MYO5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO5A_HUMAN
• UniProt AC: Q9Y4I1
• Protein Name: Unconventional myosin-Va
• Gene Name: MYO5A
• Organism: Homo sapiens (Human).
• Sequence Length: 1855
• Protein Description: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation..
• Protein Sequence: MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSALDYHELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHEITRLTNENLDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPRKEKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRKDSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASELYTK ------CCHHHHHHH	30.88	22814378
9	Ubiquitination	AASELYTKFARVWIP CHHHHHHHHCCCCCC	24.38	-
9 (in isoform 3)	Ubiquitination	-	24.38	-
31	Phosphorylation	SAELLKDYKPGDKVL HHHHHHCCCCCCEEE	19.93	-
169	Ubiquitination	SGESGAGKTVSAKYA ECCCCCCCCHHHHHH	45.26	-
170	Phosphorylation	GESGAGKTVSAKYAM CCCCCCCCHHHHHHH	20.83	22210691
172	Phosphorylation	SGAGKTVSAKYAMRY CCCCCCHHHHHHHHH	25.03	20068231
175	Phosphorylation	GKTVSAKYAMRYFAT CCCHHHHHHHHHHHE	12.83	20068231
182	Phosphorylation	YAMRYFATVSGSASE HHHHHHHEECCCCCC	12.81	22210691
184	Phosphorylation	MRYFATVSGSASEAN HHHHHEECCCCCCCC	23.75	22210691
188	Phosphorylation	ATVSGSASEANVEEK HEECCCCCCCCHHHH	38.65	24719451
199	Phosphorylation	VEEKVLASNPIMESI HHHHHHHCCHHHHHH	38.69	-
205	Phosphorylation	ASNPIMESIGNAKTT HCCHHHHHHCCCCCC	20.58	28634298
211	Phosphorylation	ESIGNAKTTRNDNSS HHHCCCCCCCCCCCC	28.69	28634298
212	Phosphorylation	SIGNAKTTRNDNSSR HHCCCCCCCCCCCCC	27.11	28634298
217	Phosphorylation	KTTRNDNSSRFGKYI CCCCCCCCCCCEEEE	26.25	29514088
218	Phosphorylation	TTRNDNSSRFGKYIE CCCCCCCCCCEEEEE	37.57	29514088
222	Acetylation	DNSSRFGKYIEIGFD CCCCCCEEEEEEECC	40.10	22424773
241	Phosphorylation	IIGANMRTYLLEKSR EECCCHHHHHHHHCE	14.04	29083192
242	Phosphorylation	IGANMRTYLLEKSRV ECCCHHHHHHHHCEE	10.02	29083192
246	Ubiquitination	MRTYLLEKSRVVFQA HHHHHHHHCEEEEEC	43.46	-
247	Phosphorylation	RTYLLEKSRVVFQAE HHHHHHHCEEEEECH	22.41	29083192
289	Ubiquitination	ADNFNYTKQGGSPVI CCCCCCCCCCCCCEE	36.26	-
293	Phosphorylation	NYTKQGGSPVIEGVD CCCCCCCCCEEECCC	23.87	25262027
379	Malonylation	CHWLCHRKLATATET HHHHHHCHHHCCCCC	20.86	26320211
382	Phosphorylation	LCHRKLATATETYIK HHHCHHHCCCCCCCC	44.54	29449344
384	Phosphorylation	HRKLATATETYIKPI HCHHHCCCCCCCCCH	25.22	29449344
386	Phosphorylation	KLATATETYIKPISK HHHCCCCCCCCCHHH	26.62	29449344
387	Phosphorylation	LATATETYIKPISKL HHCCCCCCCCCHHHH	10.75	29449344
389	Malonylation	TATETYIKPISKLQA CCCCCCCCCHHHHHC	26.36	26320211
477	Phosphorylation	FKLEQEEYMKEQIPW HHHCHHHHHHHHCCC	16.85	30177828
522	Phosphorylation	MPKGTDDTWAQKLYN CCCCCCCHHHHHHHH	26.05	29759185
528	Phosphorylation	DTWAQKLYNTHLNKC CHHHHHHHHHHCCCC	25.67	29759185
530	Phosphorylation	WAQKLYNTHLNKCAL HHHHHHHHHCCCCCC	17.74	29759185
600	Phosphorylation	QDDEKAISPTSATSS CCCCCCCCCCCCCCC	27.30	30266825
602	Phosphorylation	DEKAISPTSATSSGR CCCCCCCCCCCCCCC	24.97	30266825
603	Phosphorylation	EKAISPTSATSSGRT CCCCCCCCCCCCCCC	32.69	30266825
605	Phosphorylation	AISPTSATSSGRTPL CCCCCCCCCCCCCCC	24.16	23403867
606	Phosphorylation	ISPTSATSSGRTPLT CCCCCCCCCCCCCCC	30.43	27486199
610	Phosphorylation	SATSSGRTPLTRTPA CCCCCCCCCCCCCCC	26.61	21712546
613	Phosphorylation	SSGRTPLTRTPAKPT CCCCCCCCCCCCCCC	33.43	23898821
615	Phosphorylation	GRTPLTRTPAKPTKG CCCCCCCCCCCCCCC	23.51	21712546
653	Phosphorylation	LMETLNATTPHYVRC HHHHHCCCCCCEEEE	39.52	-
671	Phosphorylation	NDFKFPFTFDEKRAV CCCCCCCCCCHHHHH	30.34	30242111
721	Phosphorylation	MKQKDVLSDRKQTCK HHHHHHHCCHHHHHH	34.91	23312004
757	Phosphorylation	FRAGQVAYLEKLRAD EEHHHHHHHHHHCHH	19.28	-
828	Phosphorylation	IQKYWRMYVVRRRYK HHHHHHHHHHHHHHH	6.29	-
834	Phosphorylation	MYVVRRRYKIRRAAT HHHHHHHHHHHHHHH	14.68	-
846	Phosphorylation	AATIVLQSYLRGFLA HHHHHHHHHHHHHHH	23.21	24719451
902	Acetylation	CFRRMMAKRELKKLK HHHHHHHHHHHHHCC	28.63	7681477
918	Phosphorylation	EARSVERYKKLHIGM CHHHHHHHHHHHHHH	10.04	-
943	Phosphorylation	VDEQNKDYKCLVEKL HHHCCCCHHHHHHHH	12.76	30576142
979	Ubiquitination	QLSEEEAKVATGRVL HCCHHHHHHHHHHHH	35.36	-
982	Phosphorylation	EEEAKVATGRVLSLQ HHHHHHHHHHHHHHH	28.63	29255136
987	Phosphorylation	VATGRVLSLQEEIAK HHHHHHHHHHHHHHH	25.75	-
1028	Ubiquitination	EQLVSNLKEENTLLK HHHHHHHHHHCHHHH	68.20	-
1032	Phosphorylation	SNLKEENTLLKQEKE HHHHHHCHHHHHHHH	36.43	23312004
1050	Methylation	HRIVQQAKEMTETME HHHHHHHHHHHHHHH	43.62	115973545
1055	Phosphorylation	QAKEMTETMEKKLVE HHHHHHHHHHHHHHH	22.82	26546556
1058	Ubiquitination	EMTETMEKKLVEETK HHHHHHHHHHHHHHH	40.35	-
1078	Phosphorylation	LNDERLRYQNLLNEF CCHHHHHHHHHHHHH	13.32	-
1086	Phosphorylation	QNLLNEFSRLEERYD HHHHHHHHHHHHHHH	29.76	-
1113	Phosphorylation	PKPGHKRTDSTHSSN CCCCCCCCCCCCCCC	38.82	24043423
1113 (in isoform 3)	Phosphorylation	-	38.82	21406692
1115	Phosphorylation	PGHKRTDSTHSSNES CCCCCCCCCCCCCCC	27.66	22617229
1115 (in isoform 3)	Phosphorylation	-	27.66	21406692
1116	Phosphorylation	GHKRTDSTHSSNESE CCCCCCCCCCCCCCC	28.69	22617229
1118	Phosphorylation	KRTDSTHSSNESEYI CCCCCCCCCCCCCEE	34.64	22617229
1119	Phosphorylation	RTDSTHSSNESEYIF CCCCCCCCCCCCEEE	36.69	24043423
1119 (in isoform 3)	Phosphorylation	-	36.69	21406692
1122	Phosphorylation	STHSSNESEYIFSSE CCCCCCCCCEEEEHH	39.69	27251789
1124	Phosphorylation	HSSNESEYIFSSEIA CCCCCCCEEEEHHHH	19.28	28450419
1127	Phosphorylation	NESEYIFSSEIAEME CCCCEEEEHHHHCCC	19.94	21406692
1128	Phosphorylation	ESEYIFSSEIAEMED CCCEEEEHHHHCCCC	23.44	21406692
1138	Phosphorylation	AEMEDIPSRTEEPSE HCCCCCCCCCCCCCC	52.77	27251789
1138 (in isoform 3)	Phosphorylation	-	52.77	21406692
1140	Phosphorylation	MEDIPSRTEEPSEKK CCCCCCCCCCCCCCC	49.38	21406692
1144	Phosphorylation	PSRTEEPSEKKVPLD CCCCCCCCCCCCCCC	66.39	21406692
1153	Phosphorylation	KKVPLDMSLFLKLQK CCCCCCHHHHHHHHH	18.68	26270265
1203	Phosphorylation	IRGAELEYESLKRQE CCCCHHHHHHHHHHH	24.36	28796482
1205	Phosphorylation	GAELEYESLKRQELE CCHHHHHHHHHHHHH	37.99	29255136
1207	Acetylation	ELEYESLKRQELESE HHHHHHHHHHHHHHH	62.40	18530817
1207	Ubiquitination	ELEYESLKRQELESE HHHHHHHHHHHHHHH	62.40	-
1213	Phosphorylation	LKRQELESENKKLKN HHHHHHHHHHHHHHH	60.12	16097034
1232	Ubiquitination	LRKALSEKSAPEVTA HHHHHHHCCCCCCCC	48.84	-
1233	Phosphorylation	RKALSEKSAPEVTAP HHHHHHCCCCCCCCC	45.03	22210691
1245	Phosphorylation	TAPGAPAYRVLMEQL CCCCCHHHHHHHHHH	10.53	18083107
1253	Phosphorylation	RVLMEQLTSVSEELD HHHHHHHHCCCHHCC	27.12	27251275
1254	Phosphorylation	VLMEQLTSVSEELDV HHHHHHHCCCHHCCC	32.04	27251275
1256	Phosphorylation	MEQLTSVSEELDVRK HHHHHCCCHHCCCCH	25.72	27251275
1312	Phosphorylation	KGEIAQAYIGLKETN CCCHHHHHHCCCCCC	5.39	28674419
1339	Phosphorylation	DGELWLVYEGLKQAN CCCEEEHHHHHHHHH	11.34	-
1355	Phosphorylation	LLESQLQSQKRSHEN HHHHHHHHHHHHHHH	46.38	25332170
1400	Phosphorylation	PEARIEASLQHEITR HHHHHHHHHHHHHHH	18.77	18452278
1409	Phosphorylation	QHEITRLTNENLDLM HHHHHHHHHHCHHHH	36.88	20068231
1416	Sulfoxidation	TNENLDLMEQLEKQD HHHCHHHHHHHHHHH	2.85	21406390
1452	Phosphorylation	VGQMENISPGQIIDE CCCCCCCCCCCCCCC	34.26	29255136
1480	2-Hydroxyisobutyrylation	FQGMLEYKKEDEQKL CCHHHHCCHHHHHHH	40.07	-
1511	Phosphorylation	LIPGLPAYILFMCVR CCCCCCHHHHHHHHH	9.02	27251275
1531	Phosphorylation	NDDQKVRSLLTSTIN CCHHHHHHHHHHHHH	30.62	20068231
1534	Phosphorylation	QKVRSLLTSTINSIK HHHHHHHHHHHHHHH	29.17	20068231
1535	Phosphorylation	KVRSLLTSTINSIKK HHHHHHHHHHHHHHH	27.53	20068231
1536	Phosphorylation	VRSLLTSTINSIKKV HHHHHHHHHHHHHHH	20.95	20068231
1539	Phosphorylation	LLTSTINSIKKVLKK HHHHHHHHHHHHHHH	31.75	20068231
1572	Phosphorylation	LHCLKQYSGEEGFMK HHHHHHHCCCCCCCC	36.92	-
1650	Phosphorylation	PTGLRKRTSSIADEG CCCCCHHCCCCCCCC	29.84	29255136
1651	Phosphorylation	TGLRKRTSSIADEGT CCCCHHCCCCCCCCC	24.63	29255136
1652	Phosphorylation	GLRKRTSSIADEGTY CCCHHCCCCCCCCCC	22.60	29255136
1658	Phosphorylation	SSIADEGTYTLDSIL CCCCCCCCCCHHHHH	15.98	30278072
1659	Phosphorylation	SIADEGTYTLDSILR CCCCCCCCCHHHHHH	19.03	23403867
1660	Phosphorylation	IADEGTYTLDSILRQ CCCCCCCCHHHHHHH	24.75	23403867
1663	Phosphorylation	EGTYTLDSILRQLNS CCCCCHHHHHHHHHC	27.00	23403867
1743	Phosphorylation	MNSGAKETLEPLIQA CCCCHHHHHHHHHHH	35.40	-
1760	Phosphorylation	LLQVKKKTDDDAEAI HHHHHCCCCCCHHHH	54.24	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO5A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO5A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MELPH_HUMAN	MLPH	physical	14730011
DYL1_HUMAN	DYNLL1	physical	10844022
DYL2_HUMAN	DYNLL2	physical	10844022
RB27A_HUMAN	RAB27A	physical	12006666
DYL2_HUMAN	DYNLL2	physical	11546872
MELPH_HUMAN	MLPH	physical	12062444
EXOC3_HUMAN	EXOC3	physical	22172676
EXOC4_HUMAN	EXOC4	physical	22172676
MYH11_HUMAN	MYH11	physical	26344197
PLST_HUMAN	PLS3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 214450: Griscelli syndrome 1 (GS1)
• 609227: Griscelli syndrome 3 (GS3)
• 256710: Elejalde syndrome (ELEJAS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-600, AND MASSSPECTROMETRY.
PubMed: 19413330

"Global phosphoproteome analysis on human HepG2 hepatocytes usingreversed-phase diagonal LC.";
Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K.,Demol H., Martens L., Goethals M., Vandekerckhove J.;
Proteomics 5:3589-3599(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213, AND MASSSPECTROMETRY.
PubMed: 16097034