MYH11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYH11_HUMAN
• UniProt AC: P35749
• Protein Name: Myosin-11
• Gene Name: MYH11
• Organism: Homo sapiens (Human).
• Sequence Length: 1972
• Subcellular Localization: Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
• Protein Description: Muscle contraction..
• Protein Sequence: MAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAQKGQLSDDEKFLF CCCCCCCCCCCCEEE	34.82	24972180
23	Phosphorylation	VDKNFINSPVAQADW ECCCCCCCHHHHHHH	18.88	26657352
40	Phosphorylation	KRLVWVPSEKQGFEA HHHEECCCHHCCCEE	48.05	-
49	Phosphorylation	KQGFEAASIKEEKGD HCCCEECCCCHHHCC	41.04	23403867
67	Acetylation	VELVENGKKVTVGKD EEEECCCCEEEECHH	56.50	30585641
78	Acetylation	VGKDDIQKMNPPKFS ECHHHHHHCCCCCCC	40.76	22638993
83	Ubiquitination	IQKMNPPKFSKVEDM HHHCCCCCCCCCHHH	64.62	-
85	Phosphorylation	KMNPPKFSKVEDMAE HCCCCCCCCCHHHHH	41.75	29514088
94	Phosphorylation	VEDMAELTCLNEASV CHHHHHHHHCCHHHH	13.37	26657352
100	Phosphorylation	LTCLNEASVLHNLRE HHHCCHHHHHHHHHH	21.02	23532336
129	"N6,N6,N6-trimethyllysine"	CVVVNPYKHLPIYSE EEEECCCCCCCCCCH	39.66	-
129	Methylation	CVVVNPYKHLPIYSE EEEECCCCCCCCCCH	39.66	-
142	Phosphorylation	SEKIVDMYKGKKRHE CHHHHHHHCCCCCCC	16.48	-
143	Acetylation	EKIVDMYKGKKRHEM HHHHHHHCCCCCCCC	58.58	7668381
146	Acetylation	VDMYKGKKRHEMPPH HHHHCCCCCCCCCCC	68.60	7669835
155	Phosphorylation	HEMPPHIYAIADTAY CCCCCCHHHHHHHHH	6.74	18083107
162	Phosphorylation	YAIADTAYRSMLQDR HHHHHHHHHHHCCCC	12.81	-
173	Phosphorylation	LQDREDQSILCTGES CCCCCCCCEEEECCC	29.83	21712546
176	S-palmitoylation	REDQSILCTGESGAG CCCCCEEEECCCCCC	4.35	29575903
177	Phosphorylation	EDQSILCTGESGAGK CCCCEEEECCCCCCC	40.30	-
184	Ubiquitination	TGESGAGKTENTKKV ECCCCCCCCCCHHHH	52.73	-
194	Phosphorylation	NTKKVIQYLAVVASS CHHHHHHHHHHHHHC	5.87	-
200	Phosphorylation	QYLAVVASSHKGKKD HHHHHHHHCCCCCCC	22.74	23312004
201	Phosphorylation	YLAVVASSHKGKKDT HHHHHHHCCCCCCCC	21.34	23312004
208	Phosphorylation	SHKGKKDTSITGELE CCCCCCCCCCCHHHH	30.79	23312004
209	Phosphorylation	HKGKKDTSITGELEK CCCCCCCCCCHHHHH	28.43	26657352
211	Phosphorylation	GKKDTSITGELEKQL CCCCCCCCHHHHHHH	25.11	27499020
232	Ubiquitination	LEAFGNAKTVKNDNS HHHHCCCEECCCCCC	58.83	21906983
232	Ubiquitination	LEAFGNAKTVKNDNS HHHHCCCEECCCCCC	58.83	21906983
233	Phosphorylation	EAFGNAKTVKNDNSS HHHCCCEECCCCCCC	34.01	-
235	Ubiquitination	FGNAKTVKNDNSSRF HCCCEECCCCCCCCC	64.91	-
239	Phosphorylation	KTVKNDNSSRFGKFI EECCCCCCCCCCEEE	26.25	29514088
240	Phosphorylation	TVKNDNSSRFGKFIR ECCCCCCCCCCEEEE	37.57	29514088
244	Ubiquitination	DNSSRFGKFIRINFD CCCCCCCEEEEEEEE	34.60	-
255	Phosphorylation	INFDVTGYIVGANIE EEEECCEEEECCCHH	5.31	18767875
268	Ubiquitination	IETYLLEKSRAIRQA HHHHHHHHHHHHHHH	45.25	-
269	Phosphorylation	ETYLLEKSRAIRQAR HHHHHHHHHHHHHHC	19.98	18767875
345	Phosphorylation	FSEEEQLSILKVVSS CCHHHHHHHHHHHHH	26.10	24719451
362	Acetylation	QLGNIVFKKERNTDQ HHCCEEEEECCCCCC	42.71	7665131
363	Acetylation	LGNIVFKKERNTDQA HCCEEEEECCCCCCC	50.90	19817961
367	Phosphorylation	VFKKERNTDQASMPD EEEECCCCCCCCCCC	35.39	26329039
371	Phosphorylation	ERNTDQASMPDNTAA CCCCCCCCCCCCHHH	25.80	25159151
376	Phosphorylation	QASMPDNTAAQKVCH CCCCCCCHHHHHHHH	30.65	26329039
390	Phosphorylation	HLMGINVTDFTRSIL HHCCCCCHHCCHHHC	22.40	24532841
393	Phosphorylation	GINVTDFTRSILTPR CCCCHHCCHHHCCCC	26.73	24532841
395	Phosphorylation	NVTDFTRSILTPRIK CCHHCCHHHCCCCHH	20.92	21406692
398	Phosphorylation	DFTRSILTPRIKVGR HCCHHHCCCCHHCCH	14.62	21406692
402	Phosphorylation	SILTPRIKVGRDVVQ HHCCCCHHCCHHHHH	39.66	27251275
491	Sulfoxidation	QQLFNHTMFILEQEE HHHHHHCHHHCCHHH	1.21	28183972
547	Ubiquitination	WFPKATDKSFVEKLC CCCCCCCHHHHHHHH	41.25	-
548	Phosphorylation	FPKATDKSFVEKLCT CCCCCCHHHHHHHHH	37.02	24719451
555	Phosphorylation	SFVEKLCTEQGSHPK HHHHHHHHCCCCCCC	41.60	20860994
559	Phosphorylation	KLCTEQGSHPKFQKP HHHHCCCCCCCCCCC	35.99	26657352
566	Phosphorylation	SHPKFQKPKQLKDKT CCCCCCCCCCCCCCC	20.88	27251275
589	Phosphorylation	GKVDYNASAWLTKNM CCCCCCCCHHHHCCC	19.15	27499020
604	Phosphorylation	DPLNDNVTSLLNASS CCCCHHHHHHHHHCC	21.66	26657352
605	Phosphorylation	PLNDNVTSLLNASSD CCCHHHHHHHHHCCC	26.95	26657352
633	Ubiquitination	VGLDQMAKMTESSLP HCHHHHHHHCHHCCC	40.80	-
637	Phosphorylation	QMAKMTESSLPSASK HHHHHCHHCCCCCCH	28.19	26657352
638	Phosphorylation	MAKMTESSLPSASKT HHHHCHHCCCCCCHH	37.76	26657352
641	Phosphorylation	MTESSLPSASKTKKG HCHHCCCCCCHHCCC	50.93	28509920
643	Phosphorylation	ESSLPSASKTKKGMF HHCCCCCCHHCCCCC	45.24	23312004
645	Phosphorylation	SLPSASKTKKGMFRT CCCCCCHHCCCCCHH	35.18	23312004
650	Phosphorylation	SKTKKGMFRTVGQLY CHHCCCCCHHHHHHH	8.92	27251275
652	Phosphorylation	TKKGMFRTVGQLYKE HCCCCCHHHHHHHHH	20.09	24719451
657	Phosphorylation	FRTVGQLYKEQLGKL CHHHHHHHHHHHHHH	12.46	20068231
658	Methylation	RTVGQLYKEQLGKLM HHHHHHHHHHHHHHH	47.80	51082281
666	Phosphorylation	EQLGKLMTTLRNTTP HHHHHHHHHHHCCCC	32.87	24719451
667	Phosphorylation	QLGKLMTTLRNTTPN HHHHHHHHHHCCCCC	15.11	24719451
678	S-palmitoylation	TTPNFVRCIIPNHEK CCCCCEEEECCCCCC	2.51	29575903
687	Phosphorylation	IPNHEKRSGKLDAFL CCCCCCCCCCCCHHH	51.88	26657352
718	Methylation	CRQGFPNRIVFQEFR HHCCCCCCCCHHHHH	27.04	-
761	Phosphorylation	LELDPNLYRIGQSKI HHCCCCHHHHCCCCH	13.56	23917254
766	Phosphorylation	NLYRIGQSKIFFRTG CHHHHCCCCHHHHCC	23.62	-
767	Acetylation	LYRIGQSKIFFRTGV HHHHCCCCHHHHCCH	35.33	-
767	Ubiquitination	LYRIGQSKIFFRTGV HHHHCCCCHHHHCCH	35.33	-
826	Phosphorylation	IQRNCAAYLKLRNWQ HHHHHHHHHHHCCHH	5.95	28152594
828	Ubiquitination	RNCAAYLKLRNWQWW HHHHHHHHHCCHHHH	32.50	21906983
828	Acetylation	RNCAAYLKLRNWQWW HHHHHHHHHCCHHHH	32.50	24502337
828	Ubiquitination	RNCAAYLKLRNWQWW HHHHHHHHHCCHHHH	32.50	21906983
842	Ubiquitination	WRLFTKVKPLLQVTR HHHHHCHHHHHHHHH	31.35	-
881	Acetylation	ELKELEQKHSQLTEE HHHHHHHHHHHHHHH	35.53	27178108
883	Phosphorylation	KELEQKHSQLTEEKN HHHHHHHHHHHHHHH	33.64	26657352
886	Phosphorylation	EQKHSQLTEEKNLLQ HHHHHHHHHHHHHHH	34.17	23312004
900	Phosphorylation	QEQLQAETELYAEAE HHHHHHHHHHHHHHH	34.01	-
903	Phosphorylation	LQAETELYAEAEEMR HHHHHHHHHHHHHHH	9.00	-
968	Ubiquitination	EEEAARQKLQLEKVT HHHHHHHHHHHHHHH	32.42	-
1009	Phosphorylation	KLLEERISDLTTNLA HHHHHHHHHHHHCHH	32.56	26657352
1012	Phosphorylation	EERISDLTTNLAEEE HHHHHHHHHCHHHHH	20.73	29514088
1013	Phosphorylation	ERISDLTTNLAEEEE HHHHHHHHCHHHHHH	35.22	29514088
1016	Phosphorylation	SDLTTNLAEEEEKAK HHHHHCHHHHHHHHH	24.99	27251275
1034	Phosphorylation	KLKNKHESMISELEV HHCHHHHHHHHHHHH	22.57	26657352
1041	Phosphorylation	SMISELEVRLKKEEK HHHHHHHHHHHHHHH	15.79	27251275
1059	Ubiquitination	ELEKLKRKLEGDASD HHHHHHHHHHCCHHH	49.67	-
1065	Phosphorylation	RKLEGDASDFHEQIA HHHHCCHHHHHHHHH	45.62	26657352
1088	Acetylation	LKMQLAKKEEELQAA HHHHHHHCHHHHHHH	65.83	72623995
1088	Ubiquitination	LKMQLAKKEEELQAA HHHHHHHCHHHHHHH	65.83	-
1111	Acetylation	AQKNNALKKIRELEG HHHHHHHHHHHHHHC	43.68	7668389
1121	Phosphorylation	RELEGHISDLQEDLD HHHHCHHHHHHHHHH	26.96	26657352
1153	Phosphorylation	EELEALKTELEDTLD HHHHHHHHHHHHHHC	46.80	22199227
1158	Phosphorylation	LKTELEDTLDSTATQ HHHHHHHHHCCHHHH	24.08	22817901
1161	Phosphorylation	ELEDTLDSTATQQEL HHHHHHCCHHHHHHH	24.05	26657352
1162	Phosphorylation	LEDTLDSTATQQELR HHHHHCCHHHHHHHH	33.13	26657352
1164	Phosphorylation	DTLDSTATQQELRAK HHHCCHHHHHHHHHH	30.76	22210691
1177	Phosphorylation	AKREQEVTVLKKALD HHHHHHHHHHHHHCC	21.26	-
1187	Phosphorylation	KKALDEETRSHEAQV HHHCCHHHHHHHHHH	35.11	23312004
1189	Phosphorylation	ALDEETRSHEAQVQE HCCHHHHHHHHHHHH	32.85	26657352
1209	Phosphorylation	AQAVEELTEQLEQFK HHHHHHHHHHHHHHH	25.60	28258704
1216	Acetylation	TEQLEQFKRAKANLD HHHHHHHHHHHHHHH	51.66	7668397
1226	Ubiquitination	KANLDKNKQTLEKEN HHHHHHHHHHHHHHC	50.85	-
1266	Phosphorylation	AQVQELQSKCSDGER HHHHHHHHHCCHHHH	48.53	23312004
1291	Phosphorylation	KLQNEVESVTGMLNE HHHHHHHHHHHHCHH	30.10	26657352
1293	Phosphorylation	QNEVESVTGMLNEAE HHHHHHHHHHCHHHH	26.59	26657352
1298	Phosphorylation	SVTGMLNEAEGKAIK HHHHHCHHHHHHHHH	44.10	27251275
1312	Phosphorylation	KLAKDVASLSSQLQD HHHHHHHHHHHHHHH	28.74	26657352
1314	Phosphorylation	AKDVASLSSQLQDTQ HHHHHHHHHHHHHHH	17.34	26657352
1315	Phosphorylation	KDVASLSSQLQDTQE HHHHHHHHHHHHHHH	39.96	26657352
1335	Phosphorylation	TRQKLNVSTKLRQLE HHHHCCHHHHHHHHH	20.82	23312004
1336	Phosphorylation	RQKLNVSTKLRQLEE HHHCCHHHHHHHHHH	29.80	23312004
1347	O-linked_Glycosylation	QLEEERNSLQDQLDE HHHHHHHHHHHHHHH	33.36	28411811
1347	Phosphorylation	QLEEERNSLQDQLDE HHHHHHHHHHHHHHH	33.36	26657352
1354	Phosphorylation	SLQDQLDEEMEAKQN HHHHHHHHHHHHHHH	68.76	27251275
1367	Phosphorylation	QNLERHISTLNIQLS HHHHHHHHHHEEECC	22.25	26657352
1368	Phosphorylation	NLERHISTLNIQLSD HHHHHHHHHEEECCC	24.18	28857561
1374	Phosphorylation	STLNIQLSDSKKKLQ HHHEEECCCCHHHHH	24.38	26657352
1377	Acetylation	NIQLSDSKKKLQDFA EEECCCCHHHHHHHH	59.94	7664345
1378	Acetylation	IQLSDSKKKLQDFAS EECCCCHHHHHHHHH	63.77	7669847
1385	Phosphorylation	KKLQDFASTVEALEE HHHHHHHHHHHHHHH	32.74	26657352
1386	Phosphorylation	KLQDFASTVEALEEG HHHHHHHHHHHHHHH	20.95	28857561
1395	Acetylation	EALEEGKKRFQKEIE HHHHHHHHHHHHHHH	70.11	7668405
1405	Phosphorylation	QKEIENLTQQYEEKA HHHHHHHHHHHHHHH	25.80	-
1408	Phosphorylation	IENLTQQYEEKAAAY HHHHHHHHHHHHHHH	19.08	26657352
1415	Phosphorylation	YEEKAAAYDKLEKTK HHHHHHHHHHHHHHH	14.64	26657352
1421	Phosphorylation	AYDKLEKTKNRLQQE HHHHHHHHHHHHHHH	24.95	-
1444	Phosphorylation	DNQRQLVSNLEKKQR HHHHHHHHHHHHHHH	44.27	26657352
1448	Acetylation	QLVSNLEKKQRKFDQ HHHHHHHHHHHHHHH	58.32	7672231
1449	Acetylation	LVSNLEKKQRKFDQL HHHHHHHHHHHHHHH	46.06	7669859
1452	Acetylation	NLEKKQRKFDQLLAE HHHHHHHHHHHHHHH	51.29	72594365
1452	Methylation	NLEKKQRKFDQLLAE HHHHHHHHHHHHHHH	51.29	72594365
1452	Ubiquitination	NLEKKQRKFDQLLAE HHHHHHHHHHHHHHH	51.29	-
1465	Phosphorylation	AEEKNISSKYADERD HHHHCCCHHHHHHHH	26.37	-
1467	Phosphorylation	EKNISSKYADERDRA HHCCCHHHHHHHHHH	22.64	18083107
1484	Acetylation	EAREKETKALSLARA HHHHHHHHHHHHHHH	48.71	11922559
1484	Ubiquitination	EAREKETKALSLARA HHHHHHHHHHHHHHH	48.71	-
1487	Phosphorylation	EKETKALSLARALEE HHHHHHHHHHHHHHH	25.50	28060719
1518	Phosphorylation	AEMEDLVSSKDDVGK HHHHHHHCCCCHHCC	38.68	23312004
1519	Phosphorylation	EMEDLVSSKDDVGKN HHHHHHCCCCHHCCH	32.40	23312004
1539	Phosphorylation	KSKRALETQMEEMKT HHHHHHHHHHHHHHH	33.78	19060867
1546	Phosphorylation	TQMEEMKTQLEELED HHHHHHHHHHHHHHH	36.76	21082442
1558	Phosphorylation	LEDELQATEDAKLRL HHHHHHCCHHHHHHH	22.80	-
1562	Ubiquitination	LQATEDAKLRLEVNM HHCCHHHHHHHHHHH	46.60	-
1601	Phosphorylation	LQRQLHEYETELEDE HHHHHHHHHHHCHHH	19.87	23312004
1603	Phosphorylation	RQLHEYETELEDERK HHHHHHHHHCHHHHH	44.99	23312004
1619	Acetylation	RALAAAAKKKLEGDL HHHHHHHHHHHCCCH	45.79	7668417
1635	Phosphorylation	DLELQADSAIKGREE HHHHHHHHHHCCHHH	34.60	26657352
1649	Ubiquitination	EAIKQLRKLQAQMKD HHHHHHHHHHHHHHH	54.25	-
1667	Phosphorylation	ELEDARASRDEIFAT HHHHHHHCHHHHHHH	34.41	26657352
1674	Phosphorylation	SRDEIFATAKENEKK CHHHHHHHHHHHHHH	27.75	23312004
1680	Acetylation	ATAKENEKKAKSLEA HHHHHHHHHHHHHHH	70.39	7669871
1681	Acetylation	TAKENEKKAKSLEAD HHHHHHHHHHHHHHH	55.67	7668429
1684	Phosphorylation	ENEKKAKSLEADLMQ HHHHHHHHHHHHHHH	35.98	27499020
1701	Methylation	EDLAAAERARKQADL HHHHHHHHHHHHHHH	34.66	115385365
1719	Phosphorylation	ELAEELASSLSGRNA HHHHHHHHHHCCCHH	44.42	27251275
1720	Phosphorylation	LAEELASSLSGRNAL HHHHHHHHHCCCHHH	22.43	27251275
1722	Phosphorylation	EELASSLSGRNALQD HHHHHHHCCCHHHHH	37.34	27251275
1729	Phosphorylation	SGRNALQDEKRRLEA CCCHHHHHHHHHHHH	65.32	27251275
1731	Acetylation	RNALQDEKRRLEARI CHHHHHHHHHHHHHH	51.62	7669883
1756	Phosphorylation	QGNMEAMSDRVRKAT HCCHHHHHHHHHHHH	29.34	26657352
1763	Phosphorylation	SDRVRKATQQAEQLS HHHHHHHHHHHHHHH	25.01	23403867
1770	Phosphorylation	TQQAEQLSNELATER HHHHHHHHHHHHHHH	28.14	26657352
1775	Phosphorylation	QLSNELATERSTAQK HHHHHHHHHHHHHHH	44.55	23403867
1810	Phosphorylation	EMEGAVKSKFKSTIA HHHHHHHHHHHHHHH	36.40	20860994
1811	Acetylation	MEGAVKSKFKSTIAA HHHHHHHHHHHHHHH	51.60	7680073
1813	Acetylation	GAVKSKFKSTIAALE HHHHHHHHHHHHHHH	50.88	7680085
1814	Phosphorylation	AVKSKFKSTIAALEA HHHHHHHHHHHHHHH	28.33	20068231
1815	Phosphorylation	VKSKFKSTIAALEAK HHHHHHHHHHHHHHH	18.41	20068231
1868	Phosphorylation	ERKMAEQYKEQAEKG HHHHHHHHHHHHHHH	14.16	-
1925	Methylation	GREVNALKSKLRRGN HHHHHHHHHHHHCCC	43.04	-
1934	Phosphorylation	KLRRGNETSFVPSRR HHHCCCCCCCCCCCC	31.31	23532336
1935	Phosphorylation	LRRGNETSFVPSRRS HHCCCCCCCCCCCCC	20.33	28857561
1937 (in isoform 4)	Phosphorylation	-	4.16	24670416
1939	Phosphorylation	NETSFVPSRRSGGRR CCCCCCCCCCCCCCE	34.72	26657352
1942	Phosphorylation	SFVPSRRSGGRRVIE CCCCCCCCCCCEEEE	44.48	26657352
1944 (in isoform 3)	Phosphorylation	-	18.57	24670416
1954	Phosphorylation	VIENADGSEEETDTR EEECCCCCCCCCCCC	42.24	23911959
1958	Phosphorylation	ADGSEEETDTRDADF CCCCCCCCCCCCCCC	46.05	26657352
1960	Phosphorylation	GSEEETDTRDADFNG CCCCCCCCCCCCCCC	37.56	30242111
1961	Phosphorylation	SEEETDTRDADFNGT CCCCCCCCCCCCCCC	39.67	24719451
1968	Phosphorylation	RDADFNGTKASE--- CCCCCCCCCCCC---	25.25	28857561
1971	Phosphorylation	DFNGTKASE------ CCCCCCCCC------	100.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYH11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYH11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYH11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYO1E_HUMAN	MYO1E	physical	22939629
C4BPA_HUMAN	C4BPA	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
MYL6_HUMAN	MYL6	physical	26496610
RAD51_HUMAN	RAD51	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
1433E_HUMAN	YWHAE	physical	26496610
ARPC5_HUMAN	ARPC5	physical	26496610
ARP3_HUMAN	ACTR3	physical	26496610
RBP1_HUMAN	RALBP1	physical	26496610
POC1A_HUMAN	POC1A	physical	26496610
ASTE1_HUMAN	ASTE1	physical	26496610
MED4_HUMAN	MED4	physical	26496610
LRC59_HUMAN	LRRC59	physical	26496610
CING_HUMAN	CGN	physical	26496610
INF2_HUMAN	INF2	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
TBC31_HUMAN	TBC1D31	physical	26496610
UBX2A_HUMAN	UBXN2A	physical	26496610
PLBL2_HUMAN	PLBD2	physical	26496610
TM189_HUMAN	TMEM189	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13
• : q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
• 132900:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1954, AND MASSSPECTROMETRY.
PubMed: 18318008

"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1539 AND THR-1546, ANDMASS SPECTROMETRY.
PubMed: 19367720