCCCC | 27.47 | 25690035 | |
| 407 | Phosphorylation | KPQHVTETFHPDPNW CCCEECCCCCCCCCC | 20.20 | 25690035 | |
| 415 | Ubiquitination | FHPDPNWKNFQKPGT CCCCCCCCCCCCCCC | 55.30 | 21890473 | |
| 415 (in isoform 1) | Ubiquitination | - | 55.30 | 21890473 | |
| 419 | Ubiquitination | PNWKNFQKPGTWRGS CCCCCCCCCCCCCCC | 41.08 | - | |
| 422 | Phosphorylation | KNFQKPGTWRGSLDE CCCCCCCCCCCCCCH | 22.10 | 22617229 | |
| 426 | Phosphorylation | KPGTWRGSLDESSLG CCCCCCCCCCHHHCC | 24.87 | 19664994 | |
| 430 | Phosphorylation | WRGSLDESSLGFGYP CCCCCCHHHCCCCCC | 30.45 | 30266825 | |
| 431 | Phosphorylation | RGSLDESSLGFGYPK CCCCCHHHCCCCCCC | 30.39 | 30266825 | |
| 436 | Phosphorylation | ESSLGFGYPKFISHQ HHHCCCCCCCCCCHH | 10.86 | 20068231 | |
| 438 | Ubiquitination | SLGFGYPKFISHQDI HCCCCCCCCCCHHHH | 47.01 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 426 | S | Phosphorylation | Kinase | CHUK | O15111 | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | SMURF2 | Q9HAU4 | PMID:23973329 |
| - | K | Ubiquitination | E3 ubiquitin ligase | SMURF1 | Q9HCE7 | PMID:19458200 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRAF4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRAF4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426, AND MASSSPECTROMETRY. | |
