dbPTM

UBE2O_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBE2O_HUMAN
UniProt AC	Q9C0C9
Protein Name	(E3-independent) E2 ubiquitin-conjugating enzyme
Gene Name	UBE2O
Organism	Homo sapiens (Human).
Sequence Length	1292
Subcellular Localization	Cytoplasm . Nucleus . Mainly localizes to the cytoplasm.
Protein Description	E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. [PubMed: 23455153]
Protein Sequence	MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPDKKGESKTKSEAESASPEETPDGSASPVEMQDEGAEEPHEAGEQLPPFLLKEGRDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHIGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPLEQPVAPEDKGVVISEEAATAAVQGAVAMAAPMAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIVEEEKMEAVPDVERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPEGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLEKAQALPNGVPKASSSPEPPAVAELSDSGQQEPEDGGPAPGEASQGSDSEGGAQGLASASRDHTDQTSETAPDASVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPECTEDK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	VPAPAPASDSASGPS CCCCCCCCCCCCCCC	30.92	28348404
42	Phosphorylation	APAPASDSASGPSSD CCCCCCCCCCCCCCC	23.10	28348404
44	Phosphorylation	APASDSASGPSSDSG CCCCCCCCCCCCCCC	56.01	28348404
47	Phosphorylation	SDSASGPSSDSGPEA CCCCCCCCCCCCCCC	50.75	28348404
48	Phosphorylation	DSASGPSSDSGPEAG CCCCCCCCCCCCCCC	38.64	28348404
50	Phosphorylation	ASGPSSDSGPEAGSQ CCCCCCCCCCCCCCC	59.19	26074081
56	Phosphorylation	DSGPEAGSQRLLFSH CCCCCCCCCEEEEEE	21.12	26074081
62	Phosphorylation	GSQRLLFSHDLVSGR CCCEEEEEECCCCCC	18.96	28348404
67	Phosphorylation	LFSHDLVSGRYRGSV EEEECCCCCCCCCEE	25.50	22210691
70	Phosphorylation	HDLVSGRYRGSVHFG ECCCCCCCCCEEEEE	23.89	30108239
73	Phosphorylation	VSGRYRGSVHFGLVR CCCCCCCEEEEEEEE	11.92	23025827
87	Phosphorylation	RLIHGEDSDSEGEEE EEEECCCCCCCCCCC	38.44	29255136
89	Phosphorylation	IHGEDSDSEGEEEGR EECCCCCCCCCCCCC	51.99	29255136
98	Phosphorylation	GEEEGRGSSGCSEAG CCCCCCCCCCCCCCC	23.38	29255136
99	Phosphorylation	EEEGRGSSGCSEAGG CCCCCCCCCCCCCCC	46.79	29255136
102	Phosphorylation	GRGSSGCSEAGGAGH CCCCCCCCCCCCCCC	33.72	29255136
115	Phosphorylation	GHEEGRASPLRRGYV CCCCCCCCCCCCCEE	24.09	23401153
121	Phosphorylation	ASPLRRGYVRVQWYP CCCCCCCEEEEEECC	5.35	26074081
127	Phosphorylation	GYVRVQWYPEGVKQH CEEEEEECCHHHHHH	3.70	26074081
132	Ubiquitination	QWYPEGVKQHVKETK EECCHHHHHHHHHCC	45.61	23000965
136	Ubiquitination	EGVKQHVKETKLKLE HHHHHHHHHCCCCCC	58.50	23000965
141	Ubiquitination	HVKETKLKLEDRSVV HHHHCCCCCCCCCCC	51.92	27667366
176	Ubiquitination	VNIDCAVKLIGTNCI EECCCEEEEECCCEE	18.83	33845483
180	Phosphorylation	CAVKLIGTNCIIYPV CEEEEECCCEEEEEC	21.66	20068231
185	Phosphorylation	IGTNCIIYPVNSKDL ECCCEEEEECCCCHH	4.92	28152594
189	Phosphorylation	CIIYPVNSKDLQHIW EEEEECCCCHHHHHH	27.99	28152594
217	Ubiquitination	LGKVYDLKNQIILKL CCEEEECCCCEEEEE	43.86	33845483
223	Ubiquitination	LKNQIILKLSNGARC CCCCEEEEECCCCCE	39.19	29967540
283	Ubiquitination	VQWLSGVKPVLSTKS CHHHHCCCCCCCCCC	32.69	23000965
289	Ubiquitination	VKPVLSTKSKFRVVV CCCCCCCCCCEEEEE	48.55	23000965
289	Acetylation	VKPVLSTKSKFRVVV CCCCCCCCCCEEEEE	48.55	25953088
311	Acetylation	LKVTWITKSFCPGGT EEEEEEECCCCCCCC	32.19	26051181
312	Phosphorylation	KVTWITKSFCPGGTD EEEEEECCCCCCCCC	24.35	28060719
318	Phosphorylation	KSFCPGGTDSVSPPP CCCCCCCCCCCCCCC	30.89	30624053
320	Phosphorylation	FCPGGTDSVSPPPSV CCCCCCCCCCCCCCC	25.08	26552605
322	Phosphorylation	PGGTDSVSPPPSVIT CCCCCCCCCCCCCCC	35.32	21815630
326	Phosphorylation	DSVSPPPSVITQENL CCCCCCCCCCCCCCC	31.74	28060719
329	Phosphorylation	SPPPSVITQENLGRV CCCCCCCCCCCCCCC	27.89	28060719
360	Ubiquitination	CLYVFPAKVEPAKIA EEEEEECCCCCCEEE	47.58	33845483
365	Ubiquitination	PAKVEPAKIAWECPE ECCCCCCEEEEECCC	43.61	27667366
367	Ubiquitination	KVEPAKIAWECPEKN CCCCCEEEEECCCCC	8.70	24816145
373	Ubiquitination	IAWECPEKNCAQGEG EEEECCCCCCCCCCC	42.33	32015554
381	Phosphorylation	NCAQGEGSMAKKVKR CCCCCCCHHHHHHHH	15.97	30576142
384	Acetylation	QGEGSMAKKVKRLLK CCCCHHHHHHHHHHH	49.83	25953088
392	Ubiquitination	KVKRLLKKQVVRIMS HHHHHHHHHCEEEEE	48.58	24816145
399	Phosphorylation	KQVVRIMSCSPDTQC HHCEEEEECCCCCCC	14.74	29255136
401	Phosphorylation	VVRIMSCSPDTQCSR CEEEEECCCCCCCCC	20.64	19664994
404	Phosphorylation	IMSCSPDTQCSRDHS EEECCCCCCCCCCCC	34.55	29255136
407	Phosphorylation	CSPDTQCSRDHSMED CCCCCCCCCCCCCCC	30.81	21712546
411	Phosphorylation	TQCSRDHSMEDPDKK CCCCCCCCCCCCCCC	28.31	30576142
423	Phosphorylation	DKKGESKTKSEAESA CCCCCCCCHHHHHHC	49.43	30278072
425	Phosphorylation	KGESKTKSEAESASP CCCCCCHHHHHHCCC	47.47	23927012
429	Phosphorylation	KTKSEAESASPEETP CCHHHHHHCCCCCCC	40.89	23927012
431	Phosphorylation	KSEAESASPEETPDG HHHHHHCCCCCCCCC	41.97	30278072
435	Phosphorylation	ESASPEETPDGSASP HHCCCCCCCCCCCCC	25.64	30278072
439	Phosphorylation	PEETPDGSASPVEMQ CCCCCCCCCCCCCCC	32.71	30278072
441	Phosphorylation	ETPDGSASPVEMQDE CCCCCCCCCCCCCCC	31.04	23401153
475	Phosphorylation	GRDDRLHSAEQDADD CCCCCCCCCCCCCCH	37.79	28450419
488	Phosphorylation	DDEAADDTDDTSSVT CHHHCCCCCCCCCEE	36.00	30576142
491	Phosphorylation	AADDTDDTSSVTSSA HCCCCCCCCCEECCC	26.22	30576142
492	Phosphorylation	ADDTDDTSSVTSSAS CCCCCCCCCEECCCC	29.79	26657352
493	Phosphorylation	DDTDDTSSVTSSASS CCCCCCCCEECCCCC	31.35	30576142
495	Phosphorylation	TDDTSSVTSSASSTT CCCCCCEECCCCCCC	20.93	27251275
496	Ubiquitination	DDTSSVTSSASSTTS CCCCCEECCCCCCCC	23.04	21890473
496	Phosphorylation	DDTSSVTSSASSTTS CCCCCEECCCCCCCC	23.04	27251275
497	Phosphorylation	DTSSVTSSASSTTSS CCCCEECCCCCCCCC	23.86	27251275
499	Ubiquitination	SSVTSSASSTTSSQS CCEECCCCCCCCCCC	30.11	22817900
499	Phosphorylation	SSVTSSASSTTSSQS CCEECCCCCCCCCCC	30.11	27251275
501	Ubiquitination	VTSSASSTTSSQSGS EECCCCCCCCCCCCC	28.36	22817900
501	Phosphorylation	VTSSASSTTSSQSGS EECCCCCCCCCCCCC	28.36	30576142
502	Phosphorylation	TSSASSTTSSQSGSG ECCCCCCCCCCCCCC	28.47	30576142
503	Phosphorylation	SSASSTTSSQSGSGT CCCCCCCCCCCCCCC	26.86	30576142
508	Ubiquitination	TTSSQSGSGTSRKKS CCCCCCCCCCCCCCC	44.11	24816145
511	Phosphorylation	SQSGSGTSRKKSIPL CCCCCCCCCCCCCCC	45.70	30576142
514	Ubiquitination	GSGTSRKKSIPLSIK CCCCCCCCCCCCCHH	53.13	33845483
515	Phosphorylation	SGTSRKKSIPLSIKN CCCCCCCCCCCCHHH	32.26	30266825
519	Phosphorylation	RKKSIPLSIKNLKRK CCCCCCCCHHHHHHH	26.60	23927012
521	Ubiquitination	KSIPLSIKNLKRKHK CCCCCCHHHHHHHHH	53.50	21906983
521	Acetylation	KSIPLSIKNLKRKHK CCCCCCHHHHHHHHH	53.50	25953088
524	Ubiquitination	PLSIKNLKRKHKRKK CCCHHHHHHHHHHHC	69.65	22817900
526	Ubiquitination	SIKNLKRKHKRKKNK CHHHHHHHHHHHCCC	52.47	22817900
533	Ubiquitination	KHKRKKNKITRDFKP HHHHHCCCCCCCCCC	55.10	24816145
568	Ubiquitination	DGSVECNIRSNDLFP CCCEEEEECCCCCEE	8.48	22053931
593	Ubiquitination	PGDFVVDKRVQSCPD CCCEEEECCCCCCCC	42.74	22053931
593	2-Hydroxyisobutyrylation	PGDFVVDKRVQSCPD CCCEEEECCCCCCCC	42.74	-
593	Ubiquitination	PGDFVVDKRVQSCPD CCCEEEECCCCCCCC	42.74	22053931
595	Ubiquitination	DFVVDKRVQSCPDPA CEEEECCCCCCCCCH	6.39	21890473
597	Phosphorylation	VVDKRVQSCPDPAVY EEECCCCCCCCCHHE	25.43	26552605
598	Ubiquitination	VDKRVQSCPDPAVYG EECCCCCCCCCHHEE	2.18	22817900
598	Glutathionylation	VDKRVQSCPDPAVYG EECCCCCCCCCHHEE	2.18	22555962
604	Phosphorylation	SCPDPAVYGVVQSGD CCCCCHHEEEECCCC	13.30	28796482
609	Phosphorylation	AVYGVVQSGDHIGRT HHEEEECCCCCCCCE	34.28	26552605
620	Ubiquitination	IGRTCMVKWFKLRPS CCCEEEEEEEECCCC	21.74	21906983
623	Ubiquitination	TCMVKWFKLRPSGDD EEEEEEEECCCCCCC	42.33	22817900
643	Phosphorylation	EEEDVSVYDIADHPD CCCCCEEEECCCCCC	8.30	27642862
647	Ubiquitination	VSVYDIADHPDFRFR CEEEECCCCCCCCCC	54.94	22817900
655	Phosphorylation	HPDFRFRTTDIVIRI CCCCCCCCCEEEEEE	26.55	29083192
656	Phosphorylation	PDFRFRTTDIVIRIG CCCCCCCCEEEEEEC	21.33	29083192
665	Phosphorylation	IVIRIGNTEDGAPHK EEEEECCCCCCCCCC	30.18	29083192
672	Ubiquitination	TEDGAPHKEDEPSVG CCCCCCCCCCCCCCC	66.84	21906983
689	Ubiquitination	ARVDVSSKVEVVWAD EEEECCCCEEEEEEC	34.60	33845483
779	Ubiquitination	KGVVISEEAATAAVQ CCEEECHHHHHHHHH	36.49	27667366
780	Ubiquitination	GVVISEEAATAAVQG CEEECHHHHHHHHHH	13.18	27667366
782	Phosphorylation	VISEEAATAAVQGAV EECHHHHHHHHHHHH	23.38	-
784	Ubiquitination	SEEAATAAVQGAVAM CHHHHHHHHHHHHHH	6.98	27667366
785	Ubiquitination	EEAATAAVQGAVAMA HHHHHHHHHHHHHHH	5.10	27667366
790	Ubiquitination	AAVQGAVAMAAPMAG HHHHHHHHHHHHHHH	4.95	21890473
791	Ubiquitination	AVQGAVAMAAPMAGL HHHHHHHHHHHHHHH	2.34	21890473
794	Ubiquitination	GAVAMAAPMAGLMEK HHHHHHHHHHHHHHH	12.01	21890473
795	Ubiquitination	AVAMAAPMAGLMEKA HHHHHHHHHHHHHHH	3.86	21890473
800	Ubiquitination	APMAGLMEKAGKDGP HHHHHHHHHHCCCCC	44.81	23000965
801	Ubiquitination	PMAGLMEKAGKDGPP HHHHHHHHHCCCCCC	48.77	23000965
804	Ubiquitination	GLMEKAGKDGPPKSF HHHHHHCCCCCCHHH	65.46	27667366
805	Ubiquitination	LMEKAGKDGPPKSFR HHHHHCCCCCCHHHH	74.12	27667366
809	Ubiquitination	AGKDGPPKSFRELKE HCCCCCCHHHHHHHH	66.42	27667366
810	Ubiquitination	GKDGPPKSFRELKEA CCCCCCHHHHHHHHH	35.00	27667366
815	Ubiquitination	PKSFRELKEAIKILE CHHHHHHHHHHHHHH	40.11	23000965
815	Neddylation	PKSFRELKEAIKILE CHHHHHHHHHHHHHH	40.11	32015554
816	Ubiquitination	KSFRELKEAIKILES HHHHHHHHHHHHHHH	69.15	21890473
819	Ubiquitination	RELKEAIKILESLKN HHHHHHHHHHHHHCC	48.57	23000965
820	Ubiquitination	ELKEAIKILESLKNM HHHHHHHHHHHHCCC	4.16	21890473
821	Ubiquitination	LKEAIKILESLKNMT HHHHHHHHHHHCCCC	2.88	22817900
822	Ubiquitination	KEAIKILESLKNMTV HHHHHHHHHHCCCCH	58.46	22817900
823	Phosphorylation	EAIKILESLKNMTVE HHHHHHHHHCCCCHH	40.99	29978859
825	Ubiquitination	IKILESLKNMTVEQL HHHHHHHCCCCHHHH	54.69	23000965
826	Ubiquitination	KILESLKNMTVEQLL HHHHHHCCCCHHHHH	36.33	23000965
827	Ubiquitination	ILESLKNMTVEQLLT HHHHHCCCCHHHHHH	4.20	22817900
828	Phosphorylation	LESLKNMTVEQLLTG HHHHCCCCHHHHHHC	30.22	29255136
834	Phosphorylation	MTVEQLLTGSPTSPT CCHHHHHHCCCCCCC	44.18	29255136
836	Phosphorylation	VEQLLTGSPTSPTVE HHHHHHCCCCCCCCC	21.55	29255136
838	Phosphorylation	QLLTGSPTSPTVEPE HHHHCCCCCCCCCCC	49.38	29255136
839	Phosphorylation	LLTGSPTSPTVEPEK HHHCCCCCCCCCCCC	23.20	29255136
840	Ubiquitination	LTGSPTSPTVEPEKP HHCCCCCCCCCCCCC	42.83	23000965
841	Phosphorylation	TGSPTSPTVEPEKPT HCCCCCCCCCCCCCC	36.95	29255136
841	Ubiquitination	TGSPTSPTVEPEKPT HCCCCCCCCCCCCCC	36.95	21890473
842	Ubiquitination	GSPTSPTVEPEKPTR CCCCCCCCCCCCCCC	15.23	21890473
846	Ubiquitination	SPTVEPEKPTREKKF CCCCCCCCCCCHHHH	63.50	21906983
847	Ubiquitination	PTVEPEKPTREKKFL CCCCCCCCCCHHHHH	34.72	22817900
848	Phosphorylation	TVEPEKPTREKKFLD CCCCCCCCCHHHHHH	63.63	23927012
851	Ubiquitination	PEKPTREKKFLDDIK CCCCCCHHHHHHHHH	45.60	22817900
852	Ubiquitination	EKPTREKKFLDDIKK CCCCCHHHHHHHHHH	46.54	22817900
853	Ubiquitination	KPTREKKFLDDIKKL CCCCHHHHHHHHHHH	15.57	22817900
854	Ubiquitination	PTREKKFLDDIKKLQ CCCHHHHHHHHHHHH	8.75	22817900
858	Ubiquitination	KKFLDDIKKLQENLK HHHHHHHHHHHHHHH	55.19	33845483
859	Ubiquitination	KFLDDIKKLQENLKK HHHHHHHHHHHHHHH	56.59	29967540
865	Ubiquitination	KKLQENLKKTLDNVA HHHHHHHHHHHHCEE	56.12	23000965
866	Ubiquitination	KLQENLKKTLDNVAI HHHHHHHHHHHCEEE	58.44	23000965
867	Ubiquitination	LQENLKKTLDNVAIV HHHHHHHHHHCEEEE	37.44	21890473
867	Phosphorylation	LQENLKKTLDNVAIV HHHHHHHHHHCEEEE	37.44	28348404
878	Ubiquitination	VAIVEEEKMEAVPDV EEEEEHHHHHCCCCC	45.37	21906983
879	Sulfoxidation	AIVEEEKMEAVPDVE EEEEHHHHHCCCCCC	4.52	21406390
879	Ubiquitination	AIVEEEKMEAVPDVE EEEEHHHHHCCCCCC	4.52	22817900
896	Phosphorylation	EDKPEGQSPVKAEWP CCCCCCCCCCCCCCC	42.38	29255136
904	Phosphorylation	PVKAEWPSETPVLCQ CCCCCCCCCCCEEHH	55.99	25850435
906	Phosphorylation	KAEWPSETPVLCQQC CCCCCCCCCEEHHHC	24.04	25850435
916	Ubiquitination	LCQQCGGKPGVTFTS EHHHCCCCCCEEEEC	24.71	33845483
920	Phosphorylation	CGGKPGVTFTSAKGE CCCCCCEEEECCCCC	27.41	23927012
922	Phosphorylation	GKPGVTFTSAKGEVF CCCCEEEECCCCCEE	20.57	23927012
923	Phosphorylation	KPGVTFTSAKGEVFS CCCEEEECCCCCEEE	24.64	23927012
928	Ubiquitination	FTSAKGEVFSVLEFA EECCCCCEEEEEEEC	6.21	27667366
929	Ubiquitination	TSAKGEVFSVLEFAP ECCCCCEEEEEEECC	3.48	27667366
930	Phosphorylation	SAKGEVFSVLEFAPS CCCCCEEEEEEECCC	30.85	24719451
943	Ubiquitination	PSNHSFKKIEFQPPE CCCCCCCEEEECCHH	45.52	33845483
952	Ubiquitination	EFQPPEAKKFFSTVR EECCHHHHHHHHHHH	48.75	33845483
953	Ubiquitination	FQPPEAKKFFSTVRK ECCHHHHHHHHHHHH	59.70	32142685
954	Ubiquitination	QPPEAKKFFSTVRKE CCHHHHHHHHHHHHH	6.03	27667366
965	Ubiquitination	VRKEMALLATSLPEG HHHHHHHHHHCCCCC	3.38	23000965
966	Ubiquitination	RKEMALLATSLPEGI HHHHHHHHHCCCCCE	8.94	23000965
981	Methylation	MVKTFEDRMDLFSAL EEEEHHHHHHHHHHH	17.20	115919373
990	Ubiquitination	DLFSALIKGPTRTPY HHHHHHHCCCCCCCC	60.74	23000965
991	Ubiquitination	LFSALIKGPTRTPYE HHHHHHCCCCCCCCC	23.09	23000965
1038	Ubiquitination	PNLYDNGKVCVSLLG CCCCCCCEEEEEECC	38.42	-
1094	Phosphorylation	DRGLQEGYENSRCYN CCCCHHHHHCCCHHH	15.93	27642862
1100	Phosphorylation	GYENSRCYNEMALIR HHHCCCHHHHHHHHH	17.04	24043423
1112	Sulfoxidation	LIRVVQSMTQLVRRP HHHHHHHHHHHHHCC	1.22	21406390
1154	Ubiquitination	ETHALLEKAQALPNG HHHHHHHHHHHCCCC	45.85	-
1166	Phosphorylation	PNGVPKASSSPEPPA CCCCCCCCCCCCCCC	37.16	26074081
1167	Phosphorylation	NGVPKASSSPEPPAV CCCCCCCCCCCCCCE	55.56	26074081
1168	Phosphorylation	GVPKASSSPEPPAVA CCCCCCCCCCCCCEE	30.68	25137130
1178	Phosphorylation	PPAVAELSDSGQQEP CCCEEECCCCCCCCC	22.64	25137130
1180	Phosphorylation	AVAELSDSGQQEPED CEEECCCCCCCCCCC	34.82	25137130
1196	Phosphorylation	GPAPGEASQGSDSEG CCCCCCCCCCCCCCC	30.67	30576142
1199	Phosphorylation	PGEASQGSDSEGGAQ CCCCCCCCCCCCCHH	30.26	25137130
1201	Phosphorylation	EASQGSDSEGGAQGL CCCCCCCCCCCHHHH	39.58	25137130
1210	Phosphorylation	GGAQGLASASRDHTD CCHHHHHHHCCCCCC	31.64	30278072
1211	Ubiquitination	GAQGLASASRDHTDQ CHHHHHHHCCCCCCC	11.72	24816145
1212	Ubiquitination	AQGLASASRDHTDQT HHHHHHHCCCCCCCC	35.43	24816145
1212	Phosphorylation	AQGLASASRDHTDQT HHHHHHHCCCCCCCC	35.43	30278072
1216	Phosphorylation	ASASRDHTDQTSETA HHHCCCCCCCCCCCC	33.81	27732954
1219	Phosphorylation	SRDHTDQTSETAPDA CCCCCCCCCCCCCCC	31.19	27732954
1220	Phosphorylation	RDHTDQTSETAPDAS CCCCCCCCCCCCCCC	27.58	22496350
1222	Phosphorylation	HTDQTSETAPDASVP CCCCCCCCCCCCCCC	43.17	29116813
1223	Ubiquitination	TDQTSETAPDASVPP CCCCCCCCCCCCCCC	8.91	22817900
1224	Ubiquitination	DQTSETAPDASVPPS CCCCCCCCCCCCCCC	45.16	22817900
1227	Phosphorylation	SETAPDASVPPSVKP CCCCCCCCCCCCCCC	42.40	27732954
1231	Phosphorylation	PDASVPPSVKPKKRR CCCCCCCCCCCCCCC	36.38	25159151
1233	Ubiquitination	ASVPPSVKPKKRRKS CCCCCCCCCCCCCHH	56.29	-
1235	Ubiquitination	VPPSVKPKKRRKSYR CCCCCCCCCCCHHHH	53.87	-
1236	Ubiquitination	PPSVKPKKRRKSYRS CCCCCCCCCCHHHHH	67.00	24816145
1237	Ubiquitination	PSVKPKKRRKSYRSF CCCCCCCCCHHHHHH	58.34	24816145
1240	Phosphorylation	KPKKRRKSYRSFLPE CCCCCCHHHHHHCCC	24.78	25849741
1241	Phosphorylation	PKKRRKSYRSFLPEK CCCCCHHHHHHCCCC	17.20	29514088
1242	Methylation	KKRRKSYRSFLPEKS CCCCHHHHHHCCCCC	28.20	115388531
1243	Phosphorylation	KRRKSYRSFLPEKSG CCCHHHHHHCCCCCC	23.93	25159151
1248	Ubiquitination	YRSFLPEKSGYPDIG HHHHCCCCCCCCCCC	47.44	21906983
1249	Ubiquitination	RSFLPEKSGYPDIGF HHHCCCCCCCCCCCC	41.73	22817900
1263	Ubiquitination	FPLFPLSKGFIKSIR CCCCCCCHHHHHHHH	66.57	33845483
1267	Ubiquitination	PLSKGFIKSIRGVLT CCCHHHHHHHHHHHH	37.25	24816145
1268	Ubiquitination	LSKGFIKSIRGVLTQ CCHHHHHHHHHHHHH	16.83	24816145
1288	Glutathionylation	LEAGMPECTEDK--- HHCCCCCCCCCC---	4.10	22555962
1292	Ubiquitination	MPECTEDK------- CCCCCCCC-------	56.88	24816145
1293	Ubiquitination	PECTEDK-------- CCCCCCC--------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
836	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBE2O_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBE2O_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF10_HUMAN	RNF10	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
WDR26_HUMAN	WDR26	physical	22939629
ZN687_HUMAN	ZNF687	physical	22939629
TRAF6_HUMAN	TRAF6	physical	23381138
SMAD7_HUMAN	SMAD7	physical	23455153
SMAD6_HUMAN	SMAD6	physical	23455153
DPOA2_HUMAN	POLA2	physical	22863883
POP7_HUMAN	POP7	physical	22863883
BAP1_HUMAN	BAP1	physical	24703950
UBE2O_HUMAN	UBE2O	physical	24703950
CAVN1_HUMAN	PTRF	physical	28514442
PLD1_HUMAN	PLD1	physical	28514442
PKHG4_HUMAN	PLEKHG4	physical	28514442
MYO5A_HUMAN	MYO5A	physical	28514442
LZTR1_HUMAN	LZTR1	physical	28514442
ZNF92_HUMAN	ZNF92	physical	28514442
RIC8B_HUMAN	RIC8B	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBE2O_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-836, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-89; SER-399;SER-401; SER-836; THR-838 AND SER-839, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-89; SER-399;SER-401; THR-435; SER-441; SER-836 AND THR-838, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-838; SER-839 ANDTHR-841, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-896, AND MASSSPECTROMETRY.	17287340 [Abstract]