| UniProt ID | POC1A_HUMAN | |
|---|---|---|
| UniProt AC | Q8NBT0 | |
| Protein Name | POC1 centriolar protein homolog A | |
| Gene Name | POC1A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 407 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Component of both mother and daughter centrioles. | |
| Protein Description | Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.. | |
| Protein Sequence | MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | AVTCVDFSINTKQLA CCEEEECEECHHHHH | 15.51 | 24505115 | |
| 61 | Ubiquitination | AYRFTGHKDAVTCVN CCCCCCCCCCEEEEE | 49.04 | - | |
| 65 | Phosphorylation | TGHKDAVTCVNFSPS CCCCCCEEEEEECCC | 16.68 | 25850435 | |
| 70 | Phosphorylation | AVTCVNFSPSGHLLA CEEEEEECCCCCEEE | 16.98 | 25850435 | |
| 72 | Phosphorylation | TCVNFSPSGHLLASG EEEEECCCCCEEECC | 37.33 | 25850435 | |
| 78 | Phosphorylation | PSGHLLASGSRDKTV CCCCEEECCCCCCEE | 36.95 | 25850435 | |
| 80 | Phosphorylation | GHLLASGSRDKTVRI CCEEECCCCCCEEEE | 34.51 | 25850435 | |
| 90 | Ubiquitination | KTVRIWVPNVKGEST CEEEEEECCCCCCCC | 25.54 | 29967540 | |
| 93 | Ubiquitination | RIWVPNVKGESTVFR EEEECCCCCCCCEEE | 64.70 | - | |
| 97 | Phosphorylation | PNVKGESTVFRAHTA CCCCCCCCEEEEEEC | 21.25 | 24719451 | |
| 128 | Ubiquitination | ASDDKTVKVWATHRQ CCCCCEEEEEEECHH | 36.97 | 29967540 | |
| 129 | Ubiquitination | SDDKTVKVWATHRQK CCCCEEEEEEECHHH | 3.50 | 29967540 | |
| 132 | Ubiquitination | KTVKVWATHRQKFLF CEEEEEEECHHHHHH | 11.24 | 29967540 | |
| 167 | Ubiquitination | IVSASDDKTVKLWDK EEECCCCCCEEEECC | 61.27 | 29967540 | |
| 170 | Ubiquitination | ASDDKTVKLWDKSSR CCCCCCEEEECCCCH | 49.44 | 29967540 | |
| 174 | Ubiquitination | KTVKLWDKSSRECVH CCEEEECCCCHHHHH | 38.46 | - | |
| 252 | Phosphorylation | ITASSDSTLKILDLM EEECCCCCEEEEHHH | 36.74 | - | |
| 319 | Phosphorylation | KVPRPPATLASSMGN CCCCCCHHHHHCCCC | 28.73 | 25693802 | |
| 319 (in isoform 2) | Phosphorylation | - | 28.73 | 24719451 | |
| 322 (in isoform 2) | Phosphorylation | - | 24.78 | 24043423 | |
| 322 | Phosphorylation | RPPATLASSMGNLPE CCCHHHHHCCCCCCC | 24.78 | 25693802 | |
| 323 (in isoform 2) | Phosphorylation | - | 25.71 | 24043423 | |
| 323 | Phosphorylation | PPATLASSMGNLPEV CCHHHHHCCCCCCCC | 25.71 | 25693802 | |
| 328 (in isoform 2) | Phosphorylation | - | 43.49 | 24043423 | |
| 330 (in isoform 2) | Phosphorylation | - | 9.68 | 24043423 | |
| 337 (in isoform 2) | Phosphorylation | - | 38.31 | 24719451 | |
| 339 (in isoform 2) | Phosphorylation | - | 31.93 | 24719451 | |
| 341 | Phosphorylation | VPPGRGRSVESVQSQ CCCCCCCCHHHHCCC | 32.82 | 27251275 | |
| 344 | Ubiquitination | GRGRSVESVQSQPQE CCCCCHHHHCCCCCC | 24.25 | 29967540 | |
| 344 | Phosphorylation | GRGRSVESVQSQPQE CCCCCHHHHCCCCCC | 24.25 | 27251275 | |
| 347 | Phosphorylation | RSVESVQSQPQEPVS CCHHHHCCCCCCCCC | 41.49 | 27251275 | |
| 354 | Ubiquitination | SQPQEPVSVPQTLTS CCCCCCCCCCHHHHH | 38.50 | 29967540 | |
| 354 | Phosphorylation | SQPQEPVSVPQTLTS CCCCCCCCCCHHHHH | 38.50 | 27251275 | |
| 374 | Phosphorylation | VGQLDVLTQTVSILE HHHHHHHHHHHHHHH | 23.26 | 27251275 | |
| 376 | Phosphorylation | QLDVLTQTVSILEQR HHHHHHHHHHHHHHH | 15.81 | 27251275 | |
| 378 | Phosphorylation | DVLTQTVSILEQRLT HHHHHHHHHHHHHHC | 25.50 | 27251275 | |
| 385 | Phosphorylation | SILEQRLTLTEDKLK HHHHHHHCCCHHHHH | 33.55 | - | |
| 387 | Phosphorylation | LEQRLTLTEDKLKQC HHHHHCCCHHHHHHH | 36.58 | - | |
| 392 | Ubiquitination | TLTEDKLKQCLENQQ CCCHHHHHHHHHHHH | 44.71 | 29967540 | |
| 406 | Phosphorylation | QLIMQRATP------ HHHHHHCCC------ | 31.55 | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of POC1A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of POC1A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of POC1A_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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